Effects of overexpression of human GLUT4 gene on maternal diabetes and fetal growth in spontaneous gestational diabetic C57BLKS/J Lepr(db/+) mice

Diabetes

Volumn 48, Issue 5, 1999, Pages 1061-1069

  Ishizuka, Tatsuya ^a   Klepcyk, Patrick ^a   Liu, Sha ^a   Panko, Laura ^c   Liu, Shifan ^a   Gibbs, E Michael ^b   Friedman, Jacob E ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PFIZER INC   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER; INOSITOL PHOSPHATE; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; LEPTIN RECEPTOR; PHOSPHOTRANSFERASE;

ADOLESCENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY FAT; CALORIC INTAKE; CONTROLLED STUDY; FEMALE; FETUS WEIGHT; GENE MUTATION; GENE OVEREXPRESSION; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; INSULIN RELEASE; MACROSOMIA; MATERNAL DIABETES MELLITUS; MOUSE; MUSCLE METABOLISM; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SKELETAL MUSCLE; TRANSGENIC MOUSE;

ANIMALS; BLOOD GLUCOSE; CARRIER PROTEINS; DIABETES, GESTATIONAL; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; FETAL MACROSOMIA; GENE EXPRESSION; GLUCOSE TRANSPORTER TYPE 4; HETEROZYGOTE; HUMANS; INSULIN; MALE; MICE; MICE, INBRED C57BL; MONOSACCHARIDE TRANSPORT PROTEINS; MUSCLE PROTEINS; MUSCLE, SKELETAL; MUTATION; PREGNANCY; PREGNANCY IN DIABETICS; RECEPTOR, INSULIN; RECEPTORS, CELL SURFACE;

EID: 0032941788     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.48.5.1061     Document Type: Article

References (53)

