Aminoglycoside binding in the major groove of duplex RNA: The thermodynamic and electrostatic forces that govern recognition

Journal of Molecular Biology

Volumn 298, Issue 1, 2000, Pages 95-110

  Jin, Emily ^a   Katritch, Vsevolod ^b   Olson, Wilma K ^b,c   Kharatisvili, Malkhaz ^b   Abagyan, Ruben ^d   Pilch, Daniel S ^a,c  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

^d NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aminoglycoside RNA recognition; Binding induced drug protonation; Drug induced alteration in RNA structure; Isothermal titration calorimetry; RNA bending and hydration

Indexed keywords

AMINOGLYCOSIDE; RNA; SODIUM; TOBRAMYCIN;

ARTICLE; BASE PAIRING; BINDING AFFINITY; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA BINDING; ELECTRICITY; ENTHALPY; HUMAN; HYDROGEN BOND; PH; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTON TRANSPORT; RNA SEQUENCE; RNA STRUCTURE; THERMODYNAMICS;

EID: 0034696752     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.3639     Document Type: Article

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