Age-related changes in LTP and antioxidant defenses are reversed by an α-lipoic acid-enriched diet

Neurobiology of Aging

Volumn 20, Issue 6, 1999, Pages 655-664

  McGahon, Bernadette M ^a   Martin, Donen S D ^a   Horrobin, David F ^b   Lynch, Marina A ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b Laxdale Ltd   (United Kingdom)

Author keywords

Lipoic acid; Arachidonic acid; Glutamate release; Hippocampus; IL 1; Long term potentiation

Indexed keywords

ALPHA TOCOPHEROL; ARACHIDONIC ACID; FATTY ACID DERIVATIVE; GLUTAMIC ACID; INTERLEUKIN 1BETA; LINOLEIC ACID; LINOLENIC ACID; PALMITIC ACID; SUPEROXIDE DISMUTASE; THIOCTIC ACID;

AGED; AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DENTATE GYRUS; DIET; HIPPOCAMPUS; LONG TERM POTENTIATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

AGING; ANIMALS; ANTIOXIDANTS; BRAIN; DIET; GLUTAMIC ACID; LONG-TERM POTENTIATION; MALE; RATS; RATS, WISTAR; THIOCTIC ACID; TIME FACTORS;

EID: 0033393805     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-4580(99)00050-0     Document Type: Article

References (40)

