Induction of TIMP-1 expression in rat hepatic stellate cells and hepatocytes: A new role for homocysteine in liver fibrosis

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1455, Issue 1, 1999, Pages 12-22

  Torres, Luis ^a   García Trevijano, Elena R ^a   Rodríguez, José A ^a   Carretero, M Victoria ^a   Bustos, Matilde ^a   Fernández, Estefanía ^a   Eguinoa, Ezequiel ^a   Mato, José M ^a   Avila, Matías A ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

Author keywords

Extracellular matrix; Fibrosis; Hyperhomocysteinemia; Liver; Risk factor

Indexed keywords

COMPLEMENTARY DNA; HOMOCYSTEINE; MESSENGER RNA; METALLOPROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; HYPERHOMOCYSTEINEMIA; LIVER CELL; LIVER FIBROSIS; LIVER INJURY; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RAT; STELLATE CELL;

ANIMALS; BLOTTING, NORTHERN; CELLS, CULTURED; CYSTEINE; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION; HOMOCYSTEINE; LIVER; LIVER CIRRHOSIS, EXPERIMENTAL; MERCAPTOETHANOL; MUSCLE, SMOOTH, VASCULAR; POLYMERASE CHAIN REACTION; PROCOLLAGEN; RATS; RNA, MESSENGER; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TRANSCRIPTION FACTOR AP-1;

EID: 0345035265     PISSN: 09254439     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4439(99)00049-6     Document Type: Article

References (56)

