The stratum corneum chymotryptic enzyme that mediates shedding and desquamation of skin cells is highly overexpressed in ovarian tumor cells

Cancer

Volumn 86, Issue 10, 1999, Pages 2074-2082

  Tanimoto, Hirotoshi ^a   Underwood, Lowell J ^a   Shigemasa, Kazushi ^b   Yan, Yan ^a   Clarke, John ^a   Parmley, Tim H ^a   O'Brien, Timothy J ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

Ovarian tumor; Overexpression; Serine protease; Stratum corneum chymotryptic enzyme; Tumor cell shedding

Indexed keywords

ARTICLE; CONTROLLED STUDY; DESQUAMATION; HUMAN; HUMAN TISSUE; METASTASIS; OVARY CARCINOMA; OVARY TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRATUM CORNEUM; TUMOR GROWTH;

BLOTTING, NORTHERN; BLOTTING, WESTERN; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; IMMUNOHISTOCHEMISTRY; KALLIKREINS; KERATOLYTIC AGENTS; OVARIAN NEOPLASMS; POLYMERASE CHAIN REACTION; SERINE ENDOPEPTIDASES; SKIN;

EID: 0033571558     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0142(19991115)86:10<2074::AID-CNCR27>3.0.CO;2-3     Document Type: Article

References (13)

1. Neurath H. The diversity of proteolytic enzymes. In: Beynon RJ, Bond JS, editors. Proteolytic enzymes. Oxford, UK: IRL Press, 1989:1-13.
2. Liotta LA, Steeg PS, Stetler-Stevenson WG. Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell 1991;64:327-36.
3. Duffy MJ. The role of proteolytic enzymes in cancer invasion and metastasis. Clin Exp Metastasis 1992;10:145-55.
4. Tryggvason K, Höyhtyä M, Salo T. Proteolytic degradation of extracellular matrix in tumor invasion. Biochem Biophys Acta 1987;907:191-217.
5. Tanimoto H, Yan Y, Clarke J, Korourian S, Shigemasa K, Parmley TH, et al. Hepsin: a cell surface serine protease identified in hepatoma cells is overexpressed in ovarian cancer. Cancer Res 1997;57:2884-7.
6. Egelrud T. Purification and preliminary characterization of stratum corneum chymotryptic enzyme: a proteinase that may be involved in desquamation. J Invest Dermatol 1993; 101:200-4.
7. Hansson L, Strömqvist M, Bäckman A, Wallbrandt P, Carlstein A, Egelrud T. Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. J Biol Chem 1994;269:19420-6.
8. Sondell B, Thornell LE, Stigbrand T, Egelrud T. Immunolocalization of stratum corneum chymotryptic enzyme in human skin and oral epithelium with monoclonal antibodies: evidence of a proteinase specifically expressed in keratinizing squamous epithelia. J Histochem Cytochem 1994;42:459-65.
9. Sondell B, Thornell LE, Egelrud T. Evidence that stratum corneum chymotryptic enzyme is transported to the stratum corneum extracellular space via lamellar bodies. J Invest Dermatol 1995;104:819-23.
10. Franzke CW, Baici A, Bartels J, Christophers E, Wiedow O. Antileukoprotease inhibits stratum corneum chymotryptic enzyme. J Biol Chem 1996;271:21886-90.
11. Shigemasa K, Hu C, West CM, Clarke J, Parham GP, Parmley TH, et al. p16 overexpression: a potential early indicator of transformation in ovarian carcinoma. J Soc Gynecol Invest 1997;4:95-102.
12. Tanimoto H, Mehta KD, Parmley TH, Shigemasa K, Parham GP, Clarke J, et al. Expression of the farnesyltransferase B-subunit gene in human ovarian carcinoma: correlation to K-ras mutation. Gynecol Oncol 1997;66:308-12.
13. Hall JL, Dudley L, Dobner PR, Lewis SA, Cowan NJ. Identification of two human β-tubulin isotypes. Mol Cell Biol 1983;3:854-62.