Residual MHC class II expression on mature dendritic cells and activated B cells in RFX5-deficient mice

Immunity

Volumn 8, Issue 2, 1998, Pages 143-155

  Clausen, Björn E ^a   Waldburger, Jean Marc ^b   Schwenk, Frieder ^a   Barras, Emmanuèle ^b   Mach, Bernard ^b   Rajewsky, Klaus ^a   Förster, Irmgard ^a   Reith, Walter ^b  

^a UNIVERSITY OF COLOGNE   (Germany)

^b UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE ACTIVATION; CONTROLLED STUDY; DENDRITIC CELL; GENE MUTATION; GENE TARGETING; GENETIC HETEROGENEITY; MACROPHAGE ACTIVATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL;

EID: 0032006980     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80467-7     Document Type: Article

References (62)

1. Benichou, B., and Strominger, J.L. (1991). Class II-antigen-negative patient and mutant B-cell lines represent at least three, and probably four, distinct genetic defects defined by complementation analysis. Proc. Natl. Acad. Sci. USA 88, 4285-4288.
2. Benoist, C., and Mathis, D. (1989). Positive selection of the T cell repertoire: where and when does it occur? Cell 58, 1027-1033.
3. Benoist, C., and Mathis, D. (1990). Regulation of major histocompatibility complex class-II genes: X, Y and other letters of the alphabet. Annu. Rev. Immunol. 8, 681-715.
4. Bhattacharya, A., Dorf, M.E., and Springer, T.A. (1981). A shared alloantigenic determinant on Ia antigens encoded by the I-A and I-E subregions: evidence for I region gene duplication. J. Immunol. 127, 2488-2495.
5. Boehm, U., Klamp, T., Groot, M., and Howard, J.C. (1997). Cellular responses to interferon-gamma. Annu. Rev. Immunol. 15, 749-795.
6. Brocker, T., Riedinger, M., and Karjalainen, K. (1997). Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo. J. Exp. Med. 185, 541-550.
7. Cardell, S., Merkenschlager, M., Bodmer, H., Chan, S., Cosgrove, D., Benoist, C., and Mathis, D. (1994). The immune system of mice lacking conventional MHC class II molecules. Adv. Immunol. 55, 423-440.
8. + T cells in major histocompatibility complex class II-deficient mice. J. Exp. Med. 182, 993-1004.
9. Chang, C.H., and Flavell, R.A. (1995). Class II transactivator regulates the expression of multiple genes involved in antigen presentation. J. Exp. Med. 181, 765-767.
10. Chang, C.H., Guerder, S., Hong, S.C., van Ewijk, W., and Flavell, R. A. (1996). Mice lacking the MHC class II transactivator (CIITA) show tissue-specific impairment of MHC class II expression. Immunity 4, 167-178.
11. Coffman, R.L. (1982). Surface antigen expression and immunoglobulin gene rearrangement during mouse pre-B cell development. Immunol. Rev. 69, 5-23.
12. Cosgrove, D., Gray, D., Dierich, A., Kaufman, J., Lemeur, M., Benoist, C., and Mathis, D. (1991). Mice lacking MHC class II molecules. Cell 66, 1051-1066.
13. Cresswell, P. (1996). Invariant chain structure and MHC class II function. Cell 84, 505-507.
14. Crowley, M., Inaba, K., Witmer-Pack, M., and Steinman, R.M. (1989). The cell surface of mouse dendritic cells: FACS analyses of dendritic cells from different tissues including thymus. Cell, Immunol. 118, 108-125.
15. de Preval, C., Hadam, M.R., and Mach, B. (1988). Regulation of genes for HLA class II antigens in cell lines from patients with severe combined immunodeficiency. N. Engl. J. Med. 318, 1295-1300.
16. Douhan, J., Lieberson, R., Knoll, J.H., Zhou, H., and Glimcher, L.H. (1997). An isotype-specific activator of major histocompatibility complex (MHC) class II genes that is independent of class II transactivator. J. Exp. Med. 185, 1885-1895.
17. Douhan, J., III, Hauber, I., Eibl, M.M., and Glimcher, L.H. (1996). Genetic evidence for a new type of major histocompatibility complex class II combined immunodeficiency characterized by a dyscoordinate regulation of HLA-D alpha and beta chains. J. Exp. Med. 183, 1063-1069.
18. Durand, B., Sperisen, P., Emery, P., Barras, E., Zufferey, M., Mach, B., and Reith, W. (1997). RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency. EMBO J. 16, 1045-1055.
19. Elliott, E.A., Drake, J.R., Amigorena, S., Elsemore, J., Webster, P., Mellman, I., and Flavell, R.A. (1994). The invariant chain is required for intracellular transport and function of major histocompatibility complex class II molecules. J. Exp. Med. 179, 681-694.
20. Förster, I., and Rajewsky, K. (1987). Expansion and functional activity of Ly-1+ B cells upon transfer of peritoneal cells into allotype-congenic, newborn mice. Eur. J. Immunol. 17, 521-528.
