Cutting edge: Activation of HIV-1 transcription by the MHC class II transactivator

Journal of Immunology

Volumn 164, Issue 8, 2000, Pages 3941-3945

  Saifuddin, Mohammed ^a   Roebuck, Kenneth A ^a   Chang, Cheong hee ^b   Ting, Jenny P Y ^c   Spear, Gregory T ^a  

^a RUSH UNIVERSITY   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN P24; LUCIFERASE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MHC CLASS 2 TRANSACTIVATOR; MUTANT PROTEIN; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; DNA TRANSFECTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; PROVIRUS; REGULATORY MECHANISM; T LYMPHOCYTE SUBPOPULATION; TRANSCRIPTION REGULATION; VIRUS REPLICATION;

EID: 0034655103     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.8.3941     Document Type: Article

References (50)

1. Al-Harthi, L., and K. A. Roebuck. 1998. Human immunodeficiency virus type-1 transcription: role of the 5′-untranslated leader region. Int. J. Mol. Med. 1:875.
2. Gaynor, R. 1992. Cellular transcription factors involved in the regulation of HIV-1 gene expression [published erratum appears in 1992, AIDS 6:following 606]. AIDS 6:347.
3. Roebuck, K. A., and M. Saifuddin. 1999. Regulation of HIV-1 transcription. Gene Expression 8:67.
4. Van Lint, C., C. A. Amella, S. Emiliani, M. John, T. Jie, and E. Verdin. 1997. Transcription factor binding sites downstream of the human immunodeficiency virus type 1 transcription start site are important for virus infectivity. J. Virol. 71:6113.
5. Burley, S. K., and R. G. Roeder. 1996. Biochemistry and structural biology of transcription factor IID (TFIID). Annu. Rev. Biochem. 65:769.
6. Orphanides, G., T. Lagrange, and D. Reinberg. 1996. The general transcription factors of RNA polymerase II. Genes Dev. 10:2657.
7. Benkirane, M., R. F. Chun, H. Xiao, V. V. Ogryzko, B. H. Howard, Y. Nakatani, and K. T. Jeang. 1998. Activation of integrated provirus requires histone acetyltransferase, p300 and P/CAF are coactivators for HIV-1 Tat. J. Biol. Chem. 273: 24898.
8. Hottiger, M. O., and G. J. Nabel. 1998. Interaction of human immunodeficiency virus type I Tat with the transcriptional coactivators p300 and CREB binding protein. J. Virol 72:8252.
9. Marzio, G., M. Tyagi, M. I. Gutierrez, and M. Giacca. 1998. HIV-1 tat transactivator recruits p300 and CREB-binding protein histone acetyltransferases to the viral promoter. Proc. Natl. Acad. Sci. USA 95:13519.
10. Song, C. Z., P. M. Loewenstein, and M. Green. 1994. Transcriptional activation in vitro by the human immunodeficiency virus type 1 Tat protein: evidence for specific interaction with a coactivator(s). Proc. Natl. Acad. Sci. USA 91:9357.
11. Boss, J. M. 1997. Regulation of transcription of MHC class II genes. Curr. Opin. Immunol. 9:107.
12. Mach, B., V. Steimle, E. Martinez-Soria, and W. Reith. 1996. Regulation of MHC class II genes: lessons from a disease. Annu. Rev. Immunol. 14:301.
13. Muhlethaler-Mottet, A., L. A. Otten, V. Steimle, and B. Mach. 1997. Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA. EMBO J. 16:2851.
14. Chang, C. H., and R. A. Flavell. 1995. Class II transactivator regulates the expression of multiple genes involved in antigen presentation. J. Exp. Med. 181: 765.
15. Chin, K. C., C. Mao, C. Skinner, J. L. Riley, K. L. Wright, C. S. Moreno, G. R. Stark. J. M. Boss, and J. P. Ting. 1994. Molecular analysis of G1B and G3A IFN gamma mutants reveals that defects in CIITA or RFX result in defective class II MHC and Ii gene induction. Immunity 1:687.
16. Chin, K. C., G. Li, and J. P. Ting. 1997. Activation and transdominant suppression of MHC class II and HLA-DMB promoters by a series of C-terminal class II transactivator deletion mutants. J. Immunol. 159:2789.
