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1
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0023886025
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Human class II major histocompatibility complex genes and proteins
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Kappes D, Strominger JL. Human class II major histocompatibility complex genes and proteins. Annu Rev Biochem. 57:1988;991-1028.
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(1988)
Annu Rev Biochem
, vol.57
, pp. 991-1028
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Kappes, D.1
Strominger, J.L.2
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2
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0024121471
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Active suppression of major histocompatibility complex class II gene expression during differentiation from B cells to plasma cells
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Latron F, Jotterand-Bellomo M, Maffei A, Scarpellino L, Bernard M, Strominger JL, Accolla RS. Active suppression of major histocompatibility complex class II gene expression during differentiation from B cells to plasma cells. Proc Natl Acad Sci USA. 85:1988;2229-2233.
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Proc Natl Acad Sci USA
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Latron, F.1
Jotterand-Bellomo, M.2
Maffei, A.3
Scarpellino, L.4
Bernard, M.5
Strominger, J.L.6
Accolla, R.S.7
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3
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0342401140
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Immune interferon activates multiple class II major histocompatibility complex genes and the associated invariant chain gene in human endothelial cells and dermal fibroblasts
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Collins T, Korman AJ, Wake CT, Boss JM, Kappes DJ, Fiers W, Ault KA, Gimbrone MA Jr, Strominger JL, Pober JS. Immune interferon activates multiple class II major histocompatibility complex genes and the associated invariant chain gene in human endothelial cells and dermal fibroblasts. Proc Natl Acad Sci USA. 81:1984;4917-4921.
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Proc Natl Acad Sci USA
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, pp. 4917-4921
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Collins, T.1
Korman, A.J.2
Wake, C.T.3
Boss, J.M.4
Kappes, D.J.5
Fiers, W.6
Ault, K.A.7
Gimbrone M.A., Jr.8
Strominger, J.L.9
Pober, J.S.10
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4
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0027492915
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Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes: Comparison with IL-4 and modulation by IFN-γ Or IL-10
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De Waal Malefyt R, Figdor CG, Huijbens R, Mohan-Peterson S, Bennett B, Culpepper J, Dang W, Zurawski G, De Vries JE. Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes: comparison with IL-4 and modulation by IFN-γ or IL-10. J Immunol. 151:1993;6370-6380.
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(1993)
J Immunol
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, pp. 6370-6380
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De Waal Malefyt, R.1
Figdor, C.G.2
Huijbens, R.3
Mohan-Peterson, S.4
Bennett, B.5
Culpepper, J.6
Dang, W.7
Zurawski, G.8
De Vries, J.E.9
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5
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0028842529
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IFN-β acts downstream of IFN-induced CIITA mRNA accumulation to block MHC class II gene expression and requires the 48 kD DNA binding protein, ISGF3-γ
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of special interest. Describes additional level of class II expression that occurs in the presence of the essential MHC class II regulatory factor CIITA. Previous work had suggested that MHC class expression was limited solely by CIITA.
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Lu H-T, Riley JL, Babcock GT, Huston M, Stark GR, Boss JM, Ransohoff RM. IFN-β acts downstream of IFN-induced CIITA mRNA accumulation to block MHC class II gene expression and requires the 48 kD DNA binding protein, ISGF3-γ of special interest J Exp Med. 182:1995;1517-1525 Describes additional level of class II expression that occurs in the presence of the essential MHC class II regulatory factor CIITA. Previous work had suggested that MHC class expression was limited solely by CIITA.
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(1995)
J Exp Med
, vol.182
, pp. 1517-1525
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Lu, H.-T.1
Riley, J.L.2
Babcock, G.T.3
Huston, M.4
Stark, G.R.5
Boss, J.M.6
Ransohoff, R.M.7
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6
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0027378549
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Transforming growth factor-β1 repression of the HLA-DRα gene is mediated by conserved proximal promoter elements
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Reimold AM, Kara CJ, Rooney JW, Glimcher LH. Transforming growth factor-β1 repression of the HLA-DRα gene is mediated by conserved proximal promoter elements. J Immunol. 151:1993;4173-4182.
