Tyrosine phosphorylation and Syk activation are involved in thrombin-induced aggregation of epinephrine-potentiated platelets

Journal of Biochemistry

Volumn 121, Issue 2, 1997, Pages 325-330

  Wang, Xiaoying ^a   Yanagi, Shigeru ^a   Yang, Cheng ^a   Inatome, Ryoko ^a   Yamamura, Hirohei ^a  

^a KOBE UNIVERSITY   (Japan)

Author keywords

Epinephrine; Potentiation; Syk; Thrombin; Tyrosine phosphorylation

Indexed keywords

ADRENALIN; ALPHA 2 ADRENERGIC RECEPTOR; CYCLIC AMP; GENISTEIN; PHENOXYBENZAMINE; PROSTACYCLIN; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; THROMBIN; TYROSINE;

ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; NORMAL HUMAN; PROTEIN PHOSPHORYLATION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION;

EID: 0031051272     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a021590     Document Type: Article

References (28)

1. Steen, V.M. and Holmsen, H. (1985) Synergism between thrombin and epinephrine in human platelets: different dose-response relationship for aggregation and dense granule secretion. Thromb. Hemost, 54, 680-683
2. Kinlough-Rathbone, R.L. and Mustard, J.F. (1986) Synergism of agonists in Platelet Responses and Metabolism (Holmsen, H., eds.) pp. 193-207, CRC Press, Boca Raton, FL
3. Packham, M.A., Guccione, M.A., Chang, P.-L., and Mustard, J.F. (1973) Platelet aggregation and release: effects of low concentrations of thrombin or collagen. Am. J. Physiol. 220, 38-47
4. Grant, J.A. and Scrutton, M.C. (1980) Positive interaction between agonists in the aggregation response of human blood platelets: interaction between ADP, adrenaline and vasopressin. Br. J. Haematol. 44, 109-125
5. Hallam, T.J., Scrutton, M.C., and Wallis, R.B. (1982) Synergistic responses and receptor occupancy in rabbit blood platelets. Thromb. Res. 27, 435-445
6. Ardlie, N.G., Cameron, H.A., and Garrett, J. (1984) Platelet activation by circulating levels of hormones: a possible link in coronary heart disease. Thromb. Res. 36, 315-322
7. Siess, W. (1989) Molecular mechanisms of platelet activation. Physiol. Rev. 69, 58-178
8. Ware, J.A., Smith, M., and Salzman, E.W. (1987) Synergism of platelet-aggregating agents: role of elevation of cytoplasmic calcium. J. Clin. Invest. 80, 267-271
9. Bushfield, M., McNicol, A., and Macintyre, D.E. (1987) Possible mechanisms of the potentiation of blood-platelet activation by adrenaline. Biochem. J. 241, 671-676
10. Steen, V.M., Tysnes, O.B., and Holmsen, H. (1988) Synergism between thrombin and adrenaline (epinephrine) in human platelets: marked potentiation of inositol phospholipid metabolism. Biochem. J. 253, 581-586
11. Clark, E.A. and Brugge, J. (1993) Tyrosine phosphorylation in platelets: potential roles in intracellular signal transduction. Trends Cardiovasc. Mes. 3, 218-227
12. Ferrell, J.E. and Martin, G.S. (1988) Platelet tyrosine-specific protein phosphorylation is regulated by thrombin. Mol. Cell. Biol. 8, 3603-3610
13. Golden, A. and Brugge, J.S. (1989) Thrombin treatment induces rapid changes in tyrosine phosphorylation in platelets. Proc. Natl. Acad. Sci. USA 86, 901-905
14. Nakamura, S. and Yamamura, H. (1989) Thrombin and collagen induce rapid phosphorylation of a common set of cellular proteins on tyrosine in human platelets. J. Biol. Chem. 264, 7089-7091
15. Asahi, M., Yanagi, S., Ohta, S., Inazu, T., Sakai, K., Takeuchi, F., Taniguchi, T., and Yamamura, H. (1992) Thrombin-induced human platelet aggregation is inhibited by protein-tyrosine kinase inhibitors, ST638 and genistein. FEBS Lett. 309, 10-14
16. Salari, H., Duronio, V., Howard, S.L., Demos, M., Jones, K., Reany, A., Hudson, A.T., and Pelech, S.L. (1990) Erbstatin blocks platelet activating factor-induced protein-tyrosine phosphorylation, polyphosphoinositide hydrolysis, protein kinase C activation, serotonin secretion and aggregation of rabbit platelets. FEBS Lett. 263, 104-108
17. Shattil, S.J., Cunningham, M., Wiedmer, T., Zhao, J., Sims, P.J., and Brass, L.F. (1992) Regulation of glycoprotein IIb-IIIa receptor function studied with platelets permeabilized by the pore-forming complement proteins C5b-9. J. Biol. Chem. 267, 18424-18431
18. syk expressed in hematopoietic cells. Cell. Signall. 7, 185-193
19. Huang, M.M., Bolen, J.B., Barnwell, J.W., Shattil, S.J., and Brugge, J.S. (1991) Membrane glycoprotein IV (CD38) is physically associated with the Fyn, Lyn, and Yes protein tyrosine kinases in human platelets. Proc. Natl. Acad. Sci. USA 88, 7844-7848
20. Lipfert, L., Haimovich, B., Schaller, M.D., Cobb, B.S., Parsons, J.T., and Brugge, J.S. (1992) Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets. J. Cell. Biol. 119, 905-912
21. 2+ mobilization in platelets. J. Biol. Chem. 268, 2277-2279
22. Wong, S., Reynolds, A.B., and Papkoff, J. (1992) Platelet activation leads to increased c-src kinase activity and association of c-src with an 85-kDa tyrosine phosphoprotein. Oncogene 7, 2407-2415
23. 2. Biochem. Biophys. Res. Commun. 170, 259-263
24. 2, Biochim. Biophys. Acta 1178, 281-285
25. Brass, L.F., Hoxie, J.A., Kieber-Emmons, T., Manning, D.R., Poncz, M., and Woolkalis, M. (1993) Agonist receptors and G proteins as mediators of platelet activation. Adv. Exp. Med. Biol. 344, 17-36
26. 2+ mobilization through the distinct pathways. EMBO J. 13, 1341-1349
27. Pumiglia, K.M., Huang, C.-K., and Feinstein, M.B. (1990) Elevation of cAMP, but not cGMP, inhibits thrombin-stimulated tyrosine phosphorylation in human platelets. Biochem. Biophys. Res. Commun. 171, 738-745
28. syk in N-formyl-methionyl-leucyl-phenylalanine receptor signaling. Biochem. Biophys. Res. Commun. 212, 887-893