The new human tissue kallikrein gene family: Structure, function, and association to disease

Endocrine Reviews

Volumn 22, Issue 2, 2001, Pages 184-204

  Yousef, George M ^a,b   Diamandis, Eleftherios P ^a,b  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

KALLIKREIN; KALLIKREIN 1; NUCLEOTIDE; PROSTATE SPECIFIC ANTIGEN; PROTEIN; SERINE PROTEINASE; STEROID HORMONE; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; CHROMOSOME; DISEASE ASSOCIATION; ENZYME ACTIVITY; GENE EXPRESSION; GENE LOCUS; GENE MAPPING; GENOME; HORMONAL REGULATION; HUMAN; MULTIGENE FAMILY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROSTATE CARCINOMA; PROTEIN EXPRESSION; REVIEW; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; CHROMOSOME MAPPING; HUMANS; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; NEOPLASMS; PHYLOGENY; SEQUENCE HOMOLOGY, AMINO ACID; TISSUE KALLIKREINS;

EID: 0035018273     PISSN: 0163769X     EISSN: None     Source Type: Journal    
DOI: 10.1210/er.22.2.184     Document Type: Review

References (251)

1. 1. Kraut H, Frey EK, Werle E 1930 Der Nachweis eines Kreislaufhormon in de Pankreasdruse. Hoppe-Seylers Z Physiol Chem 189: 97-106
2. 2. Werle E 1934 Zur Kenntnis des haushalts des Kallikreins. Biochem Z 269:415-434
3. 3. Fiedler F 1979 Enzymology of glandular kallikreins. In: Erdos EG (ed) Bradykinin, Kallidin and Kallikrein. Springer-Verlag, Berlin, pp 103-161
4. 4. Movat HZ 1979 The plasma kallikrein-kinin system ad its interrelationship with other components of blood. In: Erdos EG (ed) Bradykinin, Kallidin and Kallikrein, Springer-Verlag, Berlin, pp 1-89
5. 5. Asakai R, Davie EW, Chung DW 1937 Organization of the gene for human Factor XI. Biochemistry 26:7221-7228
6. 6. Yu H, Bowden DW, Spray BJ, Roch SS, Freedman BI 1998 Identification of human plasma kallikrein gene polymorphisms and evaluation of their role in end-stage renal disease. Hypertension 31:906-911
7. 7. Bhoola KD, Figueroa CD, Worthy K 1992 Bioregulation of kinins: kallikreins, kininogens, and kininases. Pharmacol Rev 44:1-80
8. 8. Beraldo WT, Andrade SP 1997 Discovery of bradykinin and the kallikrein-kinin system. In: Farmer SG (ed) The Kinin System. Academic Press, San Diego, CA, vol 1:1-8
9. 9. Clements JA 1997 The molecular biology of the kallikreins and their roles in inflammation. In: Farmer SG (ed) The Kinin System. Academic Press, San Diego, CA, vol 5:71-97
10. 10. Clements JA 1989 The glandular kallikrein family of enzymes: tissue-specific expression and hormonal regulation. Endocr Rev 10:393-419
11. 11. Margolius HS 1998 Kallikreins, kinins and cardiovascular diseases: a short review. Biol Res 31:135-141
12. 12. Margolius HS 1998 Tissue kallikreins structure, regulation, and participation in mammalian physiology and disease. Clin Rev Allergy Immunol 16:337-349
13. 13. Diamandis EP, Yousef GM, Luo LY, Magklara A, Obiezu CV 2000 The new human kallikrein gene family: implications in carcinogenesis. Trends Endocrinol Metab 11:54-60
14. 14. Deperthes D, Marceau F, Frenette G, Lazure C, Tremblay RR, Dube JY 1997 Human kallikrein hK2 has low kininogenase activity while prostate specific antigen (hK2) has none. Biochim Biophys Acta 1343:102-106
15. 15. Charlesworth MC, Young CYE, Miller VM, Tindall DJ 1999 Kininogenase activity of prostate-derived human glandular kallikrein (hK2) purified from seminal fluid. J Androl 20:220-229
16. 16. Evans BA, Drinkwater CC, Richards RI 1987 Mouse glandular kallikrein genes. Structure and partial sequence analysis of the kallikrein gene locus. J Biol Chem 262:8027-8034
17. 17. Bell RA, Fahnestock M 1988 Sequence and comparative analysis of three cDNAs from Mastomys natalensis, an African rat. J Cell Biol 107:615a
18. 18. Wines DR, Brady JM, Pritchett DB, Roberts JL, MacDonald RJ 1989 Organization and expression of the rat kallikrein gene family. J Biol Chem 264:7653-7662
19. 19. Murray SR, Chao J, Lin F, Chao L 1990 Kallikrein multigene families and the regulation of their expression. J Cardiovasc Pharmacol 15[Suppl]:S7-S15
20. 20. Howies PN, Dickinson DP, DiCaprio LL, Woodworth-Gutai M, Gross KW 1984 Use of a cDNA recombinant for the γ-subunit of mouse nerve growth factor to localize members of the multigene family near the TAM-1 locus on chromosome 7. Nucleic Acids Res 12:2791-2805
21. 21. Mason AJ, Evans BA, Cox DR, Shine J, Richards RI 1983 Structure of mouse kallikrein gene family suggests a role in specific processing of biologically active peptides. Nature 303:300-307
22. 22. Drinkwater CC, Evans BA, Richards RI 1987 Mouse glandular kallikrein genes: identification and characterization of the genes encoding the epidermal growth factor binding proteins. Biochemistry 26:6750-6756
23. 23. Ashley PL, MacDonald RJ 1985 Kallikrein-related mRNAs of the rat submaxilliary gland: nucleotide sequences of four distinct types including tonin. Biochemistry 24:4512-4519
24. 24. Chen Y, Chao J, Chen L 1988 Molecular cloning and characterization of two rat renal kallikrein genes. Biochemistry 27:7189 -7196
25. 25. Brady JM, Wines DR, MacDonald RJ 1989 Expression of two kallikrein gene family members in the rat prostate. Biochemistry 28:5203-5210
26. 26. Inoue H, Fukui K, Miyake Y 1989 Identification and structure of the rat true tissue kallikrein gene expressed in the kidney. J Biochem (Tokyo) 108:834-840
27. 27. Shai S, Woodley-Miller C, Chao J, Chao L 1989 Characterization of genes encoding rat tonin and a kallikrein-like serine protease. Biochemistry 28:5334-5343
28. 28. Wines DR, Brady JM, Southard EM, MacDonald RJ 1991 Evolution of the rat kallikrein gene family: gene conversion leads to functional diversity. J Mol Evol 32:476-492
29. 29. Brady JM, MacDonald RJ 1990 The expression of two kallikrein gene family members in the rat kidney. Arch Biochem Biophys 278:342-349
30. 30. Ma JX, Chao J, Chao L 1992 Molecular cloning and characterization of rKLK10, a cDNA encoding T-kininogenase from rat submandibular gland and kidney. Biochemistry 31:10922-10928
31. 31. Clements JA, Matheson BA, Funder JW 1990 Tissue-specific developmental expression of the kallikrein gene family in the rat. J Biol Chem 265:1077-1081
32. 32. Clements JA, Mukhtar A, Verity K, Pullar M, McNeill P, Cummins J, Fuller PJ 1996 Kallikrein gene expression in human pituitary tissues. Clin Endocrinol (Oxf) 44:223-231
