메뉴 건너뛰기




Volumn 178, Issue , 2000, Pages 148-165

Lessons from the bare lymphocyte syndrome: Molecular mechanisms regulating MHC class II expression

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOMODULATING AGENT; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; REGULATOR PROTEIN; TRANSACTIVATOR PROTEIN;

EID: 0034511922     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-065X.2000.17813.x     Document Type: Review
Times cited : (73)

References (174)
  • 5
    • 0000014141 scopus 로고
    • Combined immunodeficiency with defective expression in MHC class II genes
    • Rosen FS, Seligman M, eds. Immunodeficiencies. Chur, Switzerland: Harwood Academic Publishers
    • (1993) , pp. 141-154
    • Griscelli, C.1    Lisowska-Grospierre, B.2    Mach, B.3
  • 15
    • 0025875025 scopus 로고
    • Sequences homologous to class II MHC W, X, and Y elements mediate constitutive and IFN-γ-induced expression of human class II-associated invariant chain gene
    • (1991) J Immunol , vol.146 , pp. 3183-3189
    • Brown, A.M.1    Barr, C.L.2    Ting, J.P.3
  • 16
    • 0027442671 scopus 로고
    • Human major histocompatibility complex class II-associated invariant chain gene promoter. Functional analysis and in vivo protein/DNA interactions of constitutive and IFN-γ-induced expression
    • (1993) J Biol Chem , vol.268 , pp. 26328-26333
    • Brown, A.M.1    Wright, K.L.2    Ting, J.P.3
  • 19
    • 0030028779 scopus 로고    scopus 로고
    • Invariant chain structure and MHC class II function
    • (1996) Cell , vol.84 , pp. 505-507
    • Cresswell, P.1
  • 20
    • 0030982711 scopus 로고    scopus 로고
    • Induction of MHC class I expression by the MHC class II transactivator CIITA
    • (1997) Immunity , vol.6 , pp. 591-600
    • Martin, B.K.1
  • 26
    • 0024290444 scopus 로고
    • Congenital immunodeficiency with a regulatory defect in MHC class II gene expression lacks a specific HLA-DR promoter binding protein, RF-X
    • (1988) Cell , vol.53 , pp. 897-906
    • Reith, W.1
  • 27
    • 0031055891 scopus 로고    scopus 로고
    • RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency
    • (1997) EMBO J , vol.16 , pp. 1045-1055
    • Durand, B.1
  • 28
    • 11944266638 scopus 로고
    • A novel DNA binding regulatory factor is mutated in primary MHC class II deficiency (bare lymphocyte syndrome)
    • (1995) Genes Dev , vol.9 , pp. 1021-1032
    • Steimle, V.1
  • 29
    • 0004419978 scopus 로고    scopus 로고
    • A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients
    • (1998) Nat Genet , vol.20 , pp. 273-277
    • Masternak, K.1
  • 31
  • 35
    • 0002637945 scopus 로고
    • Clinical and immunological studies in a patient with the "bare lymphocyte" syndrome
    • Touraine JL, Gluckman E, Griscelli C, eds. Bone marrow transplantation in Europe. Amsterdam: Excerpta Medica
    • (1981) , pp. 201-208
    • Kuis, W.1
  • 36
    • 0002629328 scopus 로고
    • Defective expression of HLA-D-region determinants in children with congenital agammaglobulinemia and malabsorption: A new syndrome
    • Albert ED, Baur MP, Mayr WR, eds. Histocompatibility testing 1984. Berlin Heidelberg: Springer-Verlag
    • (1984) , pp. 645-650
    • Hadam, M.R.1
  • 44
    • 0030064029 scopus 로고    scopus 로고
    • Human T cell repertoire generation in the absence of MHC class II expression results in a circulating CD4+CD8-population with altered physicochemical properties of complementarity-determining region 3
    • (1996) J Immunol , vol.156 , pp. 895-906
    • Henwood, J.1
  • 48
    • 0027131208 scopus 로고
    • CLass II MHC transcriptional mutants are defective in higher order complex formation
    • (1993) J Immunol , vol.151 , pp. 6942-6953
    • Riley, J.L.1    Boss, J.M.2
  • 49
    • 0024366508 scopus 로고
    • Congenital immunodeficiencies associated with absence of HLA class II antigens on lymphocytes result from distinct mutations in trans-acting factors
    • (1989) Hum Immunol , vol.26 , pp. 288-309
    • Hume, C.R.1    Lee, J.S.2
  • 50
    • 0025762568 scopus 로고
    • Class II-antigen-negative patient and mutant B-cell lines represent at least three, and probably four, distinct genetic defects defined by complementation analysis
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 4285-4288