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(1993)
J Immunol
, vol.151
, pp. 4173-4182
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Reimold, A.M.1
Kara, C.J.2
Rooney, J.W.3
Glimcher, L.H.4
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7
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0027442671
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Human major histocompatibility complex class II-associated invariant chain gene promoter. Functional analysis and in vivo protein/DNA interactions of constitutive and IFN-induced expression
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Brown AM, Wright KL, Ting JP-Y. Human major histocompatibility complex class II-associated invariant chain gene promoter. Functional analysis and in vivo protein/DNA interactions of constitutive and IFN-induced expression. J Biol Chem. 268:1993;26328-26333.
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(1993)
J Biol Chem
, vol.268
, pp. 26328-26333
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Brown, A.M.1
Wright, K.L.2
Ting, J.-Y.3
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8
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0029132892
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The two novel MHC class II transactivators RFX5 and CIITA both control expression of HLA-DM genes
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Kern I, Steimle V, Siegrist C, Mach B. The two novel MHC class II transactivators RFX5 and CIITA both control expression of HLA-DM genes. Int Immunol. 7:1996;1295-1299.
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(1996)
Int Immunol
, vol.7
, pp. 1295-1299
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Kern, I.1
Steimle, V.2
Siegrist, C.3
Mach, B.4
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9
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0028924986
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Class II transactivator regulates the expression of multiple genes involved in antigen presentation
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Chang C-H, Flavell RA. Class II transactivator regulates the expression of multiple genes involved in antigen presentation. J Exp Med. 181:1995;765-767.
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(1995)
J Exp Med
, vol.181
, pp. 765-767
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Chang, C.-H.1
Flavell, R.A.2
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10
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0024518769
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Combined immunodeficiency with defective expression in MHC class II genes
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Griscelli C, Lisowska Grospierre B, Mach B. Combined immunodeficiency with defective expression in MHC class II genes. Immunodefic Rev. 1:1989;135-153.
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(1989)
Immunodefic Rev
, vol.1
, pp. 135-153
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Griscelli, C.1
Lisowska Grospierre, B.2
Mach, B.3
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11
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0025762568
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Class II-antigen-negative patient and mutant B-cell lines represent at least three, and probably four, distinct genetic defects defined by complementation analysis
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Benichou B, Strominger JL. Class II-antigen-negative patient and mutant B-cell lines represent at least three, and probably four, distinct genetic defects defined by complementation analysis. Proc Natl Acad Sci USA. 88:1991;4285-4288.
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(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 4285-4288
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Benichou, B.1
Strominger, J.L.2
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12
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0026556640
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Genetic complexity of regulatory mutants defective for HLA class II expression
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Seidl C, Saraiya C, Osterweil Z, Fu YP, Lee JS. Genetic complexity of regulatory mutants defective for HLA class II expression. J Immunol. 148:1992;1576-1584.
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(1992)
J Immunol
, vol.148
, pp. 1576-1584
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Seidl, C.1
Saraiya, C.2
Osterweil, Z.3
Fu, Y.P.4
Lee, J.S.5
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13
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0026587777
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Single base pair substitutions within the HLA-DRA gene promoter separate the functions of the X1 and X2 boxes
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Sloan JH, Hasegawa SL, Boss JM. Single base pair substitutions within the HLA-DRA gene promoter separate the functions of the X1 and X2 boxes. J Immunol. 148:1992;2591-2599.
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(1992)
J Immunol
, vol.148
, pp. 2591-2599
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Sloan, J.H.1
Hasegawa, S.L.2
Boss, J.M.3
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14
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0024290444
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Congenital immunodeficiency with a regulatory defect in MHC class II gene expression lacks a specific HLA-DR promoter binding protein, RF-X
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Reith W, Satola S, Herreo-Sanchez C, Amaldi I, Lisowska-Grospierre B, Griscelli C, Hadam MR, Mach B. Congenital immunodeficiency with a regulatory defect in MHC class II gene expression lacks a specific HLA-DR promoter binding protein, RF-X. Cell. 53:1988;897-906.
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(1988)
Cell
, vol.53
, pp. 897-906
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Reith, W.1
Satola, S.2
Herreo-Sanchez, C.3
Amaldi, I.4
Lisowska-Grospierre, B.5
Griscelli, C.6
Hadam, M.R.7
Mach, B.8
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15
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0027256459
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Protease treatment of nuclear extracts distinguishes between class II major histocompatibility complex X1 box DNA-binding proteins in wild type and class II deficient B cells
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Hasegawa SL, Riley JL, Sloan JH, Boss JM. Protease treatment of nuclear extracts distinguishes between class II major histocompatibility complex X1 box DNA-binding proteins in wild type and class II deficient B cells. J Immunol. 150:1993;1781-1793.
