Presence of renin within intramitochondrial dense bodies of the rat adrenal cortex

American Journal of Physiology - Endocrinology and Metabolism

Volumn 271, Issue 3 34-3, 1996, Pages

  Peters, Jörg ^a   Kränzlin, Bettina ^b   Schaeffer, Sabine ^b   Zimmer, Jutta ^b   Resch, Stefan ^b   Bachmann, Sebastian ^b   Gretz, Norbert ^b   Hackenthal, Eberhard ^b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b NONE

Author keywords

aldosterone; electron microscopy; morphology; steroids

Indexed keywords

ALDOSTERONE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR;

ADRENAL CORTEX; ANIMAL TISSUE; ARTICLE; ELECTRON MICROSCOPY; ENZYME LOCALIZATION; GLOMERULOSA CELL; MITOCHONDRIAL MEMBRANE; NEPHRECTOMY; NONHUMAN; PLASMA RENIN ACTIVITY; PRIORITY JOURNAL; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; RENIN RELEASE; TISSUE SPECIFICITY; ZONA GLOMERULOSA;

EID: 0029794074     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1996.271.3.e439     Document Type: Article

References (37)

1. Aguilera, G., A. Schirar, A. Baukal, and K. J. Catt. Circulating angiotensin II and adrenal receptors after nephrectomy. Nature Lond. 289: 507-509, 1981.
2. Bachmann, S., J. Peters, E. Engler, D. Ganten, and J. Mullins. Transgenic rats carrying the mouse renin gene-morphological characterization of a low renin hypertension model. Kidney Int. 41: 24-36, 1992.
3. Burnham, C. E., C. L. Hawelu-Johnson, B. M. Frank, and K. R. Lynch. Molecular cloning of rat renin cDNA and its gene. Proc. Natl. Acad. Sci. USA 84: 5605-5609, 1987.
4. Deschepper, C. F., S. H. Mellon, F. Cumin, J. D. Baxter, and W. F. Ganong. Analysis by immunocytochemistry and in situ hybridization of renin and its mRNA in kidney, testis, adrenal, and pituitary of the rat. Proc. Natl. Acad. Sci. USA 83: 7552-7556, 1986.
5. Dicou, E., and P. Brachet. Precursors of the nerve growth factor τ subunit and renin bind to microtubules. Eur. J. Biochem. 143: 381-387, 1984.
6. Doi, Y., K. Atarashi, R. Franco-Saenz, and P. J. Mulrow. Effect of changes in sodium or potassium balance, and nephrectomy, on adrenal renin and aldosterone concentrations. Hypertension Dallas 6, Suppl. 1: 124-129, 1984.
7. Doi, Y., R. Franco-Saenz, and P. J. Mulrow. Evidence for an extrarenal source of inactive renin in rats. Hypertension Dallas 6: 627-632, 1984.
8. Dzau, V. J., D. W. Burt, and R. E. Pratt. Molecular biology of the renin-angiotensin system. Am. J. Physiol. 255 (Renal Fluid Electrolyte Physiol. 24): F563-F573, 1988.
9. Giacomelli, F., J. Wiener, and D. Spiro. Cytological alterations related to stimulation of the zona glomerulosa of the adrenal gland. J. Cell Biol. 26: 500-521, 1965.
10. Hackenthal, E., R. Hackenthal, and U. Hilgenfeldt. Isorenin, pseudorenin, cathepsin D and renin: a comparative enzymatic study of angiotensin-forming enzymes. Biochim. Biophys. Acta 522: 574-588, 1978.
11. Hackenthal, E., R. Hackenthal, and K. G. Hofbauer. No evidence for product inhibition of the renin-angiotensinogen reaction in the rat. Circ. Res., Suppl. 2: II49-II54, 1977.
12. Hare, G. M., A. Y. Loh, and D. H. Osmond. Extrarenal production and activation of human plasma prorenin: the evidence after venous occlusion. Can. J. Physiol. Pharmacol. 67: 59-67, 1989.
13. Hatano, O., Y. Sagara, T. Omura, and A. Takakusu. Immunocytochemical localization of adrenodoxin in bovine adrenal cortex by protein A-gold technique. Histochemistry 91: 89-97, 1989.
14. Kai, O., R. Fujioka, and M. Yasuda. Light and electron microscopic studies of intramitochondrial bodies in bovine adrenocortical cells by proteolytic digestion. Histochemistry 57: 217-221, 1978.
15. Kifor, I., T. J. Moore, F. Fallo, E. Sperling, A. Menachery, C.-Y. Chiou, and G. H. Williams. The effect of sodium intake on angiotensin content of the rat adrenal gland. Endocrinology 128: 1277-1283, 1991.
16. Kim, S., M. Hosoi, K. Nakajima, and K. Yamamoto. Immunological evidence that kidney is primary source of circulating inactive prorenin in rats. Am. J. Physiol. 260 (Endocrinol. Metab. 23): E526-E536, 1991.
