Neuroprotective effects of α-lipoic acid and its enantiomers demonstrated in rodent models of focal cerebral ischemia

Neuropharmacology

Volumn 35, Issue 3, 1996, Pages 369-375

  Wolz, P ^a   Krieglstein, J ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Dihydrolipoic acid; Focal cerebral ischemia; Lipoic acid; Lipoic acid enantiomers; Neuroprotection

Indexed keywords

DIHYDROLIPOATE; NEUROPROTECTIVE AGENT; THIOCTIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; BRAIN ISCHEMIA; CONTROLLED STUDY; ENANTIOMER; HISTOLOGY; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0029939624     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/0028-3908(95)00172-7     Document Type: Article

References (38)

1. Astrup J., Siesjö B. K. and Symon L. (1981) Thresholds in cerebral ischemia: the ischemic penumbra. Stroke 12: 723-725.
2. Attwell D., Miller B. and Sarantis M. (1993) Arachidonic acid as a messenger in the central nervous system. Semin. Neurosci. 5: 159-169.
3. Aust S. D., Morehouse L. A. and Thomas C. E. (1985) Role of metals in oxygen radical reactions. Free Rad. Biol. Med. 1: 3-25.
4. Backhauß C., Karkoutly C., Welsch M. and Krieglstein J. (1992) A mouse model of focal cerebral ischemia for screening neuroprotective drug effects. J. Pharm. Meth. 27: 27-32.
5. Bast A. and Haenen G. R. M. M. (1988) Interplay between lipoic acid and glutathione in the protection against microsomal lipid peroxidation. Biochim. Biophys. Acta 963: 558-561.
6. Beck T. and Bielenberg G. W. (1991) The effects of two 21-aminosteroids on overt infarct size 48 hours after middle cerebral artery occlusion in the rat. Brain Res. 560: 159-162.
7. Benveniste H., Drejer J., Schousboe A. and Diemer N. H. (1984) Elevation of extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J. Neurochem. 43: 1369-1374.
8. Bromont C., Marie C. and Bralet J. (1989) Increased lipid peroxidation in vulnerable brain regions after transient forebrain ischemia. Stroke 20: 918-924.
9. Chan P. H. (1994) Oxygen radicals in focal cerebral ischemia. Brain Pathol. 4: 59-65.
10. Choi D. W. (1988) Glutamate neurotoxicity and diseases of the nervous system. Neuron 1: 623-634.
11. Ehrenthal W. and Prellwitz W. (1986) Biochemie und Pharmakologie der Liponsäure. In: Interdisziplinäre Bestandsaufnahme der Polyneuropathien (Neuendörfer B. and Sailer D., Eds), pp. 154-166. Perimed Fachbuchverlag, Erlangen.
12. Greenamyre J. T., Garcia-Osuna M. and Greene J. G. (1994) The endogenous cofactors, thioctic acid and dihydrolipoic acid, are neuroprotective against NMDA and malonic acid lesions of striatum. Neurosci. Lett. 171: 17-20.
13. Hakim A. M. (1987) The cerebral ischemic penumbra. Can. J. Neurol. Sci. 14: 557-559.
14. Hall E. D. (1993) Cerebral ischemia, free radicals and antioxidant protection. Free Rad. Dam. Antiox. Interact. 21: 334-339.
15. Hall E. D. and Braughler J. M. (1989) Central nervous system trauma and stroke. Free Rad. Biol. Med. 6: 303-313.
16. Haramaki N., Packer L., Assadnazari H. and Zimmer G. (1993) Cardiac recovery during post-ischemic reperfusion is improved by combination of vitamin E with dihydrolipoic acid. Biochem. Biophys. Res. Commun. 196: 1101-1107.
17. Jocelyn P. C. (1967) The standard redox potential of cysteine-cystine from the thiol-disulphide exchange reaction with glutathione and lipoic acid. Eur. J. Biochem. 2: 327-331.
18. Kagan V. E., Shvedova A., Serbinova E., Khan S., Swanson C., Powell R. and Packer L. (1992) Dihydrolipoic acid - a universal antioxidant both in the membrane and in the aqueous phase. Biochem. Pharmacol. 44: 1637-1649.
19. McCord J. M. (1985) Oxygen-derived free radicals in postischemic tissue injury. N. Eng. J. Med. 312: 159-163.