1. Refsum H., Ueland P.M., Nygard O., Vollset S.E. Homocysteine and cardiovascular disease. Annu. Rev. Med. 49:1998;31-62.
2. S.H. Mudd, H.L. Levy, F. Skovby, Disorders of transsulfuration, in: C.R. Scriver, A.L. Beaudet, W.S. Sly, D. Valle (Eds.), The Metabolic and Molecular Basis of Inherited Disease, McGraw-Hill, New York, 1995, pp. 693-734.
3. Selhub J., Jacques P.F., Wilson P.W., Rush D., Rosenberg I.H. Vitamin status and intake as primary determinants of homocysteinemia in an elderly populations. J. Am. Med. Assoc. 270:1993;2693-2698.
4. Varela-Moreiras G., Alonso-Aperte E., Rubio M., Gasso M., Deulofeu R., Alvarez L., Caballeria J., Rodes J., Mato J.M. Carbon tetrachloride-induced hepatic injury is associated with global DNA hypomethylation and homocysteinemia. Effect of S-adenosylmethionine treatment. Hepatology. 22:1995;1310-1315.
5. Halsted C.H., Villanueva J., Chandler C.J., Stabler S.P., Allen R.H., Muskhelishvili L., James S.J., Poirier L. Ethanol feeding of micropigs alters methionine metabolism and increases hepatocellular apoptosis and proliferation. Hepatology. 23:1996;497-505.
6. Hultberg B., Berglund M., Andersson A., Frank A. Elevated plasma homocysteine in alcoholics. Alcohol Clin. Exp. Res. 17:1993;687-689.
7. Cravo M.L., Gloria L.M., Selhub J., Nadeau M.R., Camilo M.E., Resende M.P., Cardoso J.N., Leitao C.N., Mira F.C. Hyperhomocysteinemia in chronic alcoholism: correlation with folate, vitamin B-12, and vitamin B-6 status. Am. J. Clin. Nutr. 63:1996;220-224.
8. Finkelstein J.D., Martin J.J. Methionine metabolism in mammals: distribution of homocysteine between competitive pathways. J. Biol. Chem. 259:1984;9508-9513.
9. Finkelstein J.D. The metabolism of homocysteine: pathways and regulation. Eur. J. Pediatr. 157:1998;S40-S44.
10. Stamler J.S., Osborne J.A., Jakaki O., Rabbani L.E., Mullins M., Singel D., Loscalzo J. Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen. J. Clin. Invest. 91:1993;308-318.
11. Lentz S.R. Homocysteine and vascular disfunction. Life Sci. 61:1997;1205-1215.
12. Tsai J.C., Perrella M.A., Yoshizumi M., Hsieh C.M., Haber E., Schlegel R., Lee M.E. Promotion of vascular smooth muscle cell growth by homocysteine: a link to atherosclerosis. Proc. Natl. Acad. Sci. USA. 91:1994;6369-6373.
13. Tsai J.C., Wang H., Perrella M.A., Yoshizumi M., Sibinga N.E.S., Tan L.C., Haber E., Chang T.H.T., Schlegel R., Lee M.E. Induction of cyclin A gene expression by homocysteine in vascular smooth muscle cells. J. Clin. Invest. 97:1996;146-153.
14. Majors A., Ehrhart L.A., Pezacka E.H. Homocysteine as a risk factor for vascular disease. Enhanced collagen production and accumulation by smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 17:1997;2074-2081.
15. Tyagi S.C. Homocysteine redox receptor and regulation of extracellular matrix components in vascular cells. Am. J. Physiol. 274:1998;C396-C405.
16. Karmin O., Lynn E.G., Chung Y.H., Siow Y.L., Man R.Y.K., Choy P.C. Homocysteine stimulates the production and secretion of cholesterol in hepatic cells. Biochim. Biophys. Acta. 1393:1998;317-324.
17. Woesner J.F. Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J. 5:1991;2145-2154.
18. Arthur M.J.P. Collagenases and liver fibrosis. J. Hepatol. 22:1995;43-48.
19. Herbst H., Wege T., Milani S., Pellegrini G., Orzechowski H.D., Bechstein W.O., Neuhaus P., Gressner A.M., Schuppan D. Tissue inhibitor of metalloproteinase-1 and -2 RNA expression in rat and human liver fibrosis. Am. J. Pathol. 150:1997;1647-1659.
20. Benyon R.C., Iredale J.P., Goddard S., Winwood P.J., Arthur M.J.P. Expression of tissue inhibitor of metalloproteinases 1 and 2 is increased in fibrotic human liver. Gastroenterology. 110:1996;821-831.
21. Iredale J.P., Benyon C., Arthur M.J.P., Ferris W.F., Alcolado R., Winwood P.J., Clark N., Murphy G. Tissue inhibitor of metalloproteinase-1 messenger RNA expression is enhanced relative to interstitial collagenase messenger RNA in experimental liver injury and fibrosis. Hepatology. 24:1996;176-184.
22. Roeb E., Purucker E., Breuer B., Nguyen H., Heinrich P.C., Rose-John S., Matern S. TIMP expression in toxic and cholestatic liver injury in rat. J. Hepatol. 27:1997;535-544.
23. 4-cirrhotic rats are heterogeneous with regard to proliferation, expression of extracellular matrix components, interleukin-6 and connexin 43. Lab. Invest. 69:1993;210-216.
24. González-Cadavid N.F., Vernet D., Fuentes A., Rodríguez J.A., Swerdloff R., Rajfer J. Up-regulation of the levels of androgen receptor and its mRNA by androgens in smooth-muscle cells from rat penis. Mol. Cell. Endocrinol. 90:1993;219-229.
25. Avila M.A., Carretero M.V., Rodriguez E.N., Mato J.M. Regulation by hypoxia of methionine adenosyltransferase activity and gene expression in rat hepatocytes. Gastroenterology. 114:1998;364-371.
26. Otero G., Avila M.A., de la Peña L., Emfietzoglou D., Cansado J., Popescu G.F., Notario V. Altered processing of precursor transcripts and increased levels of the subunit I of mitochondrial cytochrome c oxidase in syrian hamster fetal cells initiated with ionizing radiation. Carcinogenesis. 18:1997;1569-1575.
27. Liang P., Pardee A.B. Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science. 257:1992;967-971.
28. Hamon G.H., Cameron G.N. The EMBL data library. Nucleic Acids Res. 14:1986;5-10.