    • Benichou, B.1    Strominger, J.L.2
  • 52
    • 0020524109 scopus 로고
    • Human B cell variants immunoselected against a single Ia antigen subset have lost expression in several Ia antigen subsets
    • (1983) J Exp Med , vol.157 , pp. 1053-1058
    • Accolla, R.S.1
  • 54
    • 0032715354 scopus 로고    scopus 로고
    • Analysis of the defect in IFN-γ induction of MHC class II genes in G1B cells: Identification of a novel and functionally critical leucine-rich motif (62-LYLYLQL-68) in the regulatory factor X 5 transcription factor
    • (1999) J Immunol , vol.163 , pp. 6622-6630
    • Brickey, W.J.1    Wright, K.L.2    Zhu, X.S.3    Ting, J.P.4
  • 58
    • 0030862342 scopus 로고    scopus 로고
    • Analysis of mutations and chromosomal localisation of the gene encoding RFX5, a novel transcription factor affected in major histocompatibility complex class II deficiency
    • (1997) Hum Mutat , vol.10 , pp. 430-435
    • Villard, J.1
  • 61
    • 0033565743 scopus 로고    scopus 로고
    • Discoordinate expression of invariant chain and MHC class II genes in class II transactivator-transfected fibroblasts defective for RFX5
    • (1999) J Immunol , vol.163 , pp. 794-801
    • Peijnenburg, A.1
  • 63
    • 7144261730 scopus 로고    scopus 로고
    • Genetic and molecular definition of complementation group D in MHC class II deficiency
    • (1998) Hum Mol Genet , vol.7 , pp. 879-885
    • Fondaneche, M.C.1
  • 64
    • 0034072751 scopus 로고    scopus 로고
    • Founder effect for a 26-bp deletion in the RFXANK gene in North African major histocompatibility complex class II-deficient patients belonging to complementation group B
    • (2000) Immunogenetics , vol.51 , pp. 261-267
    • Wiszniewski, W.1
  • 67
    • 0025883415 scopus 로고
    • Human chromosome 16 encodes a factor involved in induction of class II major histocompatibility antigens by interferon γ
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 6077-6081
    • Bono, M.R.1
  • 68
    • 0028924986 scopus 로고
    • Class II transactivator regulates the expression of multiple genes involved in antigen presentation
    • (1995) J Exp Med , vol.181 , pp. 765-767
    • Chang, C.H.1    Flavell, R.A.2
  • 70
    • 0034016674 scopus 로고    scopus 로고
    • Defective MHC class II expression m an MHC class II deficiency patient is caused by a novel deletion of a splice donor site in the MHC class II transactivator gene
    • (2000) Immunogenetics , vol.51 , pp. 42-49
    • Peijnenburg, A.1
  • 73
    • 0034096381 scopus 로고    scopus 로고
    • A functionally essential domain of RFX5 mediates activation of MHC class II promoters by promoting cooperative binding between RFX and NF-Y
    • (2000) Mol Cell Biol , vol.20 , pp. 3364-3376
    • Villard, J.1
  • 74
    • 0034703272 scopus 로고    scopus 로고
    • Dissection of functional NF-4-RFX cooperative interactions on the MHC class II Ea promoter
    • (2000) J Mol Biol , vol.302 , pp. 539-552
    • Caretti, G.1
  • 75
    • 0033119624 scopus 로고    scopus 로고
    • Orientation and positional mapping of the subunits of the multicomponent transcription factors RFX and X2BP to the major histocompatibility complex class II transcriptional enhancer
    • (1999) Nucleic Acids Res , vol.27 , pp. 1635-1641
    • Westerheide, S.D.1    Boss, J.M.2
  • 78
    • 0040187734 scopus 로고    scopus 로고
    • The fungal CPCR1 protein, which binds specifically to β-lactam biosynthesis genes, is related to human regulatory factor X transcription factors
    • (2000) J Biol Chem , vol.275 , pp. 9348-9357
    • Schmitt, E.K.1    Kuck, U.2
  • 79
    • 0034708205 scopus 로고    scopus 로고
    • Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding
    • (2000) Nature , vol.403 , pp. 916-921
    • Gajiwala, K.S.1
  • 82
    • 0025870067 scopus 로고
    • In vivo footprinting of MHC class II genes: Bare promoters in the bare lymphocyte syndrome
    • (1991) Science , vol.252 , pp. 709-712
    • Kara, C.J.1    Glimcher, L.H.2
  • 84
    • 0024528896 scopus 로고
    • Inherited immunodeficiency with a defect in a major histocompatibility complex class II promoter-binding protein differs in the chromatin structure of the HLA-DRA gene
    • (1989) Mol Cell Biol , vol.9 , pp. 296-302
    • Gönczy, P.1
  • 85
