Improving axonal growth and functional recovery after experimental spinal cord injury by neutralizing myelin associated inhibitors

Brain Research Reviews

Volumn 36, Issue 2-3, 2001, Pages 204-212

  Fouad, Karim ^a,b   Dietz, Volker ^b   Schwab, Martin E ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b BALGRIST UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

Functional recovery; IN 1; Myelin; Plasticity; Regeneration; Spinal cord injury

Indexed keywords

MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY IN 1; MYELIN PROTEIN; PROTEIN ANTIBODY; PROTEIN NOGO A; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; CENTRAL NERVOUS SYSTEM; DISEASE COURSE; DISEASE MODEL; ELECTROPHYSIOLOGY; ENZYME INHIBITION; GROWTH INHIBITION; MOTOR DYSFUNCTION; NERVE CELL PLASTICITY; NERVE FIBER GROWTH; NERVE FIBER REGENERATION; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; REVIEW; SENSORY DYSFUNCTION; SPINAL CORD INJURY;

ANIMALS; ANTIBODIES, MONOCLONAL; DISEASE MODELS, ANIMAL; GROWTH CONES; HUMANS; MYELIN PROTEINS; NERVE REGENERATION; RATS; RECOVERY OF FUNCTION; SPINAL CORD; SPINAL CORD INJURIES;

EID: 0034750201     PISSN: 01650173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-0173(01)00096-0     Document Type: Review

References (100)

