Protein export from the nucleus

Traffic

Volumn 2, Issue 10, 2001, Pages 684-689

  Ossareh Nazari, B ^a   Gwizdek, C ^a   Dargemont, C ^a  

^a INSTITUT JACQUES MONOD   (France)

Author keywords

Exportin; NES; Nuclear pore complex; Nuclear transport; Ran

Indexed keywords

CARRIER PROTEIN; CELL NUCLEUS RECEPTOR; EXPORTIN; GUANOSINE TRIPHOSPHATASE; NUCLEAR PORE PROTEIN; NUCLEAR PROTEIN; RAN PROTEIN; UNCLASSIFIED DRUG;

ADAPTATION; ANIMAL CELL; CELL FUNCTION; CELL NUCLEUS; CELL TRANSPORT; CONTROLLED STUDY; CYTOPLASM; EUKARYOTIC CELL; EVOLUTION; GENE EXPRESSION; GENE TARGETING; GENETICS; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTECTION; PROTEIN INTERACTION; PROTEIN TRANSPORT; REGULATORY MECHANISM; REVIEW; TRANSCRIPTION REGULATION;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CARRIER PROTEINS; CELL NUCLEUS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KARYOPHERINS; NUCLEAR PORE; PROTEIN TRANSPORT;

EID: 0034789829     PISSN: 13989219     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0854.2001.21002.x     Document Type: Review

References (71)

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2. Localization of nucleus-specific protein as shown by transplantation experiments in Amoebae proteus
3. Major nucleolar proteins shuttle between nucleus and cytoplasm
4. Nopp140 shuttles on tracks between nucleolus and cytoplasm
5. Nuclear export of proteins: The role of nuclear retention
6. Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm
7. The HIV-1 Rev trans-activator shuttles between the nucleus and the cytoplasm
8. Identification of a signal for rapid export of proteins from the nucleus
9. The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs
10. Regulation of nuclear localization: A key to a door
11. Identification of a novel nuclear pore-associated protein as a functional target of the HIV-1 Rev protein in yeast
12. A human nucleoporin-like protein that specifically interacts with HIV Rev
13. Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteins
14. Leptomycin B is an inhibitor of nuclear export: Inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA
15. Crm1 is an export receptor for leucine-rich nuclear export signals
16. Crm1 is responsible for intracellular transport mediated by the nuclear export signal
17. Evidence for a role of Crm1 in signal-mediated nuclear protein export
18. Higher order chromosome structure is affected by cold-sensitive mutations in a Schizosaccharomyces pombe gene Crm1+ which encodes a 115-kD protein preferentially localized in the nucleus and its periphery
19. Leptomycin B targets a regulatory cascade of Crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression
20. The human homologue of yeast Crm1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88
21. Exportin 1 (Crm1p) is an essential nuclear export factor
22. Crm1-mediated recycling of snurportin 1 to the cytoplasm
23. Cse1p is required for export of Srp1p/importin-alpha from the nucleus in Saccharomyces cerevisiae
24. Export of importin a from the nucleus is mediated by a specific nuclear transport factor
25. Cse1p is involved in export of yeast importin a from the nucleus
26. Exportin 4: A mediator of a novel nuclear export pathway in higher eukaryotes
27. The karyopherin Kap142p/Msn5p mediates nuclear import and nuclear export of different cargo proteins
28. The receptor Msn5 exports the phosphorylated transcription factor Pho4 out of the nucleus
29. Nuclear export of Far1p in response to pheromones requires the export receptor Msn5p/Ste21p
30. The nuclear exportin Msn5 is required for nuclear export of the Mig1 glucose repressor of Saccharomyces cerevisiae
31. Calreticulin is a receptor for nuclear export
32. The yeast RNA1 gene product necessary for RNA processing is located in the cytosol and apparently excluded from the nucleus
33. Molecular characterization of the SUMO-1 modification of RanGAP1 and its role in nuclear envelope association
34. SUMO-1 modification and its role in targeting the Ran GTPase-activating protein, RanGAP1, to the nuclear pore complex
35. Characterization of proteins that interact with the cell-cycle regulatory protein Ran/TC4
36. Nup358, a cytoplasmically exposed nucleoporin with peptide repeats, Ran-GTP binding sites, zinc fingers, a cyclophilin A homologous domain, and a leucine-rich region
37. A giant nucleopore protein that binds Ran/TC4
38. NTF2 mediates nuclear import of Ran
39. Nuclear import of Ran is mediated by the transport factor NTF2
40. Domains of Crm1 involved in the formation of the Crm1, RanGTP, and leucine-rich nuclear export sequences trimeric complex
41. A role for RanBP1 in the release of Crm1 from the nuclear pore complex in a terminal step of nuclear export
42. Receptor-mediated substrate translocation through the nuclear pore complex without nucleotide triphosphate hydrolysis
43. NXT1 is necessary for the terminal step of Crm1-mediated nuclear export
44. A member of the Ran-binding protein family, Yrb2p, is involved in nuclear protein export
45. Disruption of the YRB2 gene retards nuclear protein export, causing a profound mitotic delay, and can be rescued by overexpression of XPO1/Crm1
46. Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein export
47. Human RanBP3, a group of nuclear RanGTP binding proteins
48. Protein import into nuclei. Association and dissociation reactions involving transport substrate, transport factors, and nucleoporins
49. The nuclear pore complex: From molecular architecture to functional dynamics
50. The yeast nuclear pore complex: Composition, architecture, and transport mechanism
51. A nuclear pore complex protein that contains zinc finger motifs, binds DNA, and faces the nucleoplasm
52. The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complex
53. Nup153 is an M9-containing mobile nucleoporin with a novel Ran-binding domain
54. Nup50, a nucleoplasmically oriented nucleoporin with a role in nuclear protein export
55. The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear export
56. Mapping interactions between nuclear transport factors in living cells reveals pathways through the nuclear pore complex
57. Proteomic analysis of nucleoporin interacting proteins
58. The RNA export factor Gle1p is located on the cytoplasmic fibrils of the NPC and physically interacts with the FG-nucleoporin Rip1p, the DEAD-box protein Rat8p/Dbp5p and a new protein Ymr 255p
59. Putative reaction intermediates in Crm1-mediated nuclear protein export
60. Exploring nuclear pore complex structure and function in molecular detail
61. The essential yeast nucleoporin NUP159 is located on the cytoplasmic side of the nuclear pore complex and serves in karyopherin-mediated binding of transport substrate
62. RanGTP-regulated interactions of Crm1 with nucleoporins and a shuttling DEAD-box helicase
63. Kinetic analysis of translocation through nuclear pore complexes
64. Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export
65. RanGTP-binding protein NXT1 facilitates nuclear export of different classes of RNA in vitro
66. The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human
67. NXT1 (p15) is a crucial cellular cofactor in TAP-dependent export of intron-containing RNA in mammalian cells
68. Overexpression of TAP/p15 heterodimers bypasses nuclear retention and stimulates nuclear mRNA export
69. Two distinct classes of Ran-binding sites on the nucleoporin Nup-358
70. The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1
71. A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2