Development of prostate-specific antigen promoter-based gene therapy for androgen-independent human prostate cancer

Journal of Urology

Volumn 160, Issue 1, 1998, Pages 220-229

  Gotoh, Akinobu ^b   Ko, Song Chu ^b   Shirakawa, Toshiro ^b   Cheon, Jun ^b   Kao, Chinghai ^a   Miyamoto, Tadayuki ^b   Gardner, Thomas A ^b   Ho, Ling Jun ^b   Cleutjens, Catharina B J ^b   Trapman, Jan ^b   Graham, Frank L ^b   Chung, Leland W K ^b  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b NONE

Author keywords

Androgen; Gene therapy; Hormonal refractory cancer; Prostate cancer; PSA; Tissue specific promoter

Indexed keywords

ACICLOVIR; ANDROGEN; PROSTATE SPECIFIC ANTIGEN; THYMIDINE KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CASTRATION; CONTROLLED STUDY; GENE EXPRESSION; GENE THERAPY; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; TARGET CELL; TUMOR GROWTH; TUMOR VOLUME;

EID: 0032323792     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(01)63094-5     Document Type: Article

References (44)

1. Scher, H. I. and Kelly, W. K.: Flutamide withdrawal syndrome: its impact on clinical trials in hormone-refractory prostate cancer. J. Clin. Oncol., 11: 1566, 1993.
2. Dijkman, G. A., van Moorselaar, R. J. A., van Ginckel, R., van Stratum, P., Wouters, L., Debruyne, F. M. J., Schalken, J. A. and de Coster, R.: Antitumoral effects of liarozole in androgen-dependent and independent R3327-Dunning prostate adenocarcinomas. J. Urol., 151: 217, 1994.
3. Thalmann, G. N., Anizinis, P. E., Chang, S. M., Zhau, H. Y. E., Kim, E., Hopwood, V. L., Pathak, S., von Eschenbach, A. C. and Chung, L. W. K.: Androgen-independent cancer progression and bone metastasis in the LNCaP model of human prostate cancer. Cancer Res., 54: 2577, 1994.
4. Cleave, M. E., Hsieh, J. T., von Eschenbach, A. C. and Chung, L. W. K.: Prostate and bone fibroblasts induce human prostate cancer growth in vivo: implications for bidirectional tumor-stromal cell interaction in prostate carcinoma growth and metastasis. J. Urol., 147: 1151, 1992.
5. Chung, L. W. K.: The role of stroma-epithelial interaction in normal and malignant growth. Cancer Surv., 23: 33, 1995.
6. Zhang, W.-W., Fang, X., Mazur, W., French, B. A., Georges, R. N. and Roth, J. A.: High-efficiency gene transfer and high-level expression of wild-type p53 in human lung cancer cells mediated by recombinant adenovirus. Cancer Gene Therapy, 1: 5, 1994.
7. Ko, S.-C., Gotoh, A., Thalmann, G. N., Zhau, H. E., Johnston, D. A., Zhang, W.-W., Kao, C. and Chung, L. W. K.: Molecular therapy with recombinant p53 adenovirus in an androgen independent, metastatic human prostate cancer model. Human Gene Therapy, 7: 1683, 1996.
8. O'Malley, B. W. J., Chen, S.-H., Schwartz, M. R. and Woo, S. L. C.: Adenovirus-mediated gene therapy for human head and neck squamous cell cancer in a nude mouse model. Cancer Res., 55: 1080, 1995.
9. Ko, S.-C., Cheon, J., Kao, C., Gotoh, A., Shirakawa, T., Sikes, R. A., Karsenty, G. and Chung, L. W. K.: Osteocalcin promoter-based toxic gene therapy for the treatment of osteosarcoma in experimental models. Cancer Res., 56: 4614, 1996.
10. Obiri, N. I., Hillman, G. G., Haas, G. P., Sud, S. and Puri, R. K.: Expression of high affinity interleukin-4 receptors on human renal cell carcinoma cells and inhibition of tumor cell growth in vitro by interleukin-4. J. Clin. Invest., 91: 88, 1993.
11. Liu, T. J., el-Naggar, A. K., McDonnel, T. J., Steck, K. D., Wang, M., Taylor, D. L. and Clayman, G. L.: Apoptosis induction mediated by wild-type p53 adenoviral gene transfer in squamous cell carcinoma of the head and neck. Cancer Res., 55: 3117, 1995.
12. Linnik, M. D., Zahos, P., Geschwind, M. D. and Federoff, H. J.: Expression of bcl-2 from a defective herpes simplex virus-1 vector limits neuronal death in focal cerebral ischemia. Stroke, 26: 1670, 1995.
13. Yang, C., Cirielli, C., Capogrossi, M. C. and Passaniti, A.: Adenovirus-mediated wild-type p53 expression induces apoptosis and suppresses tumorigenesis of prostatic tumor cells. Cancer Res., 55: 4210, 1995.
14. Vile, R. G. and Hart, I. R.: In vitro and in vivo targeting of gene expression to melanoma cells. Cancer Res., 53: 962, 1993.
15. Macri, P. and Gordon, J. W.: Delayed morbidity and mortality of albumin/SV40 T-antigen transgenic mice after insertion of an alpha-fetoprotein/herpes virus thymidine kinase transgene and treatment with ganciclovir. Human Gene Therapy, 5: 175, 1994.
16. Shimizu, K.: Selective gene therapy of malignant gliomas using brain-specific promoters: its efficacy and basic investigations. Japanese Journal of Clinical Medicine, 52: 3053, 1994.
17. Wang, M. C., Valenzuela, L. A., Murphy, G. P. and Chu, T. M.: Purification of a human prostate specific antigen. Invest. Urol., 17: 159, 1979.
18. Lilja, H.: A kallikrein-like serine protease in prostatic fluid cleaves the predominant seminal vesicle protein. J. Clin. Invest., 76: 1899, 1985.
19. Watt, K. W. K., Lee, P.-J., M'Timkulu, T., Chan, W.-P. and Loor, R.: Human prostate-specific antigen: structural and functional similarity with serine proteases. Proc. Natl. Acad. Sci. USA, 83: 3166, 1986.
20. Stamey, T. A., Yang, N., Hay, A. R., McNeal, J. E., Feiha, F. S. and Redwine, E.: Prostate-specific antigen as a serum marker for adenocarcinoma of the prostate. N. Engl. J. Med., 317: 909, 1987.
21. Karr, J. F., Kantor, J. A., Hand, P. H., Eggensperger, D. L. and Schlom, J.: The presence of prostate-specific antigen-related genes in primates and the expression of recombinant human prostate-specific antigen in a transfected murine cell line. Cancer Res., 55: 2455, 1995.
22. Pang, S., Taneja, S., Dardashti, K., Cohan, P., Kaboo, R., Sokoloff, M., Tso, C.-L., de Kernion, J. B. and Belldegrun, A. S.: Prostate tissue specificity of the prostate-specific antigen promoter isolated from a patient with prostate cancer. Human Gene Therapy, 6: 1417, 1995.
23. Pang, S., Sokoloff, M., Taneja, S., Dardashti, K., Kaboo, R., de Kernion, J. B. and Belldegrun, A. S.: Prostate tissue-specific gene therapy utilizing a unique prostate specific antigen-cytomegalovirus (PSA-CMV) promoter. J. Urol., 153: 307A, 1995.
24. Rodriguez, R., Schuur, E. R., Lim, H. Y., Henderson, G. A., Simons, J. W. and Henderson, D. R.: Prostate attenuated replication competent adenovirus (ARCA) CN706: a selective cytotoxic for prostate-specific antigen-positive prostate cancer cells. Cancer Res., 57: 2559, 1997.
25. Hitt, M. M. and Graham, F. L.: Adenovirus E1A under the control of heterolougous promoters: wide variation in E1A expression levels has little effect on virus replication. Virol., 179: 667, 1990.
26. Wu, H. C., Hsieh, J. T., Gleave, M. E., Brown, N. M., Pathak, S. and Chung, L. W. K.: Derivation of androgen-independent human LNCaP Prostatic cancer cell sublines: role of bone stromal cells. Int. J. Cancer, 57: 406, 1994.
27. Horoszewicz, J. S., Leong, S. S., Kawinski, E., Karr, J. P., Rosenthal, H., Chu, T. M., Mirand, E. A. and Murphy, G. P.: LN-CaP model of human prostatic carcinoma. Cancer Res., 43: 1809, 1983.
28. Kaighn, M. E., Narayan, K. S., Ohnuki, Y., Lechner, J. F. and Jones, L. W.: Establishment and characterization of a human prostatic carcinoma cell line (PC-3). Invest. Urol., 17: 16, 1979.
29. Stone, K. R., Mickey, D. D., Wunderli, H., Mickey, G. H. and Paulson, D. F.: Isolation of a human prostate carcinoma cell line (DU145). Int. J. Cancer, 21: 274, 1978.
30. Zhau, H. Y. E., Hong, S.-J. and Chung, L. W. K.: A fetal rat urogenital sinus mesenchymal cell line (rUGM) accelerated growth and conferral of androgen-induced growth responsiveness to a human bladder cancer epithelial cell line in vivo. Int. J. Cancer, 56: 706, 1994.
31. Hsieh, J. T., Wu, H. C., Gleave, M. E., von Eschenbach, A. C. and Chung, L. W. K.: Autoregulation of prostate-specific antigen gene expression in human prostate carcinoma (LNCaP) subline. Cancer Res., 53: 2852, 1993.
32. de Ruiter, P. E., Teuwen, R., Trapman, J., Dijkema, R. and Brinkmann, A. O.: Synergism between androgens and protein kinase-C on androgen-regulated gene expression. Mol. Cell. Endocrinol., 110: R1, 1995.
33. Cleutjens, K. B. J. M., van der Korput, H. A. G. M., van Eekelen, C. C. E. M., van Rooij, H. C. J., Faber, P. W. and Trapman, J.: An androgen response element in a far upstream enhancer region is essential for high, androgen-regulated activity of the prostate-specific antigen promoter. Mol. End., 11: 148, 1997.
34. de Wet, J. R., Wood, K. V., de Luca, M., Helinski, D. R. and Subramani, S.: Firefly luciferase gene: sturucture and expression in mammalian cells. Mol. Cell. Biol., 7: 725, 1987.
35. Bett, A. J., Haddara, W., Prevec, L. and Graham, F. L.: An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3. Proc. Natl. Acad. Sci. USA, 91: 8802, 1994.
36. Ives, D. H., Furham, J. P. and Tucker, V. S.: Rapid determination of nucleotide kinase and nucleotidase activities with tritium-labeled substances. Anal. Biochem., 28: 192, 1969.
37. Sanchez-Prieto, R., Vargas, J. A., Carnero, A., Marchetti, E., Romero, J., Durantez, A., Lacal, J. C. and Ramon Y Cajal, S.: Modulation of cellular chemoresistance in keratinocytes by activation of different oncogenes. Int. J. Cancer, 60: 235, 1995.
38. Gleave, M. Hsieh, J. T., Gao, C. A., von Eschenbach, A. C. and Chung, L. W. K.: Acceleration of human prostate cancer growth in vivo by factors produced by prostate and bone fibroblasts. Cancer Res., 51: 3753, 1991.
39. Schuur, E. R., Henderson, G. A., Kmetec, L. A., Miller, J. D., Lamparski, H. G. and Henderson, D. R.: Prostate-specific antigen expression is regulated by an upstream enhancer. J. Biol. Chem., 271: 7043, 1996.
40. Riegman, P. H., Vlietstra, R. J., van der Korput, J. A., Brinkmann, A. O. and Trapman, J.: The promoter of the prostate-specific antigen gene contains a functional androgen responsive element. Mol. Endocrinol., 5: 1921, 1991.
41. Kuriyama, S., Yoshikawa, M., Ishizaka, S., Tsujii, T., Ikenaka, K., Kagawa, T., Morita, N. and Mikoshiba, K.: A potential approach for gene therapy targeting hepatoma using a liver-specific promoter on a retroviral vector. Cell Structure & Function, 16: 503, 1991.
42. Ko, A. S. C., Gotoh, G., Kao, C. and Chung, L. W. K.: Tissue targeted toxic gene therapy for an androgen-independent and metastatic human prostate cancer model. J. Urol., 155: 623A, 1996.
43. Kato, S., Endoh, H., Masuhiro, Y., Kitamoto, T., Uchiyama, S., Sasaki, H., Masushige, S., Gotoh, Y., Nishida, E., Kawashima, H., Metzger, D. and Chambon, P.: Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science, 270: 1491, 1995.
44. Onate, S. A., Tsai, S. Y., Tsai, M.-J. and O'Malley, B. W.: Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science, 270: 1354, 1995.