Involvement of N-methyl-D-aspartate receptor and free radical in homocysteine-mediated toxicity on rat cerebellar granule cells in culture

Neuroscience Letters

Volumn 216, Issue 2, 1996, Pages 117-120

  Kim, Won Ki ^a   Pae, Young Sook ^a  

^a Ewha Womans University School of Medicine   (South Korea)

Author keywords

Cerebellar granule cell; Free radical; Homocysteine; Lactate dehydrogenase; N Methyl D aspartate

Indexed keywords

6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; CATALASE; FREE RADICAL; HOMOCYSTEINE; LACTATE DEHYDROGENASE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CEREBELLUM; CONTROLLED STUDY; GRANULE CELL; NEUROTOXICITY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030604041     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(96)13011-1     Document Type: Article

References (20)

1. [1] Allen, I.C., Grieve, A. and Griffiths, R., Differential changes in the content of amino acid neurotransmitters in discrete regions of the rat brain prior to the onset and during the course of homocysteine-induced seizures, J. Neurochem., 46 (1986) 1582-1592.
2. [2] Blennow, G., Folbergrova, J., Nilsson, B. and Siesjo, B.K., Cerebral metabolic and circulatory changes in the rat during sustained seizures induced by DL-homocysteine. Brain Res., 179 (1979) 129-146.
3. [3] Drejer, J. and Schousboe, A., Selection of a pure cerebellar granule cell culture by kainate treatment, Neurochem. Res., 14 (1988) 751-754.
4. [4] Gibson, J.B., Carson, N.A.J. and Neill, D.W., Pathological findings in homocysteinuria, J. Clin. Pathol., 17 (1964) 427-437.
5. [5] Joosten, E., vander Berg, A., Riezler, R., Naurath, H.J., Lindenbaum, J., Stabler, S.P. and Allen, R.H., Metabolic evidence that deficiencies of vitamin B-12 (cobalamin), folate, and vitamin B-6 occur commonly in elderly people, Am. J. Clin. Nutr., 58 (1993) 468-476.
6. [6] Kim, W.-K., Rayudu, P.V., Choi, Y.-B., Kumar, S., Stamler, J.S. and Lipton, S.A., Homocysteine: an NMDA agonist and glycine site partial antagonist that induces cortical neurotoxicity, Soc. Neurosci. Abstr., 21 (1995) 521.
7. [7] Kubova, H., Folbergrova, J. and Mares, P., Seizures induced by homocysteine in rats during ontogenesis, Epilepsia, 36 (1995) 750-756.
8. [8] Malinow, M.R., Hyperhomocysteinemia: a common and easily reversible risk factor for occlusive atherosclerosis, Circulation, 81 (1990) 2004-2006.
9. [9] McCully, K.S., Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis, Am. J. Pathol., 56 (1969) 111-128.
10. [10] Meldrum, B. and Garthwaite, J., Excitatory amino acid neurotoxicity and neurodegenerative disease, Trends Pharmacol. Sci., 11 (1990) 379-387.
11. [11] Olney, J.W., Zorumski, C., Price, M.T. and Labryuere, J., L-Cysteine, a bicarbonate-sensitive endogenous excitotoxin, Science, 248 (1990) 596-599.
12. [12] Olszewski, A.J. and McCully, K.S., Homocysteine metabolism and the oxidative modification of proteins and lipids, Free Radical Biol. Med., 14 (1993) 683-693.
13. [13] Selhub, J., Jacques, P.F., Wilson, P.W.F., Rush, D. and Rosenberg, I.H., Vitamin status and intake as primary determinants of homocysteinemia in an elderly population, J. Am. Med. Assoc., 270 (1993) 2693-2698.
14. [14] Selhub, J., Jacques, P.F., Bostom, A.G., D'Agostino, R.B., Wilson, P.W., Belanger, A.J., O'Leary, D.H., Wolf, P.A., Schaefer, E.J. and Rosenberg, I.H., Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis, N. Engl. J. Med., 332 (1995) 286-291.
15. [15] Simon, R.P., Swan, J.H., Griffiths, T. and Meldrum, B.S., Blockade of N-methyl-D-asparate receptors may protect against ischemic damage in the brain, Science, 226 (1984) 850-852.
16. [16] Slivka, A. and Cohen, G., Brain ischemia markedly elevates levels of the neurotoxic amino acid, cysteine, Brain Res., 608 (1993) 33-37.
17. [17] Stabler, S.P., Marcell, P.D., Podell, E.R., Allen, R.H., Savage, D.G. and Lindenbaum, J., Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry, J. Clin. Invest., 81 (1988) 466-474.
18. [18] Starkebaum, G. and Harlan, J.M., Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine, J. Clin. invest., 77 (1986) 405-410.
19. [19] Wall, R.T., Harlan, J.M., Harker, L.A. and Striker, G.E., Homocysteine-induced endothelial cell injury in vitro: a model for the study of vascular injury, Thromb. Res., 18 (1980) 113-121.
20. [20] Zhang, D. and Lipton, S.A., L-Homocysteic acid selectively activates N-methyl-D-aspartate receptors of rat retinal ganglion cells, Neurosci. Lett., 136 (1992) 173-177.