33. 33. Clements JA, Mukhtar A, Ehrlich A, Fuller P 1992 A re-evaluation of the tissue-specific pattern of expression of the rat kallikrein gene family. In: Fritz H, Muller-Esterl W, Jochum M, Roscher A, Lyuppertz K (eds) Recent Progress on Kinins. Agents and Actions Supplement. Birkhauser Verlag, Basel, vol 38/1:34-41
34. 34. Evans BA, Yun ZX, Close JA, Tregear GW, Kitamura N, Nakanishi S, Callen DF, Baker E, Hyland VJ, Sutherland GR, Richards RI 1988 Structure and chromosomal localization of the human renal kallikrein gene. Biochemistry 27:3124-3129
35. 35. Richards RI, Holman K, Shen Y, Kozman H, Harley H, Brook D, Shaw D 1991 Human glandular kallikrein genes: genetic and physical mapping of the KLK1 locus using a highly polymorphic microsatellite PCR marker. Genomics 11:77-82
36. 36. Riegman PHJ, Vlietstra RJ, Klaassen P, Van der Korput JAGM, Guerts van Kessel A, Romijn JC, Trapman J 1989 The prostate-specific antigen gene and the human glandular kallikrein-1 gene are tandemly located on chromosome 19. FEBS Lett 247:123-126
37. 37. Riegman PHJ, Vlietstra RJ, Suurmeijer L, Cleutjens CBJM, Trapman J 1992 Characterization of the human kallikrein locus. Genomics 14:6-11
38. 38. Qin H, Kemp J, Yip M, Lam-Po-Tang PRL, Morris BJ 1991 Localization of human glandular kallikrein-1 gene to chromosome 19q13.3-13.4 by in-situ hybridization. Hum Hered 41:222-226
39. 39. Wang MC, Valenzuela LA, Murphy GP, Chu TM 1979 Purification of a human prostate-specific antigen. Invest Urol 17:159-163
40. 40. Wang MC, Papsidero LD, Kuriyama M, Valenzuela LA, Murphy GP, Chu TM 1981 Prostate antigen: a new potential marker for prostatic cancer. Prostate 21:89-96
41. 41. Wang MC, Valenzuela LA, Murphy GP, Chu TM 1977 Tissue specific and tumor specific antigens in human prostate. Fed Proc 36:1254
42. 42. Papsidero LD, Wang MC, Valenzuela LA, Murphy GP, Chu TM 1980 A prostate antigen in sera of prostatic cancer patients. Cancer Res 40:2428-2432
43. 43. Rittenhouse HG, Finlay JA, Mikolajczyk SD, Partin AW 1998 Human kallikrein 2 (hK2) and prostate-specific antigen (PSA): two closely related, but distinct, kallikreins in the prostate. Crit Rev Clin Lab Sci 35:275-368
44. 44. Diamandis EP 1999 Prostate specific antigen - its usefulness in clinical medicine. Trends Endocrinol Metab 25:14-16
45. 45. Oesterling JE 1991 Prostate-specific antigen: a critical assessment of the most useful tumor marker for adenocarcinoma of the prostate. J Urol 145:907-923
46. 46. Catalona WJ, Smith DS, Ratliff TL, Dodds KM, Coplen DE, Yuan JJ, Petros JA, Andriole GL 1991 Measurement of prostate-specific antigen in serum as a screening test for prostate cancer. N Engl J Med 324:1156-1161
47. 47. Catalona WJ 1996 Clinical utility of measurements of free and total prostate-specific antigen (PSA): a review. Prostate Suppl 7:64-69
48. 48. Pannek J, Partin AW 1997 Prostate-specific antigen: what's new in 1997. Oncology 9:1273-1278
49. 49. McCormack RT, Rittenhouse HG, Finlay JA, Sokoloff RL, Wang TJ, Wolfert RL, Lilja H, Oesterling JE 1995 Molecular forms of prostate-specific antigen and the human kallikrein gene family: a new era. Urology 45:729-744
50. 50. Lilja H 1993 Structure, function and regulation of the enzyme activity of prostate-specific antigen. World J Urol 11:188-191
51. 51. Malm J, Lilja H 1995 Biochemistry of prostate-specific antigen, PSA. Scand J Clin Lab Invest Suppl 221:15-22
52. 52. Chu TM 1997 Prostate-specific antigen and early detection of prostate cancer. Tumour Biol 18:123-134
53. 53. Stamey TA, Yang N, Hay AR, McNeal JE, Freiha FS, Redwine E 1987 Prostate-specific antigen as a serum marker for adenocarcinoma of the prostate. N Engl J Med 317:909-916
54. 54. Diamandis EP, Yu H 1995 New biological function of prostate-specific antigen? J Clin Endocrinol Metab 80:1515-1517
55. 55. Diamandis EP 1998 Prostate-specific antigen or human kallikrein 3? Recent developments. Tumor Biol 19:65-68
56. 56. Diamandis EP, Yu H 1997 Nonprostatic sources of prostate-specific antigen. In: Oesterling JE (ed) The Urologic Clinics of North America: Prostate-Specific Antigen: The Best Prostatic Tumor Marker. WB Saunders, Philadelphia, PA, vol 14:275-282
57. 57. Black MH, Diamandis EP 2000 The diagnostic and prognostic utility of prostate specific antigen for diseases of the breast. Breast Cancer Res Treat 59:1-14
58. 58. Stenman U-H 1999 New ultrasensitive assays facilitate studies on the role of human glandular kallikrein (hK2) as a marker for prostatic disease. Clin Chem 45:753-754
59. 59. Klee G, Goodmanson M, Jacobsen S, Young C, Finlay J, Rittenhouse HG, Wolfert RL, Tindall DJ 1999 Highly sensitive automated chemiluminometric assay for measuring free human glandular kallikrein-2. Clin Chem 45:800-806
60. 60. Black M, Magklara A, Obiezu C, Melegos D, Diamandis EP 1999 Development of an ultrasensitive immunoassay for human glandular kallikrein with no cross-reactivity from prostate-specific antigen. Clin Chem 45:790-799
61. 61. Kwiatkowski MK, Recker F, Piironen T, Pettersson K, Otto T, Wernli M, Tscholl R 1998 In prostatism patients the ratio of human glandular kallikrein to free PSA improves the discrimination between prostate cancer and benign hyperplasia within the diagnostic "gray zone" of total PSA 4 to 10 ng/mL. Urology 52:360-365
62. 62. Magklara A, Scorilas A, Catalona WJ, Diamandis EP 1999 The combination of human glandular kallikrein and free prostate-specific antigen (PSA) enhances discrimination between prostate cancer and benign prostatic hyperplasia in patients with moderately increased total PSA. Clin Chem 45:1960-1966
63. 63. Nam RK, Diamandis EP, Toi A, Trachtenberg J, Magklara A, Scorilas A, Papanastasiou P, Jewett MAS, Narod SA 2000 Serum human glandular kallikrein-2 protease levels predict the presence of prostate cancer among men with elevated prostate-specific antigen. J Clin Oncol 18:1036-1042
64. 64. Partin AW, Catalona WJ, Finlay JA, Darte C, Tindall DJ, Young CY, Klee GG, Chan DW, Rittenhouse HG, Wolfert RL, Woodrum DL 1999 Use of human glandular kallikrein 2 for the detection of prostate cancer: preliminary analysis. Urology 54:839-845
65. 65. Becker C, Piironen T, Kiviniemi J, Lilja H, Pettersson K 2000 Sensitive and specific immunodetection of human glandular kallikrein 2 in serum. Clin Chem 46:198-206
