Effects of an inhibitor of poly(ADP-ribose) polymerase, desmethylselegiline, trientine, and lipoic acid in transgenic ALS mice

Experimental Neurology

Volumn 168, Issue 2, 2001, Pages 419-424

  Andreassen, Ole A ^a   Dedeoglu, Alpaslan ^a   Friedlich, Avi ^b   Ferrante, Kimberly L ^a   Hughes, Duncan ^b   Szabo, Cesar ^c   Beal, M Flint ^b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c INOTEK CORPORATION   (United States)

Author keywords

Amyotrophic lateral sclerosis; Apoptosis; Copper; Free radicals; Lipoic acid; Oxidative damage; Poly(ADP ribose) polymerase; Trienterine

Indexed keywords

10 (N METHYL N PROPARGYLAMINOMETHYL)DIBENZO[B,F]OXEPIN; FREE RADICAL; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; NEUROPROTECTIVE AGENT; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NORSELEGILINE; THIOCTIC ACID; TRIENTINE; UNCLASSIFIED DRUG;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; IN VITRO STUDY; MOUSE; NERVE CELL DEGENERATION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; TRANSGENIC MOUSE;

EID: 0035068202     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.2001.7633     Document Type: Article

References (35)

1. Prevention of mutant SOD1 motoneuron degeneration by copper chelators in vitro
2. ALS, SOD and peroxynitrite
3. Amyotrophic lateral sclerosis: Recent insights from genetics and transgenic mice
4. ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease and SOD1-containing inclusions
5. Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1
6. Reduced apoptosis after nerve growth factor and serum withdrawal: Conversion of tetrameric glyceraldehyde-3-phosphate dehydrogenase to a dimer
7. Involvement of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and p53 in neuronal apoptosis: Evidence that GAPDH is upregulated by p53
8. Poly(ADP-ribose) polymerase gene disruption renders mice resistent to cerebral ischemia
9. Protective effects of 5-iodo-6-amino-1,2 benzopyrone, an inhibitor of poly(ADP-ribose) synthetase against peroxynitrite-induced glial damage and stroke development
10. Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase
11. Hydroxyl radical formation from cuprous ion and hydrogen peroxide: A spin-trapping study
12. Antioxidants and inhibitors of glutamatergic transmission have therapeutic benefit in a transgenic model of familial amyotrophic lateral sclerosis
13. Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation
14. (R)alpha-Lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate
15. The copper chelator d-penicillamine delays onset of disease and extends survival in a transgenic mouse model of familial amyotrophic lateral sclerosis
16. Nuclear localization of overexpressed glyceraldehyde-3-phosphate dehydrogenase in cultured cerebellar neurons undergoing apoptosis
17. Glyceraldehyde-3-phosphate dehydrogenase, the putative target of the antiapoptotic compounds CGP 3466 and R-(-)-deprenyl
18. Selegiline is ineffective in a collaborative double-blind, placebo-controlled trial for treatment of amyotrophic lateral sclerosis
19. Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model
20. Poly(ADPribose) polymerase activation mediates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism
21. Comparison of the effect of alpha-lipoic acid and alphatocopherol supplementation on measures of oxidative stress
22. Age-related changes in LTP and antioxidant defenses are reversed by an alpha-lipoic acid-enriched diet
23. Lack of apoptosis in mice with ALS
24. Deprenyl and desmethylselegiline protect mesencephalic neurons from toxicity induced by glutathione depletion
25. L-(-)desmethylselegiline, a metabolite of selegiline [L-(-)-deprenyl], protects mesencephalic dopamine neurons from excitotoxicity in vitro
26. Benefit of a combined treatment with trientine and ascorbate in familial amyotrophic lateral sclerosis model mice
27. α-lipoic acid protects against reperfusion injury following cerebral ischemia in rats
28. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
29. Glyceraldehyde-3-phosphate dehydrogenase: Nuclear translocation participates in neuronal and nonneuronal cell death
30. Suppression of experimental allergic encephalomyelitis by administration of 5-iodo-6-amino-1,2-benzopyrone, a novel inhibitor of poly(ADP-ribose) synthetase
31. Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly(ADP-ribose) synthase
32. 1-antiproteinase inactivation by oxidized and reduced lipoic acid
33. Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis
34. Neuroprotective effects of alpha-lipoic acid and its enantiomers demonstrated in rodent models of focal cerebral ischemia
35. An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria