Interactions of phosphodiester and phosphorothioate oligonucleotides with intestinal epithelial Caco-2 cells

Pharmaceutical Research

Volumn 13, Issue 7, 1996, Pages 1028-1037

  Beck, G F ^a,c   Irwin, W J ^a   Nicklin, P L ^b   Akhtar, S ^a  

^a ASTON UNIVERSITY   (United Kingdom)

^b Ciba Pharmaceuticals   (United Kingdom)

^c ROCHE PRODUCTS LTD   (United Kingdom)

Author keywords

Antisense oligonucleotides; Caco 2 cells; Cell binding; Cellular uptake; Drug delivery; Intestinal cells

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CELL SURFACE PROTEIN; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE;

ARTICLE; BIOAVAILABILITY; CELL CULTURE; COLON ADENOCARCINOMA; CONTROLLED STUDY; ENDOCYTOSIS; HUMAN; HUMAN CELL; INTESTINE ABSORPTION; INTESTINE CELL; INTESTINE EPITHELIUM; MEMBRANE BINDING; PARTITION COEFFICIENT; PRIORITY JOURNAL;

AZIDES; CACO-2 CELLS; ENZYME INHIBITORS; EPITHELIAL CELLS; EPITHELIUM; HUMANS; HYDROGEN-ION CONCENTRATION; OLIGONUCLEOTIDES, ANTISENSE; PHOSPHORUS RADIOISOTOPES; PRONASE; PROTEIN BINDING; SODIUM AZIDE; SODIUM CHLORIDE; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE; TRITIUM;

EID: 0029781792     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016002606705     Document Type: Article

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