1. Motor recovery after serial spinal cord lesions of defined descending pathways in cats
2. NI-35/250/nogo-a: A neurite growth inhibitor restricting structural plasticity and regeneration of nerve fibers in the adult vertebrate CNS
3. Recovery of locomotion after chronic spinalization in the adult cat
4. Lack of evidence that myelin-associated glycoprotein is a major inhibitor of axonal regeneration in the CNS
5. Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection
6. A sensitive and reliable locomotor rating scale for open field testing in rats
7. Recovery from spinal cord injury mediated by antibodies to neurite growth inhibitors
8. Regeneration of lesioned corticospinal tract fibers in the adult rat induced by a recombinant, humanized IN-1 antibody fragment
9. How does the human brain deal with a spinal cord injury?
10. Recovery of locomotion after ventral and ventrolateral spinal lesions in the cat. I. Deficits and adaptive mechanisms
11. Application of neutralizing antibodies against NI-35/250 myelin-associated neurite growth inhibitory proteins to the adult rat cerebellum induces sprouting of uninjured purkinje cell axons
12. Expanding roles for the Schwann cell: Ensheathment, myelination, trophism and regeneration
13. Neuronal cyclic amp controls the developmental loss in ability of axons to regenerate
14. Central nervous system regeneration: Oligodendrocytes and myelin as non-permissive substrates for neurite growth
15. Antibody against myelin-associated inhibitor of neurite growth neutralizes nonpermissive substrate properties of CNS white matter
16. Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1
17. Spinal cord repair in adult paraplegic rats: Partial restoration of hind limb function
18. Axonal elongation into peripheral nervous system 'bridges' after central nervous system injury in adult rats
19. Locomotor capacity attributable to step training versus spontaneous recovery after spinalization in adult cats
20. Human neuronal control of automatic functional movements: Interaction between central programs and afferent input
21. Locomotor activity in spinal man
22. Locomotor capacity of spinal cord in paraplegic patients
23. Locomotor pattern in paraplegic patients: Training effects and recovery of spinal cord function
24. The syndromes of spinal cord dysfunction
25. Inhibition of neurite growth by the NG2 chondroitin sulfate proteoglycan
26. The Eph family in the patterning of neural development
27. Regeneration of brainstem-spinal axons after lesion and immunological disruption of myelin in adult rat
28. Spinal cord repair: From experimental models to human application
29. Treadmill training in incomplete spinal cord injured rats
30. Modification of group I field potentials in the intermediate nucleus of the cat spinal cord after chronic axotomy of an extensor nerve
31. Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration
32. Endogenous progenitors remyelinate demyelinated axons in the adult CNS
33. Fetal transplants rescue axial muscle representation in M1 cortex of neonatally transected rats that develop weight support
34. Different forms of impairment of the fore-hindlimb coordination after partial spinal lesions in cats
35. Cellular delivery of neurotrophin-3 promotes corticospinal axonal growth and partial functional recovery after spinal cord injury
36. From spinal shock to spasticity: Neuronal adaptations to a spinal cord injury
37. Spinal shock and injury: Experimental therapeutic approaches
38. Regenerating the damaged central nervous system
39. A therapeutic vaccine approach to stimulate axon regeneration in the adult mammalian spinal cord
40. Traumatic spinal cord injury produced by controlled contusion in mouse
41. Axonal regeneration and physiological activity following transection and immunological disruption of myelin within the hatchling chick spinal cord
42. Suppression of the onset of myelination extends the permissive period for the functional repair of embryonic spinal cord
43. BDNF and NT-4/5 prevent atrophy of rat rubrospinal neurons after cervical axotomy, stimulate GAP-43 and Talpha1-tubulin mRNA expression, and promote axonal regeneration
44. Myelin-associated glycoprotein inhibits neurite/axon growth and causes growth cone collapse
45. Repair of adult rat corticospinal tract by transplants of olfactory ensheathing cells
46. Schwann cells induce sprouting in motor and sensory axons in the adult rat spinal cord
47. Incomplete spinal cord injury: Neuronal mechanisms of motor recovery and hyperreflexia
48. Transplants of fibroblasts genetically modified to express BDNF promote regeneration of adult rat rubrospinal axons and recovery of forelimb function
49. Effects of training on the recovery of full-weight-bearing stepping in the adult spinal cat
50. Comparing deficits following excitotoxic and contusion injuries in the thoracic and lumbar spinal cord of the adult rat
51. Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth
52. Locomotor recovery in spinal cord injured rats treated with an antibody neutralizing the myelin associated neurite growth inhibitor Nogo-A
53. Validation of the weight-drop contusion model in rats: A comparative study of human spinal cord injury
54. The effects of unilateral pyramidal tract section on hindlimb motor performance in the rat
55. Efficient testing of motor function in spinal cord injured rats
56. Referred phantom sensations and cortical reorganization after spinal cord injury in humans
57. Assessment of behavioural recovery following spinal cord injury in rats
58. Complete locomotor recovery following corticospinal tract lesions: Measurement of ground reaction forces during overground locomotion in rats
59. A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration
60. Effects on movement of surgical incisions into the human spinal cord
61. Bovine CNS myelin contains neurite growth-inhibitory activity associated with chondroitin sulfate proteoglycans
62. Correlative analyses of lesion development and functional status after graded spinal cord contusive injuries in the rat
63. Field potentials mapping of neurons in the lumbar spinal cord activated following stimulation of the mesencephalic locomotor region
64. Emerging roles for semaphorins in neural regeneration
65. Use-dependent gain change in the reflex contribution to extensor activity in walking cats
66. Surface-stimulation technology for grasping and walking neuroprosthesis
67. Functional switch between motor tracts in the presence of the mAb IN-1 in the adult rat
68. Sprouting and regeneration after pyramidotomy and blockade of the myelin-associated neurite growth inhibitors NI 35/250 in adult rats
69. Functional regeneration of sensory axons into the adult spinal cord
70. Functional recovery of paraplegic rats and motor axon regeneration in their spinal cords by olfactory ensheathing glia
71. Fetal cell grafts into resection and contusion/compression injuries of the rat and cat spinal cord
72. Regeneration of long spinal axons in the rat
73. Spontaneous long-term remyelination after traumatic spinal cord injury in rats
74. Lesioned corticospinal tract axons regenerate in myelin-free rat spinal cord
75. Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion
76. Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitors
77. Sprouting and regeneration of lesioned corticospinal tract fibres in the adult rat spinal cord
78. Degeneration and regeneration of axons in the lesioned spinal cord
79. Oligodendrocytes and CNS myelin are nonpermissive substrates for neurite growth and fibroblast spreading in vitro
80. Dissociated neurons regenerate into sciatic but not optic nerve explants in culture irrespective of neurotrophic factors
81. High molecular weight protein of human central nervous system myelin inhibits neurite outgrowth: An effect which can be neutralized by the monoclonal antibody IN-1
82. Identification and characterization of a bovine neurite growth inhibitor (bNI-220)
83. Cues from developmental models of spinal cord regeneration for the repair of the injured adult CNS
84. Experimental strategies to promote axonal regeneration after traumatic central nervous system injury
85. Clearance of myelin constituents and axonal sprouting in the transected postcommissural fornix of the adult rat
86. La influencia del neurotropismo en la regeneracion de los centros nerviosos
87. Neurite growth inhibitors restrict plasticity and functional recovery following corticospinal tract lesions
88. Increased lesion-induced sprouting of corticospinal fibres in the myelin-free rat spinal cord
89. Injury pattern effect on motor recovery after traumatic spinal cord injury
90. Demyelination in spinal cord injury
91. Spontaneous corticospinal axonal plasticity and functional recovery after adult central nervous system injury
92. Laufband locomotion with body weight support improved walking in persons with severe spinal cord injuries
93. Laufband therapy based on 'rules of spinal locomotion' is effective in spinal cord injured persons
94. Paw and limb use in skilled and spontaneous reaching after pyramidal tract, red nucleus and combined lesions in the rat: Behavioral and anatomical dissociations
95. Proximal and distal impairments in rat forelimb use in reaching follow unilateral pyramidal tract lesions
96. Spinal cord contusion in the rat: Production of graded, reproducible, injury groups
97. Bridging Schwann cell transplants promote axonal regeneration from both the rostral and caudal stumps of transected adult rat spinal cord
98. Retrograde regulation of growth-associated gene expression in adult rat Purkinje cells by myelin-associated neurite growth inhibitory proteins
99. Compensatory sprouting and impulse rerouting after unilateral pyramidal tract lesion in neonatal rats
100. Functional recovery and enhanced corticofugal plasticity after unilateral pyramidal tract lesion and blockade of myelin-associated neurite growth inhibitors in adult rats