29. Bilofsky H.S., Burks C. The GeneBank data bank. Nucleic Acids Res. 16:1988;1861-1864.
30. Pearson W.R., Lipmann D.J. Improved tools for biological sequence comparison. Proc. Natl. Acad. Sci. USA. 85:1988;2444-2448.
31. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:1987;156-159.
32. Thomas P.S. Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. Proc. Natl. Acad. Sci. USA. 77:1980;5201-5205.
33. Genovese G., Rowe D., Kream B. Construction of DNA squences complementary to rat alpha 1 and alpha 2 collagen mRNA and their use in studying the regulation of type I collagen synthesis by 1,25-dihydroxyvitamin D. Biochemistry. 23:1984;6210-6216.
34. Schreiber E., Matthias P., Muller M.M., Schaffner W. Rapid detection of octamers binding proteins with miniextracts prepared from a small number of cells. Nucleic Acids Res. 17:1989;6419.
35. Docherty A.J.P., Lyons A., Smith B.J., Wright E.M., Stephens P.E., Harris T.J.R. Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity. Nature. 318:1985;66-69.
36. Overall C.M., Wrana J.L., Sudek J. Independent regulation of collagenase72 KD progelatinase, and metalloendoproteinase inhibitor expression in human fibroblast by transforming growth factor-β J. Biol. Chem. 264:1989;1860-1869.
37. Edwards D.R., Murphy G., Reynolds J.J., Whitham S.E., Docherty A.J., Angel P., Heath J.K. Transforming growth factor beta modulates expression of collagenase and metalloproteinase inhibitor. EMBO J. 6:1987;1899-1904.
38. Friedman S.L. The cellular basis of hepatic fibrosis. New Engl. J. Med. 328:1993;1828-1835.
39. Iredale J.P., Murphy G., Hembry R.M., Friedman S.L., Arthur M.J.P. Human hepatic lipocytes synthesize tissue inhibitor of metalloproteinases-1. J. Clin. Invest. 90:1992;282-287.
40. Murawaki Y., Ikuta Y., Idobe Y., Kitamura Y., Kawasaki H. Tissue inhibitor of metalloproteinase-1 in the liver of patients with chronic liver disease. J. Hepatol. 26:1997;1213-1219.
41. Roeb E., Graeve L., Hoffmann R., Decker K., Edwards D.R., Heinrich P.C. Regulation of tissue inhibitor of metalloproteinases-1 gene expression by cytokines and dexametasone in rat hepatocytes primary cultures. Hepatology. 18:1993;1437-1442.
42. Kordula T., Güttgemann I., Rose-John S., Roeb E., Osthues A., Tschesche H., Koj A., Heinrich P.C., Graeve L. Synthesis of tissue inhibitor of metalloproteinase-1 (TIMP-1) in human hepatoma cells (HepG2). FEBS Lett. 313:1992;143-147.
43. Logan S.K., Garabedian M.J., Campbell C.E., Werb Z. Synergistic transcriptional activation of the tissue inhibitor of metalloproteinases-1 promoter via functional interaction of AP-1 and Ets-1 transcription factors. J. Biol. Chem. 271:1996;774-782.
44. Botelho F.M., Edwards D.R., Richards C.D. Oncostatin stimulates c-fos to bind a transcriptionally responsive AP-1 element within the tissue inhibitor of metalloproteinase-1 promoter. J. Biol. Chem. 273:1998;5211-5218.
45. Dalton M.L., Gadson P.F., Wrenn R.W., Rosenquist T.H. Homocysteine signal cascade: production of phospholipids, activation of protein kinase C, and the induction of c-fos and c-myb in smooth muscle cells. FASEB J. 11:1997;703-711.
46. Brown J.C. III, Rosenquist T.H., Monaghan D.T. ERK2 activation by homocysteine in vascular smooth muscle cells. Biochem. Biophys. Res. Commun. 251:1998;669-676.
47. Mc Cully K.S. Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis. Am. J. Pathol. 56:1969;111-121.
48. Kossakowska A.E., Edwards D.R., Lee S.S., Urbanski L.S., Stabbler A.L., Zhang C.L., Phillips B.W., Zhang Y., Urbanski S.J. Altered balance between matrix metalloproteinases and their inhibitors in experimental biliary fibrosis. Am. J. Pathol. 153:1998;1895-1902.
49. Li J., Rosman A.S., Leo M.A., Nagai Y., Lieber C.S. Tissue inhibitor of metalloproteinase is increased in the serum of precirrhotic and cirrhotic alcoholic patients and can serve as a marker of fibrosis. Hepatology. 19:1994;1418-1423.
50. G. Klastin, H.O. Conn, Hepatic lesions in disorders of protein and amino acid metabolism, in: Histopathology of the Liver, Oxford University Press, New York, 1993, pp. 241-245.
51. Bellamy M.F., McDowell I.F., Ramsey M.W., Brownlee M., Bones C., Newcombe R.G., Lewis M.J. Hyperhomocysteinemia after an oral methionine load acutely impairs endothelial function in healthy adults. Circulation. 98:1998;1848-1852.
52. Durand P., Lussier-Cacan S., Blache D. Acute methionine load-induced hyperhomocysteinemia enhances platelet aggregation, thromboxane biosynthesis, and macrophage-derived tissue factor activity in rats. FASEB J. 11:1997;1157-1168.
53. Tyagi S.C., Kumar G.S., Borders S. Reduction-oxidation (redox) state regulation of extracellular matrix metalloproteinases and tissue inhibitors in cardiac normal and transformed fibroblast cells. J. Cell. Biochem. 61:1996;139-151.
54. S. Segal, S.O. Thier, Cystinuria, in: C.R. Scriver, A.L. Beaudet, W.S. Sly, D. Valle, (Eds.), The Metabolic and Molecular Basis of Inherited Disease, McGraw-Hill, New York, 1995, pp. 3581-3601.
55. 2 and antioxidants have opposite effects on activation of NF-kB and AP-1 in intact cells: AP-1 as a secondary antioxidant-responsive factor. EMBO J. 12:1993;2005-2015.
56. S. Degli Esposti, M.A. Zern, Peptide hormone and cytokine regulation of matrix synthesis, in: M.A. Zern, L.M. Reid (Eds.), Extracellular matrix, Marcel Dekker, New York, 1993, pp. 331-349.