Leptin administration prevents spontaneous gestational diabetes in heterozygous Leprdb/+ mice: Effects on placental leptin and fetal growth

Endocrinology

Volumn 142, Issue 7, 2001, Pages 2888-2897

  Yamashita, Hiroshi ^a   Shao, Jianhua ^a   Ishizuka, Tatsuya ^a   Klepcyk, Patrick J ^a   Muhlenkamp, Peggy ^a   Qiao, Liping ^a   Hoggard, Nigel ^b   Friedman, Jacob E ^a,c  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ROWETT RESEARCH INSTITUTE   (United Kingdom)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; LEPTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALORIC INTAKE; CONTROLLED STUDY; ENERGY BALANCE; FEMALE; FETUS GROWTH; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; GROWTH REGULATION; HORMONAL REGULATION; INSULIN TOLERANCE TEST; MALE; MOUSE; NONHUMAN; PLACENTA; PREGNANCY DIABETES MELLITUS; PRIORITY JOURNAL;

EID: 0034988820     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.142.7.8227     Document Type: Article

References (68)

1. Effects of diabetic pregnancy on the fetus and newborn
2. Maternal complications of fetal macrosomia
3. Fetal nutrition and cardiovascular disease in adult life
4. Congenital susceptibility to NIDDM. Role of the intrauterine environment
5. Evidence for an insulin resistance in the adult offspring of pregnant streptozotocin-diabetic rats
6. Delay in pulmonary glycogen degradation in fetuses of streptozotocin diabetic rats
7. db/+ mice
8. Abnormal splicing of the leptin receptor in diabetic mice
9. db affects body composition and leptin homeostasis in adult mice
10. Non-adipose tissue production of leptin: Leptin as a novel placenta-derived hormone in humans
11. Longitudinal changes in maternal serum leptin concentrations, body composition and resting metabolic rate in pregnancy
12. Ontogeny of the expression of leptin and its receptor in the murine fetus and placenta
13. Expression of placental leptin and leptin receptor transcripts in early pregnancy and at term
14. Leptin receptor in human term placenta: In situ hybridization and immunohistochemical localization
15. Identification of a placental enhancer for the human leptin gene
16. Placental leptin
17. Serum leptin concentration during pregnancy and their relationship to fetal growth
18. Cord blood leptin is associated with size at birth and predicts infancy weight gain in humans. ALSPAC study team. Avon longitudinal study of pregnancy and childhood
19. Macrosomia revisited: Ponderal index and leptin delineate subtypes of fetal overgrowth
20. A positive umbilical venous-arterial difference of leptin level and its rapid decline after birth
21. Recombination mouse OB protein; evidence for a peripheral signal linking adiposity and central neural networks
22. Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice
23. Effect of leptin on insulin sensitivity in normal rats
24. Leptin selective decrease visceral adiposity and enhances insulin action
25. Leptin has acute effects on glucose and lipid metabolism in both lean and gold thioglucose-obese mice
26. Acute stimulation of glucose metabolism in mice by leptin treatment
27. Inhibition of insulin secretion by leptin in normal rodent islets of Langerhans
28. Effect of leptin on insulin secretion from isolated rat pancreatic islets
29. Leptin suppression of insulin secretion and gene expression in human pancreatic islets: Implications for the development of adipogenic diabetes mellitus
30. Hyperleptinemia of pregnancy associated with the appearance of a circulating form of the leptin receptor
31. Leptin, the product of Ob gene, promotes angiogenesis
32. Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells
33. Expression of leptin receptor in lung: Leptin as a growth factor
34. Rat insulinoma-derived pancreatic beta cells express a functional leptin receptor that mediates a proliferative response
35. Impact of maternal fuel and nutritional state on fetal growth
36. Obesity and pregnancy: Complications and cost
37. Banting lecture: Of pregnancy and progeny
38. Insulin secretion and insulin resistance in pregnancy and GDM. Implications for diagnosis and management
39. Longitudinal change in glucose metabolism during pregnancy in obese women with normal glucose tolerance and gestational diabetes mellitus
40. Insulin sensitivity and beta cell responsiveness to glucose during late pregnancy in lean and moderately obese women with normal glucose tolerance or mild gestational diabetes
41. Impaired tyrosine kinase activity and insulin receptor substrate-1 expression in obese women with gestational diabetes mellitus
42. Cloning and characterization of human leptin receptor using a biologically active leptin immunoadhesin
43. Leptin concentrations in amniotic fluid, venous and arterial cord blood: High leptin synthesis in the fetus and inverse correlation with placental weight
44. db) mutation
45. Divergent signaling capacities of the long and short isoforms of the leptin receptor
46. Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation
47. Direct antidiabetic effect of leptin through triglyceride depletion of tissues
48. Inhibitory effects of leptin-related synthetic peptide 116-130 on food intake and body weight gain in female C57BL/6J ob/ob mice may not be mediated by peptide activation of the long isoform of the leptin receptor
49. Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
50. Correction of diet-induced hyperglycemia, hyperinsulinemia, and skeletal muscle insulin resistance by moderate hyperleptinemia
51. Glucose metabolism and insulin sensitivity in transgenic mice overexpressing leptin with lethal yellow agouti mutation: Usefulness of leptin for the treatment of obesity-associated diabetes
52. In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: Overlapping but distinct pathways from insulin
53. Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion
54. Inhibition of glucose-induced insulin secretion by long-term preexposure of pancreatic islets to leptin
55. Leptin normalizes the impaired response of proinsulin mRNA to long chain fatty acids in heterozygous Zucker diabetic fatty rats
56. The leptin receptor mediates apparent autocrine regulation of leptin gene expression
57. The effect of leptin on Lep expression is tissue-specific and nutritionally regulated
58. Retinoids stimulate leptin synthesis and secretion in human syncytiotrophoblast
59. Augmentation of leptin synthesis and secretion through activation of protein kinases A and C in cultured human trophoblastic cells
60. Leptin is not necessary for gestation and parturition but regulates maternal nutrition via a leptin resistance state
61. Regulation of neuronal and glial proteins by leptin: Implications for brain development
62. Leptin production and release in the dually in vitro perfused human placenta
63. Leptin secretion to both the maternal and fetal circulation in the ex vivo perfused human term placenta
64. Alterations in fetal adipose tissue leptin expression correlate with the development of adipose tissue
65. Gestational diabetes mellitus
66. Overexpression of placental leptin in diabetic pregnancy
67. Placental leptin in normal, diabetic and fetal growth-retarded pregnancies
68. Fetal pancreatic islets express functional leptin receptors and leptin stimulates proliferation of fetal islet cells