66. 66. Becker C, Piironen T, Pettersson K, Bjork T, Wojno KJ, Oesterling JE, Lilja H 2000 Discrimination of men with prostate cancer from those with benign disease by measurements of human glandular kallikrein 2 (hK2) in serum. J Urol 163:311-316
67. 67. Yousef GM, Diamandis EP 2000 The expanded human kallikrein gene family: locus characterization and molecular cloning of a new member KLK-L3. Genomics 65:184-194
68. 68. Yousef GM, Chang A, Scorilas A, Diamandis EP 2000 Genomic organization of the human kallikrein gene family on chromosome 19q13.3-q13.4. Biochem Biophys Res Commun 16:125-133
69. 69. Yousef GM, Scorilas A, June K, Ahsworth LK, Diamandis EP 2001 Molecular cloning of the human kallikrein 15 gene (KLK15): up-regulaton in prostate cancer. J Biol Chem 276:53-61
70. 70. Nelson PS, Gan L, Ferguson C, Moss P, Gelinas R, Hood L, Wang K 1999 Molecular cloning and characterization of prostase, an androgen-regulated serine protease with prostate-restricted expression. Proc Natl Acad Sci USA 96:3114-3119
71. 71. Yousef GM, Obiezu CV, Luo LY, Black MH, Diamandis EP 1999 Prostase/KLK-L1 is a new member of the human kallikrein gene family, is expressed in prostate and breast tissues, and is hormonally regulated. Cancer Res 59:4252-4256
72. 72. Stephenson SA, Verity K, Ashworth LK, Clements JA 1999 Localization of a new prostate-specific antigen-related serine protease gene, KLK4, is evidence for an expended human kallikrein gene family cluster on chromosome 19q13.3-13.4. J Biol Chem 274:23210-23214
73. 73. Anisowicz A, Sotiropoulou G, Stenman G, Mok SC, Sager R 1996 A novel protease homolog differentially expressed in breast and ovarian cancer. Mol Med 2:624-636
74. 74. Little SP, Dixon EP, Norris F, Buckley W, Becker GW, Johnson M, Dobbins JR, Wyrick T, Miller JR, MacKellar W, Hepburn D, Corvalan J, McClure D, Liu X, Stephenson D, Clements J, Johnstone EM 1997 Zyme, a novel and potentially amyloidogenic enzyme cDNA isolated from Alzheimer's disease brain. J Biol Chem 272:25135-25142
75. 75. Ekholm E, Egelrud T 1999 Stratum corneum chymotryptic enzyme in psoriasis. Arch Dermatol Res 291:195-200
76. 76. Liu XL, Wazer DE, Watanabe K, Band V 1996 Identification of a novel serine protease-like gene, the expression of which is down-regulated during breast cancer progression. Cancer Res 56:3371-3379
77. 77. Yousef GM, Magklara A, Diamandis EP 2000 KLK12 is a novel serine protease and a new member of the human kallikrein gene family-differential expression in breast cancer. Genomics 69:331-341
78. 78. Yousef GM, Chang A, Diamandis EP 2000 Identification and characterization of KLK-L4, a new kallikrein-like gene which appears to be down-regulated in breast cancer tissues. J Biol Chem 275: 11891-11898
79. 79. Hu JC-C, Zhang C, Sun X, Yang Y, Cao X, Ryu O, Simmer JP 2000 Characterization of the mouse and human PRSS17 genes their relationship to other serine proteases and the expression of PRSS17 in developing mouse incisors. Gene 251:1-8
80. 80. Yousef GM, Diamandis EP 1999 The new kallikrein-like gene KLK-L2: molecular characterization, mapping, tissue expression and hormonal regulation. J Biol Chem 274:37511-37516
81. 81. Brattsand M, Egelrud T 1999 Purification, molecular cloning, and expression of a human stratum corneum trypsin-like serine protease with possible function in desquamation. J Biol Chem 274: 30033-30040
82. 82. Yamashiro K, Tsuruoko N, Kodama S, Tsujimoto M, Yamamura T, Tanaka T, Nakazato H, Yamaguchi N 1997 Molecular cloning of a novel trypsin-like serine protease (neurosin) preferentially expressed in brain. Biochim Biophys Acta 1350:11-14
83. 83. Yousef GM, Luo LY, Scherer SW, Sotiropoulou G, Diamandis EP 1999 Molecular characterization of zyme/protease M/neurosin, a hormonally-regulated kallikrein-like serine protease. Genomics 62: 251-259
84. 84. Hansson L, Stromqvist M, Backman A, Wallbrandt P, Carlstein A Egelrud T 1994 Cloning, expression and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase. J Biol Chem 269:19420-19426
85. 85. Yousef GM, Scorilas A, Magklara A, Soosaipillai A, Diamandis EP 2000 The KLK7 (PRSS6) gene encoding for the stratum corneum chymotryptic enzyme is a new member of the human kallikrein gene family-genomic characterization mapping tissue expression and hormonal regulation. Gene 254:119-128
86. 86. Yoshida S, Taniguchi M, Hirata A Shiosaka S 1998 Sequence analysis and expression of human neuropsin cDNA and gene. Gene 213:9-16
87. 87. Luo L, Herbrick J-A, Scherer SW, Beatty B, Squire J, Diamandis EP 1998 Structural characterization and mapping of the normal epithelial cell-specific 1 gene. Biochem Biophys Res Commun 247: 580-586
88. 88. Yoshida S, Taniguchi M, Suemoto T, Oka T, He X, Shiosaka S 1998 cDNA cloning and expression of a novel serine protease, TLSP. Biochim Biophys Acta 1399:225-228
89. 89. Yousef GM, Scorilas A, Diamandis EP 2000 Genomic organization mapping tissue expression and hormonal regulation of trypsin-like serine protease (TLSP PRSS20), a new member of the human kallikrein gene family. Genomics 63:88-96
90. 90. Yousef GM, Magklara A, Chang A, Jung K, Katsaros D, Diamandis EP, Cloning of a new member of the human kallikrein gene family, KLK14, which is down-regulated in different malignancies. Cancer Res, in press
91. 91. Berg T, Bradshaw RA, Carretero OA, Chao J, Chao L, Clements JA, Fahnestock M, Fritz H, Gauthier F, MacDonald RJ, Margolius HS, Morris BJ, Richards RI, Scicli AG 1992 A common nomenclature for members of the tissue (glandular) kallikrein gene families. In: Fritz H, Muller-Esterl W, Jochum M, Roscher A, Luppertz K(eds) Recent Progress on Kinins. Agents and Actions Supplement. Birkhauser Verlag, Basel, vol 38/1:19-25
92. 92. Diamandis EP, Yousef GM, Clements J, Ashworth LK, Yoshida S, Egelrud T, Nelson PS, Shiosaka S, Little S, Lilja H, Stenman U-H, Rittenhouse HG, Wain 2000 New nomenclature for the human tissue kallikrein gene family. Clin Chem 46:1855-1858
93. 93. Fukushima D, Kitamura N, Nakanishi S 1985 Nucleotide sequence of cloned cDNA for human pancreatic kallikrein. Biochemistry 24:8037-8043
94. 94. Schedlich LJ, Bennetts BH, Morris BJ 1987 Primary structure of a human glandular kallikrein gene. DNA 6:429-437
