Suppression of human anti-porcine T-cell immune responses by major histocompatibility complex class II transactivator constructs lacking the amino terminal, domain

Transplantation

Volumn 66, Issue 1, 1998, Pages 103-111

  Yun, Sheng ^a   Gustafsson, Kenth ^a   Fabre, John W ^a,b  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANIMAL CELL; ANTIGEN RECOGNITION; ARTICLE; GENE MUTATION; GRAFT REJECTION; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE;

EID: 0032528308     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199807150-00016     Document Type: Article

References (35)

1. Fabre JW. The role of polymorphic donor peptides in allograft recognition and rejection. Immunol Rev 1996; 154: 21.
2. Lawson JH, Platt JL. Molecular barriers to xenotransplantation. Transplantation 1996; 62: 303.
3. Birmele B, Thibault G, Nivet H, Gruel Y, Bardos P, Lebranchu Y. Human lymphocyte adhesion to xenogeneic porcine endothelial cells: modulation by human TNF-α and involvement of VLA-4 and LFA-1. Transplant Immunol 1996; 4: 265.
4. Murray AG, Khodadoust MM, Poher JS, Bothwell AL. Porcine aortic endothelial cells activate human T cells: direct presentation of MHC antigens and costimulation by ligands for human CD2 and CD28. Immunity 1994; 1: 57.
5. Davis TA, Craighead N, Williams AJ, Scadron A, June CH, Lee KP. Primary porcine endothelial cells express membrane-bound B7-2 (CD86) and a soluble factor that co-stimulate cyclosporin A-resistant and CD28-dependent human T cell proliferation. Int Immunol 1996; 8: 1099.
6. Pescovitz MD, Sachs DH, Lunney JK, Hsu SM. Localization of class II MHC antigens on porcine renal vascular endothelium. Transplantation 1984; 37: 627.
7. Daar AS, Fuggle SV, Fabre JW, Ting A, Morris PJ. The detailed distribution of MHC class II antigens in normal human organs. Transplantation 1984; 38: 293.
8. Fabre JW. The rat kidney allograft model: was it all too good to be true? Transplantation 1982; 34: 223.
9. Steimle V, Otten LA, Zufferey M, Mach B. Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome) Cell 1993; 75: 135.
10. Chang C-H, Flavell RA. Class II transactivator regulates the expression multiple genes involved in antigen presentation. J Exp Med 1995; 181: 765.
11. Riley JL, Westerheide SD, Price JA, Brown JA, Boss JM. Activation of class II MHC genes requires both the X box region and the class II transactivator (CIITA). Immunity 1995; 2: 533.
12. Zhou H, Glimcher LH. Human MHC class II gene transcription directed by the carboxyl terminus of CIITA, one of the defective genes in type II MHC combined immune deficiency. Immunity 1995; 2: 545.
13. Zhou H, Su HS, Zhang X, Douhan J III, Glimcher LH. CIITA-dependent and -independent class II MHC expression revealed by a dominant negative mutant. J Immunol 1997; 158: 4741.
14. Yun S, Gustafsson K, Fabre JW. Suppression of MHC class II expression by human class II trans-activator constructs lacking the N-terminal domain. Int Immunol 1997; 9: 1545.
15. Chin K-C, Li GGX, Ting JPY. Importance of acidic, proline/ serine/threonine-rich, and GTP-binding regions in the major histocompatibility complex class II transactivator: generation of transdominant-negative mutants. Proc Natl Acad Sci USA 1997; 94: 2501.
16. Kalderon D, Roberts BL, Richardson WD. A short amino acid sequence able to specify nuclear location. Cell 1984; 39: 499.
17. Schmoeckel M, Nollert G, Shahmohammadi M, Muller-Hocker J, et al. Transgenic human decay accelerating factor makes normal pigs function as a concordant species. J Heart Lung Transplant 1997; 16: 758.
18. Kaeffer B, Bottreau E, Phan-Thanh L, Olivier M, Salmon H. Histocompatible miniature, boar model: selection of transformed cell lines of B and T lineages producing retrovirus. Int J Cancer 1990; 46: 481.
19. Dalchau R, Fabre JW. Identification and unusual tissue distribution of the canine and human homologues of Thy-1 (ø). J Exp Med 1979; 149: 576.
20. Chang C-H, Hong S-C, Hughes CCW, Janeway CA Jr, Flavell RA. CIITA activates the expression of MHC class II genes in mouse T cells. Int Immunol 1995; 7: 1515.
21. Editorial. Guidance on xenotransplantation sought. Nature Med 1997; 3: 935.
22. Bach FH, Winkler H, Ferran C, Hancock WW, Robson FC. Delayed xenograft rejection. Immunol Today 1996; 17: 379.
23. Lawson JH, Platt, JL. Molecular barriers to xenotransplantation. Transplantation 1996; 62: 303.
24. Inverardi L, Clissi B, Stolzer AL, Bender JR, Sandrin MS, Pardi R. Human natural killer lymphocytes directly recognize evolutionarily conserved oligosaccharide ligands expressed by xenogeneic tissues. Transplantation 1997; 63: 1318.
25. Dorling A, Lombardi G, Binns R, Lechler RI. Detection of primary direct and indirect human anti-porcine T cell responses using a porcine dendritic cell population. Eur J Immunol 1996; 26: 1378.
26. Hart DNJ, Fabre JW. Demonstration and characterization of Ia-positive dendritic cells in the interstitial connective tissues of rat heart and other tissues, but not brain. J Exp Med 1981; 154: 347.
27. Pober JS, Collins T, Gimbrone MA, Libby P, Reiss CS. Inducible expression of class II MHC antigens and the immunogenicity of vascular endothelium. Transplantation 1986; 41: 141.
28. Page C, Thompson C, Yacoub M, Rose M. Human endothelial stimulation of allogeneic T cells via a CTLA-4 independent pathway. Transplant Immunol 1994; 2: 342.
29. Milton AD, Spencer SC, Fabre JW. The effects of cyclosporine on the induction of donor class I and class II MHC antigens in heart and kidney allografts in the rat. Transplantation 1986; 42: 337.
30. Bach FH, Robson SC, Winkler H, Ferran C, Stuhlmeier KM, Wrighton CJ, Hancock WW. Barriers to xenotransplantation. Nature Med 1995; 1: 869.
31. Hatano M, Aizawa S-I, Soejima T, Shigemoto K, Taniguch M, Tokuhisa T. Specific inhibition of class II MHC gene expression by anti-sense RNA. Int Immunol 1989; 1: 260.
32. Martin BK, Chin K-C, Olsen JC, Skinner CA, Dey A, Ozato K, Ting JP-Y. Induction of MHC class I expression by the MHC class II transactivator CIITA. Immunity 1997; 6: 591.
33. Gobin SJP, Peijnenburg A, Keijsers V, van den Elsen PJ. Site α is crucial for two routes of IFN-γ-induced MHC class I transactivation: the ISRE-mediated route and a novel pathway involving CIITA. Immunity 1997; 6: 601.
34. Taylor R. A pig in a poke? Xenotransplants and infectious disease. Nature Med 1995; 1: 728.
35. Sims TN, Elliott JF, Ramassar V, Denney DW Jr, Halloran PF. Mouse class II transactivator: cDNA sequence and amino acid comparison with the human class II transactivator. Immunogenetics 1997; 45: 220.