메뉴 건너뛰기




Volumn 86, Issue 2, 1998, Pages 461-471

Preservation of cholinergic activity and prevention of neuron death by CEP-1347/KT-7515 following excitotoxic injury of the nucleus basalis magnocellularis

Author keywords

Cholinergic; FluoroGold; K 252a; Nerve growth factor; Neuroprotection; Nucleus basalis magnocellularis

Indexed keywords

CARBAZOLE DERIVATIVE; CEP 1347; CHOLINE ACETYLTRANSFERASE; FLUOROGOLD; IBOTENIC ACID; K 252A; PROTEIN KINASE C; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG;

EID: 0032100520     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(98)00059-1     Document Type: Article
Times cited : (37)

References (59)
  • 1
    • 0020634081 scopus 로고
    • Loss of neurons in the nucleus basalis of Meynert in Alzheimer's disease, paralysis agitans and Korsakoff's disease
    • Arendt T., Bigl V., Arendt A., Tennstedt A. Loss of neurons in the nucleus basalis of Meynert in Alzheimer's disease, paralysis agitans and Korsakoff's disease. Acta neuropath. 61:1983;101-108.
    • (1983) Acta Neuropath. , vol.61 , pp. 101-108
    • Arendt, T.1    Bigl, V.2    Arendt, A.3    Tennstedt, A.4
  • 2
    • 0026512998 scopus 로고
    • K-252a inhibits nerve growth factor-induced trk proto-oncogene tyrosine phosphorylation and kinase activity
    • Berg M. M., Sternber D. W., Parada L. F., Chao M. V. K-252a inhibits nerve growth factor-induced trk proto-oncogene tyrosine phosphorylation and kinase activity. J. biol. Chem. 267:1992;13-16.
    • (1992) J. Biol. Chem. , vol.267 , pp. 13-16
    • Berg, M.M.1    Sternber, D.W.2    Parada, L.F.3    Chao, M.V.4
  • 3
    • 0028115825 scopus 로고
    • 192 IgG-saporin: I. Specific lethality for cholinergic neurons in the basal forebrain of the rat
    • Book A. A., Wiley R. G., Schweitzer J. B. 192 IgG-saporin: I. Specific lethality for cholinergic neurons in the basal forebrain of the rat. J. Neuropath. exp. Neurol. 53:1994;95-102.
    • (1994) J. Neuropath. Exp. Neurol. , vol.53 , pp. 95-102
    • Book, A.A.1    Wiley, R.G.2    Schweitzer, J.B.3
  • 4
    • 0025190264 scopus 로고
    • Differential effects of the protein kinase inhibitor K-252a on the in vitro survival of chick embryonic neurons
    • Borasio G. D. Differential effects of the protein kinase inhibitor K-252a on the in vitro survival of chick embryonic neurons. Neurosci. Lett. 108:1990;207-212.
    • (1990) Neurosci. Lett. , vol.108 , pp. 207-212
    • Borasio, G.D.1
  • 5
    • 0021988440 scopus 로고
    • Cholinergic projections from the basal forebrain to the basolateral amygdaloid complex: A combined retrograde fluorescent and immunohistochemical study
    • Carlsen J., Zaborszky L., Heimer L. Cholinergic projections from the basal forebrain to the basolateral amygdaloid complex: a combined retrograde fluorescent and immunohistochemical study. J. comp. Neurol. 234:1985;155-167.
    • (1985) J. Comp. Neurol. , vol.234 , pp. 155-167
    • Carlsen, J.1    Zaborszky, L.2    Heimer, L.3
  • 7
    • 0028220675 scopus 로고
    • Staurosporine, K-252a and K-252b stabilize calcium homeostasis and promote survival of CNS neurons in the absence of glucose
    • Cheng B., Barger S. W., Mattson M. P. Staurosporine, K-252a and K-252b stabilize calcium homeostasis and promote survival of CNS neurons in the absence of glucose. J. Neurochem. 62:1994;1319-1329.