20. Müller U. and Krieglstein J. (1995) Prolonged pretreatment with α-lipoic acid protects cultured neurons against hypoxic, glutamate-or iron-induced injury. J. Cereb. Blood Flow Metab. 15: 624-630.
21. Müller U., Lippert K., Prehn J. H. M. and Krieglstein J. (1993) Chronic treatment with thioctic acid reduces excitotoxic neuronal damage in vitro. J. Cereb. Blood Flow Metab. 13: 673 (abstr.).
22. Murase K., Hattori A., Kohno M. and Hayashi K. (1993) Stimulation of nerve growth factor synthesis/secretion in mouse astroglial cells by coenzymes. Biochem. Molec. Biol. Int. 30: 615-621.
23. Oliver C. N., Starke-Reed P. E., Stadtman E. R., Liu G. J., Carney J. M. and Floyd R. A. (1990) Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/reperfusion-induced injury to gerbil brain. Proc. natn. Acad. Sci. 87: 5144-5157.
24. Oubidar M., Boquillon M., Marie C., Schreiber L. and Bralet J. (1994) Ischemia-induced brain iron delocalization: effects of iron chelators. Free Rad. Biol. Med. 16: 861-867.
25. Patt A., Harken A. H., Burton L. K., Rodell T. C., Piermattei D., Schorr W. J., Parker N. B., Berger E. M., Horesh I. R., Terada L. S., Linas S. L., Cheronis J. C. and Repine J. E. (1988) Xanthine oxidase-derived hydrogen peroxide contributes to ischemia reperfusion-induced edema in gerbil brains. J. Clin. Invest. 81: 1556-1562.
26. Peinado J., Sies H. and Akerboom T. P. M. (1989) Hepatic lipoate uptake. Arch. Biochem. Biophys. 2: 389-395.
27. Prehn J. H. M., Karkoutly C., Nuglisch J., Peruche B. and Krieglstein J. (1992) Dihydrolipoate reduces neuronal injury after cerebral ischemia. J. Cereb. Blood Flow Metab. 12: 78-87.
28. Pruijn F. B., Haenen G. R. M. M. and Bast A. (1991) Interplay between vitamin E, glutathione and dihydrolipoic acid in protection against lipid peroxidation. Fat Sci. Technol. 6: 216-221.
29. Scholich H., Murphy M. E. and Sies H. (1989) Antioxidant activity of dihydrolipoate against microsomal lipid peroxidation and its dependence on α-tocopherol. Biochim. Biophys. Acta 1001: 256-261.
30. Silvia R. C., Piercey M. F., Hoffmann W. E., Chase R. L., Braughler J. M. and Tang A. H. (1987) U74006, an inhibitor of lipid peroxidation protects against lesion development following experimental stroke in cat: histological and metabolic analysis. Neurosci. Abstr. 13: 1495.
31. Suzuki Y. J., Tsuchiya M. and Packer L. (1991) Thioctic acid and dihydrolipoic acid are novel antioxidants which interact with reactive oxygen species. Free Rad. Res. Comm. 15: 255-263.
32. Suzuki Y. J., Tsuchiya M. and Packer L. (1993) Antioxidant activities of dihydrolipoic acid and its structural homologues. Free Rad. Res. Comm. 2: 115-122.
33. Tamura A., Graham D. I., McCulloch J. and Teasdale G. M. (1981) Focal cerebral ischemia in rats: 1. Description of technique and early neuropathological consequences following middle cerebral artery occlusion. J. Cereb. Blood Flow Metab. 1: 53-60.
34. Tang L. and Aizenman E. (1993) Allosteric modulation of the NMDA receptor by dihydrolipoic acid and lipoic acid in rat cortical neurons in vitro. Neuron 11: 857-863.
35. Traystman R. J., Kirsch J. R. and Koehler R. C. (1992) Oxygen radical mechanism of brain injury following ischemia and reperfusion. J. appl. Physiol. 4: 1185-1195.
36. Welsh F. A., Sakamoto T., McKee A. E. and Sims R. E. (1987) Effects of lactacidosis on pyridin nucleotide stability during ischemia in mouse brain. J. Neurochem. 49: 846-851.
37. White B. C., Daya A., DeGracia D. J., O'Neil B. J., Skjärlund J. M., Trumble S., Krause G. S. and Rafols J. A. (1993) Fluorescent histochemical localization of lipid peroxidation during brain reperfusion following cardiac arrest. Acta Neuropathol. 86: 1-9.
38. Whittemore S. R. and Seiger A. (1987) The expression, localization and functional significance of β-nerve growth factor in the central nervous system. Brain Res. Rev. 12: 439-464.