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Volumn 7, Issue 9, 1999, Pages 1979-1991

tRNA(Phe) binds aminoglycoside antibiotics

Author keywords

Aminoglycoside antibiotics; RNA recognition; Small molecules; tRNA

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; FRAMYCETIN; KANAMYCIN A; LEAD; NEOMYCIN; PHENYLALANINE TRANSFER RNA; SPERMINE;

EID: 0032860283     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00170-4     Document Type: Article
Times cited : (67)

References (71)
  • 7
    • 0002957724 scopus 로고
    • Gesteland, R. F., Atkins, J. F., Eds.; Cold Springs Harbor Laboratory: New York
    • Davies, J.; von Ahsen, U.; Schroeder, R. In The RNA World; Gesteland, R. F., Atkins, J. F., Eds.; Cold Springs Harbor Laboratory: New York, 1993; pp 185-204.
    • (1993) In the RNA World; , pp. 185-204
    • Davies, J.1    Von Ahsen, U.2    Schroeder, R.3
  • 40
    • 0345231281 scopus 로고    scopus 로고
    • Denaturation studies in the presence of Neo-Neo (10 μM) are not shown because irregular melting curves were obtained, most likely due to aggregation
    • Denaturation studies in the presence of Neo-Neo (10 μM) are not shown because irregular melting curves were obtained, most likely due to aggregation.
  • 41
    • 0345231280 scopus 로고    scopus 로고
    • Phe (0.2 μM) could only be preformed at low concentration (<10 μM). At higher Neo-Neo concentrations, aggregates are formed
    • Phe (0.2 μM) could only be preformed at low concentration (<10 μM). At higher Neo-Neo concentrations, aggregates are formed.
  • 51
    • 0344800355 scopus 로고    scopus 로고
    • Preliminary CD studies suggest a conformational change upon addition of aminoglycosides
    • Preliminary CD studies suggest a conformational change upon addition of aminoglycosides.
  • 61
    • 0345663339 scopus 로고    scopus 로고
    • 65
    • 65.
  • 62
    • 0345663338 scopus 로고    scopus 로고
    • Aminoglycoside-induced cleavage occurs under a variety of conditions. It is therefore unlikely that it is induced by RNases, although enhanced susceptibility of tRNA to trace RNases cannot be excluded
    • Aminoglycoside-induced cleavage occurs under a variety of conditions. It is therefore unlikely that it is induced by RNases, although enhanced susceptibility of tRNA to trace RNases cannot be excluded.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.