    • (1994) J. Neurochem. , vol.62 , pp. 1319-1329
    • Cheng, B.1    Barger, S.W.2    Mattson, M.P.3
  • 8
    • 0026507637 scopus 로고
    • How inaccurate is the Abercrombie correction factor for cell counts?
    • Clarke P. G. H. How inaccurate is the Abercrombie correction factor for cell counts? Trends Neurosci. 15:1992;211-212.
    • (1992) Trends Neurosci. , vol.15 , pp. 211-212
    • Clarke, P.G.H.1
  • 9
    • 0027385474 scopus 로고
    • Recovery of choline acetyltransferase activity without sprouting of the residual acetylcholine innervation in adult rat cerebral cortex after lesion of the nucleus basalis
    • Cossette P., Umbriaco D., Zamar N., Hamel E., Descarries L. Recovery of choline acetyltransferase activity without sprouting of the residual acetylcholine innervation in adult rat cerebral cortex after lesion of the nucleus basalis. Brain Res. 630:1993;195-206.
    • (1993) Brain Res. , vol.630 , pp. 195-206
    • Cossette, P.1    Umbriaco, D.2    Zamar, N.3    Hamel, E.4    Descarries, L.5
  • 10
    • 0020686674 scopus 로고
    • AD: A disorder of cortical cholinergic innervation
    • Coyle J. T. AD: a disorder of cortical cholinergic innervation. Science. 219:1983;1184-1190.
    • (1983) Science , vol.219 , pp. 1184-1190
    • Coyle, J.T.1
  • 12
    • 0028013250 scopus 로고
    • Effects of brain derived neurotrophic factor and nerve growth factor on remaining neurons in the lesioned nucleus basalis magnocellularis
    • Dekker A. J., Fagan A. M., Gage F. H., Thal L. J. Effects of brain derived neurotrophic factor and nerve growth factor on remaining neurons in the lesioned nucleus basalis magnocellularis. Brain Res. 639:1994;149-155.
    • (1994) Brain Res. , vol.639 , pp. 149-155
    • Dekker, A.J.1    Fagan, A.M.2    Gage, F.H.3    Thal, L.J.4
  • 13
    • 0026602935 scopus 로고
    • Delayed treatment with NGF improves acquisition of a spatial task in rats with lesions of the nucleus basalis magnocellularis: Evaluation of the involvement of different neurotransmitter systems
    • Dekker A. J., Gage F. H., Thal L. J. Delayed treatment with NGF improves acquisition of a spatial task in rats with lesions of the nucleus basalis magnocellularis: evaluation of the involvement of different neurotransmitter systems. Neuroscience. 48:1992;111-119.
    • (1992) Neuroscience , vol.48 , pp. 111-119
    • Dekker, A.J.1    Gage, F.H.2    Thal, L.J.3
  • 14
    • 0026654156 scopus 로고
    • Effect of delayed treatment with nerve growth factor on choline acetyltransferase activity in the cortex of rats with lesions of the nucleus basalis magnocellularis: Dose requirements
    • Dekker A. J., Thal L. J. Effect of delayed treatment with nerve growth factor on choline acetyltransferase activity in the cortex of rats with lesions of the nucleus basalis magnocellularis: dose requirements. Brain Res. 584:1992;55-63.
    • (1992) Brain Res. , vol.584 , pp. 55-63
    • Dekker, A.J.1    Thal, L.J.2
  • 15
    • 0028353076 scopus 로고
    • Grafting of nerve growth factor-producing fibroblasts reduces behavioral deficits in rats with lesions of the nucleus basalis magnocellularis
    • Dekker A. J., Winkler J., Ray J., Thal L. J., Gage F. H. Grafting of nerve growth factor-producing fibroblasts reduces behavioral deficits in rats with lesions of the nucleus basalis magnocellularis. Neuroscience. 60:1994;299-309.