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(1993)
J Immunol
, vol.150
, pp. 1781-1793
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Hasegawa, S.L.1
Riley, J.L.2
Sloan, J.H.3
Boss, J.M.4
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16
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0026665461
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The DNA-binding defect observed in major histocompatibility complex class II regulatory mutants concerns only one member of a family of complexes binding to the X boxes of class II promoters
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Herrero-Sanchez C, Reith W, Silacci P, Mach B. The DNA-binding defect observed in major histocompatibility complex class II regulatory mutants concerns only one member of a family of complexes binding to the X boxes of class II promoters. Mol Cell Biol. 12:1992;4076-4083.
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(1992)
Mol Cell Biol
, vol.12
, pp. 4076-4083
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Herrero-Sanchez, C.1
Reith, W.2
Silacci, P.3
Mach, B.4
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17
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0027994698
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Functional complementation of major histocompatibility complex class II regulatory mutants by the purified X-box-binding protein RFX
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Durand B, Kobr M, Reith W, Mach B. Functional complementation of major histocompatibility complex class II regulatory mutants by the purified X-box-binding protein RFX. Mol Cell Biol. 14:1994;6839-6847.
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(1994)
Mol Cell Biol
, vol.14
, pp. 6839-6847
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Durand, B.1
Kobr, M.2
Reith, W.3
Mach, B.4
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18
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11944266638
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A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymphocyte syndrome)
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of outstanding interest. This paper describes the cloning of a gene (RFX5) encodong one of the subunits of RFX. Mutations in RFX5 are responsible for some, but not all, of the cases of the bare lymphocyte syndrome.
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Steimle V, Durand B, Emmanuele B, Zufferey M, Hadam MR, Mach B, Reith W. A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymphocyte syndrome). of outstanding interest Genes Dev. 9:1995;1021-1032 This paper describes the cloning of a gene (RFX5) encodong one of the subunits of RFX. Mutations in RFX5 are responsible for some, but not all, of the cases of the bare lymphocyte syndrome.
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(1995)
Genes Dev
, vol.9
, pp. 1021-1032
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Steimle, V.1
Durand, B.2
Emmanuele, B.3
Zufferey, M.4
Hadam, M.R.5
Mach, B.6
Reith, W.7
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19
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0029997190
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RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom
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of special interest. The molecular basis for the similarity of the RFX family of proteins is presented. This similarity shows that the RFX DNA binding domain is a common structure motif that is utilized across species.
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Emery P, Durand B, Mach B, Reith W. RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom. of special interest Nucleic Acids Res. 24:1996;307-803 The molecular basis for the similarity of the RFX family of proteins is presented. This similarity shows that the RFX DNA binding domain is a common structure motif that is utilized across species.
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(1996)
Nucleic Acids Res
, vol.24
, pp. 307-803
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Emery, P.1
Durand, B.2
Mach, B.3
Reith, W.4
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20
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0026734795
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Sequences and factors: A guide to MHC class II transcription
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W.E. Paul, C. Garrision Fathman, Metzger H. Palo Alto: Annual Reviews Inc
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Glimcher LH, Kara CJ. Sequences and factors: a guide to MHC class II transcription. Paul WE, Garrision Fathman C, Metzger H. Annual Reviews of Immunology. 1992;13-50 Annual Reviews Inc, Palo Alto.
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(1992)
Annual Reviews of Immunology
, pp. 13-50
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Glimcher, L.H.1
Kara, C.J.2
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21
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0025938888
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Two distinct B cell factors bind the HLA-DRA X box region and recognize different subsets of MHC class II promoters
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Hasegawa SL, Boss JM. Two distinct B cell factors bind the HLA-DRA X box region and recognize different subsets of MHC class II promoters. Nucleic Acids Res. 19:1991;6269-6276.
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(1991)
Nucleic Acids Res
, vol.19
, pp. 6269-6276
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Hasegawa, S.L.1
Boss, J.M.2
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22
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0028804166
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Purified X2BP cooperatively binds the class II MHC X box region in the presence of purified RFX the X box factor deficient in the bare lymphocyte syndrome
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of special interest. Defines X2BP as the X2 box factor by showing cooperative interactions with RFX and X box DNA.
