TGF-β Attenuates the Class II Transactivator and Reveals an Accessory Pathway of IFN-γ Action

Journal of Immunology

Volumn 158, Issue 3, 1997, Pages 1095-1101

  Nandan, Devki ^a   Reiner, Neu E ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; GAMMA INTERFERON; HLA DR ANTIGEN; HLA-DRA; JAK1 PROTEIN, HUMAN; JAK2 PROTEIN, HUMAN; JANUS KINASE 1; JANUS KINASE 2; MHC CLASS II TRANSACTIVATOR PROTEIN; NUCLEAR PROTEIN; ONCOPROTEIN; PHOSPHOTYROSINE; PROTEIN TYROSINE KINASE; STAT1 PROTEIN; STAT1 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CELL CULTURE; GENE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; SIGNAL TRANSDUCTION;

DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; GENES, MHC CLASS II; HLA-DR ANTIGENS; HUMANS; INTERFERON TYPE II; JANUS KINASE 1; JANUS KINASE 2; NUCLEAR PROTEINS; PHOSPHORYLATION; PHOSPHOTYROSINE; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA; TUMOR CELLS, CULTURED;

EID: 0031065145     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. MacKay, R. J., and S. W. Russell. 1986. Protein changes associated with stages of activation of mouse macrophages for tumor cell killing. J. Immunol. 137:1392.
2. Flynn, J. L., J. Chan, K. J. Triebold, D. K. Dalton, T. A. Stewart, and B. R. Bloom. 1993. An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection. J. Exp. Med. 178:2249.
3. Farrar, M. A., and R. D. Schreiber. 1993. The molecular cell biology of interferon-gamma and its receptor. Annu. Rev. Immunol. 11:571.
4. Ting, J. P.-Y., and A. S. Baldwin. 1993. Regulation of MHC gene expression. Curr. Opin. Immunol. 5:8.
5. Glimcher, L. H., and C. J. Kara. 1992. Sequences and factors: a guide to MHC class II transcription. Annu. Rev. Immunol. 10:13.
6. Gallin, J. I., J. M. Farber, S. M. Holland, and T. B. Nutman. 1995. Interferon-gamma in the management of infectious diseases. Ann. Intern. Med. 123:216.
7. Steimle, V., L. A. Otten, M. Zufferey, and B. Mach. 1993. Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome). Cell 75:135.
8. Steimle, V., C.-A. Siegrist, A. Mottet, B. Lisowska-Grospierre, and B. Mach. 1994. Regulation of MHC class II expression by interferon-gamma mediated by the transactivator gene CIITA. Science 265:106.
9. Reith, W., V. Steimle, and B. Mach. 1995. Molecular defects in the bare lymphocyte syndrome and regulation of MHC class II genes. Immunol. Today 16: 539.
10. Ihle, J. N., B. A. Witthuhn, F. W. Quelle, K. Yamamoto, and O. Silvennoinen. 1995. Signaling through the hematopoietic cytokine receptors. Annu. Rev. Immunol. 13:369.
11. Quelle, F. W., W. Thierfelder, B. A. Witthuhn, B. Tang, S. Cohen, and J. N. Ihle. 1995. Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor. J. Biol. Chem. 270:20775.
12. Ihle, J. N. 1995. Cytokine receptor signalling. Nature 377:591.
13. Shaui, K., A. Ziemiecki, A. F. Wilks, A. G. Harpur, H. B. Sadowski, M. Z. Gilman, and J. E. Darnell. 1993. Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins. Nature 366:580.
14. Darnell, J. E., I. M. Kerr, and G. R. Stark. 1994. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415.
15. Chang, C. H., J. D. Fontes, M. Peterlin, and R. A. Flavell. 1994. Class II transactivator (CIITA) is sufficient for the inducible expression of major histocompatibility complex class II genes. J. Exp. Med. 180:1367.
16. McCartney-Francis, N. L., and S. M. Wahl. 1994. Transforming growth factor β: a matter of life and death. J. Leukocyte Biol. 55:401.
17. Gabrielian, K., R. Osusky, B. D. Sippy, S. J. Ryan, and D. R. Hinton. 1994. Effect of TGF-β on interferon-γ-induced HLA-DR expression in human retinal pigment epithelial cells. Invest. Ophthalmol. Vis. Sci. 35:4253.
18. Nandan, D., and N. E. Reiner. 1995. Attenuation of gamma interferon-induced tyrosine phosphorylation in mononuclear phagocytes infected with Leishmania donovani: selective inhibition of signaling through Janus kinases and Stat1. Infect. Immun. 63:4495.
19. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680.
20. Durocher, Y., A. Chapdelaine, and S. Chevalier. 1992. Identification of cytosolic protein tyrosine kinases of human prostate by renaturation after SDS/PAGE. Biochem. J. 284:653.
21. Chang, C.-H., and R. A. Flavell. 1995. Class II transactivator regulates the expression of multiple genes involved in antigen presentation. J. Exp. Med. 181: 765.
22. Wen, Z.,. Z. Zhong, and J. E. Darnell, Jr. 1995. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 82:241.
23. David, M., E. Petricoin, III, C. Benjamin, R. Pine, M. J. Weber, and A. C. Larner. 1995. Requirement for MAP kinase (ERK2) activity in interferon α- and interferon β-stimulated gene expression through STAT proteins. Science 269:1721.
24. Barinaga, M. 1995. Cell biology-two major signaling pathways meet at MAP-kinase. Science 269:1673.