    • (1994) Neuroscience , vol.60 , pp. 299-309
    • Dekker, A.J.1    Winkler, J.2    Ray, J.3    Thal, L.J.4    Gage, F.H.5
  • 16
    • 0025938569 scopus 로고
    • The basal forebrain-cortical cholinergic system: Interpreting the function consequences of excitotoxic lesions
    • Dunnet S. B., Everitt B. J., Robbins T. W. The basal forebrain-cortical cholinergic system: interpreting the function consequences of excitotoxic lesions. Trends Neurosci. 14:1991;494-501.
    • (1991) Trends Neurosci. , vol.14 , pp. 494-501
    • Dunnet, S.B.1    Everitt, B.J.2    Robbins, T.W.3
  • 17
    • 0041125361 scopus 로고
    • The organization and some projections of cholinergic neurons of the mammalian forebrain
    • Fibiger H. C. The organization and some projections of cholinergic neurons of the mammalian forebrain. Brain Res. Rev. 4:1982;327-388.
    • (1982) Brain Res. Rev. , vol.4 , pp. 327-388
    • Fibiger, H.C.1
  • 18
    • 0025782928 scopus 로고
    • Cholinergic mechanisms in learning memory and dementia: A review of recent evidence
    • Fibiger H. C. Cholinergic mechanisms in learning memory and dementia: a review of recent evidence. Trends Neurosci. 14:1991;220-223.
    • (1991) Trends Neurosci. , vol.14 , pp. 220-223
    • Fibiger, H.C.1
  • 19
    • 0016468979 scopus 로고
    • A rapid radiochemical method for the determination of choline acetyltransferase
    • Fonnum F. A rapid radiochemical method for the determination of choline acetyltransferase. J. Neurochem. 24:1975;407-409.
    • (1975) J. Neurochem. , vol.24 , pp. 407-409
    • Fonnum, F.1
  • 21
    • 0010380355 scopus 로고    scopus 로고
    • Fimbria-fornix transection and excitotoxicity produce similar neurodegeneration in septum
    • in press
    • Ginsberg S. D., Portera-Cailliau C. and Martin L. J. (1997) Fimbria-fornix transection and excitotoxicity produce similar neurodegeneration in septum. Neuroscience (in press).
    • (1997) Neuroscience
    • Ginsberg, S.D.1    Portera-Cailliau, C.2    Martin, L.J.3
  • 22
    • 0028938472 scopus 로고
    • K-252a promotes survival and choline acetyltransferase activity in striatal and basal forebrain neuronal cultures
    • Glicksman M. A., Forbes M. E., Prantner J. E., Neff N. T. K-252a promotes survival and choline acetyltransferase activity in striatal and basal forebrain neuronal cultures. J. Neurochem. 64:1995;1502-1512.
    • (1995) J. Neurochem. , vol.64 , pp. 1502-1512
    • Glicksman, M.A.1    Forbes, M.E.2    Prantner, J.E.3    Neff, N.T.4
  • 24
    • 0028229755 scopus 로고
    • Staurosporine and K-252a compounds protect hippocampal neurons against amyloid β-peptide toxicity and oxidative injury
    • Goodman Y., Mattson M. P. Staurosporine and K-252a compounds protect hippocampal neurons against amyloid β-peptide toxicity and oxidative injury. Brain Res. 650:1994;170-174.
    • (1994) Brain Res. , vol.650 , pp. 170-174
    • Goodman, Y.1    Mattson, M.P.2
  • 25
    • 0024354790 scopus 로고
    • Attenuation of nucleus basalis of Meynert lesion-induced cholinergic deficits by nerve growth factor
    • Haroutunian V., Kanof P. D., Davis K. L. Attenuation of nucleus basalis of Meynert lesion-induced cholinergic deficits by nerve growth factor. Brain Res. 487:1989;200-203.
    • (1989) Brain Res. , vol.487 , pp. 200-203
    • Haroutunian, V.1    Kanof, P.D.2    Davis, K.L.3
  • 26
    • 0023787394 scopus 로고
    • Development of septal cholinergic neurons in culture:plating density and glial cells modulate effects of NGF on surviving fiber growth, and expression of transmitter-specific enzymes
    • Hartikka J., Hefti F. Development of septal cholinergic neurons in culture:plating density and glial cells modulate effects of NGF on surviving fiber growth, and expression of transmitter-specific enzymes. J. Neurosci. 8:1988;2967-2985.