21. Fowlkes, B.J., and Schweighoffer, E. (1995). Positive selection of T cells. Curr. Opin. Immunol. 7, 188-195.
22. Glimcher, L.H., and Kara, C.J. (1992). Sequences and factors: a guide to MHC class-II transcription. Annu. Rev. Immunol. 10, 13-49.
23. Grusby, M.J., and Glimcher, L.H. (1995). Immune responses in MHC class II-deficient mice. Annu. Rev. Immunol. 13, 417-435.
24. Hadam, M.R., Dopfer, R., Dammer, G., Derau, C., and Niethammer, D. (1986). Expression of MHC-antigens in MHC class II deficiency. In Progress in Immunodeficiency Research and Therapy II, J. Vossen and C. Griscelli, eds. (Amsterdam: Elsevier Science Publishers, Biomedical Division), pp. 89-96.
25. Hauber, I., Gulle, H., Wolf, H.M., Maris, M., Eggenbauer, H., and Eibl, M.M. (1995). Molecular characterization of major histocompatibility complex class II gene expression and demonstration of antigen-specific T cell response indicate a new phenotype in class II-deficient patients. J. Exp. Med. 181, 1411-1423.
26. Inaba, K., Inaba, M., Romani, N., Aya, H., Deguchi, M., Ikehara, S., Muramatsu, S., and Steinman, R.M. (1992). Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 176, 1693-1702.
27. Jameson, S.C., Hogquist, K.A., and Bevan, M.J. (1995). Positive selection of thymocytes. Annu. Rev. Immunol. 13, 93-126.
28. Janeway, C.A., Bottomly, K., Conrad, P., Conzen, S., Jones, B., Kaye, J., Katz, M., McVay, L., Murphy, D.B., and Tite, J. (1984). Quantitative variation in Ia antigen expression plays a central role in immune regulation. Immunol. Today 5, 99-105.
29. Jiang, W., Swiggard, W.J., Heufler, C., Peng, M., Mirza, A., Steinman, R.M., and Nussenzweig, M.C. (1995). The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing. Nature 375, 151-155.
30. Karasuyama, H., and Melchers, F. (1988). Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors. Eur. J. Immunol. 18, 97-104.
31. Kern, I., Steimle, V., Siegrist, C.A., and Mach, B. (1995). The two novel MHC class II transactivators RFX5 and CIITA both control expression of HLA-DM genes. Int. Immunol. 7, 1295-1299.
32. Klein, C., Lisowska-Grospierre, B., LeDeist, F., Fischer, A., and Griscelli, C. (1993). Major histocompatibility complex class II deficiency: clinical manifestations, immunologic features, and outcome. J. Pediatr. 123, 921-928.
33. Kontgen, F., Suss, G., Stewart, C., Steinmetz, M., and Bluethmann, H. (1993). Targeted disruption of the MHC class II Aα gene in C57BL/6 mice. Int. Immunol. 5, 957-964.
34. Levine, F., and Pious, D. (1984). Revertants from the HLA class II regulatory mutant 6.1.6: implications for the regulation of Ia gene expression. J. Immunol. 132, 959-962.
35. Mach, B., Steimle, V., Martinez-Soria, E., and Reith, W. (1996). Regulation of MHC class II genes: lessons from a disease. Annu. Rev. Immunol. 14, 301-331.
36. Mannhalter, J.W., Wolf, H.M., Ahmad, R., Dopfer, R., Niethammer, D., and Eibl, M.M. (1986). Antigen presentation in MHC class II deficiency. In Progress in Immunodeficiency Research and Therapy II, J. Vossen and C. Griscelli, eds. (Amsterdam: Elsevier Science Publishers, Biomedical Division), pp. 107-112.
37. Moreno, C.S., Emery, P., West, J.E., Durand, B., Reith, W., Mach, B., and Boss, J.M. (1995). Purified X2 binding protein (X2BP)cooperatively binds the class II MHC X box region in the presence of purified RFX, the X box factor deficient in the bare lymphocyte syndrome. J. Immunol. 155, 4313-4321.
38. Muhlethaler-Mottet, A., Otten, L.A., Steimle, V., and Mach, B. (1997). Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA. EMBO J. 16, 2851-2860.
39. Nocera, A., Barocci, S., De Palma, R., and Gorski, J. (1993). Analysis of transcripts of genes located within the HLA-D region in B cells from an HLA-severe combined immunodeficiency individual. Hum. Immunol. 38, 231-234.
40. Noelle, R., Krammer, P.H., Ohara, J., Uhr, J.W., and Vitetta, E.S. (1984). Increased expression of Ia antigens on resting B cells: an additional role for B-cell growth factor. Proc. Natl. Acad. Sci. USA 81, 6149-6153.
41. Ono, S.J., Bazil, V., Sugawara, M., and Strominger, J.L. (1991). An isotype-specific trans-acting factor is defective in a mutant B cell line that expresses HLA-DQ, but not -DR or -DP. J. Exp. Med. 173, 629-637.
42. Reith, W., Satola, S., Sanchez, C.H., Amaldi, I., Lisowska-Grospierre, B., Griscelli, C., Hadam, M.R., and Mach, B. (1988). Congenital immunodeficiency with a regulatory defect in MHC class II gene expression lacks a specific HLA-DR promoter binding protein, RF-X. Cell 53, 897-906.
