Comparison of the effect of α-lipoic acid and α-tocopherol supplementation on measures of oxidative stress

Free Radical Biology and Medicine

Volumn 27, Issue 9-10, 1999, Pages 1114-1121

  Marangon, Karine ^a   Devaraj, Sridevi ^a   Tirosh, Oren ^b   Packer, Lester ^b   Jialal, Ishwarlal ^a,c  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Alpha lipoate; Alpha tocopherol; Antioxidant; Free radicals; LDL oxidation; Plasma oxidation

Indexed keywords

2,2' AZOBIS(2 AMIDINOPROPANE); ALPHA TOCOPHEROL; COPPER; ISOPROSTANE; LOW DENSITY LIPOPROTEIN; THIOCTIC ACID;

ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; IN VITRO STUDY; LIPID OXIDATION; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; OXIDATIVE STRESS; PRIORITY JOURNAL; URINALYSIS;

ADMINISTRATION, ORAL; ADULT; ANTIOXIDANTS; BLOOD PROTEINS; DINOPROST; DRUG SYNERGISM; FEMALE; FREE RADICALS; HUMANS; LIPOPROTEINS, LDL; MALE; MIDDLE AGED; OXIDATION-REDUCTION; OXIDATIVE STRESS; THIOCTIC ACID; VITAMIN E;

EID: 0033231196     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(99)00155-0     Document Type: Article

References (35)