    • (1988) J. Neurosci. , vol.8 , pp. 2967-2985
    • Hartikka, J.1    Hefti, F.2
  • 27
    • 0024094842 scopus 로고
    • K-252a, a potent protein kinase inhibitor, blocks NGF-induced neurite outgrowth and changes in the phosphorylation of proteins in PC12h cells
    • Hashimoto S. K-252a, a potent protein kinase inhibitor, blocks NGF-induced neurite outgrowth and changes in the phosphorylation of proteins in PC12h cells. J. Cell Biol. 107:1988;1531-1539.
    • (1988) J. Cell Biol. , vol.107 , pp. 1531-1539
    • Hashimoto, S.1
  • 28
    • 0031022977 scopus 로고    scopus 로고
    • Differential modulation of the cholinergic phenotype of the nucleus basalis magnocelluaris neurons by applying NGF at the cell body or cortical terminal fields
    • Hu L., Cote S. L., Cuello C. Differential modulation of the cholinergic phenotype of the nucleus basalis magnocelluaris neurons by applying NGF at the cell body or cortical terminal fields. Expl Neurol. 143:1997;162-171.
    • (1997) Expl Neurol. , vol.143 , pp. 162-171
    • Hu, L.1    Cote, S.L.2    Cuello, C.3
  • 31
    • 0026595294 scopus 로고
    • K-252 compounds; Modulators of neurotrophin signal transduction
    • Knusel B., Hefti F. K-252 compounds; modulators of neurotrophin signal transduction. J. Neurochem. 59:1992;1987-1996.
    • (1992) J. Neurochem. , vol.59 , pp. 1987-1996
    • Knusel, B.1    Hefti, F.2
  • 33
    • 0028920679 scopus 로고
    • Regulation of TrkA and ChAT expression in developing rat basal forebrain: Evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neurons
    • Li Y., Holtzman D. M., Kromer L. F., Kaplan D. R., Chua-Couzens J., Clary D. O., Knusel B., Mobley W. C. Regulation of TrkA and ChAT expression in developing rat basal forebrain: evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neurons. J. Neurosci. 15:1995;2888-2905.
    • (1995) J. Neurosci. , vol.15 , pp. 2888-2905
    • Li, Y.1    Holtzman, D.M.2    Kromer, L.F.3    Kaplan, D.R.4    Chua-Couzens, J.5    Clary, D.O.6    Knusel, B.7    Mobley, W.C.8
  • 34
    • 0026598881 scopus 로고
    • Widespread neuronal degeneration after ibotenic acid lesioning of cholinergic neurons in the nucleus basalis revealed by in situ hybridization
    • Lindefors N., Boatel M. L., Mahy N., Persson H. Widespread neuronal degeneration after ibotenic acid lesioning of cholinergic neurons in the nucleus basalis revealed by in situ hybridization. Neurosci. Lett. 135:1992;262-264.
    • (1992) Neurosci. Lett. , vol.135 , pp. 262-264
    • Lindefors, N.1    Boatel, M.L.2    Mahy, N.3    Persson, H.4
  • 35
    • 0026773098 scopus 로고
    • Nerve growth factor regulation of choline acetyltransferase gene expression in rat embryo basal forebrain cultures
    • Lorenzi M. V., Knusel B., Hefti F., Strauss W. L. Nerve growth factor regulation of choline acetyltransferase gene expression in rat embryo basal forebrain cultures. Neurosci. Lett. 140:1992;185-188.
    • (1992) Neurosci. Lett. , vol.140 , pp. 185-188
    • Lorenzi, M.V.1    Knusel, B.2    Hefti, F.3    Strauss, W.L.4
  • 36
    • 0024309694 scopus 로고
    • Spatial learning in rats: Correlation with cortical choline acetyltransferase and improvement with NGF following nbm damage
    • Mandel R. J., Gage F. H., Thal L. J. Spatial learning in rats: correlation with cortical choline acetyltransferase and improvement with NGF following nbm damage. Expl Neurol. 104:1989;208-217.