43. Reith, W., Kobr, M., Emery, P., Durand, B., Siegrist, C.A., and Mach, B. (1994a). Cooperative binding between factors RFX and X2bp to the X and X2 boxes of MHC class II promoters. J. Biol. Chem. 269, 20020-20025.
44. Reith, W., Siegrist, C.A., Durand, B., Barras, E., and Mach, B. (1994b). Function of major histocompatibility complex class II promoters requires cooperative binding between factors RFX and NF-Y. Proc. Natl. Acad. Sci. USA 91, 554-558.
45. Reith, W., Steimle, V., Lisowska-Grospierre, B., Fischer, A., and Mach, B. (1998). Molecular basis of major histocompatibility class II deficiency. In Primary Immunodeficiency Diseases: A Molecular and Genetic Approach, H.D. Ochs, C.I.E. Smith, and J. Puck, eds. (New York: Oxford University Press), in press.
46. Rieux-Laucat, F., Le Deist, F., Selz, F., Fischer, A., and de Villartay, J. P. (1993). Normal T cell receptor V beta usage in a primary immunodeficiency associated with HLA class II deficiency. Eur. J. Immunol. 23, 928-934.
47. Roes, J., and Rajewsky, K. (1993). Immunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cells. J. Exp. Med. 177, 45-55.
48. + dendritic cell population in mouse Peyer's patches. Eur. J. Immunol. 26, 1801-1806.
49. Scheicher, C., Mehlig, M., Zecher, R., and Reske, K. (1992). Dendritic cells from mouse bone marrow: in vitro differentiation using low doses of recombinant granulocyte-macrophage colony-stimulating factor. J. Immunol. Meth. 154, 253-264.
50. Scholl, T., Mahanta, S.K., and Strominger, J.L. (1997). Specific complex formation between the type II bare lymphocyte syndrome-associated transactivators CIITA and RFX5. Proc. Natl. Acad. Sci. USA 94, 6330-6334.
51. Schuurman, H.J., van de Wijngaert, F.P., Huber, J., Schuurman, R.K., Zegers, B.J., Roord, J.J., and Kater, L. (1985). The thymus in "bare lymphocyte" syndrome: significance of expression of major histocompatibility complex antigens on thymic epithelial cells in intrathymic T-cell maturation. Hum. Immunol. 13, 69-82.
52. Schwenk, F., Baron, U., and Rajewsky, K. (1995). A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells. Nucleic Acids Res. 23, 5080-5081.
53. Seidl, C., Saraiya, C., Osterweil, Z., Fu, Y.P., and Lee, J.S. (1992). Genetic complexity of regulatory mutants defective for HLA class II gene expression. J. Immunol. 148, 1576-1584.
54. Springer, T., Galfre, G., Secher, D.S., and Milstein, C. (1979). Mac-1: a macrophage differentiation antigen identified by monoclonal antibody. Eur. J. Immunol. 9, 301-306.
55. Steimle, V., Otten, L.A., Zufferey, M., and Mach, B. (1993). Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome). Cell 75, 135-146.
56. Steimle, V., Siegrist, C.A., Mottet, A., Lisowska-Grospierre, B., and Mach, B. (1994). Regulation of MHC class II expression by interferon-gamma mediated by the transactivator gene CIITA. Science 265, 106-109.
57. Steimle, V., Durand, B., Barras, E., Zufferey, M., Hadam, M.R., Mach, B., and Reith, W. (1995). A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymphocyte syndrome). Genes Dev. 9, 1021-1032.
58. Steinman, R.M., Pack, M., and Inaba, K. (1997). Dendritic cells in the T-cell areas of lymphoid organs. Immunol. Rev. 156, 25-37.
59. Torres, R.M., and Kühn, R. (1997). Laboratory protocols for conditional gene targeting. (Oxford: Oxford University Press),
60. van Ewijk, W., Ron, Y., Monaco, J., Kappler, J., Marrack, P., LeMeur, M., Gerlinger, P., Durand, B., Benoist, C., and Mathis, D. (1988). Compartmentalization of MHC class II gene expression in transgenic mice. Cell 53, 357-370.
61. Villard, J., Reith, W., Barras, E., Gos, A., Morris, M.A., Antonorakis, S.E., van den Elsen, P.J., and Mach, B. (1997). Analysis of mutations and chromosomal localisation of the gene encoding RFX5, a novel transcription factor affected in major histocompatibility complex class II deficiency. Human Mutation 10, 430-435.
62. Zegers, B.J.M., Rijkers, G.T., Roord, J.J., Koning, F., Schuurman, H.J., Heijnen, C.H., Kuis, W., van de Berg, H., and Stoop, J.W. (1986). Defective expression of MHC antigens on mononuclear cells in two siblings with combined immunodeficiency: delineation of the class II antigen defect. In Progress in Immunodeficiency Research and Therapy II, J. Vossen and C. Griscelli, eds. (Amsterdam: Elsevier Science Publishers, Biomedical Division), pp. 97-105.