1. Buchanan TA, Metzger BE: Gestational diabetes mellitus. In Advances in Endocrinology and Metabolism, vol. 4. Mazzaferri EL, Bar RS, Eds. Chicago, Mosby Yearbook, 1993, p. 29-46
2. Ramas RM, Kitzmuller JL: Diagnosis and management of gestational diabetes. Diabetes Rev 2:43-52, 1994
3. American Diabetes Association: Medical Management of Pregnancy Complicated by Diabetes. Jovanovic-Peterson LE, Ed. Alexandria, VA, American Diabetes Association, 1993
4. Kjos SL, Peters RK, Xiang A, Henry OA, Motoro M, Buchanan TA: Predicting future diabetes in Latino women with gestational diabetes: utility of early post-partum glucose tolerance testing. Diabetes 44:586-591, 1995
5. National Diabetes Data Group: Classification and diagnosis of diabetes mellitus and other categories of glucose tolerance. Diabetes 28:1039-1057, 1979
6. Metzger BE: Summary and recommendations of the Third International Workshop Conference on Gestational Diabetes Mellitus. Diabetes 40 (Suppl. 2): 197-201, 1991
7. Pettitt DJ, Nelson RG, Saad MF, Bennett PH, Knowler WC: Diabetes and obesity in the offspring of Pima Indian women with diabetes during pregnancy. Diabetes Care 16:310-314, 1993
8. Catalano PM, Tyzbir ED, Roman NM, Amini SB, Sims EA: Longitudinal changes in insulin resistance and insulin release in non-obese pregnant women. Am J Obstet Gynecol 165:1667-1671, 1991
9. Rossi G, Sherwin RS, Penzias AS, Lapaczewski P, Jacob RJ, Shulman GI, Diamond MP: Temporal changes in insulin resistance and secretion in 24 h fasted conscious pregnant rats. Am J Physiol 265:E845-E851, 1993
10. Kuhl C: Insulin secretion and insulin resistance in pregnancy and GDM. Diabetes 40 (Suppl. 2):18-24, 1991
11. Buchanan TA, Metzger BE, Freinkel N, Bergman RN: Insulin sensitivity and beta cell responsiveness to glucose during late pregnancy in lean and moderately obese women with normal glucose tolerance or mild gestational diabetes. Am J Obstet Gynecol 162:1008-1014, 1990
12. Kautzky-Willer A, Prager R, Waldhausl W, Pacini G, Thomaseth K, Wagner OF, Ulm M, Streli C, Ludvik B: Pronounced Insulin resistance and inadequate β-cell secretion characterize lean gestational diabetes during and after pregnancy. Diabetes Care 20:1717-1723, 1997
13. Ryan EA, O'Sullivan MJ, Skyler JS: Insulin action during pregnancy: studies with the euglycemic clamp technique. Diabetes 34:380-389, 1985
14. Garvey WT, Maianu L, Zhu JH, Hancock JA, Golichowski AM: Multiple defects in the adipocyte glucose transport system cause cellular insulin resistance in gestational diabetes: heterogeneity in the number and a novel abnormality in subcellular localization of GLUT4 glucose transporters. Diabetes 42: 1773-1785, 1993
15. Garvey WT, Maianu L, Hancock JA, Golichowski AM, Baron A: Gene expression of GLUT4 in skeletal muscle from insulin-resistant patients with obesity, IGT, GDM, and NIDDM. Diabetes 41:465-475, 1992
16. Kasuga M, Karlsson FA, Kahn CR: Insulin stimulates the phosphorylation of the β-subunit of its own receptor. Science 217:185-187, 1982
17. White MF, Shoelson SE, Keutmann E, Kahn CR: A cascade of tyrosine autophosphorylation in the β-subunit activates the phosphotransferase of the insulin receptor. J Biol Chem 263:2969-2980, 1988
18. Wilden PA, Siddle K, Haring HE, Backer JM, White MF, Kahn CR: The role of insulin receptor kinase domain autophosphorylation in receptor-mediated activities. Analysis with insulin and anti-receptor antibodies. J Biol Chem 267:13719-13726, 1992
19. Tamemoto H, Kadowaki T, Tobe K, Takeshi Y, Sakura H, Hayakawa T, Terauchi Y, Ueki K, Kaburagi Y, Satoh S, Sekihara H, Yoshioka S, Horikoshi H, Furuta Y, Ikawa Y, Kasuga M, Yazaki Y, Aizawa S: Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature 372:182-186, 1994
20. Araki E, Lipes MA, Patti ME, Bruning JC, Hagg B, Johnson RS, Kahn CR: Alternative pathway for insulin-signaling in mice with targeted disruption of the IRS-1 gene. Nature 72:186-189, 1994
21. White MF, Kahn CR: The insulin-signaling system. J Biol Chem 269:1-4, 1994
22. Backer JM, Myers MG Jr, Shoelson SE, Chin DJ, Sun XJ, Mirapeix M, Hu P, Margolis B, Skolnik EY, Schlessinger J, White MF: Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation. EMBO J 11:3469-3479, 1992
23. Herbst JJ, Andrews GC, Contillo LG, Singleton DH, Genereux PE, Gibbs ME, Lienhard GE: Effect of the activation of phosphotidylinositol 3-kinase by a thiophosphotyrosine peptide on glucose transport in 3T3-L1 adipocytes. J Biol Chem 270:26000-26005, 1995
24. Wiese RJ, Mastick CC, Lazar DF, Saltiel AR: Activation of mitogen-activated protein kinase and phosphatidylinositol 3′ kinase is not sufficient for the hormonal stimulation of glucose uptake, lipogenesis, or glycogen synthesis in 3T3-L1 adipocytes. J Biol Chem 270:3442-3446, 1995
25. Hummel KPM, Dickie M, Coleman DL: Diabetes, a new mutation in the mouse. Science 153:1127-1128, 1966