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Moreno CS, Emery P, West JE, Durand B, Reith W, Mach B, Boss JM. Purified X2BP cooperatively binds the class II MHC X box region in the presence of purified RFX the X box factor deficient in the bare lymphocyte syndrome. of special interest J Immunol. 155:1995;4313-4321 Defines X2BP as the X2 box factor by showing cooperative interactions with RFX and X box DNA.
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(1995)
J Immunol
, vol.155
, pp. 4313-4321
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Moreno, C.S.1
Emery, P.2
West, J.E.3
Durand, B.4
Reith, W.5
Mach, B.6
Boss, J.M.7
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23
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0027998318
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Cooperative binding between factors RFX and X2bp to the X and X2 boxes of MHC class II promoters
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Reith W, Kobr M, Emery P, Durand B, Siegrist C-A, Mach B. Cooperative binding between factors RFX and X2bp to the X and X2 boxes of MHC class II promoters. J Biol Chem. 269:1994;20020-20025.
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(1994)
J Biol Chem
, vol.269
, pp. 20020-20025
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Reith, W.1
Kobr, M.2
Emery, P.3
Durand, B.4
Siegrist, C.-A.5
Mach, B.6
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24
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0025787609
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Repression of class II major histocompatibility complex genes by cyclic AMP is mediated by conserved promoter elements
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Ivashkiv LB, Glimcher LH. Repression of class II major histocompatibility complex genes by cyclic AMP is mediated by conserved promoter elements. J Exp Med. 174:1991;1583-1592.
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(1991)
J Exp Med
, vol.174
, pp. 1583-1592
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Ivashkiv, L.B.1
Glimcher, L.H.2
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25
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0028920041
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Recombinant rat CBF-C, the third subunit of CBF/NFY, allows formation of a protein-DNA complex with CBF-A and CBF-B and with yeast HAP2 and HAP3
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Sinha S, Maity SN, Lu J, De Crombrugghe B. Recombinant rat CBF-C, the third subunit of CBF/NFY, allows formation of a protein-DNA complex with CBF-A and CBF-B and with yeast HAP2 and HAP3. Proc Natl Acad Sci USA. 92:1995;1624-1628.
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(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 1624-1628
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Sinha, S.1
Maity, S.N.2
Lu, J.3
De Crombrugghe, B.4
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26
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0028883954
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CCAAT-box binding protein NF-Y (CBF, CP1) recognizes the minor groove and distorts DNA
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Ronchi A, Bellorini M, Mongelli N, Mantovani R. CCAAT-box binding protein NF-Y (CBF, CP1) recognizes the minor groove and distorts DNA. Nucleic Acids Res. 23:1995;4565-4572.
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Nucleic Acids Res
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, pp. 4565-4572
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Ronchi, A.1
Bellorini, M.2
Mongelli, N.3
Mantovani, R.4
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27
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0026081823
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Affinity-purified CCAAT-box-binding protein (YEBP) functionally regulates expression of a human class II major histocompatibility complex gene and the herpes simplex virus thymidine kinase gene
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Zeleznik-Le NJ, Azizkhan JC, Ting JP-Y. Affinity-purified CCAAT-box-binding protein (YEBP) functionally regulates expression of a human class II major histocompatibility complex gene and the herpes simplex virus thymidine kinase gene. Proc Natl Acad Sci USA. 88:1991;1873-1877.
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Proc Natl Acad Sci USA
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, pp. 1873-1877
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Zeleznik-Le, N.J.1
Azizkhan, J.C.2
Ting, J.-Y.3
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28
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0028054792
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Function of major histocompatibility complex class II promoters requires cooperative binding between factors RFX and NF-Y
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Reith W, Siegrist CA, Durand B, Barras E, Mach B. Function of major histocompatibility complex class II promoters requires cooperative binding between factors RFX and NF-Y. Proc Natl Acad Sci USA. 91:1994;554-558.
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Proc Natl Acad Sci USA
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Reith, W.1
Siegrist, C.A.2
Durand, B.3
Barras, E.4
Mach, B.5
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29
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0028876195
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Molecular defects in the bare lymphocyte syndrome and regulation of MHC class II genes
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Reith W, Steimle V, Mach B. Molecular defects in the bare lymphocyte syndrome and regulation of MHC class II genes. Immunol Today. 16:1995;539-546.
