Changes in gene transcription during aβ-mediated cell death

Molecular Psychiatry

Volumn 1, Issue 1, 1996, Pages 65-71

  Iwasaki, K ^a   Sunderland, T ^a   Kusiak, J W ^b   Wolozin, B ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b Molecular Neurobiology Unit

Author keywords

Alzheimer's disease; Amyloid; Apoptosis; Bcl 2; Fos; Jun; Neurons; Toxicity

Indexed keywords

AMYLOID BETA PROTEIN; BACTERIOPHAGE T7 INDUCED DNA POLYMERASE; BISBENZIMIDE; DNA DIRECTED DNA POLYMERASE; DNA FRAGMENT; GLUCOSE DEHYDROGENASE; MESSENGER RNA; PROTEIN BCL 2; PROTEIN C FOS; PROTEIN C JUN;

ANIMAL; APOPTOSIS; ARTICLE; BRAIN CORTEX; CELL CULTURE; CELL CYCLE; CELL NUCLEUS; CYTOLOGY; DNA PROBE; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; NERVE CELL; PHYSIOLOGY; RAT;

AMYLOID BETA-PROTEIN; ANIMALS; APOPTOSIS; BISBENZIMIDE; CELL CYCLE; CELL NUCLEUS; CELLS, CULTURED; CEREBRAL CORTEX; DNA FRAGMENTATION; DNA PROBES; DNA-DIRECTED DNA POLYMERASE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCOSE 1-DEHYDROGENASE; GLUCOSE DEHYDROGENASES; NEURONS; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; RATS; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 0030090426     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Martin S, Green D, Cotter T. Dicing with death: dissecting the components of the apoptosis machinery. TIBS 1994; 19: 26-30.
2. Thompson C. Apoptosis in the pathogenesis and treatment of disease. Science 1995; 267: 1456-1462.
3. Zakeri Z, Lockshin RA. Physiological cell death during development and its relationship to aging. Ann NY Acad Sci 1994; 719: 212-229.
4. Freeman R, Estus S, Johnson E. Analysis of cell cycle-related gene expression in postmitotic neurons: selective induction of cyclin D1 during programmed cell death. Neuron 1994; 12: 343-355.
5. Gavrieli Y, Sherman Y, Ben SS. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992; 119: 493-501.
6. Lassmann H et al. Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ. Acta Neuropathol (Berl) 1995; 89: 35-41.
7. Smale G et al. Evidence for apoptotic cell death in Alzheimer's disease. Exp Neurol 1995; 133: 225-230.
8. Su JH, Anderson AJ, Cummings BJ, Cotman CW. Immunohistochemical evidence for apoptosis in Alzheimer's disease. NeuroReport 1994; 5: 2529-2533.
9. Selkoe D. Normal and abnormal biology of the β-amyloid precursor protein. Ann Rev Neurosci 1994; 17: 489-517.
10. Goate A et al. Segregation of a missence mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 1991; 349: 704-706.
11. Levy E et al. Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch-type. Science 1990; 248: 1124-1126.
12. Citron M et al. Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production. Nature 1992; 360: 672-674.
13. 717) mutants. Science 1994; 264: 1336-1340.
14. Pike C, Walencewicz A, Glabe C, Cotman C. In vitro aging of β-amyloid protein causes peptide aggregation and neurotoxicity. Brain Res 1991; 563: 311-314.
15. Yankner BA, Duffy LK, Kirschner DA. Neurotrophic and neurotoxic effects of amyloid β protein: reversal by tachykinin neuropeptides. Science 1990; 250: 279-282.
16. Forloni G et al. Apoptosis mediated neurotoxicity induced by chronic application of β amyloid fragment 25-35. NeuroReport 1993; 4: 523-526.
17. Loo D et al. Apoptosis is induced by β-amyloid in cultured central nervous system neurons. PNAS 1993; 90: 7951-7955.
18. Hertz E et al. Preparation of primary cortical cultures of mouse cortical neurons. In: Shahar A, de Vellis J, Vernadakis A, Haber B (eds). A Dissection and Tissue Culture Manual of the Nervous System. Alan R Liss: New York, 1989, pp 183-186.
19. Wood K, Dipasquale B, Youle R. In situ labeling of granule cells for apoptosis-associated DNA fragmentation reveals different mechanisms of cell loss in developing cerebellum. Neuron 1993; 11: 621-632.
20. Behl C, Davis J, Lesley R, Schubert D. Hydrogen peroxide mediates amyloid β protein toxicity. Cell 1994; 77: 1-20.
21. Smeyne RJ et al. Continuous c-fos expression precedes programmed cell death in vivo. Nature 1993; 363: 166-169.
22. Garcia I, Matinou I, Tsujimoto Y, Martinou J-C. Prevention of programmed cell death of sympathetic neurons by the bcl-2 proto-oncogene. Science 1992; 258: 302-304.
23. Zhong L-T et al. Bcl-2 inhibits death of central neural cells induced by multiple agents. PNAS 1993; 90: 4533-4537.
24. Oltvai ZN, Milliman CL, Korsmeyer SJ. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993; 74: 609-619.
25. Caelles C, Helmberg A, Karin M. p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes. Nature 1994; 370: 220-223.
26. Estus S et al. Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis. J Cell Biol 1994; 127: 1717-1727.
27. Shimuzu S et al. Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL. Nature 1995; 374: 811-813.
28. Chittenden T et al. Induction of apoptosis by the Bcl-2 homogue Bak. Nature 1995; 374: 733-736.
29. Tamura T et al. An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes. Nature 1995; 376: 596-599.