Binding affinity of adenosine receptor agonists and antagonists at human cloned A3 adenosine receptors

Life Sciences

Volumn 63, Issue 5, 1998, Pages PL81-PL87

  Varani, K ^a   Cacciari, B ^a   Baraldi, P G ^a   Dionisotti, S ^b   Ongini, E ^b   Borea, P A ^a  

^a UNIVERSITY OF FERRARA   (Italy)

^b Schering Plough Research Institute   (Italy)

Author keywords

A(2A) adenosine receptor antagonists; Adenosine binding; Human A3 adenosine receptor

Indexed keywords

2 ANILINOADENOSINE; 2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 4 AMINO 8 CHLORO 1 PHENYL 1,2,4 TRIAZOLO[4,3 A]QUINOXALINE; 4 AMINOBENZYL 5' N METHYLCARBOXAMIDOADENOSINE; 4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; 5 AMINO 2 (2 FURYL) 7 (2 PHENYLETHYL)PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; 5 AMINO 2 (2 FURYL) 7 (3 PHENYLPROPYL)PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; 8 (3,4 DIMETHOXYSTYRYL) 7 METHYL 1,3 DIPROPYLXANTHINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; 9 CHLORO 2 (2 FURYL) 5,6 DIHYDRO 5 IMINO 1,2,4 TRIAZOLO[2,3 C]QUINAZOLINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A3 RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; ADENOSINE RECEPTOR STIMULATING AGENT; UNCLASSIFIED DRUG;

ARTICLE; BINDING KINETICS; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; MOLECULAR CLONING; RECEPTOR AFFINITY;

ANIMALIA; OVIS ARIES;

EID: 17644430943     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0024-3205(98)00289-6     Document Type: Article

References (20)

1. 1. B.B. FREDHOLM, M.P. ABBRACCHIO, G. BURNSTOK, J.W. DALY, T.K. HARDEN, K.A. JACOBSON, P. LEFF and M. WILLIAMS, Pharmacol. Rev. 46 143-156 (1994).
2. 2. J. LINDEN, TIPS 15, 298-306 (1994).
3. 3. S. DIONISOTTI, E. ONGINI, C. ZOCCHI, B. KULL, G. ARSLAN and B.B. FREDHOLM, Br. J. Pharmacol. 121, 353-360 (1997).
4. 4. C.A. SALVATORE, M.J. JACOBSON, H.E. TAYLOR, J. LINDEN and R.G. JOHNSON, Proc. Natl. Acad. Sci. 90 10365-10369 (1993).
5. 5. Y.C. KIM, X. JI and K.A. JACOBSON, J. Med. Chem. 39 4142-4148 (1996).
6. 6. G. CRISTALLI, A. ELEUTERI, S. VITTORI, R. VOLPINI, M.J. LOHSE and K.N. KLOTZ, J. Med. Chem. 35 2363-2368 (1992).
7. 7. J. SHIMADA, K. SUZUKI, H. NONAKA, A. ISHII and S. ICHIKAWA, J. Med. Chem. 35 2342-2345 (1992).
8. 8. F. GATTA, M.R. DEL GIUDICE, A. BORIONI, P.A. BOREA, S. DIONISOTTI and E. ONGINI, Eur. J. Med. Chem. 28 569-577 (1993).
9. 9. K.A. JACOBSON, C. GALLO-RODRIGUEZ, N. MELMAN, B. FISHER, M. MAILLARD, A. VAN BERGEN, P.J.M. VAN GALEN and Y. KARTON, J. Med. Chem. 36 1333-1342 (1993).
10. 10. P.G. BARALDI, B. CACCIARI, G. SPALLUTO, X. JI, M.E. OLAH, G. STILES, S. DIONISOTTI, C. ZOCCHI, E. ONGINI and K.A. JACOBSON, J. Med. Chem., 39, 802-806 (1996).
11. 11. S.M. POUCHER, J.R. KEDDIE, S.M. STOGGAL, P. SINGH, P.W.R. CAULKETT, G. JONES and M.G. COLLIS, Br. J. Pharmacol. 115, 1096-1102 (1995).
12. 12. Y.C. CHENG and W.H. PRUSOFF, Biochem. Pharmacol. 22 3099-3108 (1973).
13. 13. P.G. MUNSON and D. RODBARD, Anal. Biochem. 107 220-239 (1990).
14. 14. BRADFORD, M.M. Anal. Biochem. 72, 248 (1976).
15. 15. K.N. KLOTZ, J. HESSLING, J. HEGLER, C. OWMAN, B. KULL, B.B. FREDHOLM and M.J. LOHSE, Naunyn-Schmied. Arch. Pharmacol., 357, 1-9 (1998).
16. 16. P.J.M. VAN GALEN, A.H. VAN DER BERGEN, C. GALLO-RODRIGUEZ, N. MELMAN, M.E. OLAH, A.P. IJZERMAN, G.L. STILES and K.A. JACOBSON, Mol. Pharmacol. 45 1101-1111 (1994).
17. 17. J.A. AUCHAMPACH, A. RIZVI, Y. QIU, X.L. TANG, C. MALDONADO, S. TESCHNER and R. BOLLI, Circ. Res., 80, 800-809 (1997).
18. 18. T.V. DUNWIDDIE, L. DIAO, H.O. KIM, J. JIANG, K.A. JACOBSON, J. Neuroscience, 17, 607-614 (1997).
19. 19. S.M. SIDDIQI, K.A. JACOBSON, J.L. ESKER, M.E. OLAH, X. JI, N. MELMAN, K.N. TIWARI, J.A. SECRIST III, S.W. SCHNELLER, G. CRISTALLI, G.L. STILES, C.R. JOHNSON and A.P. IJZERMAN, J. Med. Chem. 38 1174-1188 (1995).
20. 20. C. ZOCCHI, E. ONGINI, A. CONTI, A. MONOPOLI, A. NEGRETTI, P.G. BARALDI and S. DIONISOTTI, J. Pharm. and Exper. Ther. 276, 398-404 (1996).