    • 0032851812 scopus 로고    scopus 로고
    • The molecular biology of the CCAAT-binding factor NF-Y
    • (1999) Gene , vol.239 , pp. 15-27
    • Mantovani, R.1
  • 86
    • 0028804166 scopus 로고
    • Purified X2 binding protein (X2BP) cooperatively binds the class II MHC X box region in the presence of purified RFX, the X box factor deficient in the bare lymphocyte syndrome
    • (1995) J Immunol , vol.155 , pp. 4313-4321
    • Moreno, C.S.1
  • 89
    • 0031572574 scopus 로고    scopus 로고
    • Formation of a regulatory factor X/X2 box-binding protein/nuclear factor-Y multiprotein complex on the conserved regulatory regions of HLA class II genes
    • (1997) J Immunol , vol.159 , pp. 3899-3909
    • Louis-Plence, P.1    Moreno, C.S.2    Boss, J.M.3
  • 90
    • 0028101265 scopus 로고
    • CCAAT box binding protein NF-Y facilitates in vivo recruitment of upstream DNA binding transcription factors
    • (1994) EMBO J , vol.13 , pp. 4042-4053
    • Wright, K.L.1
  • 94
    • 0027057979 scopus 로고
    • Structural constraints within a trimeric transcriptional regulatory region: Constitutive and interferon-γ inducible expression of the HLA-DRA gene
    • (1992) J Biol Chem , vol.267 , pp. 23728-23734
    • Vilen, B.J.1    Penta, J.F.2    Ting, J.P.-Y.3
  • 96
    • 0030856452 scopus 로고    scopus 로고
    • Efficient repression of endogenous major histocompatibility complex class II expression through dominant negative CIITA mutants isolated by a functional selection strategy
    • (1997) Mol Cell Biol , vol.17 , pp. 4249-4258
    • Bontron, S.1    Ucla, C.2    Mach, B.3    Steimle, V.4
  • 98
    • 0031571793 scopus 로고    scopus 로고
    • Activation and transdominant suppression of MHC class II and HLA-DMB promoters by a series of C-terminal class II transactivator deletion mutants
    • (1997) J Immunol , vol.159 , pp. 2789-2794
    • Chin, K.C.1    Li, G.2    Ting, J.P.3
  • 99
    • 0030951017 scopus 로고    scopus 로고
    • Importance of acidic, proline/serine/threonine-rich, and GTP-binding regions in the major histocompatibility complex class II transactivator: Generation of transdominant-negative mutants
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 2501-2506
    • Chin, K.C.1    Li, G.G.2    Ting, J.P.3
  • 101
    • 0029075521 scopus 로고
    • Human MHC class II gene transcription directed by the carboxyl terminus of CIITA, one of the defective genes in type II MHC combined immune deficiency
    • (1995) Immunity , vol.2 , pp. 545-553
    • Zhou, H.1    Glimcher, L.H.2
  • 103
    • 0033591330 scopus 로고    scopus 로고
    • Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-κB
    • (1999) J Biol Chem , vol.274 , pp. 14560-14567
    • Inohara, N.1
  • 104
    • 0032528308 scopus 로고    scopus 로고
    • Suppression of human anti-porcine T-cell immune responses by major histocompatibility complex class II transactivator constructs lacking the amino terminal domain
    • (1998) Transplantation , vol.66 , pp. 103-111
    • Yun, S.1    Gustafsson, K.2    Fabre, J.W.3
  • 111
    • 0032568658 scopus 로고    scopus 로고
    • CIITA stimulation of transcription factor binding to major histocompatibility complex class II and associated promoters in vivo
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 6267-6272
    • Wright, K.L.1
  • 118
    • 0032528424 scopus 로고    scopus 로고
    • HLA class II expression in uninducible hepatocarcinoma cells after transfection of AIR-1 gene product CIITA: Acquisition of antigen processing and presentation capacity
    • (1998) J Immunol , vol.161 , pp. 814-820
    • Sartoris, S.1
  • 125
    • 0032908350 scopus 로고    scopus 로고
    • Two distinct y interferon-inducible promoters of the major histocompatibility complex class II transactivator gene are differentially regulated by STAT1, interferon regulatory factor 1, and transforming growth factor β
    • (1999) Mol Cell Biol , vol.19 , pp. 431-440
    • Piskurich, J.F.1    Linhoff, M.W.2    Wang, Y.3    Ting, J.P.4
  • 127
    • 0030586657 scopus 로고    scopus 로고
    • Stat1 α expression is involved in IFN-γ induction of the class II transactivator and class II MHC genes
    • (1996) J Immunol , vol.157 , pp. 1559-1568
    • Lee, Y.J.1    Benveniste, E.N.2
  • 132
    • 0031093495 scopus 로고    scopus 로고
