The Syk tyrosine kinase suppresses malignant growth of human breast cancer cells

Nature

Volumn 406, Issue 6797, 2000, Pages 742-747

  Coopman, Peter J P ^a,c   Do, Michael T H ^a   Barth, Mara ^a   Bowden, Emma T ^a   Hayes, Andrew J ^a   Basyuk, Eugenia ^c   Blancato, Jan K ^a   Vezza, Phyllis R ^a   McLeskey, Sandra W ^a,b   Mangeat, Paul H ^c   Mueller, Susette C ^a  

^a GEORGETOWN UNIVERSITY   (United States)

^b GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE KINASE;

ARTICLE; BREAST CANCER; CANCER GROWTH; CANCER INHIBITION; CELL DIFFERENTIATION; CELL PROLIFERATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; BREAST; BREAST NEOPLASMS; CATALYSIS; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; ENZYME PRECURSORS; FEMALE; GENES, TUMOR SUPPRESSOR; HUMANS; IN SITU NICK-END LABELING; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; PROTEIN-TYROSINE KINASES; RNA, MESSENGER; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0034680108     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35021086     Document Type: Article

References (29)

1. Cheng, A. M. & Chan, A. C. Protein tyrosine kinases in thymocyte development. Curr. Opin. Immunol. 9, 528-533 (1997).
2. Kurosaki, T. Molecular mechanisms in B cell antigen receptor signaling. Curr. Opin. Immunol. 9, 309-318 (1997).
3. Chu, D. H., Morita, C. T. & Weiss, A. The Syk family of protein tyrosine kinases in T-cell activation and development. Immunol. Rev. 165, 167-180 (1998).
4. Indik, Z. K., Park, J. G., Pan, X. Q. & Schreiber, A. D. Induction of phagocytosis by a protein tyrosine kinase. Blood 85, 1175-1180 (1995).
5. Fluck, M., Zurcher, G., Andres, A. C. & Ziemiecki, A. Molecular characterization of the murine Syk protein tyrosine kinase cDNA, transcripts and protein. Biochem. Res. Commun. 213, 273-281 (1995).
6. Coopman, P. J., Do, M. T. H., Thompson, E. W. & Mueller, S. C. Phagocytosis of cross-linked gelatin matrix by human breast carcinoma cells correlates with their invasive capacity. Clin. Canc. Res. 4, 507-515 (1998).
7. Coopman, P. J., Thomas, D. M., Gehlsen, K. R. & Mueller, S. C. Integrin α3β1 participates in the phagocytosis of extracellular matrix molecules by human breast cancer cells. Mol. Biol. Cell 7, 1789-1804 (1996).
8. Thompson, E. W. et al. Association of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines. J. Cell Physiol. 150, 534-544 (1992).
9. Law, C. L. et al. Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex. J. Biol. Chem. 269, 12310-12319 (1994).
10. 2 in porcine platelets and phosphorylates GTPase activating protein on tyrosine residue(s). J. Biochem. (Tokyo) 116, 1176-1181 (1994).
11. syk expression. J. Biol. Chem. 270, 26533-26537 (1995).
12. Brunner, N. et al. lacZ transduced human breast cancer xenografts as an in vivo model for the study of invasion and metastasis. Eur. J. Cancer 384, 1990-1995 (1992).
13. Kurebayashi, J. et al. Quantitative demonstration of spontaneous metastasis by MGF-7 human breast cancer cells cotransfected with fibroblast growth factor 4 and LacZ. Cancer Res. 53, 2178-2187 (1993).
14. 2+ mobilization through distinct pathways. EMBO J. 13, 1341-1349 (1994).
15. Peters, J. D., Furlong, M. T., Asai, D. J., Harrison, M. L. & Geahlen, R. L. Syk, activated by cross-linking the B-cell antigen receptor, localizes to the cytosol where it interacts with and phosphorylates alpha-tubulin on tyrosine. J. Biol. Chem. 271, 4755-4762 (1996).
16. Lingle, W. L. & Salisbury, J. L. Altered centrosome structure is associated with abnormal mitoses in human breast tumors. Am. J. Pathol. 155, 1941-1951 (1999).
17. Miranti, C. K., Leng, L., Maschberger, P., Brugge, J. S. & Shattil, S. J. Identification of a novel integrin signaling pathway involving the kinase Syk and the guanine nucleotide exchange factor Vav1. Curr. Biol. 8, 1289-1299 (1998).
18. Williams, S. et al. Reconstitution of T cell antigen receptor-induced Erk2 kinase activation in Lck-negative JCaM1 cells by Syk. Eur. J. Biochem. 245, 84-90 (1997).
19. Deckert, M., Tartare-Deckert, S., Couture, C., Mustelin, T. & Altman, A. Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product. Immunity 5, 591-604 (1996).
20. Law, C. L., Chandran, K. A., Sidorenko, S. P. & Clark, E. A. Phospholipase C-gammal interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk. Mol. Cell. Biol. 16, 1305-1315 (1996).
21. Minobe, K. et al. Allelic loss on chromosome 9q is associated with lymph node metastasis of primary breast cancer. Jpn. J. Cancer Res. 89, 916-922 (1998).
22. Turner, M. et al. Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature 378, 298-302 (1993).
23. Cheng, A. M. et al. Syk tyrosine kinase required for mouse viability and B-cell development. Nature 378, 303-306 (1995).
24. Murphy, M. A. et al. Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice. Mol. Cell Biol. 18, 4872-4882 (1998).
25. Schaeren-Wiemers, N. & Gerfin-Moser, A. A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured and in situ hybridization using digoxigenin-labelled cRNA probes. Histochemistry 100, 431-440 (1993).
26. Emmert-Buck, M. R. et al. Laser capture microdissection. Science 274, 998-1001 (1996).
27. Yagi, S., Suzuki, K., Hasegawa, A., Okuman, K. & Ra, C. Cloning of the cDNA for the deleted Syk kinase homologous to Zap-70 from burner lisophilic leukemia cell line (KU812). Biochem. Biophys. Res. Commun. 200, 28-34 (1994).
28. Pinkel, D. et al. Cytogenetic analysis by in hybridization with fluorescently labeled nucleic acid probes. Cold Spring Harbor Symp. Quant. Biol. 51, 151-157 (1986).
29. Fang, W., Hartrmann, N., Chow, D. T., Rogel, A. T. & Wellstein, A. Pleiotrophin stimulates fibroblasts and endothelial and epithelial cells and is expressed in human cancer. J. Biol. Chem. 267, 25889-25897 (1992).