Pyrazolopyridine derivatives act as competitive antagonists of brain adenosine A1 receptors: [35S]GTPγS binding studies

European Journal of Pharmacology

Volumn 365, Issue 2-3, 1999, Pages 309-315

  Ito, Harunobu ^c   Maemoto, Takuya ^c   Akahane, Atsushi ^b   Butcher, Steven P ^c   Olverman, Henry J ^a   Finlayson, Keith ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b ASTELLAS PHARMA INC   (Japan)

^c NONE

Author keywords

35S GTP S binding; Adenosine A1 receptor; Cortex, rat; FK453; Schild analysis

Indexed keywords

1 [3 (2 PHENYLPYRAZOLO[1,5 A]PYRIDIN 3 YL)ACRYLOYL]PIPERIDINE 2 ACETIC ACID; 1,3 DIETHYL 8 PHENYLXANTHINE; 2 (2 HYDROXYETHYL) 1 [3 (2 PHENYLPYRAZOLO[1,5 A]PYRIDIN 3 YL)ACRYLOYL]PIPERIDINE; 2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 2 CHLORO 6 N CYCLOPENTYLADENOSINE; 2 CHLOROADENOSINE; 6 N CYCLOPENTYLADENOSINE; 6 OXO 3 (2 PHENYLPYRAZOLO[1,5 A]PYRIDIN 3 YL) 1(6H) PYRIDAZINEBUTYRIC ACID; 8 (1 PHENYLPROPYL) 1,3 DIPROPYLXANTHINE; 8 (2 NOR 1 ADAMANTYL) 1,3 DIPROPYLXANTHINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; 8 CYCLOPENTYLTHEOPHYLLINE; 8 PHENYLTHEOPHYLLINE; 9 CHLORO 2 (2 FURYL) 5,6 DIHYDRO 5 IMINO 1,2,4 TRIAZOLO[2,3 C]QUINAZOLINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A1 RECEPTOR; ADENOSINE DERIVATIVE; CYCLOHEXYLADENOSINE; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); KFM 19; PHENYLISOPROPYLADENOSINE; UNCLASSIFIED DRUG; XANTHINE DERIVATIVE;

ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; DRUG RECEPTOR BINDING; IN VITRO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ADENOSINE; ANIMALS; BINDING, COMPETITIVE; CEREBRAL CORTEX; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); MALE; PROTEIN BINDING; PYRAZOLES; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P1;

EID: 0032939907     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00882-6     Document Type: Article

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