95. 95. Lundwall A 1989 Characterization of the gene for prostate-specific antigen, a human glandular kallikrein. Biochem Biophys Res Commun 161:1151-1159
96. 96. Riegman PHJ, Klassen P, Van der Korput JAGM, Romijn JC, Trapman J 1988 Molecular cloning and characterization of novel prostate antigen cDNAs. Biochem Biophys Res Commun 155: 181-188
97. 97. Riegman PHJ, Vlietstra RJ, Van der Korput JAGM, Romijn JC, Trapman J 1989 Characterization of the prostate-specific antigen gene: a novel human kallikrein-like gene. Biochem Biophys Res Commun 159:95-102
98. 98. Underwood LJ, Tanimoto H, Wang Y, Shigemasa K, Parmley TH, O'Brien TJ 1999 Cloning of tumor-associated differentially expressed gene-14, a novel serine protease overexpressed by ovarian carcinoma. Cancer Res 59:4435-4439
99. 99. Goyal J, Cowan JM, Wazer DE, Lee SW, Band V 1998 The role for NES1 serine. Protease as a novel tumor suppressor. Cancer Res 58:4782-4786
100. 100. Mitsui S, Yamada T, Okui A, Kominami K, Uemura H, Yamaguchi N 2000 A novel isoform of a kallikrein-like protease TLSP/ Hippostasin (PRSS20), is expressed in the human brain and prostate. Biochem Biophys Res Commun 272:205-211
101. 101. Foussias G, Yousef GM, Diamandis EP 2000 Identification and molecular characterization of a novel member of the siglec family (Siglec 9). Genomics 67:171-178
102. 102. Crocker PR, Clark EA, Filbin M, Gordon S, Jones Y, Kehrl JH, Kelm S, Le Douarin N, Powell L, Roder J, Schnaar RL, Sgroi DC, Stamenkovic K, Schauer R, Schachner M, van den Berg TK, van der Merwe PA, Watt SM, Varki A 1998 Siglecs: a family of sialic-acid binding lectins. Glycobiology 8:5-6
103. 103. Kelm S, Schauer R, Crocker PR 1996 The sialoadhesins-a family of sialic acid-dependent cellular recognition molecules within the immunoglobulin superfamily. Glycoconj J 13:913-926
104. 104. Dayhoff MO 1978 Atlas of protein sequence and structure. Nat Biomed Res Found [Suppl 3]:79-81
105. 105. Creighton TE 1993 Proteins: Structures and Molecular Properties, ed 2. WH Freeman and Company, New York
106. 2+ and extracellular protease inhibitors. Eur J Biochem 262:781-789
107. 107. Tanimoto H, Underwood LJ, Shigemasa K, Yan Y, Clarke J, O'Brien TJ 1999 The stratum corneum chymotryptic enzyme that mediates shedding and desquamation of skin cells is highly overexpressed in ovarian tumor cells. Cancer 86:2074-2082
108. 108. Van Leeuwen BH, Evans BA, Tregear GW, Richards R 1986 Mouse glandular kallikrein genes. Identification, structure and expression of the renal kallikrein gene. J Biol Chem 261:5529-5535
109. 109. Van Leeuwen BH, Penschow JD, Coghlan JP, Richards RI 1987 Cellular basis for the differential response of mouse kallikrein genes to hormonal induction. EMBO J 6:1705-1713
110. 110. Clements JA, Matheson BA, Wines DR, Brady JM, MacDonald RJ, Funder JW 1988 Androgen dependence of specific kallikrein gene family members expressed in the rat prostate. J Biol Chem 31:16132-16137
111. 111. Penschow JD, Drinkwater CC, Haralambidis J, Coghlan JP 1991 Sites of expression and induction of glandular kallikrein gene expression in mice. Mol Cell Endocrinol 81:135-146
112. 112. Miller DH, Chao J, Margolius HS 1984 Tissue kallikrein synthesis and its modification by testosterone or low dietary sodium. Biochem J 218:237-243
113. 113. Miller DH, Lindley JG, Margolius HS 1985 Tissue kallikrein levels and synthesis rates are not changed by an acute physiological dose of aldosterone. Proc Soc Exp Biol Med 180:121-125
114. 114. Clements JA, Fuller PJ, McNally M, Nikolaidis I, Fundet JW 1986 Estrogen regulation of kallikrein gene expression in the rat anterior pituitary. Endocrinology 119:268-273
115. 115. Clements JA, Matheson BA, MacDonald RJ, Funder JW 1989 The expression of the kallikrein gene family in the rat pituitary oestrogen effects and the expression of an additional family member in the neurointermediate lobe. J Neuroendocrinol 1:199-203
116. 116. Pritchett DB, Roberts JL 1987 Dopamine regulates expression of the glandular-type kallikrein gene at the transcriptional level in the pituitary. Proc Natl Acad Sci USA 84:5545-5549
117. 117. Clements JA, Mukhtar A, Ehrlich A, Yap B 1994 Kallikrein gene expression in the human uterus. Braz J Med Biol Res 27:1855-1863
118. 118. Riegman PHJ, Vlietstra RJ, van der Korput JAGM, Brinkmann AO, Trapman J 1991 The promoter of the prostate-specific antigen gene contains a functional androgen responsive element. Mol Endocrinol 5:1921-1930
119. 119. Cleutjens KBJM, van Eekelen CCEM, van der Korput HAGM, Brinkman AO, Trapman J 1996 Two androgen response regions cooperate in steroid hormone regulated activity of the prostate-specific antigen promoter. J Biol Chem 271:6379-6388
120. 120. Luke MC, Coffey DS 1994 Human androgen receptor binding to the androgen response element of prostate specific antigen. J Androl 15:41-51
121. 121. Schuur ER, Henderson GA, Kmetec LS, Miller JD, Lamparski HG, Henderson DR 1996 Prostate-specific antigen expression is regulated by an upstream enhancer. J Biol Chem 271:7043-7051
122. 122. Cleutjens KB, van der Korput HA, van Eekelen CC, van Rooij HCJ, Faber PW, Trapman J 1997 An androgen response element in a far upstream enhancer region is essential for high, androgen-regulated activity of the prostate-specific antigen promoter. Mol Endcrinol 11:148-161
123. 123. Yu H, Diamandis EP, Zarghami N, Grass L 1994 Induction of prostate specific antigen production by steroids and tamoxifen in breast cancer cell lines. Breast Cancer Res Treat 32:291-300
124. 124. Yu H, Diamandis EP, Monne M, Croce CM 1995 Oral contraceptive-induced expression of prostate specific antigen in the female breast. J Biol Chem 270:6615-6618
125. 125. Zarghami N, Grass L, Diamandis EP 1997 Steroid hormone regulation of prostate specific antigen gene expression in breast cancer. Br J Cancer 75:579-588
126. 126. Rodriguez R, Schuur ER, Lim HY, Henderson GA, Simons JW, Henderson DR 1997 Prostate attenuated replication competent adenovirus (ARCA) CN706: a selective cytotoxic for prostate-specific antigen-positive prostate cancer cells. Cancer Res 57: 2559-25563
127. 127. Cleutjens KB, van der Korput HA, Ehren-van Eekelen CC, Sikes RA, Fasciana C, Chung LW, Trapman J 1997 A 6-kb promoter fragment mimics in transgenic mice the prostate-specific and androgen-regulated expression of the endogenous prostate-specific antigen gene in humans. Mol Endocrinol 11:1256-1265
