N-methyl-D-aspartate receptor agonists modulate homocysteine-induced developmental abnormalities

FASEB Journal

Volumn 13, Issue 12, 1999, Pages 1523-1531

  Rosenquist, T H ^a   Schneider, A M ^a   Monaghan, D T ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Neural crest defects; Neural tube defects; Orofacial defects; Prevention

Indexed keywords

GLYCINE; HOMOCYSTEINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR STIMULATING AGENT;

ANIMAL CELL; ARTICLE; CHEMICAL TERATOGENESIS; COMPETITIVE INHIBITION; DEVELOPMENTAL DISORDER; NEURAL CREST; NEURAL TUBE; NEURULATION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR INTRINSIC ACTIVITY;

ANIMALIA; GALLUS GALLUS;

EID: 0032876813     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.13.12.1523     Document Type: Article

References (54)

1. Botto, L. D., Khoury, M. J., Mulinare, J., and Erickson, J. D. (1996) Periconceptional multivitamin use and the occurrence of conotruncal heart defects: results from a population-based, case-control study. Pediatrics 98, 911-917
2. Christensen, B., and Rosenblatt, D. S. (1995) Effects of folate deficiency on embryonic development. Baillieres. Clin. Haematol. 8, 617-637
3. Czeizel, A. E., Toth, M., and Rockenbauer, M. (1996) Population-based case control study of folic acid supplementation during pregnancy. Teratology 53, 345-351
4. Eskes, T. K., and Steegers-Theunissen, R. P. (1994) Primary prevention of neural tube defects with folic acid. Eur. J. Obstet. Gynecol. Reprod. Biol. 53, 147-152
5. Shaw, G. M., O'Malley, C. D., Wasserman, C. R., Tolarova, M. M., and Lammer, E. J. (1995) Maternal periconceptional use of multivitamins and reduced risk for conotruncal heart defects and limb deficiencies among offspring. Am. J. Med. Genet. 59, 536-545
6. Mills, J. L., McPartlin, J. M., Kirke, P. N., Lee, Y. J., Conley, M. R., Weir, D. G., and Scott, J. M. (1995) Homocysteine metabolism in pregnancies complicated by neural-tube defects. Lancet 345, 149-151
7. Steegers-Theunissen, R. P., Boers, G. H., Trijbels, F. J., Finkelstein, J. D., Blom, H. J., Thomas, C. M., Borm, G. F., Wouters, M. G., and Eskes, T. K. (1994) Maternal hyperhomocysteinemia: a risk factor for neural-tube defects? Metabolism 43, 1475-1480
8. Steegers-Theunissen, R. P., Boers, G. H., Blom, H. J., Nijhuis, J. G., Thomas, C. M., Borm, G. F., and Eskes, T. K. (1995) Neural tube defects and elevated homocysteine levels in amniotic fluid. Am. J. Obstet. Gynecol. 172, 1436-1441
9. Rosenquist, T. H., Ratashak, S. A., and Selhub, J. (1996) Homocysteine induces congenital heart and neural tube defects. Effect of folic acid. Proc. Natl. Acad. Sci. USA 93, 15227-15232
10. Kim, W. K., and Pae, Y. S. (1996) Involvement of N-methyl-D-aspartate receptor and free radical in homocysteine-mediated toxicity on rat cerebellar granule cells in culture. Neurosci. Lett. 216, 117-120
11. Kim, W. K., Rayudu, P. V., Choi, Y.-B., Kumar, S., Stamler, J. S., and Lipton, S. A. (1995) Homocysteine: an NMDA agonist and glycine site partial antagonist that induces cortical neurotoxicity. Soc. Neurosci. 21, 521 (abstr.)
12. Lipton, S. A., Kim, W. K., Choi, Y. B., Kumar, S., D'Emilia, D. M., Rayudu, P. V., Arnelle, D. R., and Stamler, J. S. (1997) Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor. Proc. Natl. Acad. Sci. USA 94, 5923-5928
13. Cornell-Bell, A. H., Thomas, P. G., and Smith, S. J. (1990) The excitatory neurotransmitter glutamate causes filopodia formation in cultured hippocampal astrocytes. Glia 3, 322-324
14. Komuro, H., and Rakic, P. (1993) Modulation of neuronal migration by NMDA receptors. Science 260, 95-97
15. Rashid, N. A., and Cambray-Deakin, M. A. (1992) N-methyl-D-aspartate effects on the growth, morphology and cytoskeleton of individual neurons in vitro. Brain. Res. Dev. Brain. Res. 67, 301-308
