Structure-based discovery of ligands targeted to the RNA double helix

Biochemistry

Volumn 36, Issue 38, 1997, Pages 11402-11407

  Chen, Qi ^a   Shafer, Richard H ^a   Kuntz, Irwin D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; DNA B; DOUBLE STRANDED RNA; LIGAND; LIVIDOMYCIN;

ARTICLE; MOLECULAR RECOGNITION; MOLECULAR STABILITY; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; RNA CONFORMATION; RNA DEGRADATION;

AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; CIRCULAR DICHROISM; COMPUTER SIMULATION; KANAMYCIN; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; NEOMYCIN; NUCLEIC ACID CONFORMATION; NUCLEIC ACID DENATURATION; PAROMOMYCIN; POLY A-U; RNA, DOUBLE-STRANDED; SOFTWARE; TITRIMETRY;

EID: 0030954877     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi970756j     Document Type: Article

References (23)

1. Wilson, W. D., Ratmeyer, L., Zhao, M., Strekowski, L., and Boykin, D. (1993) Biochemistry 32, 4098-4104.
2. McConnaughie, A. W., Spychala, J., Zhao, M., Boykin, D., and Wilson, W. D. (1994) J. Med. Chem. 37, 1063-1069.
3. Kuntz, I. D., Meng, E. C., and Shoichet, B. K. (1994) Acc. Chem. Res. 27, 117-123.
4. Fasman, G. D. (1975) Handbook of Biochemistry and Molecular Biology, Vol. I, 3rd ed., CRC Press, Cleveland.
5. Ivanov, V. I., and Krylov, D. Y. (1992) Methods Enzymol. 211, 111-127.
6. Gschwend, D. A., and Kuntz, I. D. (1996) J. Compt.-Aided Mol. Des. 10, 123-132.
7. Kuntz, I. D., Blaney, J. M., Oatley, S. J., Langridge, R., and Ferrin, T. E. (1982) J. Mol. Biol. 161, 269-288.
8. Meng, E. C., Shoichet, B. K., and Kuntz, I. D. (1992) J. Comput. Chem. 13, 505-524.
9. Ferrin, T. E., Huang, C. C., and Javis, L. E. (1988) J. Mol. Graphics 6, 13-27.
10. Schindelin, H., Zhang, M., Bald, R., Furste, J. P., Erdmann, V. A., and Heinemann, U. (1995) J. Mol. Biol. 249, 595-603.
11. Shoichet, B. K., and Kuntz, I. D. (1993) Protein Eng. 6, 723-732.
12. Heinemann, U., Alings, C., and Bansal, M. (1992) EMBO J. 11, 1931-1939.
13. DesJarlais, R. L., and Dixon, J. S. (1994) J. Comput.-Aided Mol. Des. 8, 231-242.
14. Minyat, E. E., Ivanov, V. I., Kritzyn, A. M., Minchenkova, L. E., and Schyolkina, A. K. (1979) J. Mol. Biol. 128, 397-409.
15. Rastinejad, F., Evilia, C., and Lu, P. (1995) Methods Enzymol. 261, 560-575.
16. Metzler, W. J., and Lu, P. (1989) J. Mol. Biol. 205, 149-164.
17. Sahasrabudhe, P. V., Pon, R. T., and Gmeiner, W. H. (1996) Biochemistry 35, 13597-13608.
18. Cundliffe, E. (1989) Annu. Rev. Microbiol. 43, 207-233.
19. Sage, T. K., Hertel, K. J., and Uhlenbeck, O. C. (1995) RNA 1, 95-101.
20. Zapp, M. L., Stern, S., and Green, M. R. (1993) Cell 74, 969-978.
21. Fourmy, D., Recht, M. I., Blanchard, S. C., and Puglisi, J. D. (1996) Science 274, 1367-371.
22. Robinson, H., and Wang, A. H. (1996) Nucleic Acids Res. 24, 676-682.
23. Chen, Q., Kuntz, I. D., and Shafer, R. H. (1996) Proc. Natl. Acad. Sci. U.S.A. 93, 2635-2639.