128. 128. Latham JP, Searle PF, Mautner V, James ND 2000 Prostate-specific antigen promoter/enhancer driven gene therapy for prostate cancer: construction and testing of a tissue-specific adenovirus vector. Cancer Res 60:334-341
129. 129. Martiniello-Wilks R, Garcia-Aragon J, Daja MM, Russell P, Both GW, Molloy PL, Lockett LJ, Russell PJ 1998 In vivo gene therapy for prostate cancer: preclinical evaluation of two different enzyme-directed prodrug therapy systems delivered by identical adenovirus vectors. Hum Gene Ther 9:1617-1626
130. 130. Gotoh A, Ko SC, Shirakawa T, Cheon J, Kao C, Miyamoto T, Gardner TA, Ho LJ, Cleutjens CB, Trapman J, Graham FL, Chung LW 1998 Development of prostate-specific antigen promoter-based gene therapy for androgen-independent human prostate cancer. J Urol 160:220-229
131. 131. Dannul J, Belldegrun AS 1997 Development of gene therapy for prostate cancer using a novel promoter of prostate-specific antigen. Br J Urol 79[Suppl 1]:97-103
132. 132. Lee CG, Liu M, Sie KL, Lee MS 1996 Prostate-specific antigen promoter driven gene therapy targeting DNA polymerase-α and topoisomerase II α in prostate cancer. Anticancer Res 16:1805-1811
133. 133. Young CYF, Andrews PE, Tindall DJ 1995 Expression and androgenic regulation of human prostate-specific kallikreins. J Androl 16:97-99
134. 134. Magklara A, Grass L, Diamandis EP 2000 Differential steroid hormone regulation of human glandular kallikrein (hK2) and prostate-specific antigen (PSA) in breast cancer cell lines. Breast Cancer Res Treat 59:263-270
135. 135. Murtha P, Tindall DJ, Young CYF 1993 Androgen induction of a human prostate-specific kallikrein, hKLK2: characterization of an androgen response element in the 5′ promoter region of the gene. Biochemistry 32:6459-6464
136. 136. Hsieh M-L, Charlesworth C, Goodmanson M, Zhang S, Seay T, Klee GG, Tindall DJ, Young CY 1997 Expression of human prostate-specific glandular kallikrein protein (hK2) in the breast cancer cell line T47-D. Cancer Res 57:2651-2656
137. 137. Riegman PHJ, Vlietstra RJ, van der Korput HA, Romijn JC, Trapman J 1991 Identification and androgen-regulated expression of two major human glandular kallikrein-1 (hGK-1) mRNA species. Mol Cell Endocrinol 76:181-190
138. 138. Yu D-C, Sakamoto GT, Henderson DR 1999 Identification of the transcriptional regulatory sequences of human kallikrein 2 and their use in the construction of Calydon virus 764, an attenuated replication competent adenovirus for prostate cancer therapy. Cancer Res 59:1498-1504
139. 139. Gotoh A, Kamidono S, Chung LW 1997 Clinical application for gene therapy in prostate cancer. Hinyokika Kiyo 43:829-833
140. 140. Luo LY, Grass L, Diamandis EP 2000 The normal epithelial cell-specific 1 (NES1) gene is up-regulated by steroid hormones in the breast carcinoma cell line BT-474. Anticancer Res 20:981-986
141. 141. Young CY, Andrews PE, Montgomery BT, Tindall DJ 1992 Tissue-specific and hormonal regulation of human prostate-specific glandular kallikrein. Biochemistry 31:818-824
142. 142. Morris BJ 1989 hGK-1: a kallikrein gene expressed in human prostate. Clin Exp Pharmacol Physiol 16:345-351
143. 143. Ferguson RA, Yu H, Kalyvas M, Zammit S, Diamandis EP 1996 Ultrasensitive detection of prostate specific antigen by a time-resolved immunofluorometric assay and the Immulite® Immunochemiluminescent third generation assay: potential applications in prostate and breast cancers. Clin Chem 42:675-684
144. 144. Zarghami N, Diamandis EP 1996 Detection of prostate specific antigen mRNA and protein in breast tumors. Clin Chem 42:361-366
145. 145. Howarth DJC, Aronson IB, Diamandis EP 1997 Immunohistochemical localization of prostate specific antigen in benign and malignant breast tissues. Br J Cancer 75:1646-1651
146. 146. Magklara A, Scorilas A, López-Otin C, Vizoso F, Ruibal A, Diamandis EP 1999 Human glandular kallikrein in breast milk, amniotic fluid, and breast cyst fluid. Clin Chem 45:1774-1780
147. 147. Black MA, Magklara A, Obiezu C, Levesque MA, Sutherland DJA, Tindall DJ, Young CYF, Sauter ER, Diamandis EP 2000 Expression of a prostate-associated protein human glandular kallikrein (hK2), in breast tumors and in normal breast secretions. Br J Cancer 82:361-367
148. 148. Lovgren J, Valtonen-Andre C, Marsal K, Lilja H, Lundwall A 1999 Measurement of prostate-specific antigen and human glandular kallikrein 2 in different body fluids. J Androl 20:348-355
149. 149. Lovgren J, Rajakoski K, Karp M, Lundwall A, Lilja H 1997 Activation of the zymogen form of prostate-specific antigen by human glandular kallikrein 2. Biochem Biophys Res Commun 238:549-555
150. 150. Kumar A, Mikolajczyk SD, Goel AS, Millar LS, Saedi MS 1997 Expression of pro form of prostate-specific antigen by mammalian cells and its conversion to mature, active form by human kallikrein 2. Cancer Res 57:3111-3114
151. 151. Takayama TK, Fujikawa K, Davie EW 1997 Characterization of the precursor of prostate-specific antigen-activation by trypsin and by human glandular kallikrein. J Biol Chem 272:21582-21588
152. 152. Catalona WJ, Partin AW, Slawin KM, Brawer MK, Flanigan RC, Patel A Richie JP, deKernion JB, Walsh PC, Scardino PT, Lange PH, Subong EN, Parson RE, Gasior GH, Loveland KG, Southwick PC 1998 Use of the percentage of free prostate-specific antigen to enhance differentiation of prostate cancer from benign prostatic disease: a prospective multicenter clinical trial. JAMA 279:1542-1547
153. 153. Lilja H, Haese A, Bjork T, Frederich MG, Piironen T, Pettersson K, Huland E, Huland H 1999 Significance and metabolism of complexed and noncomplexed prostate specific antigen forms, and human glandular kallikrein 2 in clinically localized prostate cancer before and after radical prostatectomy. J Urol 162:2029-2034
154. 154. Lilja H 1997 Prostate-specific antigen: molecular forms and the human kallikrein gene family. Br J Urol 79[Suppl 1]:44-48
155. 155. Zhang WM, Finne P, Leinonen J, Vesalainen S, Nordling S, Stenman UH 1999 Measurement of the complex between prostate-specific antigen and α1-protease inhibitor in serum. Clin Chem 45:814-821
