The copper chelator d-penicillamine delays onset of disease and extends survival in a transgenic mouse model of familial amyotrophic lateral sclerosis

European Journal of Neuroscience

Volumn 9, Issue 7, 1997, Pages 1548-1551

  Hottinger, Andreas F ^a   Fine, Eric G ^a   Gurney, Mark E ^b   Zurn, Anne D ^a   Aebischer, Patrick ^a,c  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b PFIZER INC   (United States)

^c LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

Amyotrophic lateral sclerosis; Copper; Copper chelators; d penicillamine; Superoxide dismutase

Indexed keywords

CHELATING AGENT; COPPER ZINC SUPEROXIDE DISMUTASE; PENICILLAMINE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DISEASE COURSE; FAMILIAL DISEASE; GENE MUTATION; HISTOLOGY; MOTONEURON; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SURVIVAL; TRANSGENIC MOUSE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; BRAIN STEM; CELL COUNT; CHELATING AGENTS; COPPER; FACIAL NERVE; GENES; HUMANS; MICE; MICE, TRANSGENIC; MOTOR NEURONS; MUTATION; PENICILLAMINE; SUPEROXIDE DISMUTASE; SURVIVAL ANALYSIS;

EID: 0030862630     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1460-9568.1997.tb01511.x     Document Type: Article

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