17. Laird, S. M., G. P. Vinson, and B. J. Whitehouse. Steroid sequestration within the rat adrenal zona glomerulosa. J. Endocrinol. 117: 191-196, 1988.
18. Langford, K. G., Y. Zhou, L. D. Russell, J. N. Wilcox, and K. E. Bernstein. Regulated expression of testis angiotensin-converting enzyme during spermatogenesis in mice. Biol. Reprod. 48: 1210-1218, 1993.
19. Miyazaki, S., A. Sakanaka, K. Chimori, J. Kosaka, R. Goi, K. Miura, and F. Suzuki. Reno-submandibular axis controls release of extrarenal inactive renin. J. Hypertens. 6: 33-40, 1988.
20. Mizuno, K., L. H. Hoffman, J. C. McKenzie, and T. Inagami. Presence of renin secretory granules in rat adrenal gland and stimulation of renin secretion by angiotensin II but not by adrenocorticotropin. J. Clin. Invest. 82: 1007-1016, 1988.
21. Mullins, J. J., J. Peters, and D. Ganten. Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene. Nature Lond. 344: 541-544, 1990.
22. Nakamaru, M., K. S. Misono, M. Naruse, R. J. Workman, and T. Inagami. A role for the adrenal renin-angiotensin system in the regulation of potassium-stimulated aldosterone production. Endocrinology 117: 1772-1778, 1985.
23. Naruse, M., K. Naruse, T. Inagaki, and T. Inagami. Immunoreactive renin in mouse adrenal gland: localization in the inner cortical region. Hypertension Dallas 6: 275-280, 1984.
24. Oda, H., D. P. Lotshaw, R. Franco-Saenz, and P. J. Mulrow. Local generation of angiotensin II as a mechanism of aldosterone secretion in rat adrenal capsules. Proc. Soc. Exp. Biol. Med. 196: 175-177, 1991.
25. Peters, J., K. Münter, M. Bader, E. Hackenthal, J. J. Mullins, and D. Ganten. Increased adrenal renin in transgenic hypertensive rats, TGR(mREN2)27, and its regulation by cAMP, angiotensin II and calcium. J. Clin. Invest. 91: 742-747, 1993.
26. Phillips, M. I., E. A. Speakman, and B. Kimura. Levels of angiotensin and molecular biology of the tissue renin angiotensin systems. Regul. Pept. 43: 1-20, 1993.
27. Radziwill, R., M. Stuzmann, U. Hilgenfeldt, and E. Hackenthal. Converting enzyme inhibitor-induced changes of plasma angiotensinogen concentration in the rat. Eur. J. Pharmacol. 122: 59-64, 1986.
28. Rocco, S., P. Rebuffat, M. Cimolato, G. Opocher, J. Peters, G. Mazzocchi, D. Ganten, F. Mantero, and G. G. Nussdorfer. Zona glomerulosa of the adrenal gland in a transgenic strain of rat: a morphologic and functional study. Cell Tissue Res. 278: 21-28, 1994.
29. Smith, A. F. Malate Dehydrogenases. In: Methods of Enzymatic Analysis: Oxidoreductases, Transferases (3rd ed.), edited by H. U. Bergmeyer. Basel: Verlag Chemie, 1985, vol. 3, p. 163-175.
30. 3H]captopril autoradiography. Endocrinology 118: 1690-1699, 1986.
31. Sueiras-Diaz, J., D. M. Jones, M. Szelke, B. J. Leckie, E. C. H. Wallace, and J. J. Morton. Inhibitors of rat renin. In: Peptides 1988. New York: de Gruyter, 1989, p. 396-398.
32. Taugner, R., and E. Hackenthal. The Juxtaglomerular Apparatus. Berlin: Springer, 1989.
33. Taugner, R., M. Marin-Grez, R. Keilbach, and E. Hackenthal. Immunoreactive renin and angiotensin II in the afferent glomerular arterioles of rats with hypertension due to unilateral renal artery constriction. Histochemistry 76: 61-69, 1982.
34. Taugner, R., S. Yokota, C. P. Bührle, and E. Hackenthal. Cathepsin D coexists with renin in the secretory granules of juxtaglomerular epithelioid cells. Histochemistry 84: 19-22, 1986.
35. Urata, H., M. C. Khosla, F. M. Bumpus, and A. Husain. Evidence for extracellular, but not intracellular, generation of angiotensin II in the rat adrenal zona glomerulosa. Proc. Natl. Acad. Sci. USA 85: 8251-8255, 1988.
36. Yamaguchi, T., Z. Naito, G. D. Stoner, R. Franco-Saenz, and P. J. Mulrow. Role of the adrenal renin-angiotensin system on adrenocorticotropic hormone-and potassium-stimulated aldosterone production by rat adrenal glomerulosa cells in monolayer culture. Hypertension Dallas 16: 635-641, 1990.
37. Zhao, Y., M. Bader, R. Kreutz, M. Fernandez-Alfonso, F. Zimmermann, U. Ganten, R. Metzger, D. Ganten, J. Mullins, and J. Peters. Ontogenetic regulation of mouse Ren-2d renin gene in transgenic hypertensive rats, TGR(mREN2)27. Am. J. Physiol. 265 (Endocrinol. Metab. 28): E699-E707, 1993.