1. [1] Packer, L.; Witt, E. H.; Tritschler, H. J. Alpha-Lipoic acid as a biological antioxidant. Free Radic. Biol. Med. 19:227-250; 1995.
2. [2] Roy, S.; Sen, C. K.; Tritschler, H. J.; Packer, L.; Modulation of Cellular Reducing Equivalent Homeostasis by α-Lipoic Acid. Biochem. Pharmacol. 53:393-399; 1997.
3. [3] Packer, L.; Roy, S.; Sen, C. K. α-Lipoic Acid: a metabolic antioxidant and potential redox modulator of transcription. Adv. Pharmacol. 38:79-101; 1997.
4. [4] Packer, L.; W. E., Trichler, H. J., ed. Antioxidant properties and clinical applications of alpha-lipoic acid and dehydrolipoic acid. Antioxidants in disease mechanisms and therapy. Vol. 38: London: Academic Press; 1997.
5. [5] Kagan, V. E.; Serbinova, E. A.; Forte, T.; Scita, G.; Packer, L. Recycling of vitamin E in human low density lipoproteins. J. Lipid Res. 33:385-397; 1992.
6. [6] Podda, M.; Tritschler, H. J.; Ulrich, H.; Packer, L. Alpha-lipoic acid supplementation prevents symptoms of vitamin E deficiency. Biochem. Biophys. Res. Commun. 204:98-104; 1994.
7. [7] Lykkesfeldt, J.; Hagen, T. M.; Vinarsky, V.; Ames, B. N. Age-associated decline in ascorbic acid concentration, recycling, and biosynthesis in rat hepatocytes - reversal with (R)-alpha-lipoic acid supplementation. FASEB J. 12:1183-1189; 1998.
8. [8] Ziegler, D.; Gries, F. A. α-Lipoic Acid in the Treatment of Diabetic Peripheral and Cardiac Autonomic Neuropathy. Diabetes 46:S62-S66; 1997.
9. [9] Ziegler, D.; Schatz, H.; Conrad, F.; Gries, F. A.; Ulrich, H. The DEKAN Study Group; Reichel, G. Effects of treatment with antioxidant α-lipoic acid on cardiac autonomic neuropathy in NIDDM patients. Diabetes Care. 20:369-373; 1997.
10. [10] Nickander, K. K.; McPhee, B. R.; Low, P. A.; Tritschler, H. Alpha-lipoic acid: antioxidant potency against lipid perosication of neuro tissues in vitro and implications for diabetic neuropathy. Free Radic. Biol. Med. 21:631-639; 1996.
11. [11] Ziegler, D.; Hanefeld, M.; Ruhnau, K. J.; Mei§ner, H. P.; Lobisch, M.; Schutte, K.; Gries, F. A.; The ALADIN Study Group. Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant α-lipoic acid. Diabetologia 38:1425-1433; 1995.
12. [12] Ou, P.; Tritschler, H. J.; Wolff, S. P. Thioctic (lipoic) acid: a therapeutic metal-chelating antioxidant? Biochem. Pharmacol. 50:123-126; 1995.
13. [13] Witztum, J. L.; Steinberg, D. Role of oxidized low density lipoprotein in atherogenesis. J. Clin. Invest. 88:1785-1792; 1991.
14. [14] Parthasarathy, S.; Rankin, S. M. Role of oxidized LDL in atherogenesis. Prog. Lipid Res. 31:127-143; 1992.
15. [15] Devaraj, S.; Jialal, I. Oxidized low density lipoprotein and atherosclerosis. Int. J. Clin. Lab. Res. 26:178-184; 1996.
16. [16] Berliner, J. A..; Heinecke, J. W. The role of oxidized lipoproteins in atherogenesis. Free Radic. Biol. Med. 20:707-727; 1996.
17. [17] Jialal, I.; Fuller, C. J.; Huet, B. A. The effect of α-tocopherol supplementation on LDL oxidation: a dose-response study. Arterioscler. Thromb. Vase. Biol. 15:190-198; 1995.
18. [18] Devaraj, S.; Adams-Huet, B.; Fuller, C. J.; Jialal, I. Dose-response comparison of RRR-alpha-tocopherol and all-racemic alpha-tocopherol on LDL oxidation. Arterioscler. Thromb. Vasc. Biol. 17: 2273-2279; 1997.
19. [19] Sen, C. K.; Roy, S.; Khanna, S.; Packer, L. Determination of oxidized and reduced lipoic acid using high-performance liquid chromatography and coulometric detection. Methods Enzymol. 299:139-246; 1999.
20. [20] Agil, A.; Fuller, C. J.; Jialal, I. Susceptibility of plasma to ferrous iron/hydrogen peroxide-mediated oxidation: demonstration of a possible Fenton reaction. Clin. Chem. 41:220-225; 1995.
21. [21] Marangon, K.; Devaraj, S.; Jialal, I. Measurement of protein carbonyls in plasma of smokers and in oxidized LDL by an ELISA. Clin. Chem. 45:577-578; 1999.
22. [22] Davi, G.; Alessandrini, P.; Mezzetti, A.; Minotti, G.; Bucciarelli, T.; Costantini, F.; Cipollone, F.; Bon, G. B.; Ciabattoni, G.; Patrono, C. In vivo formation of 8-Epi-prostaglandin F2 alpha is increased in hypercholesterolemia. Arterioscler. Thromb. Vasc. Biol. 17:3230-3235; 1997.
23. [23] Kagan, V. E.; Shvedova, A.; Serbinova, E.; Khan, S.; Swanson, C.; Powell, R.; Packer, L. Dihydrolipoic acid - a universal antioxidant both in the membrane and in the aqueous phase. Reduction of peroxyl, ascorbyl and chromanoxyl radicals. Biochem. Pharmacol. 44:1637-1649; 1992.
24. [24] Teichert, J.; Kern, J.; Tritschler, H. J.; Ulrich, H.; Preiss, R. Investigations on the pharmacokinetics of alpha-lipoic acid in healthy volunteers. Int. J. Clin. Pharmacol. Ther. 36:625-628; 1998.
25. [25] O'Neill, C. A.; Halliwell, B.; van der Vliet, A.; Davis, P. A.; Packer, L.; Tritschler, H.; Strohman, W. J.; Rieland, T.; Cross, C. E.; Reznick, A. Z. Aldehyde-induced protein modifications in human plasma: protection by glutathione and dihydrolipoic acid [see comments]. J. Lab. Clin. Med. 124:359-370; 1994.
26. [26] Matsugo, S.; Yan, L. J.; Han, D.; Tritschler, H. J.; Packer, L. Elucidation of antioxidant activity of alpha-lipoic acid toward hydroxyl radical. Biochem. Biophys. Res. Commun. 208:161-167; 1995.
27. [27] Sumathi, R.; Jayanthi, S.; Kalpanadevi, V.; Varalakshmi, P. Effect of DL alpha-lipoic acid on tissue lipid peroxidation and antioxidant systems in normal and glycollate treated rats. Pharmacol. Res. 27:309-318; 1993.
28. [28] Roberts, L. J., II, Morrow, J. The generation and actions of isoprostanes. Biochim. Biophys. Acta. 1345:121-135; 1997.
29. [29] Davi, G.; Ciabattoni, G.; Consoli, A.; Mezzetti, A.; Falco, A.; Santarone, S.; Pennese, E.; Vitacolonna, E.; Bucciarelli, T.; Constantini, F.; Capani, F.; Patrono, C. In vivo formation of 8-isoprostaglandin f2alpha and platelet activation in diabetes mellitus: effects of improved metabolic control and vitamin E supplementation [see comments]. Circulation 99:224-229; 1999.
30. [30] Reilly, M.; Delanty, N.; Lawson, J. A.; FitzGerald, G. A. Modulation of oxidant stress in vivo in chronic cigarette smokers. Circulation 94:19-25; 1996.
31. [31] Reilly, M. P. Pratico, D.; Delanty, N.; DiMinno, G.; Tremoli, E.; Rader, D.; Kapoor, S.; Rokach, J.; Lawson, J.; Fitzgerald, G. A. Increased formation of distinct F2 isoprostanes in hypercholesterolemia. Circulation 98:2822-2828; 1998.
32. [32] Lodge, J. K.; Traber, M. G.; Packer, L. Thiol chelation of Cu2+ by dihydrolipoic acid prevents human low density lipoprotein peroxidation. Free Radic. Biol. Med. 25:287-297; 1998.
33. [33] Matsugo, S.; Yan, L. J.; Komshi, T.; Youn, H. D.; Lodge, J. K.; Ulrich, H.; Packer, L. The lipoic acid analogue 1,2-diselenolane-3-pentanoic acid protects human low density lipoprotein against oxidative modification mediated by copper ion. Biochem. Biophys. Res. Commun. 240:819-824; 1997.
34. [34] Dieber-Rotheneder, M.; Puhl, H.; Waeg, G.; Striegl, G.; Esterbauer, H. Effect of oral supplementation with D-alpha-tocopherol on the vitamin E content of human low density lipoproteins and resistance to oxidation. J. Lipid Res. 32:1325-1332; 1991.
35. [35] Reaven, P. D.; Khouw, A.; Beltz, W. F.; Parthasarathy, S.; Witztum, J. L. Effect of dietary antioxidant combinations in humans. Protection of LDL by vitamin E but not by beta-carotene. Arterioscler. Thromb. 13:590-600; 1993.