PrP deposition, microglial activation, and neuronal apoptosis in murine scrapie

Experimental Neurology

Volumn 144, Issue 2, 1997, Pages 433-438

  Williams, A ^a   Lucassen, P J ^b,c   Ritchie, D ^a   Bruce, M ^a  

^a INSTITUTE FOR ANIMAL HEALTH   (United Kingdom)

^b NETHERLANDS INSTITUTE FOR NEUROSCIENCE   (Netherlands)

^c LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; EXPERIMENTAL MODEL; HIPPOCAMPUS; MICROGLIA; MOUSE; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; SCRAPIE;

EID: 0031127379     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1997.6424     Document Type: Article

References (34)

1. Brandner S., Isenmann S., Raeber A., Fischer M., Sailer A., Kobayashi Y., Marino S., Weissmann C., Aguzzi A. Normal host prion protein necessary for scrapie-induced neurotoxicity. Nature. 379:1996;339-343.
2. Brown D. R., Herms J., Kretzschmar H. A. Mouse cortical cells lacking cellular PrP survive in culture with a neurotoxic PrP fragment. NeuroReport. 5:1994;2057-2060.
3. Brown D. R., Schmidt B., Kretzschmar H. A. Role of microglia and host prion protein in neurotoxicity of a prion protein fragment. Nature. 380:1996;345-347.
4. Bruce M. E., McBride P. A., Farquhar C. F. Precise targeting of the pathology of the sialogycoprotein, PrP, and the vacuolar degeneration in mouse scrapie. Neurosci. Lett. 106:1989;1-6.
5. DeArmond S. J., Mobley W. C., DeMott D. L., Barry R. A., Beckstead J. H., Prusiner S. B. Changes in the localization of brain prion proteins during scrapie infection. Neurology. 37:1987;1271-1280.
6. Forloni G., Angeretti N., Chiesa R., Monzani E., Salmona M., Bugiani O., Tagliavini F. Neurotoxicity of a prion protein fragment. Nature. 362:1993;543-546.
7. Foster J. D., Fraser H., Bruce M. E. Retinopathy in mice with experimental scrapie. Neuropathol. Appl. Neurobiol. 12:1986;185-196.
8. Fraser H., Dickinson A. G. Agent-strain differences in the distribution and intensity of grey matter vacuolation. J. Comp. Pathol. 83:1973;29-40.
9. J. R. Fraser, W. G. Halliday, D. Brown, P. V. Belichenko, M. Jeffrey, 1996, Mechanisms of scrapie-induced neuronal cell death, Transmissible Subacute Spongiform Encephalopathies: Prion Diseases, 107, 112, Elsevier, Paris.
10. Gavrieli Y., Sherman Y., Ben-Sasson S. A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119:1992;493-501.
11. Giese A., Groschup M. H., Hess B., Kretzschmar H. A. Neuronal death in scrapie-infected mice is due to apoptosis. Brain Pathol. 5:1995;213-221.
12. Hope J., Shearman M. S., Baxter H. C., Chong A., Kelly S. M., Price N. C. Cytotoxicity of prion protein peptide (PrP106-126) differs in mechanism from the cytotoxic activity of the Alzheimer's disease amyloid peptide, Aβ25-35. Neurodegeneration. 5:1996;1-11.
13. Jeffrey M., Goodsir C. M., Bruce M. E., McBride P. A., Farquhar C. Morphogenesis of amyloid plaques in 87V murine scrapie. Neuropathol. Appl. Neurobiol. 20:1994;535-542.
14. Jeffrey M., Goodsir C. M., Bruce M. E., McBride P. A., Fowler N., Scott J. R. Murine scrapie-infected neurons release excess prion protein into the extracellular space. Neurosci. Lett. 174:1994;39-42.
15. Jeffrey M., Goodsir C. M., Bruce M. E., McBride P. A., Scott J. R., Halliday W. G. Correlative light and electron microscopic studies of PrP localisation in 87V scrapie. Brain Res. 656:1994;329-343.