    • (1989) Expl Neurol. , vol.104 , pp. 208-217
    • Mandel, R.J.1    Gage, F.H.2    Thal, L.J.3
  • 38
    • 0028870428 scopus 로고
    • K-252a induces tyrosine phosphorylation of the focal adhesion kinase and neurite outgrowth in human neuroblastoma SH-SY5Y cells
    • Maroney A. C., Lipfert L., Forbes M. E., Glicksman M. A., Neff N. T., Siman R., Dionne C. A. K-252a induces tyrosine phosphorylation of the focal adhesion kinase and neurite outgrowth in human neuroblastoma SH-SY5Y cells. J. Neurochem. 64:1995;540-549.
    • (1995) J. Neurochem. , vol.64 , pp. 540-549
    • Maroney, A.C.1    Lipfert, L.2    Forbes, M.E.3    Glicksman, M.A.4    Neff, N.T.5    Siman, R.6    Dionne, C.A.7
  • 39
    • 0023932343 scopus 로고
    • Inhibition by K-252a, a new inhibitor of protein kinase, of nerve growth factor-induced neurite outgrowth of chick embryo dorsal root ganglion cells
    • Matsuda Y., Fukuda J. Inhibition by K-252a, a new inhibitor of protein kinase, of nerve growth factor-induced neurite outgrowth of chick embryo dorsal root ganglion cells. Neurosci. Lett. 87:1988;11-17.
    • (1988) Neurosci. Lett. , vol.87 , pp. 11-17
    • Matsuda, Y.1    Fukuda, J.2
  • 40
    • 0020585413 scopus 로고
    • Topographic analysis of the innervation of the rat neocortex and hippocampus by the basal forebrain cholinergic system
    • McKinney M., Coyle J. T., Hedreen J. C. Topographic analysis of the innervation of the rat neocortex and hippocampus by the basal forebrain cholinergic system. J. comp. Neurol. 217:1983;103-121.
    • (1983) J. Comp. Neurol. , vol.217 , pp. 103-121
    • McKinney, M.1    Coyle, J.T.2    Hedreen, J.C.3
  • 41
    • 0022639418 scopus 로고
    • Pilocarpine and physostigmine attenuate spatial memory impairments produced by lesions of the nBM
    • Murray C. L., Fibiger H. C. Pilocarpine and physostigmine attenuate spatial memory impairments produced by lesions of the nBM. Behav. Neurosci. 100:1986;23-32.
    • (1986) Behav. Neurosci. , vol.100 , pp. 23-32
    • Murray, C.L.1    Fibiger, H.C.2
  • 42
    • 0026085659 scopus 로고
    • Staurosporine, a PKC inhibitor, attenuates basal forebrain lesion induced amnesia and cholinergic neuronal deficit
    • Nabeshima T., Ogawa S., Nishimura H., Fuji K., Kameyama T., Sasaki Y. Staurosporine, a PKC inhibitor, attenuates basal forebrain lesion induced amnesia and cholinergic neuronal deficit. Neurosci. Lett. 122:1990;13-16.
    • (1990) Neurosci. Lett. , vol.122 , pp. 13-16
    • Nabeshima, T.1    Ogawa, S.2    Nishimura, H.3    Fuji, K.4    Kameyama, T.5    Sasaki, Y.6
  • 44
    • 0026684676 scopus 로고
    • Inhibition of the cellular actions of nerve growth factor by staurosporine and K-252a result from the attenuation of the activity of the trk tyrosine kinase
    • Ohmichi M., Decker S. J., Pang L., Saltiel A. R. Inhibition of the cellular actions of nerve growth factor by staurosporine and K-252a result from the attenuation of the activity of the trk tyrosine kinase. Biochemistry. 31:1992;4034-4039.
