Mechanisms of homocysteine toxicity on connective tissues: Implications for the morbidity of aging

Journal of Nutrition

Volumn 130, Issue 2 SUPPL., 2000, Pages

  Krumdieck, Carlos L ^a   Prince, Charles W ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Aging; EGF like domains; Fibrillin 1; Homocysteine; Homocysteine thiolactone; Protein homocysteinylation

Indexed keywords

EPIDERMAL GROWTH FACTOR; FIBRILLIN; HOMOCYSTEINE; HOMOCYSTEINE THIOLACTONE; M PROTEIN;

AGING; COGNITIVE DEFECT; CONFERENCE PAPER; HUMAN; HYPERHOMOCYSTEINEMIA; MORBIDITY; OSTEOPOROSIS; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PRESBYOPIA; TOXICOKINETICS;

EID: 0033969536     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/130.2.365s     Document Type: Conference Paper

References (33)

1. Bellamy, M. F. & McDowell I. F. (1997) Putative mechanisms for vascular damage by homocysteine. J. Inherit. Metab. Dis. 20: 307-315.
2. Benesch, R. & Benesch, R. E. (1956) Formation of peptide bonds by aminolysis of homocysteine thiolactone. J. Am. Chem. Soc. 78: 1597-1599.
3. Bork, P., Downing, A. K., Kieffer, B. & Campbell, I. D. (1996) Structure and distribution of modules in extracellular proteins. Q. Rev. Biophys. 29: 119-167.
4. Boushey, C. J., Beresford, S.A.A., Omenn, G. S. & Motulsky, A. G. (1995) A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. J. Am. Med. Assoc. 274: 1049-1057.
5. Brown, M. S., Herz, J. & Goldstein, J. L. (1997) Calcium cages, acid baths and recycling receptors. Nature (Lond.) 388: 629-630.
6. Brownlee, M. (1992) Glycation products and the pathogenesis of diabetic complications. Diabetes Care 15: 1835-1843.
7. 12, and serum total homocysteine levels in confirmed Alzheimer disease. Arch. Neurol. 55: 1449-1455.
8. Cleary, E. G. & Gibson, M. A. (1996) Elastic tissue, elastin and elastin associated microfibrils. In: Extracellular Matrix, Vol. 2, Molecular Components and Interactions (Comper, W. D., ed.), pp. 95-140. Harwood Academic Publishers, The Netherlands.
9. Dahlback, B. (1995) The protein C anticoagulant system: inherited defects as basis for venous thrombosis. Thromb. Res. 77: 1-43.
10. Dalton, M. L., Gadson, P. F., Jr., Wrenn, R. W. & Rosenquist, T. H. (1997) Homocysteine signal cascade: production of phospholipids, activation of protein kinase C, and the induction of c-fos and c-myc in smooth muscle cells. FASEB J. 11: 703-711.
11. Dietz, H. C., Cutting, G. R., Pyeritz, R. E., Maslen, C. L., Sakai, L. Y., Corson, G. M., Puffenberger, E. G., Hamosh, A., Nanthakumar, E. J., Curristin, S. M., Stetten, G., Meyers, D. A. & Francomano, C. A. (1991) Defects in the fibrillin gene cause the Marfan syndrome; linkage evidence and identification of a missense mutation. Nature (Lond.) 352: 337-339.
12. Dudman, N.P.B., Hicks, C., Lynch, J. F., Wilken, D.E.L. & Wang, J. (1991) Homocysteine thiolactone disposal by human arterial endothelial cells and serum in vitro. Arterioscl. Thromb. 11: 663-670.
13. Fass, D., Blaklow, S., Kim, P. S. & Berger, J. M. (1997) Molecular basis of familiar hypercholesterolemia from the structure of LDL receptor module. Nature (Lond.) 388: 691-693.
14. Hajjar, K. A., Mauri, L., Jacovina, A. T., Zhong, F., Mirza, U. A., Padovan, J. C. & Chait, B. T. (1998) Tissue plasminogen activator binding to the annexin II tail domain: direct modulation by homocysteine. J. Biol. Chem. 273: 9987-9993.