16. Uberti, D., Belloni, M., Grilli, M., Spano, P., and Memo, M. (1998) Induction of tumour-suppressor phosphoprotein p53 in the apoptosis of cultured rat cerebellar neurones triggered by excitatory amino acids. Eur. J. Neurosci. 10, 246-254
17. Wang, C., Pralong, W. F., Schulz, M. F., Rougon, G., Aubry, J. M., Pagliusi, S., Robert, A., and Kiss, J. Z. (1996) Functional N-methyl-D-aspartate receptors in O-2A glial precursor cells: a critical role in regulating polysialic acid-neural cell adhesion molecule expression and cell migration. J. Cell Biol. 135, 1565-1581
18. Balazs, R., Hack, N., Jorgensen, O. S., and Cotman, C. W. (1989) N-methyl-D-aspartate promotes the survival of cerebellar granule cells: pharmacological characterization, Neurosci. Lett. 101, 241-246
19. Michaelis, E. K. (1998) Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging. Prog. Neurobiol. 54, 369-415
20. Crews, F. T., Morrow, A. L., Criswell, H., and Breese, G. (1996) Effects of ethanol on ion channels. Int. Rev. Neurobiol. 39, 283-367
21. Elmazar, M. M., and Nau, H. (1995) Ethanol potentiates valproic acid-induced neural tube defects (NTDs) in mice due to toxicokinetic interactions. Reprod. Toxicol. 9, 427-433
22. Gofflot, F., van-Maele-Fabry, G., and Picard, J. J. (1996) Cranial nerves and ganglia are altered after in vitro treatment of mouse embryos with valproic acid (VPA) and 4-en-VPA. Brain. Res. Dev. Brain. Res. 93, 62-69
23. Johnson, V. P., Swayze, V. W., II, Sato, Y, and Andreasen, N. C. (1996) Fetal alcohol syndrome: craniofacial and central nervous system manifestations. Am. J. Med. Genet. 61, 329-339
24. Laegreid, L., Kyllerman, M., Hedner, T., Hagberg, B., and Viggedahl, G. (1993) Benzodiazepine amplification of valproate teratogenic effects in children of mothers with absence epilepsy. Neuropediatrics 24, 88-92
25. Munger, R. G., Romitti, P. A., Daack-Hirsch, S., Burns, T. L., Murray, J. C., and Hanson, J. (1996) Maternal alcohol use and risk of orificial cleft birth defects. Teratology 54, 27-33
26. Andaloro, V. J., Monaghan, D. T., and Rosenquist, T. H. (1998) Dextromethorphan and other N-methyl-D-aspartate receptor antagonists are teratogenic in the avian embryo model. Pediatric Res. 43, 1-7
27. Bostom, A. G., Jaques, P. F., Nadeau, M. R., Williams, R. R., Ellison, R. C., and Selhub, J. (1995) Post-methionine load hyperhomocysteinemia in persons with normal fasting total plasma homocysteine: initial results from the NHLBI Family Heart Study
28. Fineman, R. M., Schoenwolf, G. C., Huff, M., and Davis, P. L. (1986) Causes of windowing-induced dysmorphogenesis (neural tube defects and early amnion deficit spectrum) in chicken embryos. Am. J. Med. Genet. 25, 489-505
29. 13. Snedecor, G. W. (1962) Statistical Methods, pp. 90-92, Iowa State University Press
30. Witt, G. (1999) Proposed Mechanisms of Homocysteine Teratogenesis in the Chicken Embryo, 187 pp., Doctoral Dissertation, University of Nebraska Medical Center, College of Graduate Studies, Omaha, Nebraska
31. Wood, A. M., and Bristow, D. R. (1998) N-methyl-D-aspartate receptor desensitization is neuroprotective by inhibiting glutamate-induced apoptotic-like cell death. J. Neurochem. 70, 677-687
32. Ikonomidou, C., Bosch, F., Miksas, M., Bittigau, P., Vockler, J., Dikranian, K., Tenkova, T. I., Stefovska, V., Turski, L., and Olney, J. W. (1999) Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain. Science 283, 70-74
33. Weil, M., Jacobson, M. D., and Raff, M. C. (1997) Is programed cell death required for neural tube closure? Curr. Biol. 7, 281-284
34. Graham, A., Koentges, G., and Lumsden, A. (1996) Neural crest apoptosis and the establishment of craniofacial pattern: an honorable death. Mol. Cell. Neurosci. 8, 76-83
35. Graham, A., and Lumsden, A. (1996) Patterning the neural crest. Biochem. Soc. Symp. 62, 77-83