156. 156. Mikolajczyk SD, Millar LS, Wang TJ, Rittenhouse HG, Marks LS, Song W, Wheeler TM, Slawin KM 2000 A precursor form of prostate-specific antigen is more highly elevated in prostate cancer compared to benign transition zone prostate tissue. Cancer Res 60:756-759
157. 157. Christensson A, Laurell CB, Lilja H 1990 Enzymatic activity of prostate-specific antigen and its reactions with extracellular serine proteinase inhibitors. Eur J Biochem 194:755-763
158. 158. Stenman UH, Leinonen J, Alfthan H, Rannikko S, Tuhkanen K, Alfthan O 1991 A complex between prostate-specific antigen and α1-antichymotrypsin is the major form of prostate-specific antigen in serum of patients with prostatic cancer: assay of the complex improves clinical sensitivity for cancer. Cancer Res 51:222-226
159. 159. Chen LM, Murray SR, Chai KX, Chao L, Chao J 1994 Molecular cloning and characterization of a novel kallikrein transcript in colon and its distribution in human tissues. Braz J Med Biol Res 27:1829-1838
160. 160. Rae F, Bulmer B, Nicol D, Clements J 1999 The human tissue kallikreins (KLKs 1-3) and a novel KLK1 mRNA transcript are expressed in renal cell carcinoma cDNA library. Immunopharmacology 45:83-88
161. 161. Liu XF, Essand M, Vasmatzis G, Lee B, Pastan I 1999 Identification of three new alternate human kallikrein 2 transcripts: evidence of long transcript and alternative splicing. Biochem Biophys Res Commun 264:833-839
162. 162. Heuze N, Olayat S, Gutman N, Zani ML, Courty Y 1999 Molecular cloning and expression of an alternative hKLK3 transcript coding for a variant protein of prostate- specific antigen. Cancer Res 59: 2820-2824
163. 163. Tanaka T, Isono T, Yoshiki T, Yuasa T, Okada Y 2000 A novel form of prostate-specific antigen transcript produced by alternative splicing. Cancer Res 60:56-59
164. 164. Magklara A, Scorilas A, Katsaros D, Fracchioli S, Yousef GM, Diamandis EP, The human KLK8 (neuropsin/ovasin) gene: identification of two novel splice variants and its prognostic value in ovarian cancer. Cancer Res, in press
165. 165. Chang A, Yousef GM, Jung K, Rajpert-De Meyts E, Diamandis EP, Identification and molecular characterization of five novel kallikrein gene 13 (KLK13; KLK-L4) splice variants: differential expression in testicular cancer. Gene, in press
166. 166. Margolius HS, Horwitz D, Pisano JJ, Keiser HR 1974 Urinary kallikrein in hypertension: relationship to sodium intake and sodium-retaining steroids. Circ Res 35:820-825
167. 167. Horwitz D, Margolius HS, Keiser HR 1978 Effects of dietary potassium and race on urinary excretion of kallikrein and aldosterone in man. J Clin Endocrinol Metab 47:296-299
168. 168. Holland OB, Chud JM, Braunstein H 1980 Urinary kallikrein excretion in essential and mineralocorticoid hypertension. J Clin Invest 65:347-356
169. 169. Griesbacher T, Lembeck F 1997 Putative roles of bradykinin and the kinin system in pancreatitis: In: Farmer SG (ed) The Kinin System. Academic Press, London, vol 12:197-217
170. 170. Matsumara Y, Kimura M, Yamamoto T, Maeda H 1988 Involvement of the kinin generating cascade in enhanced vascular permeability in tumour tissue. Jpn J Cancer Res 79:1327-1334
171. 171. Roberts RA, Gullick WJ 1989 Bradykinin receptor number and sensitivity to ligand stimulation of mitogenesis by expression of mutant ras oncogene. J Cell Sci 94:527-535
172. 172. Berg T, Johansen L, Bergundhaugen H, Hansen LJ, Reddy JK, Poulsen K 1985 Demonstration of kallikrein in a rat pancreatic acinar cell carcinoma. Cancer Res 45:226-234
173. 173. Jones TH, Brown BL, Dobson PRM 1989 Bradykinin stimulates phosphoinositide metabolism and prolactin secretion in rat anterior pituitary cells. J Mol Endocrinol 2:47-53
174. 174. Jones TH, Figueroa CD, Smith C, Cullen DR, Bhoola KD 1990 Characterization of a tissue kallikrein in human prolactin-secreting adenomas. J Endocrinol 124:327-331
175. 175. Farmer SG (ed) 1997 The Kinin System. Academic Press, London
176. 176. Oesterling JE (ed) 1997 Prostate-specific antigen. The best prostatic tumor marker. Urol Clin North Am 24:247-458
177. 177. Qiu SD, Young CY, Billhartz DL, Prescott JL, Farrow GM, He WW, Tindall DJ 1990 In situ hybridization of prostate-specific antigen RNA in human prostate. J Urol 144:1550-1556
178. 178. Hakalahti L, Vihko P, Henttu P, Autio-Harmainen H, Soini Y, Vihko R 1993 Evaluation of PAP and PSA gene expression in prostatic hyperplasia and prostatic carcinoma using Northern-blot analyses, in situ hybridization and immunohistochemical stainings with monoclonal and bispecific antibodies. Int J Cancer 55:590-597
179. 179. Gallee MP, Visser-de Jong E, van der Korput JA, van der Kwast TH, Kate FJ, Schroeder FH, Trapman J 1990 Variation of prostate-specific antigen expression in different tumour growth patterns present in prostatectomy specimens. Urol Res 18:181-187
180. 180. Pretlow TG, Pretlow TP, Yang P, Kaetzel CS, Delmoro CM, Kamis S, Bodner DR, Kursh E, Resnick MI, Bradley Jr EL 1991 Tissue concentrations of prostate specific antigen in prostatic carcinoma and benign prostatic hyperplasia. Int J Cancer 49:645-649
181. 181. Magklara A, Scorilas A, Stephan C, Kristiansen GO, Hauptmann S, Jung K, Diamandis EP 2000 Decreased concentrations of prostate-specific antigen and human glandular kallikrein 2 in malignant vs. nonmalignant prostatic tissue. Urology 56:527-532
182. 182. Abrahamsson PA, Lilja H, Falkmer S, Wadstrom LB 1988 Immunohistochemical distribution of the three predominant secretory proteins in the parenchyma of hyperplastic and neoplastic prostate glands. Prostate 12:39-46
183. 183. Stege R, Grande M, Carlstrom K, Tribukait B, Pousette A 2000 Prognostic significance of tissue prostate-specific antigen in endocrine-treated prostate carcinomas. Clin Cancer Res 6:160-165
184. 184. Yu H, Giai M, Diamandis EP, Katsaros D, Sutherland DJA, Levesque MA, Roagna R, Ponzone R, Sismondi P 1995 Prostate specific antigen is a new favourable prognostic indicator for women with breast cancer. Cancer Res 55:2104-2110
185. 185. Yu H, Levesque MS, Clark GM, Diamandis EP 1998 Prognostic value of prostate-specific antigen for women with breast cancer. A large U.S. cohort study. Clin Cancer Res 4:1489-1497
186. 186. Yu H, Diamandis EP, Levesque M, Giai M, Roagna R, Ponzone R, Sismondi P, Monne M, Croce C 1996 Prostate specific antigen in breast cancer, benign breast disease and normal breast tissue. Breast Cancer Res Treat 40:171-178
