4-Amino-6-benzylamino-1,2-dihydro-2-phenyl-1,2,4-triazolo[4,3- a]quinoxalin-1-one: A new A(2A) adenosine receptor antagonist with high selectivity versus A1 receptors

Archiv der Pharmazie

Volumn 332, Issue 2, 1999, Pages 39-41

  Colotta, Vittoria ^a   Catarzi, Daniela ^a   Varano, Flavia ^a   Cecchi, Lucia ^a   Filacchioni, Guido ^a   Martini, Claudia ^b   Trincavelli, Letizia ^b   Lucacchini, Antonio ^b  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF PISA   (Italy)

Author keywords

A(2A) antagonist; Triazolo 4,3 a quinoxalin 1 one

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 4 AMINO 6 BENZYLAMINO 1,2 DIHYDRO 2 PHENYL 1,2,4 TRIAZOLO[4,3 A] QUINOXALIN 1 ONE; ADENOSINE A1 RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; CYCLOHEXYLADENOSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; BINDING AFFINITY; CYCLIZATION; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; LETTER; NONHUMAN; PRIORITY JOURNAL; REDUCTION; STRUCTURE ACTIVITY RELATION;

EID: 0033034781     PISSN: 03656233     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1521-4184(19993)332:2<39::aid-ardp39>3.3.co;2-6     Document Type: Letter

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16. 6) δ: 6.72-6.82 (m, ar), 7.11-7.39 (m. ar), 7.66-7.70 (m, ar), 7.96-8.02 (m, ar + NH), 9.08 (br s, NH), 9.92 (br s, NH), 10.11 (br s, NH), 10.39 (br s, NH), 11.40 (br s, NH). equation presented
17. 2), 6.94 (t, 1H, ar, J = 7.2 Hz), 7.03 (d, 2H, ar, J = 7.7 Hz), 7.15 (d, 1H, H-9, J = 7.2 Hz), 7.28-7.41 (m, 3H, ar), 7.75 (d, 1H, H-7, J = 7.3 Hz), 10.62 (br s, 1H, NH).
18. -1): 3320, 1730, 1710.
19. 2), 6.71 (d, 1H, ar, J = 8.1 Hz), 7.02 (t, 1H, ar, 7 = 8.1 Hz), 7.37 (t, 1H, ar, J = 7.0 Hz), 7.57 (t, 2H, ar, J = 7.3 Hz), 7.95-8.04 (m, 3H, ar), 11.04 (s, 1H, NH).
20. 6) δ: 7.36-7.63 (m, 8H, ar), 8.02 (d, 2H, ar, J = 7.7 Hz), 8.24-8.28 (m, 2H, ar), 8.58 (d, 1H, ar, J = 7.9 Hz). 8.87 (s, 1H, CH), 11.22 (br s, 1H, NH).
21. -1) : 3440, 3200, 1730, 1680.
22. -1 ): 3460, 3400, 3360, 1715.
23. -1): 3480, 3320, 3280-3060, 1720, 1660.
24. -1): 3460, 3340, 1720, 1640.
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