36. Sah, V. P., Attardi, L. D., Mulligan, G. C., Williams, B. O., Bronson, R. T., and Jacks, T. (1995) A subset of p53-deficient embryos exhibit exencephaly. Nat. Genet. 10, 175-80
37. Maden, M., Gale, E., and Zile, M. (1998) The role of vitamin A in the development of the central nervous system. J. Nutr. 128, 471s-475s
38. Fohr, K. J., Schirm, T., and Finger, W. (1995) NMDA-induced whole-cell currents and single channel conductances in tectal neurons during two stages of early development of chicken. Neurosci. Lett. 183, 87-90
39. Monyer, H., Sprengel, R., Schoepfer, R., Herb, A., Higuchi, M., Lomeli, H., Burnashev, N., Sakmann, B., and Seeburg, P. H. (1992) Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science 256, 1217-1221
40. Buller, A. L., Larson, H. C., Schneider, B. E., Beaton, J. A., Morrisett, R. A., and Monaghan, D. T. (1994) The molecular basis of NMDA receptor subtypes: native receptor diversity is predicted by subunit composition. J. Neurosci. 14, 5471-5484
41. Ishii, T., Moriyoshi, K., Sugihara, H., Sakurada, K., Kadotani, H., Yokoi, M., Akazawa, C., Shigemoto, R., Mizuno, N., and Masu, M. (1993) Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits. J. Biol. Chem. 268, 2836-2843
42. Sugihara, H., Moriyoshi, K., Ishii, T., Masu, M., and Nakanishi, S. (1992) Structures and properties of seven isoforms of the NMDA receptor generated by alternative splicing. Biochem. Biophys. Res. Commun. 185, 826-832
43. Wouters, M. G., Boers, G. H., Blom, H. J. Trijbels, F. J., Thomas, C. M., Borm, G. F., Steegers-Theunissen, R. P., and Eskes, T. K. (1993) Hyperhomocysteinemia: a risk factor in women with unexplained recurrent early pregnancy loss. Fertil. Steril. 60, 820-825
44. Goddijn-Wessels, T. A., Wouters, M. G., van de Molen, E. F., Spuijbroek, M. D., Steegers-Theunissen, R. P., Blom, H. J., Boers, G. H., and Eskes, T. K. (1996) Hyperhomocysteinemia: a risk factor for placental abruption or infarction. Eur. J. Obstetr. Gynecol. Reprod. Biol. 66, 23-29
45. Noden, D. M. (1990) Origins and assembly of avian embryonic blood vessels. Ann. N.Y. Acad. Sci. 588, 236-249
46. Hladovec, J., Sommerova, Z., and Pisarikova, A. (1997) Homo-cysteinemia and endothelial damage after methionine load. Thromb. Res. 88, 361-364
47. Wang, H., Yoshizumi, M., Lai, K., Tsai, J. C., Perrella, M. A., Haber, E., and Lee, M. E. (1997) Inhibition of growth and p21ras methylation in vascular endothelial cells by homocysteine but not cysteine. J. Biol. Chem. 272, 25380-25385
48. Robinson, L. K., Hoyme, H. E., Edwards, D. K., and Jones, K. L. (1987) Vascular pathogenesis of unilateral craniofacila defects. J. Pediatr. 111, 236-239
49. Van Straiten, H. W., Janssen, H. C., Peelers, M. C., Copp, A. J., and Hekking, J. W. (1996) Neural tube closure in the chick embryo is multiphasic. Dev. Dyn. 207, 309-318
50. Romanoff, A. L. ( 1960) The Avion Embryo: Structural and Functional Development, 780 pp., Macmillan, N.Y.
51. Refsum, H., Ueland, P. M., and Svardal, A. M. (1989) Fully automated fluorescence assay for determining total homocysteine in plasma. Clin. Chem. 35, 1921-1927
52. Tyagi, S. C. (1998) Homocysteine redox receptor and regulation of extracellular matrix components in vascular cells. Am. J. Physiol. 274, C396-C405
53. Manssor, M. A., Svardal, A. M., Schneede, J., and Ueland, P. M. (1992) Dynamic relation between reduced, oxidized and protein-bound homocysteine and other thiol components in plasma during methionine loading in healthy men. Clin. Chem. 38, 1316-1321
54. Rosenquist, T. H., Monaghan, D. T., Gadson, P. F., Dalton, M. L., G. L. Witt, and Brown, J. C. (1999) Homocysteine and the NMDA receptor: are they keys to conotruncal abnormalities? In Development of the Cardiovascular System Volume I, Heart Development (Tomanek, R. J., and Runyan, R. B., eds) JAI Press, Greenwich, Connecticut