15. Jakubowski, H. (1997) Metabolism of homocysteine thiolactone in human cell cultures. J. Biol. Chem. 272: 1935-1942.
16. Jakubowski, H. (2000) Homocysteine thiolactone: metabolic origin and protein homocysteinylation in humans. J. Nutr. 130: 377S-381S.
17. Jocelyn, P. C. (1972) Biochemistry of the SH Group. Academic Press, New York, NY.
18. Johnson, J. L. & Wadman, S. K. (1989) Molybdenum cofactor deficiency. In: The Metabolic Bases of Inherited Disease, 6th ed. (Scriver, C. R., Beaudet, A. L., Sly, W. S. & Valle, D., eds.), pp. 1463-1475. McGraw-Hill, New York, NY.
19. Kang, S. S., Wong, P.W.K. & Becker, N. (1979) Protein bound homocyst(e)ine in normal subjects and in patients with homocystinuria. Pediatr. Res. 13: 1141-1143.
20. Kang, S. S., Wong, P.W.K. & Malinow, M. R. (1992) Hyperhomocyst(e)inemia as a risk factor for occlusive vascular disease. Annu. Rev. Nutr. 12: 279-298.
21. Lee, B., Godfrey, M., Vitale, E., Hori, H., Mattei, M. G., Sarfarazi, M., Tsipouras, P., Ramirez, F. & Hollister, D. W. (1991) Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes. Nature (Lond.) 352: 330-334.
22. Lenz, S. R. & Sadler, J. E. (1991) Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine. J. Clin. Investig. 88: 1906-1914.
23. Ling, Q. & Hajjar, K. A. (2000) Inhibition of endothelial cell thromboresistance by homocysteine. J. Nutr. 130: 373S-376S.
24. Liu, G., Nellaiappan, K. & Kagan, H. M. (1997) Irreversible inhibition of lysyl oxidase by homocysteine thiolactone and its selenium and oxygen analogues. J. Biol. Chem. 272: 32370-32377.
25. McDowell, I.F.W. & Lang, D. (2000) Homocysteine and endothelial dysfunction: a link with cardiovascular disease. J. Nutr. 130: 369S-372S.
26. Miyao, M., Morita, H., Hosoi, T., Kurihara, H., Inoue, S., Hoshino, S., Shiraki, M., Yazaki, Y. & Ouchi, Y. (1998) Methylenetetrahydrofolate reductase polymorphism and bone mineral density in postmenopausal Japanese women. J. Bone Mineral Res. 13: S373, W304.
27. Mudd, S. H., Levy, H. L. & Skovby, F. (1995) Disorders of transulfuration. In: The Metabolic Bases of Inherited Disease, 7th ed. (Scriver, C. R., Beaudet, A. L., Sly, W. S. & Valle, D., eds.), pp. 1279-1327. McGraw-Hill, New York, NY.
28. Orentreich, N., Matias, J. R., DeFelice, A. & Zimmerman, J. A. (1993) Low methionine ingestion by rats extends life span. J. Nutr. 123: 269-274.
29. Pyeritz, R. E. (1993) The Marfan syndrome. In: Connective Tissue and Its Heritable Disorders, pp. 437-468. Wiley-Liss, New York, NY.
30. Refsum, H., Ueland, P. M., Nygard, O. & Vollset, S. E. (1998) Homocysteine and cardiovascular disease. Annu. Rev. Med. 49: 31-62.
31. Richie, J. P., Jr., Leutzinger, Y., Parthasarathy, S., Malloy, V., Orentreich, N. & Zimmerman, J. A. (1994) Methionine restriction increases blood glutathione and longevity in F344 rats. FASEB J. 8: 1302-1307.
32. Sakai, L. Y., Keene, D. R., Glanville, R. W. & Bachinger, H. P. (1991) Purification and partial characterization of fibrillin, a cysteine-rich structural component of connective tissue microfibrils. J. Biol. Chem. 266: 14763-14770.
33. Verhoef, P., Kok, F. J., Kruyssen, D. A., Schouten, E. G., Witteman, J. C., Grobbee, D. E., Ueland, P. M. & Refsum, H. (1997) Plasma total homocysteine, B vitamins, and risk of coronary atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 17: 989-995.