187. 187. Sauter ER, Daly M, Linahan K, Ehya H, Engstrom PF, Bonney G, Ross EA, Yu H, Diamandis E 1996 Prostate specific antigen levels in nipple aspirate fluid correlate with breast cancer risk. Cancer Epidemiol Biomarkers Prevent 5:967-970
188. 188. Balbay MD, Juang P, Ilansa N, Williams S, McConkey D, Fidler IJ, Pettaway CA 1999 Stable transfection of human prostate cancer cell line PC-3 with prostate specific antigen induces apoptosis both in-vivo and in-vitro. Proc Am Assoc Cancer Res 40:225-226 (Abstract)
189. 189. Lai LC, Erbas H, Lennard TWJ, Peaston RT 1996 Prostate-specific antigen in breast cyst fluid: possible role of prostate-specific antigen in hormone-dependent breast cancer. Int J Cancer 66:743-746
190. 190. Fortier AH, Nelson BJ, Grella DK, Holaday JW 1999 Antiangiogenic activity of prostate-specific antigen. J Natl Cancer Inst 91: 1635-1640
191. 191. Heidtmann HH, Nettelbeck DM, Mingels A, Jager R, Welker HG, Kontermann RE 1999 Generation of angiostatin-like fragments from plasminogen by prostate-specific antigen. Br J Cancer 81: 1269-1273
192. 192. Iwamura M, Hellman J, Crockett ATK, Lilha H, Gershagen S 1996 Alteration of the hormonal bioactivity of parathyroid hormone-related protein (PTHrP) as a result of limited proteolysis by prostate-specific antigen. Urology 48:317-325
193. 193. Cramer SD, Chen Z, Peehl DM 1996 Prostate specific antigen cleaves parathyroid hormone-related protein in the PTH-like domain: inactivation of PTHrP-stimulated cAMP accumulation in mouse osteoblasts. J Urol 156:526-531
194. 194. Diamandis EP 2000 Prostate-specific antigen: a cancer fighter and a valuable messenger? Clin Chem 46:896-900
195. 195. Foekens JA, Diamandis EP, Yu H, Look MP, Meljer-van Gelder ME, van Putten WLJ, Klijn JGM 1999 Expression of prostate-specific antigen (PSA) correlates with poor response to tamoxifen therapy in recurrent breast cancer. Br J Cancer 79:888-894
196. 196. Diamandis EP, Helle SJ, Yu H, Melegos DN, Lundgren S, Lonning PE 1999 Prognostic value of plasma prostate specific antigen after megestrol acetate treatment in patients with metastatic breast carcinoma. Cancer 85:891-898
197. 197. Cohen P, Graves HCB, Peehl DM, Kamarei M, Guidice LC, Rosenfeld RD 1991 Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma. J Clin Endocrinol Metab 73:401-407
198. 198. Pollak M, Beamer W, Zhang JC 1998 Insulin-like growth factors and prostate cancer. Cancer Metastasis Rev 17:383-390
199. 199. Sutkowski DM, Goode RL, Baniel J, Teater C, Cohen P, McNulty AM, Hsiung HM, Becker GW, Neubauer BL 1999 Growth regulation of prostatic stromal cells by prostate-specific antigen. J Natl Cancer Inst 91:1663-1669
200. 200. Killian CS, Corral DA, Kawinski E, Constantine RI 1993 Mitogenic response of osteoblast cells to prostate-specific antigen suggests an activation of latent TGF-β and a proteolytic modulation of cell adhesion receptor. Biochem Biophys Res Commun 192:940 -947
201. 201. Webber MM, Waghray A, Bello D 1995 Prostate-specific antigen, a serine protease, facilitates human prostate cancer cells invasion. Clin Cancer Res 1:1089-1094
202. 202. Heese A, Becker C, Noldus J, Graefen M, Huland E, Huland H, Lilja H 2000 Human glandular kallikreins 2: a potential serum marker for predicting the organ confined vs. non-organ confined growth of prostate cancer. J Urol 163:1491-1497
203. 203. Darson MF, Pacelli A, Roche Rittenhouse HG, Wolfert RL, Young CY, Klee GG, Tindall DJ, Bostwick DG 1997 Human glandular kallikrein 2 (hK2) expression in prostatic intraepithelial neoplasia and adenocarcinoma: a novel prostate cancer marker. Urology 49:857-862
204. 204. Darson MF, Pacelli A, Roche Rittenhouse HG, Wolfert RL, Saeid MS, Young CY, Klee GG, Tindall DJ, Bostwick DG 1999 Human glandular kallikrein 2 expression in prostate adenocarcinoma and lymph node metastases. Urology 53:939-944
205. 205. Obiezu CV, Scorilas A, Kim H, Diamandis EP 2000 Prostase/ KLK-L1 is differentially expressed in normal/benign vs. malignant ovarian tissues. Clin Biochem 33:234 (Abstract)
206. 206. Kim H, Scorilas A, Katsaros D, Yousef GM, Fracchioli S, Diamandis EP 2001 Human kallikrein gene 5 (KLK5) expression is an indicator of poor prognosis in ovarian cancer. Br J Cancer 84:643-650
207. 207. Haas C, De Strooper B 1999 The presenilins in Alzheimer's disease -proteolysis holds the key. Science 286:916-919
208. 208. Sondell B, Dyberg P, Anneroth GK, Ostman PO, Egelrud T 1996 Association between expression of stratum corneum chymotryptic enzyme and pathological keratinization in human oral mucosa. Acta Derm Venereol 76:177-181
209. 209. Okabe A, Momota Y, Yoshida S, Hirata A, Ito J, Nishino H, Shiosaka S 1996 Kindling induces neuropsin mRNA in the mouse brain. Brain Res 728:116-120
210. 210. Momota Y, Yoshida S, Ito J, Shibata M, Kato K, Sakurai K, Matsumoto K, Shiosaka S 1998 Blockage of neuropsin, a serine protease, ameliorates kindling epilepsy. Eur J Neurosci 10:760-764
211. 211. Kishi T, Kato M, Shimizu T, Kato K, Matsumoto K, Yoshida S, Shiosaka S, Hakoshima T 1999 Crystal structure of neuropsin, a hippocampal protease involved in kindling epileptogenesis. J Biol Chem 274:4220-4224
212. 212. Yoshida S, Shiosaka S 1999 Plasticity-related serine proteases in the brain. Int J Mol Med 3:405-409
213. 213. Mitsui S, Tsuruoka N, Yamashiro K, Nakazato H, Yamaguchi N 1999 A novel form of human neuropsin, a brain-related serine protease, is generated by alternative splicing a is expressed preferentially in human adult brain. Eur J Biochem 260:627-634
214. 214. Scarisbrick IA, Towner MD, Isackson PJ 1997 Nervous system-specific expression of a novel serine protease: regulation in the adult rat spinal cord by excitotoxic injury. J Neurosci 17:8156-8168
215. 215. Akita H, Matsuyama T, Iso H, Sugita M, Yoshida S 1997 Effects of exidative stress on the expression of limbic-specific protease neuropsin and avoidance learning in mice. Brain Res 769:86-96
216. 216. Luo LY, Diamandis EP 2000 Down-regulation of the normal epithelial cell-specific 1 (NES1) gene is associated with unfavourable outcome of prostate cancer. Clin Biochem 33:237 (Abstract)