    • (1992) Biochemistry , vol.31 , pp. 4034-4039
    • Ohmichi, M.1    Decker, S.J.2    Pang, L.3    Saltiel, A.R.4
  • 45
    • 0002083998 scopus 로고
    • Dementia: Animal models of the cognitive impairments produced by degeneration of the basal forebrain cholinergic system
    • (ed. Meltzer H. Y.) Raven, New York
    • Olton D. S. and Wenk G. L. (1987) Dementia: animal models of the cognitive impairments produced by degeneration of the basal forebrain cholinergic system. In Psychopharmacology: The Third Generation of Progress (ed. Meltzer H. Y.), pp. 941-953. Raven, New York.
    • (1987) In Psychopharmacology: The Third Generation of Progress , pp. 941-953
    • Olton, D.S.1    Wenk, G.L.2
  • 47
    • 0029072690 scopus 로고
    • Evidence for apoptotic cell death in Huntingdon disease and excitotoxic animal models
    • Portera-Cailliau C., Hedreen J. C., Price D. L., Koliatsos V. E. Evidence for apoptotic cell death in Huntingdon disease and excitotoxic animal models. J. Neurosci. 15:1995;3775-3787.
    • (1995) J. Neurosci. , vol.15 , pp. 3775-3787
    • Portera-Cailliau, C.1    Hedreen, J.C.2    Price, D.L.3    Koliatsos, V.E.4
  • 48
    • 0028081945 scopus 로고
    • Neurites induced by staurosporine in PC12 cells are resistant to colchicine and express high levels of Tau proteins
    • Rasouly D., Rahamim E., Ringel I., Ginzburg I., Murakata C., Matsuda Y., Lazarovici P. Neurites induced by staurosporine in PC12 cells are resistant to colchicine and express high levels of Tau proteins. Molec. Pharmac. 45:1994;29-35.
    • (1994) Molec. Pharmac. , vol.45 , pp. 29-35
    • Rasouly, D.1    Rahamim, E.2    Ringel, I.3    Ginzburg, I.4    Murakata, C.5    Matsuda, Y.6    Lazarovici, P.7
  • 49
    • 0021711624 scopus 로고
    • Cortical projections arising from the basal forebrain: A study of cholinergic and noncholinergic components employing combined retrograde tracing and immunohistochemical localization of choline acetyltransferase
    • Rye D. B., Wainer B. H., Mesulam M.-M., Mufson E. J., Sapers C. B. Cortical projections arising from the basal forebrain: a study of cholinergic and noncholinergic components employing combined retrograde tracing and immunohistochemical localization of choline acetyltransferase. Neuroscience. 13:1984;627-643.
    • (1984) Neuroscience , vol.13 , pp. 627-643
    • Rye, D.B.1    Wainer, B.H.2    Mesulam, M.-M.3    Mufson, E.J.4    Sapers, C.B.5
  • 50
    • 0023929304 scopus 로고
    • Animal models of Alzheimer's disease: Experimental cholinergic denervation
    • Smith G. Animal models of Alzheimer's disease: experimental cholinergic denervation. Brain Res. Rev. 13:1988;103-118.
    • (1988) Brain Res. Rev. , vol.13 , pp. 103-118
    • Smith, G.1
  • 51
    • 0020605091 scopus 로고
    • Neuron numbers in the superior cervical ganglion of the rat: A critical method of cell counting
    • Smolen A. J., Wright L. L., Cunningham T. J. Neuron numbers in the superior cervical ganglion of the rat: a critical method of cell counting. J. Neurocytol. 12:1983;739-750.
    • (1983) J. Neurocytol. , vol.12 , pp. 739-750
    • Smolen, A.J.1    Wright, L.L.2    Cunningham, T.J.3
  • 52
    • 0022222922 scopus 로고
    • Effect of unilateral decortication on choline acetyltransferase activity in the nucleus basalis and other areas of the rat brain
    • Stephens P. H., Cuello C., Sofroniew V., Pearson C. A., Tagari P. Effect of unilateral decortication on choline acetyltransferase activity in the nucleus basalis and other areas of the rat brain. J. Neurochem. 45:1985;1021-1026.
