Homocysteine thiolactone and protein homocysteinylation in human endothelial cells implications for atherosclerosis

Circulation Research

Volumn 87, Issue 1, 2000, Pages 45-51

  Jakubowski, Hieronim ^a   Zhang, Li ^a   Bardeguez, Arlene ^a   Aviv, Abram ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Atherosclerosis; Endothelial cells; HDL lipoproteins; Homocysteine; Proteins

Indexed keywords

AMINO ACID TRANSFER RNA LIGASE; FOLIC ACID; HIGH DENSITY LIPOPROTEIN; HOMOCYSTEINE THIOLACTONE; HOMOCYSTINE; METHIONINE;

ARTICLE; ATHEROSCLEROSIS; BLOOD VESSEL INJURY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; HUMAN; HUMAN CELL; METABOLIC ACTIVATION; PRIORITY JOURNAL; RNA EDITING; UMBILICAL VEIN;

EID: 0034617073     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.87.1.45     Document Type: Article

References (31)

1. Jacobsen DW. Homocysteine and vitamins in cardiovascular disease. Clin Chem. 1998;44:1833-1843.
2. Jakubowski H. Biosynthesis and reactions of homocysteine thiolactone. In: Carmel R, Jacobsen DW, eds. Homocysteine in Health and Disease. Oxford, UK: Cambridge University Press, 2000. In press.
3. Jakubowski H. tRNA synthetase proofreading of amino acids. In: Embryonic Encyclopedia of Life Sciences. London, UK: Nature Publishing Group; 2000. Available at: http://www.els.net.
4. Jakubowski H, Goldman E. Editing of errors in amino acids selection for protein synthesis. Microbiol Rev. 1992;56:412-429.
5. Jakubowski H, Fersht AR. Alternative pathways of editing noncognate amino acids by aminoacyl-tRNA synthetases. Nucleic Acids Res 1981; 9:3105-3117.
6. Fersht AR, Dingwall C. An editing mechanism for the methionyl-tRNA synthetase in the selection of amino acids for protein synthesis. Biochemistry. 1979;18:1250-1256.
7. Lys with noncognate amino acids by lysyl-tRNA synthetase. Biochemistry. 1999;38:8088-8093.
8. Jakubowski H. Metabolism of homocysteine thiolactone in human cell cultures: possible mechanism for pathological consequences of elevated homocysteine levels. J Biol Chem. 1997;272:1935-1942.
9. Jakubowski H. Homocysteine thiolactone: metabolic origin and protein homocysteinylation in humans. J Nutr. 2000;130:3775-3815.
10. Jakubowski H. Protein homocysteinylation: possible mechanism underlying pathological consequences of elevated homocysteine levels FASEB J. 1999;13:2277-2283.
11. Jakubowski H. Proofreading in vivo: editing of homocysteine by methionyl-tRNA synthetase in Escherichia coli. Proc Natl Acad Sci U S A. 1990;87:4504-4508.
12. Jakubowski H. Proofreading in vivo: editing of homocysteine by methionyl-tRNA synthetase in the yeast Saccharomyces cerevisiae. EMBO J. 1991;10:593-598.
13. Jakubowski H. Proofreading in vivo: editing of homocysteine by aminoacyl-tRNA synthetase in Escherichia coli. J Biol Chem 1995;270: 17672-17673.
14. Jakubowski H, Goldman E. Synthesis of homocysteine thiolactone by methionyl-tRNA synthetase in cultured mammalian cells. FEBS Lett. 1993;317:593-598.
15. Anderson RF, Packer JE. The radiolysis of aqueous solutions of homocysteine thiolactone. Int J Radiat Phys Chem. 1974;6:33-46.
16. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990's. Nature. 1993;262:801-809.
17. Dudman NPB, Hicks C, Lynch JF, Wilcken DEL, Wang J. Homocysteine thiolactone disposal by human arterial endothelial cells and serum in vitro. Arterioscler Thromb. 1991;11:663-670.
18. Jaffe F, Nachmann RL, Becker CG, Minick CR. Culture of human endothelial cells derived from umbilical veins. J Clin Invest. 1973;52: 2745-2751.
19. Baernstein HD. A modification of the method for determining methionine in proteins. J Biol Chem. 1934;106:451-456.
20. Rudel LL, Lee JA, Morris MD, Felts JM. Characterization of plasma lipoproteins separated and purified by agarose-column chromatography. Biochem J. 1974;139:89-95.
21. Chang JY. Manual micro-sequence analysis of polypeptides using dimethylaminoazobenzene isothiocyanate. Methods Enzymol. 1983;91:455-466.
22. Van der Molen EF, van der Huevel LP, Pothoff MT, Monnens LA, Eskes TK, Blom HJ. The effect of folic acid on the homocysteine metabolism in human umbilical vein endothelial cells (HUVECs). Eur J Clin Invest. 1996;26:304-309.
23. Jakubowski H. Calcium-dependent human serum homocysteine thiolactone hydrolase: a protective mechanism against protein N-homocysteinylation. J Biol Chem. 2000;275:3957-3962.
24. Starkerbaum G, Harlan JM. Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine. J Clin Invest. 1986;77:1370-1376.
25. Wang H, Yoshizumi M, Lai K, Tsai JC, Perrella MA, Haber E, Lee ME. Inhibition of growth and p21ras methylation in vascular endothelial cells by homocysteine but not cysteine. J Biol Chem. 1997;272:25380-25385.
26. Hajjar KA. Homocysteine-induced modulation of tissue plasminogen activator binding to its endothelial cell membrane receptor. J Clin Invest. 1993;91:2873-2879.
27. Kokame K, Kato H, Miyata T. Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. J Biol Chem. 1996;271:29659-29665.
28. Harker LA, Ross R, Slichter SJ, Scott CR. Homocysteine-induced atherosclerosis: the role of endothelial cell injury and platelet response in its genesis. J Clin Invest. 1976;58:731-741.
29. Rodgers GM, Kane WH. Activation of endogenous factor V by a homocysteine-induced vascular endothelial cell activator. J Clin Invest. 1986;77:1909-1916.
30. Liu G, Nellaiappan K, Kagan HM. Irreversible inhibition of lysyl oxidase by homocysteine thiolactone and its selenium and oxygen analogues. J Biol Chem. 1997;272:32370-32377.
31. Ferguson E, Parthasarathy S, Joseph J, Kalyanaraman B. Generation and initial characterization of a novel polyclonal antibody directed against homocysteine thiolactone-modified low density lipoprotcin. J Lipid Res. 1998;39:925-933.