Biodegradable polyalkylcyanoacrylate nanoparticles for the delivery of oligonucleotides

Journal of Controlled Release

Volumn 53, Issue 1-3, 1998, Pages 137-143

  Fattal, Elias ^a   Vauthier, Christine ^a   Aynie, Isabelle ^a   Nakada, Yuichiro ^a,b   Lambert, Gregory ^a   Malvy, Claude ^c   Couvreur, Patrick ^a  

^a UNIV PARIS SUD   (France)

^b KANEBO LTD   (Japan)

^c INSTITUT GUSTAVE ROUSSY   (France)

Author keywords

Adsorption; Intracellular delivery; Polyalkylcyanoacrylate nanoparticles; Tissue distribution

Indexed keywords

ACRYLIC ACID DERIVATIVE; ANTISENSE OLIGODEOXYNUCLEOTIDE; NANOPARTICLE; OLIGONUCLEOTIDE; POLYMER;

ADSORPTION; CONFERENCE PAPER; DRUG DELIVERY SYSTEM; DRUG STABILITY; HUMAN; HUMAN CELL; INTRAVENOUS DRUG ADMINISTRATION; LIVER DISEASE; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; TISSUE DISTRIBUTION;

ANIMALS; CELLS, CULTURED; CYANOACRYLATES; DRUG CARRIERS; HALF-LIFE; KIDNEY; LIVER; MALE; MICE; MICROSPHERES; PARTICLE SIZE; THIONUCLEOTIDES; TISSUE DISTRIBUTION;

EID: 0032580442     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(97)00246-0     Document Type: Conference Paper

References (14)

1. Hélène C., Toulmé J.J. Specific regulation of gene expression by antisense, sense and antigene nucleic acids. Biochem. Biophys. Acta. 1049:1990;99-125.
2. Zon G. Oligonucleotides as potential therapeutic agents. Pharm. Res. 5:1988;539-549.
3. Loke S.L., Stein C.A., Zhang X.H., Mori K., Nakanishi M., Subasinghe C., Cohen J.S., Necker L.M. Characterization of oligonucleotide transport into living cells. Proc. Natl. Acad. Sci. USA. 86:1989;3474-3478.
4. A Yakubov L., Deeva E.A., Zarytova V.F., Ivanova E.M., Ryte A.S., Yurchenko L.V., Vlassov V.V. Mechanism of oligonucleotide uptake by cells: Involvement of specific receptors. Proc. Natl. Acad. Sci. USA. 86:1989;6454-6458.
5. Stein C.A. Phosphorothioate antisense oligodeoxynucleotides: questions of specificity. Trends Biotechnol. 14:1996;147-149.
6. Mir L.M., Banou H., Paoletti C. Introduction of definitive amounts of non permeant molecules into living cells after electropermeabilization: direct access to the cytosol. Exp. Cell. Res. 175:1988;15-25.
7. Dash P., Lotan L., Knapp M., Kandel E.R., Goelet P. Selective elimination of mRNAs in vivo complementary oligonucleotide promote RNA degradation by an RnaseH like activity. Proc. Natl. Acad. Sci. USA. 84:1987;7896-7900.
8. Chavany C., Le Doan T., Couvreur P., Puisieux F., Hélène C. Polyalkylcyanoacrylate nanoparticles as polymeric carries for antisense oligonucleotides. Pharm. Res. 9:1992;441-449.
9. Chavany C., Saison-Behmoaras T., Le Doan T., Puisieux F., Couvreur P., Hélène C. Adsorption of oligonucleotides onto polyisohexylcyanoacrylate anoparticles protects them against nucleases and increases their cellular uptake. Pharm. Res. 11:1994;1370-1378.
10. Nakada Y., Fattal E., Foulquier M., Couvreur P. Pharmacokinetics and biodistribution of oligonucleotide adsorbed onto polyisobutylcyanoacrylate nanoparticles after intravenous administration. Pharm. Res. 13:1996;38-43.
11. Aynie I., Vauthier C., Foulquier M., Malvy C., Fattal E., Couvreur P. Development of a quantitative polyacrylamide gel electrophoresis analysis using a multichannel radioactivity counter for the evaluation of oligonucleotide-bound drug carrier. Anal. Biochem. 240:1996;202-209.
12. Schwab G., Chavany C., Duroux I., Goubin G., Lebeau J., Hélène C., Behmoaras T. Antisense oligonucleotides adsorbed to polyalkylcyanoacrylate nanoparticles specifically inhibit mutated Ha-ras-mediated cell proliferation and tumorigenicity in nude mice. Proc. Natl. Acad. Sci. USA. 91:1994;10460-10464.
13. P. Couvreur, M. Roland, P. Speiser, Process for preparing biodegradable submicroscopic particles containing a biologically active substance and their use, United States Patent (1984) n° 4 489 055.
14. G. Lambert, E. Fattal, J. Féger, P. Couvreur, personnal communication (1996).