16. Jeffrey M., Fraser J. R., Halliday W. G., Fowler N., Goodsir C. M., Brown D. A. Early unsuspected neuron and axon terminal loss in scrapie-infected mice revealed by morphometry and immunocytochemistry. Neuropathol. Appl. Neurobiol. 21:1995;41-49.
17. Jeffrey M., Scott J. R., Williams A., Fraser H. Ultrastructural features of spongiform encephalopathy transmitted to mice from three species of bovidae. Acta Neuropathol. 84:1992;559-569.
18. Kristensson K., Feuerstein B., Taraboulos A., Hyun W. C., Prusiner S. B., DeArmond S. J. Scrapie prions alter receptor-mediated calcium responses in cultured cells. Neurology. 43:1993;2335-2341.
19. Kurschner C., Morgan J. I. The cellular prion protein (PrP) selectively binds to Bcl-2 in the yeast two-hybrid system. Mol. Brain Res. 30:1996;165-168.
20. Lawson L. J., Perry V. H., Gordon S. Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain. Neuroscience. 39:1990;151-170.
21. Lucassen P. J., Chung W. C. J., Vermeulen J. P., van Lookeren Campagne M., van Dierendonck J-H., Swaab D. F. Microwave enhanced in situ end labeling of fragmented DNA: Parametric studies in relation to post mortem delay and fixation of rat and human brain. J. Histochem. Cytochem. 43:1995;1163-1171.
22. Lucassen P. J., Williams A., Chung W. C. J., Fraser H. Detection of apoptosis in murine scrapie. Neurosci. Lett. 198:1995;1-4.
23. Masters C. L., Richardson E. P. Jr. Subacute spongiform encephalopathy (Creutzfeldt-Jakob disease). The nature and progression of spongiform change. Brain. 101:1978;333-344.
24. McLean I. W., Nakane P. K. Periodate-lysine-paraformaldehyde fixative. A new fixative for immuno-electron microscopy. J. Histochem. Cytochem. 22:1974;1077-1083.
25. Sc. Eur. J. Pharmacol. 246:1993;261-267.
26. Pan K-M., Baldwin M., Nguyen J., Gasset M., Serban A., Groth D., Mehlhorn I., Huang Z., Fletterick R. J., Cohen F. E., Prusiner S. B. Conversion of α-helices into β-sheets features in the formation of the scrapie prion proteins. Proc. Natl. Acad. Sci. USA. 90:1993;10962-10966.
27. Perovic S., Pergande G., Ushijima H., Kelve M., Forrest J., Müller W. E. G. Flupirtine partially prevents neuronal injury induced by prion protein fragment and lead acetate. Neurodegeneration. 4:1995;369-374.
28. Scott J. R., Fraser H. Degenerative hippocampal pathology in mice infected with scrapie. Acta Neuropathol. 65:1984;62-68.
29. Sidman R. L., Angevine J. B. Jr., Pierce E. T. Atlas of the Mouse Brain and Spinal Cord. 1971;Harvard Univ. Press, Cambridge.
30. Whatley S. A., Powell J. F., Politopoulou G., Campbell I. C., Brammer M. J., Percy N. S. Regulation of intracellular free calcium levels by the cellular prion protein. NeuroReport. 6:1995;2333-2337.
31. Wijsman J. H., Jonker R. R., Keijzer R., van de Velde C. J. H., Cornelisse C. J., Dierendonck J. H. A new method to detect apoptosis in paraffin sections: In situ end labeling of fragmented DNA. J. Histochem. Cytochem. 41:1993;7-12.
32. Williams A. E., Lawson L. J., Perry V. H., Fraser H. Characterization of the microglial response in murine scrapie. Neuropathol. Appl. Neurobiol. 20:1994;47-55.
33. Sc, Transmissible Subacute Spongiform Encephalopathies: Prion Diseases, 167, 171, Elsevier, Paris.
34. Wyllie A. H., Kerr J. F. R., Currie A. R. Cell death: The significance of apoptosis. Int. Rev. Cytol. 68:1980;251-305.