    • TGF-β suppresses IFN-γ induction of class II MHC gene expression by inhibiting class II transactivator messenger RNA expression
    • (1997) J Immunol , vol.158 , pp. 2065-2075
    • Lee, Y.J.1
  • 133
    • 0031065145 scopus 로고    scopus 로고
    • TGF-β attenuates the class II transactivator and reveals an accessory pathway of IFN-γ action
    • (1997) J Immunol , vol.158 , pp. 1095-1101
    • Nandan, D.1    Reiner, N.E.2
  • 134
    • 0032473555 scopus 로고    scopus 로고
    • Human cytornegalovirus inhibits major histocompatibility complex class II expression by disruption of the Jak/Stat pathway
    • (1998) J Exp Med , vol.187 , pp. 675-683
    • Miller, D.M.1
  • 138
    • 0033591635 scopus 로고    scopus 로고
    • Chlamydia inhibits interferon γ-inducible major histocompatibility complex class II expression by degradation of upstream stimulatory factor 1
    • (1999) J Exp Med , vol.189 , pp. 1931-1938
    • Zhong, G.1    Fan, T.2    Liu, L.3
  • 140
    • 0028842529 scopus 로고
    • Interferon (IFN) β acts downstream of IFN-γ-induced class II transactivator messenger RNA accumulation to block major histocompatibility complex class II gene expression and requires the 48-kD DNA-binding protein, ISGF3-γ
    • (1995) J Exp Med , vol.182 , pp. 1517-1525
    • Lu, H.T.1
  • 142
  • 145
  • 146
    • 0033998024 scopus 로고    scopus 로고
    • Dendritic cells and differential usage of the MHC class II transactivator promoters in the central nervous system in experimental autoimmune encephalitis
    • (2000) Eur J Immunol , vol.30 , pp. 794-802
    • Suter, T.1
  • 148
    • 0031054681 scopus 로고    scopus 로고
    • Isolation of a B-cell-specific promoter for the human class II transactivator
    • (1997) Immunogenetics , vol.45 , pp. 266-273
    • Lennon, A.M.1
  • 152
    • 0033945777 scopus 로고    scopus 로고
    • Down-regulation of interferon-γ signaling by gene transfer of Stat1 mutant in mesangial cells
    • (2000) Kidney Int , vol.57 , pp. 455-463
    • Sakatsume, M.1
  • 153
    • 0029671440 scopus 로고    scopus 로고
    • The chicken β2-microglobulin gene is located on a non-major histocompatibility complex microchromosome: A small, G+C-rich gene with X and Y boxes in the promoter
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 1243-1248
    • Riegert, P.1
  • 155
    • 0034659727 scopus 로고    scopus 로고
    • Synergistic induction of HLA class I expression by RelA and CIITA
    • (2000) Blood , vol.95 , pp. 3804-3808
    • Girdlestone, J.1
  • 159
    • 0033198138 scopus 로고    scopus 로고
    • Reduced IL-4-, lipopolysaccharide-, and IFN-γ-induced MHC class II expression in mice lacking class II transactivator due to targeted deletion of the GTP-binding domain
    • (1999) J Immunol , vol.163 , pp. 2425-2431
    • Itoh-Lindstrom, Y.1
  • 160
    • 0032006980 scopus 로고    scopus 로고
    • Residual MHC class II expression on mature dendritic cells and activated B cells in RFX5-deficient mice
    • (1998) Immunity , vol.8 , pp. 143-155
    • Clausen, B.E.1
  • 161
    • 0021815368 scopus 로고
    • The thymus in "bare lymphocyte" syndrome: Significance of expression of major histocompatibility complex antigens on thymic epithelial cells in intrathymic T-cell maturation
    • (1985) Hum Immunol , vol.13 , pp. 69-82
    • Schuurman, H.J.1
  • 165
    • 0028938632 scopus 로고
    • Bone marrow transplantation in major histocompatibility complex class II deficiency: A single-center study of 19 patients
    • (1995) Blood , vol.85 , pp. 580-587
    • Klein, C.1
  • 166
    • 0032789704 scopus 로고    scopus 로고
    • Successful related umbilical cord blood transplantation for graft failure following T cell-depleted non-identical bone marrow transplantation in a child with major histocompatibility complex class II deficiency
    • (1999) Bone Marrow Transplant , vol.24 , pp. 437-440
    • Bonduel, M.1
  • 172
    • 0029664652 scopus 로고    scopus 로고
    • Interferon gamma (IFNγ) gene transfer of an EMT6 tumor that is poorly responsive to IFNγ stimulation: Increase in tumor immunogenicity is accompanied by induction of a mouse class II transactivator and class II MHC
    • (1996) Cancer Immunol Immunother , vol.42 , pp. 99-107
    • Panelli, M.C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.