217. 217. Schachter M 1980 Kallikreins (kininogenases): a group of serine proteases with bioregulatory actions. Pharmacol Rev 31:1-17
218. 218. Bhoola KD 1971 Comment on the conversion of pro-insulin to insulin. In: Heller G, Lederis K (eds) Subcellular Organisation and Function in Endocrine Tissues. Cambridge University Press, Cambridge, UK, pp 493-494
219. 219. Bothwell MA, Wilson WH, Shooter EM 1979 The relationship between glandular kallikrein and growth factor-processing proteases of mouse submaxillary gland. J Biol Chem 254:7287-7294
220. 220. Mason AJ, Evans BA, Cox DR, Shine J, Richards RL 1983 Structure of mouse kallikrein gene family suggests a role in specific processing of biological active peptides. Nature 303:300-307
221. 221. Kumar A, Goel AS, Hill TM Mikolajczyk SD, Millar LS, Kuus-Reichel K, Saedi MS 1996 Expression of human glandular kallikrein, hK2, in mammalian cells. Cancer Res 56:5397-5402
222. 222. Saedi MS, Cass MM, Goel AS, Granger L, Hogen KL, Okaneya T, Griffin BY, Klee GG, Young CY, Tindall DJ 1995 Overexpression of a human prostate-specific glandular kallikrein, hK2, in E. coli and generation of antibodies. Mol Cell Endocrinol 109:237-241
223. 223. Lovgren J, Piironen T, Overmo C, Dowell B, Karp M, Pettersson K, Lilja H, Lundwall A 1995 Production of recombinant PSA and hK2 and analysis of their immunologic cross-reactivity. Biochem Biophys Res Commun 213:888-895
224. 224. Herrala A, Kurkela R, Porvari K, Isomaki R, Henttu P, Vihko P 1997 Human prostate-specific glandular kallikrein is expressed as an active and an inactive protein. Clin Chem 43:279-284
225. 225. Mikolajczyk SD, Millar LS, Marker KM, Grauer LS, Goel A, Cass MM, Kumar A, Saedi MS 1997 Ala217 is important for the catalytic function and autoactivation of prostate-specific human kallikrein 2. Eur J Biochem 246:440-446
226. 226. Bourgeois L, Brillard-Bourdet M, Deperthes D, Juliano MA, Juliano L, Tremblay RR, Dube JY, Gauthier F 1997 Serpin-derived peptide substrates for investigating the substrate specificity of human tissue kallikreins hK1 and hK2. J Biol Chem 272:29590-29595
227. 227. Deperthes D, Frenette G, Brillard-Bourdet M, Bourgeois L, Gauthier F, Tremblay RR, Dube JY 1996 Potential involvement of kallikrein hK2 in the hydrolysis of the human seminal vesicle proteins after ejaculation. J Androl 17:659-665
228. 228. Dube JY, Tremblay RR 1997 Biochemistry and potential roles of prostatic kallikrein hK2. Mol Urol 1:279-285
229. 229. Frenette G, Tremblay RR, Lazure C, Dube JY 1997 Prostatic kallikrein hK2, but not prostate-specific antigen (hK3), activates single-chain urokinase-type plasminogen activator. Int J Cancer 71:897-899
230. 230. Watt KW, Lee PJ, M'Timkulu T, Chan WP, Loor R 1986 Human prostate-specific antigen: structural and functional similarity with serine proteases. Proc Natl Acad Sci USA 83:3166-3170
231. 231. Ban Y, Wang MC, Watt KW, Loor R, Chu TM 1984 The proteolytic activity of human prostate-specific antigen. Biochem Biophys Res Commun 123:482-488
232. 232. Christensson A, Laurell CB, Lilja H 1990 Enzymatic activity of prostate-specific antigen and its reactions with extracellular serine proteinase inhibitors. Eur J Biochem 194:755-763
233. 233. Akiyama K, Nakamura T, Iwanaga S, Hara M 1987 The chymotrypsin-like activity of human prostate-specific antigen, γ-seminoprotein. FEBS Lett 225:168-172
234. 234. Lilja H 1985 A kallikrein-like serine protease in prostatic fluid cleaves the predominant seminal vesicle protein. J Clin Invest 76: 1899-1903
235. 235. Foretova L, Garber JE, Sadowski NL, Verselis SJ, Li FP 1996 Prostate-specific antigen in nipple aspirate. Lancet 347:1631
236. 236. Diamandis EP, Yu H, Lopez-Otin C 1996 Prostate specific antigen - a new constituent of breast cyst fluid. Breast Cancer Res Treat 38:259-264
237. 237. Mannello F, Bocchiotti G, Bianchi G, Marcheggiani F, Gazzanelli G 1996 Quantification of prostate-specific antigen immunoreactivity in human breast cyst fluids. Breast Cancer Res Treat 38:247-252
238. 238. Filella X, Molina R, Alcover J, Carretero P, Ballesta AM 1996 Detection of nonprostatic PSA in serum and non-serum samples from women. Int J Cancer 68:424-427
239. 239. Filella X, Molina R, Alcover J, Menendez V, Gimenez N, Jo J, Carretero P, Ballesta AM 1996 Prostate-specific antigen detection by ultrasensitive assay in samples from women. Prostate 29: 311-316
240. 240. Borchert G, Yu H, Tomlinson G, Giai M, Roagna R, Ponzone R, Sgro L, Diamandis EP 1999 Prostate specific antigen molecular forms in breast cyst fluid and serum of women with fibrocystic breast disease. J Clin Lab Anal 13:75-81
241. 241. Yu H, Diamandis EP 1995 Prostate specific antigen in milk of lactating women. Clin Chem 41:54-58
242. 242. Yu H, Diamandis EP 1995 Prostate specific antigen immunoreactivity in amniotic fluid. Clin Chem 41:204-210
243. 243. Melegos DN, Yu H, Allen LC, Diamandis EP 1996 Prostate specific antigen in amniotic fluid of normal and abnormal pregnancies. Clin Biochem 29:555-562
244. 244. Woodhouse EC, Chuaqui RF, Liotta LA 1997 General mechanisms of metastasis. Cancer [Suppl] 80:1529-1537
245. 245. Chambers AF, Matrisian LM 1997 Changing views of the role of matrix metalloproteinases in metastasis. J Natl Cancer Inst 80: 1260-1270
246. 246. Harvey TJ, Hooper JD, Myers SA, Stephenson SA, Ashworth LK, Clements JA 2000 Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4. J Biol Chem 275:37397-37406
247. 247. Diamandis EP, Yousef GM, Soosaipillai AR, Grass L, Porter A, Little S, Sotiropoulou G 2000 Immunofluorometric assay of the human kallikrein 6 and preliminary clinical applications. Clin Biochem 33:369-375
248. 248. Luo LY, Grass L, Howarth DJ, Thibault P, Ong H, Diamandis EP 2001 Immunofluorometric assay of human kallikrein 10 and its identification in biological fluids and tissues. Clin Chem 47:237-246
249. 249. Diamandis EP, Yousef GM, Petraki C, Soosaipillai A 2000 Human kallikrein 6 as a biomarker of Alzheimer's disease. Clin Biochem 33:663-667
250. 250. Diamandis EP, Yousef GM, Soosaipillai A, Bunting P 2000 Human kallikrein 6 (zyme/protease M neurosin): a new biomarker of ovarian carcinoma. Clin Biochem 33:369-375
251. 251. Ying LY, Bunting P, Scorilas A, Diamandis EP, Human kallikrein 10: a novel tumor marker for ovarian carcinoma? Clin Chim Acta, in press