26. Leiter EH: The genetics of diabetes susceptibility in mice. FASEB J 3:2231-2241, 1989
27. Kaufmann RC, Amankwah KS, Dunaway G, Maroun L, Arbuthnot J, Roddick JW: An animal model of gestational diabetes. Am J Obstet Gynecol 141: 479-482, 1981
28. Kaufmann RC, Amankwah KS, Colliver JA, Arbuthnot J: Diabetic pregnancy: the effect of genetic susceptibility of diabetes on fetal weight. Am J Perinatol 4:72-74, 1987
29. Lawrence S, Warshaw J, Nielsen HC: Delayed lung maturation in the macrosomic offspring of genetically determined diabetic db/+ mice. Pediatr Res 25:173-179, 1989
30. Gibbs EM, Stock JL, McCoid SC, Stukenbrok HA, Pessin JE, Stevenson RW, Milici AJ, McNeish JD: Glycemic improvement in diabetic db/db mice by overexpression of the human insulin-regulatable glucose transporter (GLUT4). J Clin Invest 95:1512-1518, 1995
31. Broznick JT, McCoid SC, Reynolds TH, Wilson CM, Stevenson RW, Cushman SW, Gibbs EM: Regulation of cell surface GLUT4 in skeletal muscle of transgenic mice. Biochem J 321:75-81, 1997
32. Olson AL, Kiu ML, Moye-Rowley WS, Buse JB, Bell GI, Pessin JE: Hormonal/metabolic regulation of the human GLUT4/muscle-fat facilitative glucose transporter gene in transgenic mice. J Biol Chem 268:9839-9846, 1993
33. Truett GE, Walker, JA: Rapid assay of db genotype. Obesity Res 4:44S, 1996
34. Hetenyi G, Norwich K: Validity of rates of production and utilization of metabolites as determined by tracer methods in intact animals. Fed Proc 33:1841-1864, 1974
35. Friedman JE, Ishizuka T, Liu S, Farrell CJ, Bedol D, Kaung HL, Koletsky RJ, Ernsberger P: Reduced insulin receptor signaling in the obese spontaneously hypertensive Koletsky rat. Am J Physiol E1014-E1023, 1997
36. Gewolb IH, Barrett C, Wilson C, Warshaw JB: Delay in pulmonary glycogen degradation in fetuses of streptozotocin diabetic rats. Pediatr Res 16:869-873, 1982
37. Defronzo RA: Pathogenesis of type 2 diabetes: metabolic and molecular implications for identifying diabetes genes Diabetes Rev 5:177-269, 1997
38. Giorgino F, Almahfouz A, Goodyear LJ, Smith, RJ: Glucocorticoid regulation of insulin receptor and substrate IRS-1 tyrosine phosphorylation in rat skeletal muscle in vivo. J Clin Invest 91:2020-2030, 1993
39. Saad MJA, Maeda L, Brenelli SL, Carvalho CRO, Paiva RS, Velloso LA: Defects in insulin signal transduction in liver and muscle of pregnant rats. Diabetologia 40:179-186, 1997
40. Hotamisligil GS, Spiegelman BM: TNF alpha: a key component of obesity-diabetes link. Diabetes 43:1271-1283, 1994
41. Hurel S, Ofei F, Wells A: TNF-alpha and insulin sensitivity in humans: effects in vivo of antibody blockade in obese NIDDM patients and in vitro upon human cultured myotubes (Abstract). Exp Clin Endocrinol Diabetes 104 (Suppl. 2):59, 1996
42. Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM: Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest 95:2409-2415, 1995
43. Catalano P, Highman T, Huston L, Friedman JE: Relationship between reproductive hormones/TNFα and longitudinal changes in insulin sensitivity during gestation (Abstract). Diabetes 45 (Suppl. 2):175, 1996
44. Postic C, Leturque A, Printz RL, Maulard P, Loizeau M, Granner DK, Girard J: Development and regulation of glucose transporter and hexokinase expression in rat. Am J Physiol 266:E548-E559, 1994
45. Friedman JE, Sherman WM, Reid MJ, Elton CW, Dohm GL: Exercise training increases glucose transporter protein GLUT4 in skeletal muscle of obese Zucker (fa/fa) rats. FEBS Lett 268:13-16, 1990
46. Gavrilova O, Barr V, Marcus-Samuels B, Reitman M: Hyperleptinemia of pregnancy associated with the appearance of a circulating form of the leptin receptor. J Biol Chem 272:30546-30551, 1997
47. Spellacy WA, Miller S, Winegar Gynec A, Peterson PQ: Macrosomia-maternal characteristics and infant complications. Obstet Gynecol 66:158-161, 1985
48. Langer O, Levy J, Brustman L, Anyaegbunam A, Merkatz R, Divon M: Glycemic control in gestational diabetes mellitus: how tight is tight enough: small for gestational age versus large for gestational age? Am J Obstet Gynecol 161:646-653, 1989
49. Kalkhoff DK: Impact of maternal fuels and nutritional state on fetal growth. Diabetes 40 (Suppl. 2):61-65, 1991
50. Freinkel N: Banting Lecture: Of pregnancy and progeny. Diabetes 29:1023-1035, 1980
51. Sokol RJ, Kazzi GM, Kalhan SC, Pillay SK: Identifying the pregnancy at risk for intrauterine growth retardation: possible usefulness of the intravenous glucose tolerance test. Am J Obstet Gynecol 143:220-223, 1982
52. Piper JM, Field NT, Higby K, Elliott BD, Langer O: Maternal-fetal glucose metabolism and fetal growth retardation. Is there an association? J Reprod Med 41:761-766, 1996
53. Ogata ES, Paul RI, Finley SL: Limited maternal fuel availability due to hyperinsulinemia retards fetal growth and development in the rat. Pediatr Res 22:432-437, 1987