    • (1985) J. Neurochem. , vol.45 , pp. 1021-1026
    • Stephens, P.H.1    Cuello, C.2    Sofroniew, V.3    Pearson, C.A.4    Tagari, P.5
  • 53
    • 0026563244 scopus 로고
    • K-252a is a selective inhibitor of the tyrosine protein kinase activity of the trk family of oncogenes and neurotrophin receptors
    • Tarpley P., Lamballe F., Barbacid M. K-252a is a selective inhibitor of the tyrosine protein kinase activity of the trk family of oncogenes and neurotrophin receptors. Oncogene. 7:1992;371-381.
    • (1992) Oncogene , vol.7 , pp. 371-381
    • Tarpley, P.1    Lamballe, F.2    Barbacid, M.3
  • 54
    • 0029655903 scopus 로고    scopus 로고
    • Neuroprotection and selective vulnerability of neurons within the nucleus basalis magnocellularis
    • Wenk G. L. Neuroprotection and selective vulnerability of neurons within the nucleus basalis magnocellularis. Behav. Brain Res. 72:1996;17-24.
    • (1996) Behav. Brain Res. , vol.72 , pp. 17-24
    • Wenk, G.L.1
  • 55
    • 0021229845 scopus 로고
    • Nucleus basalis magnocellularis: Optimal coordinates for selective reduction of choline acetyltransferase in frontal neocortex by ibotenic acid injection
    • Wenk G., Cribbs B., McCrall L. Nucleus basalis magnocellularis: optimal coordinates for selective reduction of choline acetyltransferase in frontal neocortex by ibotenic acid injection. Expl Brain Res. 56:1984;335-340.
    • (1984) Expl Brain Res. , vol.56 , pp. 335-340
    • Wenk, G.1    Cribbs, B.2    McCrall, L.3
  • 56
    • 0027087240 scopus 로고
    • Basal forebrain neurons and memory: A biochemical, histological, and behavioral study of differential vulnerability to ibotenate and quisqualate
    • Wenk G. L., Harrington C. A., Tucker D. A., Rance N. E., Walker L. C. Basal forebrain neurons and memory: a biochemical, histological, and behavioral study of differential vulnerability to ibotenate and quisqualate. Behav. Neurosci. 106:1992;909-923.
    • (1992) Behav. Neurosci. , vol.106 , pp. 909-923
    • Wenk, G.L.1    Harrington, C.A.2    Tucker, D.A.3    Rance, N.E.4    Walker, L.C.5
  • 57
    • 0020072221 scopus 로고
    • Alzheimers disease and senile dementia: Loss of neurons in the basal forebrain
    • Whitehouse P. J., Price D. L., Struble R. G., Clark A. W., Delong M. R. Alzheimers disease and senile dementia: loss of neurons in the basal forebrain. Science. 215:1982;237-1239.
    • (1982) Science , vol.215 , pp. 237-1239
    • Whitehouse, P.J.1    Price, D.L.2    Struble, R.G.3    Clark, A.W.4    Delong, M.R.5
  • 58
    • 0028793322 scopus 로고
    • Effects of nerve growth factor treatment on rats with lesions of the nucleus basalis magnocellularis produced by ibotenic acid, quisqualic acid, and AMPA
    • Winkler J., Thal L. J. Effects of nerve growth factor treatment on rats with lesions of the nucleus basalis magnocellularis produced by ibotenic acid, quisqualic acid, and AMPA. Expl Neurol. 136:1995;234-250.
    • (1995) Expl Neurol. , vol.136 , pp. 234-250
    • Winkler, J.1    Thal, L.J.2
  • 59
    • 0028880006 scopus 로고
    • Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
    • Xia Z., Dickens M., Raingeaud J., Davis R. J., Greenberg M. E. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science. 270:1995;1326-1331.
    • (1995) Science , vol.270 , pp. 1326-1331
    • Xia, Z.1    Dickens, M.2    Raingeaud, J.3    Davis, R.J.4    Greenberg, M.E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.