Amyloidogenicity and neurotoxicity of peptides corresponding to the helical regions of PrP(c)

Journal of Neuroscience Research

Volumn 62, Issue 2, 2000, Pages 293-301

  Thompson, Andrew ^a   White, Anthony R ^a,b   McLean, Catriona ^a,b   Masters, Colin L ^a,b   Cappai, Roberto ^a,b   Barrow, Colin J ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

Author keywords

Amyloid; Circular dichroism; Copper; Helix; Neurotoxicity; Prion

Indexed keywords

AMYLOID; CONGO RED; HYDROGEN PEROXIDE; IRON COMPLEX;

AQUEOUS SOLUTION; ARTICLE; BIREFRINGENCE; BRAIN SPONGIOSIS; CIRCULAR DICHROISM; CYTOTOXICITY; ELECTRON MICROSCOPY; HUMAN; LIPID PEROXIDATION; NEUROTOXICITY; NUCLEAR MAGNETIC RESONANCE IMAGING; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN CONFORMATION;

EID: 0034667586     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-4547(20001015)62:2<293::AID-JNR14>3.0.CO;2-Y     Document Type: Article

References (44)

1. Dramatic aggregation of Alzheimer A-beta by Cu (II) is induced by conditions representing physiological acidosis
2. Solution structures of beta peptide and its constituent fragments: Relation to amyloid deposition
3. Solution conformations and aggreational properties of synthetic amyloid beta-peptides of Alzheimer's disease. Analysis of circular dichroism spectra
4. Promotion of transition metal-induced reactive oxygen species formation by β-amyloid
5. Mouse cortical cells lacking PrP survive in culture with a neurotoxic PrP fragment
6. Effects of copper on survival of prion protein knockout neurons and glia
7. Rapid induction of Alzheimer A beta amyloid formation by zinc
8. Familial prion protein mutation alters the secondary structure of recombinant mouse prion protein: Implications for the mechanism of prion formation
9. Conformational disease
10. Secondary structure analysis of the scrapie-associated protein PrP 27-30 in water by infrared spectroscopy
11. Identification of microbial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of beta-amyloid and prion proteins
12. Copper, iron and zinc imbalances in severely degenerated brain regions in Alzheimers disease - Possible relation to oxidative stress
13. Neurotoxicity of a prion protein fragment
14. Influence of mutations associated with familial prion-related encephalopathies on biological activity of prion protein peptides
15. Predicted α-helical regions of the prion protein when synthesized as peptides form amyloid
16. Synthetic peptides corresponding to different mutated regions of the amyloid gene in familial Creutzfeldt-Jakob disease show enhanced in vitro formation of morphologically differenct amyloid fibrils
17. The abeta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction
18. Cu(II) potentiation of Alzheimer A beta neurotoxicity - Correlation with cell-free hydrogen peroxide production and metal reduction
19. Reversible conversion of monomeric human prion protein between native and fibrrilogenic conformations
20. The hydrophobic core sequence modulates the neurotoxic and secondary structure properties of the prion peptide 106-126
21. Color test for detection of free terminal amino groups in the solid-phase synthesis of peptides
22. Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis
23. Amyloid plaque core protein in Alzheimer disease and Down syndrome
24. Protection of flupirtine on beta-amyloid-induced apoptosis in neuronal cells in vitro: Prevention of amyloid-induced glutathione depletion
25. Interaction between the zinc (II) and the heparin binding site of the Alzheimer's disease beta A4 amyloid precursor protein (APP)
26. The Alzheimer A beta peptide develops protease resistance in association with its polymerization into fibrils
27. Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins
28. Effect of flupirtine on bcl-2 and glutathione level in neuronal cells treated in vitro with the prion protein fragment (PrP106-126)
29. Prions and related neurological diseases
30. Prions are copper-binding proteins
31. Prion protein amyloid and neurodegeneration
32. NMR structure of the mouse prion protein domain. PrP(121-231)
33. NMR characterization of the full-length recombinant murine prion protein, mPrP(23-231)
34. Prion protein NMR structure and familial human spongiform encephalopathies
35. Redox metals and neurodegenerative disease
36. In situ oxidative catalysis by neurofibrillary tangles and senile in Alzheimer's disease: A central role for bound transition metals
37. The conformation of Alzheimer's beta peptide detemines the rate of amyloid formation and its resistance to proteolysis
38. pH-dependent stability and conformation of the recombinant human prion protein PrP(90-231)
39. Copper binding to the prion protein: Structural implications of four identical cooperative binding sites
40. Strain-specific prion -protein conformation determined by metal ions
41. Molecular biology of transmissible spongiform encephalopathies
42. Survival of cultured neurons from amyloid precursor protein knock-out mice against Alzheimer's amyloid-beta toxicity and oxidative stress
43. Exacerbation of copper toxicity in primary neuronal cultures depleted of cellular glutathione
44. Conforamational transitions in peptides containing two putative α-helices of the prion protein