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Immunol Today
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Reith, W.1
Steimle, V.2
Mach, B.3
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30
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0026316475
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Stereospecific alignment of the X and Y elements is required for major histocompatibility complex class II DRA promoter function
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Vilen BJ, Cogswell JP, Ting JP-Y. Stereospecific alignment of the X and Y elements is required for major histocompatibility complex class II DRA promoter function. Mol Cell Biol. 11:1991;2406-2415.
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Mol Cell Biol
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Vilen, B.J.1
Cogswell, J.P.2
Ting, J.-Y.3
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31
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0029617947
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Virus induction of human IFNβ gene expression requires the assembly of an enhanceosome
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Thanos D, Maniatis T. Virus induction of human IFNβ gene expression requires the assembly of an enhanceosome. Cell. 83:1995;1091-1100.
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Cell
, vol.83
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Thanos, D.1
Maniatis, T.2
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32
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0025120331
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Mutational analysis of the DRA promoter: Cis-acting sequences and trans-acting factors
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Tsang SY, Nakanishi M, Peterlin BM. Mutational analysis of the DRA promoter: cis-acting sequences and trans-acting factors. Mol Cell Biol. 10:1990;711-719.
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Mol Cell Biol
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Tsang, S.Y.1
Nakanishi, M.2
Peterlin, B.M.3
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33
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0027057979
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Structural constraints within a trimeric transcriptional regulatory region. Constitutive and interferon-inducible expression of the HLA-DRA gene
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Vilen BJ, Penta JF, Ting JP-Y. Structural constraints within a trimeric transcriptional regulatory region. Constitutive and interferon-inducible expression of the HLA-DRA gene. J Biol Chem. 267:1992;23728-23734.
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J Biol Chem
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Vilen, B.J.1
Penta, J.F.2
Ting, J.-Y.3
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34
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0029762163
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Complex architecture of major histocompatibility complex class II promoters: Reiterated motifs and conserved protein-protein interactions
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Jabrane-Ferrat N, Fontes JD, Boss JM, Peterlin BM. Complex architecture of major histocompatibility complex class II promoters: reiterated motifs and conserved protein-protein interactions. Mol Cell Biol. 16:1996;4683-4690.
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Mol Cell Biol
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Jabrane-Ferrat, N.1
Fontes, J.D.2
Boss, J.M.3
Peterlin, B.M.4
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35
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0025870067
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In vivo footprinting of MHC class II genes: Bare promoters in the bare lymphocyte syndrome
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Kara CJ, Glimcher LH. In vivo footprinting of MHC class II genes: bare promoters in the bare lymphocyte syndrome. Science. 252:1991;709-712.
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(1991)
Science
, vol.252
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Kara, C.J.1
Glimcher, L.H.2
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36
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0027131208
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Class II MHC transcriptional mutants are defective in higher order complex formation
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Riley JL, Boss JM. Class II MHC transcriptional mutants are defective in higher order complex formation. J Immunol. 151:1993;6942-6953.
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(1993)
J Immunol
, vol.151
, pp. 6942-6953
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Riley, J.L.1
Boss, J.M.2
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37
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0027490172
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Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (bare lymphocyte syndrome)
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Steimle V, Otten LA, Zufferey M, Mach B. Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (bare lymphocyte syndrome). Cell. 75:1993;135-146.
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(1993)
Cell
, vol.75
, pp. 135-146
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Steimle, V.1
Otten, L.A.2
Zufferey, M.3
Mach, B.4
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38
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0029048828
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Activation of class II MHC genes requires both the X box region and the class II transactivator (CIITA)
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of special interest. A functional characterization of CIITA is presented. CIITA was found to possess a strong transcriptional activation domain, suggesting that it may regulate class II genes as a transcriptional co-activator by interacting with factors bound to the X box region.
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Riley JL, Westerheide SD, Price JA, Brown JA, Boss JM. Activation of class II MHC genes requires both the X box region and the class II transactivator (CIITA). of special interest Immunity. 2:1995;533-543 A functional characterization of CIITA is presented. CIITA was found to possess a strong transcriptional activation domain, suggesting that it may regulate class II genes as a transcriptional co-activator by interacting with factors bound to the X box region.
