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Denaturation studies in the presence of Neo-Neo (10 μM) are not shown because irregular melting curves were obtained, most likely due to aggregation
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Phe (0.2 μM) could only be preformed at low concentration (<10 μM). At higher Neo-Neo concentrations, aggregates are formed
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Preliminary CD studies suggest a conformational change upon addition of aminoglycosides
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Preliminary CD studies suggest a conformational change upon addition of aminoglycosides.
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Aminoglycoside-induced cleavage occurs under a variety of conditions. It is therefore unlikely that it is induced by RNases, although enhanced susceptibility of tRNA to trace RNases cannot be excluded
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Aminoglycoside-induced cleavage occurs under a variety of conditions. It is therefore unlikely that it is induced by RNases, although enhanced susceptibility of tRNA to trace RNases cannot be excluded.
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