Regulation of MHC class II genes: Lessons from a disease

Annual Review of Immunology

Volumn 14, Issue , 1996, Pages 301-331

  Mach, Bernard ^a   Steimle, Viktor ^a   Martinez Soria, Eduardo ^a   Reith, Walter ^a  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

antigen presentation; bare lymphocyte syndrome (BLS); CIITA; gene regulation; MHC class II deficiency; RFX

Indexed keywords

ADENOSINE DEAMINASE; CIS ACTING ELEMENT; DNA BINDING PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TRANSCRIPTION FACTOR;

ANTIGEN PRESENTATION; AUTOIMMUNITY; CANCER IMMUNOTHERAPY; GENE EXPRESSION REGULATION; GENE MUTATION; GENE TARGETING; GENE THERAPY; GENETIC COMPLEMENTATION; GENETIC HETEROGENEITY; HUMAN; IMMUNE DEFICIENCY; IMMUNOMODULATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REVIEW; THERAPY; TRANSACTIVATION;

ANIMALS; GENE EXPRESSION REGULATION; GENES, MHC CLASS II; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; SEVERE COMBINED IMMUNODEFICIENCY;

EID: 0029877668     PISSN: 07320582     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.immunol.14.1.301     Document Type: Review

References (19)

1. Benacerraf B. 1981. Role of MHC gene products in immune regulation. Science 212:1229-38
2. Trowsdale J. 1993. Genomic structure and function in the MHC. Trends Genet. 9:117-22
3. Cresswell P. 1994. Antigen presentation. Getting peptides into MHC class II molecules. Curt Biol. 4:541-43
4. Sloan VS, Cameron P, Porter G, Gammon M, Amaya M, Mellins E, Zaller DM. 1995. Mediation of HLA-DM dissociation of peptides from HLA-DR. Nature 375:802-6
5. Denzin LK, Cresswell P. 1995. HLA-DM induces CLIP dissociation from MHC class II αβ dimers and facilitates peptide loading. Cell 82:155-65
6. Herman A, Kappler JW, Marrack P, Pullen AM. 1991. Superantigens: mechanism of T-cell stimulation and role in immune responses. Annu. Rev. Immunol. 9:745-72
7. Acha-Orbea H. 1995. Superantigens of mouse mammary tumor virus. Annu. Rev. Immunol. 13:459-86
8. Scholl PR, Geha RS. 1994. MHC class II signaling in B-cell activation. Immunol. Today 15:418-22
9. Janeway CA, Bottomly K, Conrad P, Conzen S, Jones B, Kaye J, Katz M, McVay L, Murphy DB, Tite J. 1984. Quantitative variation in la antigen expression plays a central role in immune regulation. Immunol. Today 5:55-60
10. Klein C, Lisowska Grospierre B, LeDeist F, Fischer A, Griscelli C. 1993. Major histocompatibility complex class II deficiency: clinical manifestations, immunologic features, and outcome. J. Pediatr. 123:921-28
11. Mach B, Steimle V, Reith W. 1994. MHC class H-deficient combined immunodeficiency: a disease of gene regulation. Immunol. Rev. 138:207-21
12. Bottazzo GF, Todd I, Mirakian R, Belfiore A. Pujol-Borrell R. 1986. Organ-specific autoimmunity: a 1986 overview. Immunol. Rev. 94:137-69
13. Wraith DC, McDevitt HO, Steinman L, Acha-Orbea H. 1989. T cell recognition as the target for immune intervention in autoimmune disease. Cell 57:709-15
14. Acha Orbea H, McDevitt HO. 1990. The role of class II molecules in development of insulin-dependent diabetes mellitus in mice, rats and humans. Curr. Top. Microbiol. Immunol. 156:103-19
15. Glimcher LH. Kara CJ. 1992. Sequences and factors: a guide to MHC class-II transcription. Annu. Rev. Immunol. 10:13-49
16. Guardiola J, Maffei A. 1993. Control of MHC class II gene expression in autoimmune, infectious, and neoplastic diseases. Crit. Rev. Immunol. 13:247-68
17. Erb KJ, Holtschke T, Muth K, Horak I, Schimpl A. 1994. T cell subset distribution and B cell hyperreactivity in mice expressing interleukin-4 under the control of major histocompatibility complex class I regulatory sequences. Eur. J. Immunol. 24:1143-47
18. Burstein HJ, Tepper RI, Leder P, Abbas AK. 1991. Humoral immune functions in IL-4 transgenic mice. J. Immunol. 147:2950-56
19. Go NF, Castle BE, Barre R, Kastelein R, Dang W, Mosmann TR, Moore KW, Howard M. 1990. Interleukin 10, a novel B cell stimulatory factor: unresponsiveness of X chromosome-linked immunodeficiency B cells. J. Exp. Med. 172:1625-31