Pharmacokinetics and blood-brain barrier transport of [3H]-biotinylated phosphorothioate oligodeoxynucleotide conjugated to a vector-mediated drug delivery system

Journal of Pharmacology and Experimental Therapeutics

Volumn 276, Issue 1, 1996, Pages 206-211

  Wu, Dafang ^a   Boado, Ruben J ^a   Pardridge, William M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY OX26; PHOSPHOROTHIOIC ACID DERIVATIVE; STREPTAVIDIN; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTERY PERFUSION; ARTICLE; BLOOD BRAIN BARRIER; COMPLEX FORMATION; CONTROLLED STUDY; DRUG CLEARANCE; DRUG COMBINATION; DRUG COMPARISON; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG DEVELOPMENT; DRUG PROTEIN BINDING; DRUG SYNTHESIS; DRUG TRANSPORT; INTERNAL CAROTID ARTERY; INTRAVENOUS DRUG ADMINISTRATION; MALE; NEUROPHARMACOLOGY; NONHUMAN; PHARMACOKINETICS; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIBODIES, MONOCLONAL; BACTERIAL PROTEINS; BASE SEQUENCE; BIOLOGICAL TRANSPORT; BIOTIN; BLOOD PROTEINS; BLOOD-BRAIN BARRIER; CAROTID ARTERY, INTERNAL; DRUG DELIVERY SYSTEMS; IMMUNOCONJUGATES; MALE; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDES, ANTISENSE; PERFUSION; PROPIONATES; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; STREPTAVIDIN; THIONUCLEOTIDES; TRITIUM;

EID: 0029925704     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. AGRAWAL, S., TEMSAMANI, J. AND TANG, J. Y.: Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice. Proc. Natl. Acad. Sci. U.S.A. 88: 7596-7599, 1991.
2. BOADO, R. J., KANG, Y. S., WU, D. AND PARDRIDGE, W. M.: Rapid plasma clearance and metabolism in vivo at a phosphorothioate oligodeoxynucleotide with a single, internal phosphodiester bond. Drug Metab. Dispos. 23: 1297-1300, 1995
3. BOADO, R. J. AND PARDRIDGE, W. M.: Complete inactivation of target mRNA by biotinylated antisense oligodeoxynucleotide-avidin conjugates. Bioconj. Chem. 5: 406-410, 1994.
4. CHEM, T.-L., MILLER, P. S., TS'O, P. O. P. AND COLVIN, O. M.: Disposition and metabolism of oligodeoxynucleoside methylphosphonate following a single iv injection in mice. Drug Metab. Dispos. 18: 815-818, 1990.
5. 14C-labeled phosphorothioate oligonucleotide ISIS 2105 after intravenous administration to rats. J. Pharmacol. Exp. Ther. 267: 1181-1190, 1993.
6. CRABBE, J. C., BELKNAP, J. K. AND BUCK, K. J.: Genetic animal models of alcohol and drug abuse. Science 264: 1715-1723, 1994.
7. IRIE, S., KISHIMOTO, T. AND TAVASSOLI, M.: Desialation of transferrin by rat liver endothelium. J. Clin. Invest. 82: 508-513, 1988.
8. IVERSEN, P. L., MATA, J., TRACEWELL, W. G. AND ZON, G.: Pharmacokinetics of an antisense phosphorothioate oligodeoxynucleotide against rev from human immunodeficiency virus type 1 in the adult male rat following single injections and continuous infusion. Antisense Res. Dev. 4: 43-52, 1994.
9. JEFFERIES, W. A., BBANDON, M. R., HUNT, S. V., WILLIAMS, A. F., GATTER, K. C. AND MASON, D. Y.: Transferrin receptor on endothelium of brain capillaries. Nature 312: 162-163, 1984.
10. KANG, Y.-S. AND PARDRIDGE, W. M.: Use of neutral-avidin improves pharmacokinetics and brain delivery of biotin bound to an avidin-monoclonal antibody conjugate. J. Pharmacol. Exp. Ther. 269: 344-350, 1994a.
11. KANG, Y.-S. AND PARDRIDGE, W. M.: Brain delivery of biotin bound to a conjugate of neutral avidin and cationized human albumin. Pharm. Res. 11: 1257-1264, 1994b.
12. 32P] labeled phosphodiester oligodeoxynucleotide coupled to a neutral avidin/monoclonal antibody conjugate. Drug Metab. Dispos. 23: 55-59, 1995.
13. 3H] propionate: Use in detecting and analyzing monoclonal antibodies. Methods Enzymol. 121: 670-678, 1986.
14. 2-macroglobulin. J. Biol. Chem. 270: 8381-8384, 1995.
15. LISZIEWICZ, J., SUN, D., METELEV, V , ZAMECNIK, P , GALLO, R. C. AND AGRAWAL, S.: Long-term treatment of human immunodeficiency virus-infected cells with antisense oligonucleotide phosphorothioates. Proc. Natl. Acad. Sci. U.S.A. 90: 3860-3864, 1993.
16. MATSUKURA, M., MITSUYA, H AND BRODER, S.: A new concept in AIDS treatment: an antisense approach and its current status towards clinical application. In Prospects for Antisense Nucleic Acid Therapy of Cancer and AIDS, ed. by E. Wickstrom, pp. 159-178, Wiley-Liss, Inc., New York, 1991.
17. PARDRIDGE, W. M.: Peptide Drug Delivery to the Brain, pp. 1-357, Raven Press, New York, 1991.
18. PARDRIDGE, W. M., BOADO, R. J. AND KANG, Y.-S.: Vector-mediated delivery of a peptide nucleic acid through the blood-brain barrier in vivo. Proc. Natl. Acad. Sci. U.S.A. 92: 5592-5596, 1995.
19. PARDRIDGE, W. M., KANG, Y.-S AND BUCIAK, J. L.: Transport of human recombinant brain-derived neurotrophic factor (BDNF) through the rat blood-brain barrier in vivo using vector-mediated peptide drug delivery. Pharm. Res. 11: 738-746, 1994.
20. 3H-labeled oligonucleotides. I. Comparison of a phosphodiester and a phosphorothioate. Mol. Pharmacol. 45: 932-943, 1994.
21. STEIN, C. A. AND CHENG, Y -C.: Antisense oligonucleotides as therapeutic agents - Is the bullet really magical? Science 261: 1004-1012, 1993.
22. VLASSOV, V. V. AND YAKUBOV, L. A.: Oligonucleotides in cells and in organisms: pharmacological considerations. In Prospects for Antisense Nucleic Acid Therapy of Cancer and AIDS, ed. by E. Wickstrom, pp. 243-266, Wiley-Liss, Inc., New York, 1991.
23. WAHLESTEDT, C.: Antisense oligonucleotide strategies in neuropharmacology. Trends Pharmacol. Sci. 15: 42-46, 1994.
24. WHITESELL, L., GESELOWITZ, D., CHAVANY, C., FAHMY, B., WALBRIDGE, S., ALGER, J. R. AND NECKERS, L. M.: Stability, clearance, and disposition of intraventricularly administered oligodeoxynucleotides: Implications for therapeutic application within the central nervous system. Proc. Natl. Acad. Sci. U.S.A. 90: 4665-4669, 1993.
25. ZENDEGUI, J. G., VASQUEZ, K. M., TINSLEY, J. H., KESSLER, D. J. AND HOGAN, M. E.: In vivo stability and kinetics of absorption and disposition of 3′ phosphopropyl amine oligonucleotides. Nucleic Acids Res 20: 307-314, 1992.