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(1995)
Immunity
, vol.2
, pp. 533-543
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Riley, J.L.1
Westerheide, S.D.2
Price, J.A.3
Brown, J.A.4
Boss, J.M.5
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39
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0029075521
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Human MHC class II gene transcription directed by the carboxyl terminus of CIITA, one of the defective genes in type II MHC combined immune deficiency
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of special interest. See annotation [38].
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Zhou H, Glimcher LH. Human MHC class II gene transcription directed by the carboxyl terminus of CIITA, one of the defective genes in type II MHC combined immune deficiency. of special interest Immunity. 2:1995;545-553 See annotation [38].
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(1995)
Immunity
, vol.2
, pp. 545-553
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Zhou, H.1
Glimcher, L.H.2
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40
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0028041568
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Class II transactivator (CIITA) is sufficient for the inducible expression of major histocompatibility complex class II genes
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Chang C-H, Fontes JD, Peterlin BM, Flavell RA. Class II transactivator (CIITA) is sufficient for the inducible expression of major histocompatibility complex class II genes. J Exp Med. 180:1994;1367-1374.
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(1994)
J Exp Med
, vol.180
, pp. 1367-1374
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Chang, C.-H.1
Fontes, J.D.2
Peterlin, B.M.3
Flavell, R.A.4
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41
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0028142430
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Regulation of MHC class II expression by interferon-γ mediated by the transactivator gene CIITA
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Steimle V, Siegrist C-A, Mottet A, Lisowska-Grospierre B, Mach B. Regulation of MHC class II expression by interferon-γ mediated by the transactivator gene CIITA. Science. 265:1994;106-108.
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Science
, vol.265
, pp. 106-108
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Steimle, V.1
Siegrist, C.-A.2
Mottet, A.3
Lisowska-Grospierre, B.4
Mach, B.5
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42
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0028535402
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Molecular analysis of G1B and G3A IFN-γ mutants reveals that defects in CIITA or RFX result in defective class II MHC and Ii gene induction
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Binding and cooperative interactions between two B cell-specific transcriptional coactivators
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of outstanding interest. Describes first direct interactions of CIITA with another protein, Bob1, another transcriptional activator. The results of this paper suggest that multiple transcriptional co-activators may be required for maximal class II expression.
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Fontes JD, Jabrane-Ferrat N, Toth CR, Peterlin BM. Binding and cooperative interactions between two B cell-specific transcriptional coactivators. of outstanding interest J Exp Med. 183:1996;2517-2521 Describes first direct interactions of CIITA with another protein, Bob1, another transcriptional activator. The results of this paper suggest that multiple transcriptional co-activators may be required for maximal class II expression.
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Fontes, J.D.1
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Characterization of the expressed CIITA allele in the class II MHC transcriptional mutant RJ2.2.5
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56
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0029968925
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Mice lacking the MHC class II transactivator (CIITA) show tissue-specific impairment of MHC class II expression
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of outstanding interest. Knockout of CIITA in mice results in a similar phenotype to BLS patients. Also, low levels of class II expression in thymus epithelium were evident, suggesting the possibility of an alternative CIITA independent mechanism of regulation.
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Chang C, Guerder S, Hong S, Van Ewijk W, Flavell R. Mice lacking the MHC class II transactivator (CIITA) show tissue-specific impairment of MHC class II expression. of outstanding interest Immunity. 4:1996;167-178 Knockout of CIITA in mice results in a similar phenotype to BLS patients. Also, low levels of class II expression in thymus epithelium were evident, suggesting the possibility of an alternative CIITA independent mechanism of regulation.
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57
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Genetic evidence for a new type of major histocompatibility complex class II combined immunodeficiency characterized by a dyscoordinate regulation of HLA-D α and β chains
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of special interest. A novel mutation in class II gene regulation in which genes oriented in one direction on the chromosome are not expressed is described. Understanding this mutation may tie the effects of chromatin assembly and class II regulation together.
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Douhan J III, Hauber I, Eibl MM, Glimcher LH. Genetic evidence for a new type of major histocompatibility complex class II combined immunodeficiency characterized by a dyscoordinate regulation of HLA-D α and β chains. of special interest J Exp Med. 183:1996;1063-1069 A novel mutation in class II gene regulation in which genes oriented in one direction on the chromosome are not expressed is described. Understanding this mutation may tie the effects of chromatin assembly and class II regulation together.
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J Exp Med
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Douhan J. III1
Hauber, I.2
Eibl, M.M.3
Glimcher, L.H.4
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