1. Barnes C.A. Memory deficits associated with senescence a neurophysiological and behavioral study in the rat . J Comp Physiol Psych. 93:1979;74-104.
2. Barnes C.A. Effects of aging on the dynamics of information processing and synaptic weight changes in the mammalian hippocampus. Prog Brain Res. 86:1990;89-104.
3. 6-desaturate activity. Biochim Biophys Acta. 1083:1991;187-192.
4. Bienwenga G.P., Haenen G.R., Bast A. The pharmacology of the antioxidant lipoic acid. Gen Pharmacol. 29:1997;315-331.
5. Bierhaus A., Chevion S., Chevion M., Hofmann M., Quehenberger P., Illmer T., Luther T., Berentshtein E., Tritschler H., Muller M., Wahl P., Ziegler R., Nawroth P.P. Advanced glycation end product-induced activation of NF-kappa B is suppressed by alpha-lipoic acid in cultured endothelial cells. Diabetes. 46:1997;1482-1490.
6. Bliss T.V.P., Collingridge G.L. A synaptic model of memory long-term potentiation in the hippocampus . Nature. 361:1993;31-39.
7. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of proteins utilizing the principle of protein dye binding. Anal Biochem. 72:1976;248-254.
8. Canevari L., Richter-Levin G., Bliss T.V.P. LTP in the dentate gyrus is associated with a persistent NMDA receptor-dependent enhancement of synaptosomal glutamate release. Brain Res. 667:1994;115-117.
9. Cao X., Phillis J.W. The free radical scavenger, alpha lipoic acid, protects against cerebral ischemia-reperfusion injury in gerbils. Free Radic Res. 23:1995;265-279.
10. Choi J.H., Yu B.P. Brain synaptosomal aging free radicals and membrane fluidity . Free Radic Biol Med. 18:1995;133-139.
11. Clements M.P., Bliss T.V.P., Lynch M.A. Increase in arachidonic acid in a postsynaptic membrane fraction following the induction of long-term potentiation in the dentate gyrus. Neuroscience. 45:1991;379-389.
12. Davis S, Markowska AL, Wenk GL, Barnes CA. Acetyl-L-carnitine. Behavioural, electrophysiological and neurochemical effects. Neurobiol Aging 1993;14:107-5.
13. deToledo-Morrell L., Morrell F. Electrophysiological markers of aging and memory loss in rats. Ann NY Acad Sci. 444:1985;296-311.
14. Dupree D.L., Bradley J., Turner D.A. Age-related alterations in potentiation in the CA1 region in F344 rats. Neurobiol Aging. 14:1993;249-258.
15. Haan E.A., Bowen D.M. Protection of neocortical prisms from freeze-thaw injury by dimethylsulphoxide. J Neurochem. 37:1981;243-246.
16. Herrero I., Miras-Portugal M.T., Sanchez-Prieto J. Positive feedback of glutamate exocytosis by metabotropic presynaptic receptor stimulation. Nature. 360:1992;163-166.
17. Horrobin D.F. Loss of delta-6-desaturase activity as a key factor in aging. Med Hypotheses. 7:1981;1211-1220.
18. Landfield P.W., McGaugh J.L., Lynch G. Impaired synaptic potentiation processes in the hippocampus of aged, memory-deficient rats. Brain Res. 150:1978;85-101.
19. Lynch M.A. Age-related impairment in long-term potentiation in hippocampus a role for the cytokine, IL-1β? Prog Neurobiol. 56:1998;1-19.
20. Lynch MA, Clements MP, Voss KL, Bramham CR, Bliss TVP. Is arachidonic acid a retrograde messenger in long-term potentiation? Biochem Soc Trans 1991;19:391-86.
21. Lynch M.A., Voss K.L. Membrane arachidonic acid concentration correlates with age and induction of long-term potentiation in the dentate gyrus in the rat. Eur J Neurosci. 6:1994;1008-1014.
22. Miwa H., Yamamoto M., Nishida T. Assay of free and total fatty acids (as 2-nitrophenylhydrazides) by high-performance liquid chromatography (HPLC). Clin Chim Acta. 155:1996;95-102.
23. McGahon B., Lynch M. A study of the synergism between metabotropic glutamate receptor activation and arachidonic acid in the rat hippocampus. NeuroReport. 5:1994;2353-2357.
24. McGahon B., Lynch M.A. The synergism between metabotropic glutamate receptor activation and arachidonic acid on glutamate release is occluded by induction of long-term potentiation in dentate gyrus. Neuroscience. 72:1996;847-855.
25. McGahon B., Clements M.P., Lynch M.A. The ability of aged rats to sustain long-term potentiation is restored when the age-related decrease in membrane arachidonic acid concentration is reversed. Neuroscience. 81:1997;9-16.
26. McGahon B., Lynch M.A. Analysis of the interaction between arachidonic acid and metabotropic glutamate receptor activation reveals that phospholipase C acts as a coincidence detector in the expression of long-term potentiation in the rat dentate gyrus. Hippocampus. 8:1998;1-9.
27. McGahon B.M., Martin D.S.D., Horrobin D.F., Lynch M.A. Age-related changes in synaptic function analysis of the effect of dietary supplementation with ω-3 fatty acids . Neuroscience. 94:1999;305-314.
28. Murray C, Lynch MA. Analysis of the mechanism by which dietary supplementation with vitamin E and vitamin C restores ability of aged animals to sustain long-term potentiation in dentate gyrus. J Biol Chem 1998a;273:12161-8.
29. Murray C, Lynch MA. Evidence that increased hippocampal expression of the cytokine, IL-1β, is a common trigger for age and stress-induced impairments in long-term potentiation. J Neurosci 1998b;18:2974-81.
30. Nickander K.K., McPhee B.R., Low P.A., Tritschler H. Alpha-lipoic acid antioxidant potency against lipid peroxidation of neural tissue in vitro and implications for diabetic neuropathy . Free Radic Biol Med. 21:1996;631-639.
31. O'Donnell E., Lynch M.A. Analysis of age-related changes in antioxidant defense mechanisms in the rat hippocampus. Soc Neurosci Abstr. 24:1998;1494.
32. Ordronneau P., Abdullah L., Petruse P. An efficient enzyme immunoassay for glutamate using glutaraldehyde coupling of the hapten to microtiter plates. J Immunol Meth. 142:1991;169-176.
33. Packer L. Alpha-lipoic acid a metabolic antioxidant which regulates NF-kappa B signal transduction and protects against oxidative injury . Drug Metab Rev. 30:1998;245-275.
34. Panigrahi M., Sadguna Y., Shivakumar B.R., Kolluri S.V., Roy S., Packer L., Ravindranath V. Alpha-lipoic acid protects against reperfusion injury following cerebral ischemia in rats. Brain Res. 717:1996;184-188.
35. Reiter R.J. Oxidative processes and antioxidative defense mechanisms in the aging brain. FASEB J. 9:1995;526-533.
36. Spitz D.R., Oberley L.W. An assay for superoxide dismutase activity in mammalian tissue homogenates. Anal Biochem. 179:1989;8-18.
37. Urano S., Asai Y., Makabe S., Matsuo M., Izumiyama N., Ohtsubo K., Endo T. Oxidative injury of synapse and alteration of antioxidative defense systems in rats, and its prevention by vitamin E. Eur J Biochem. 245:1997;64-70.
38. Vatassery G.T. In vitro oxidation of vitamins C and E, cholesterol and thiols in rat brain synaptosomes. Lipids. 30:1994;1007-1013.
39. Williams J.H., Errington M.L., Lynch M.A., Bliss T.V.P. Arachidonic acid induces a long-term activity dependent enhancement of synaptic transmission in the hippocampus. Nature. 341:1989;739-742.
40. Zs.-Nagy I. The membrane hypothesis of aging. London: CRC Press Inc., 1994.