17. Ting, J. P., K. L. Wright, K. C. Chin, W. J. Brickey, and G. Li. 1997. The DMB promoter: delineation, in vivo footprint, trans-activation, and trans-dominant suppression. J. Immunol. 159:5457.
18. Wright, K. L., K. C. Chin, M. Linhoff, C. Skinner, J. A. Brown, J. M. Boss, G. R. Stark, and J. P. Ting. 1998. CIITA stimulation of transcription factor binding to major histocompatibility complex class II and associated promoters in vivo. Proc. Natl. Acad. Sci. USA 95:6267.
19. Steimle, V., L. A. Otten, M. Zufferey, and B. Mach. 1993. Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome). Cell 75:135.
20. Chin, K. C., G. G. Li, and J. P. Ting. 1997. Importance of acidic, proline/serine/ threonine-rich, and GTP-binding regions in the major histocompatibility complex class II transactivalor: generation of transdominant-negative mutants. Proc. Natl. Acad. Sci. USA 94:2501.
21. Riley, J. L., S. D. Westerheide, J. A. Price, J. A. Brown, and J. M. Boss. 1995. Activation of class II MHC genes requires both the X box region and the class II transactivator (CIITA). Immunity 2:533.
22. Zhou, H., and L. H. Glimcher. 1995. Human MHC class II gene transcription directed by the carboxyl terminus of CIITA, one of the defective genes in type II MHC combined immune deficiency. Immunity 2:545.
23. Scholl, T., S. K. Mahanta, and J. L. Strominger. 1997. Specific complex formation between the type II bare lymphocyte syndrome-associated transactivators CIITA and RFX5. Proc. Natl. Acad Sci. USA 94:6330.
24. Reith, W., C. A. Siegrist, B. Durand, E. Barras, and B. Mach. 1994. Function of major histocompatibility complex class II promoters requires cooperative binding between factors RFX and NF-Y. Proc. Natl. Acad. Sci. USA 91:554.
25. Wright, K. L., B. J. Vilen, Y. Itoh-Lindstrom, T. L. Moore, G. Li, M. Criscitiello, P. Cogswell, J. B. Clarke, and J. P. Ting. 1994. CCAAT box binding protein NF-Y facilitates in vivo recruitment of upstream DNA binding transcription factors. EMBO J. 13:4042.
26. Fontes, J. D., B. Jiang, and B. M. Peterlin. 1997. The class II trans-activator CIITA interacts with the TBP-associated factor TAFII32. Nucleic Acids Res. 25:2522.
27. Fontes, J. D., S. Kanazawa, D. Jean, and B. M. Peterlin. 1999. Interactions between the class II transactivator and CREB binding protein increase transcription of major histocompatibility complex class II genes. Mol. Cell Biol. 19:941.
28. Kretsovali, A., T. Agalioti, C. Spilianakis, E. Tzortzakaki, M. Merika, and J. Papamatheakis. 1998. Involvement of CREB binding protein in expression of major histocompatibility complex class II genes via interaction with the class II transactivator. Mol. Cell. Biol. 18:6777.
29. Kwok, R. P., J. R. Lundblad, J. C. Chrivia, J. P. Richards, H. P. Bachinger, R. G. Brennan, S. G. Roberts, M. R. Green, and R. H. Goodman. 1994. Nuclear protein CBP is a coactivator for the transcription factor CREB. Nature 370:223.
30. Ogryzko, V. V., R. L. Schiltz, V. Russanova, B. H. Howard, and Y. Nakatani. 1996. The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell 87:953.
31. Chang, C. H., J. D. Fontes, M. Peterlin, and R. A. Flavell. 1994. Class II transactivator (CIITA) is sufficient for the inducible expression of major histocompatibility complex class II genes. J. Exp. Med. 180:1367.
32. Bontron, S., C. Ucla, B. Mach, and V. Steimle. 1997. Efficient repression of endogenous major histocompatibility complex class II expression through dominant negative CIITA mutants isolated by a functional selection strategy. Mol. Cell. Biol. 17:4249.
33. Saifuddin, M., M. Ghassemi, C. Patki, C. J. Parker, and G. T. Spear. 1994. Host cell components affect the sensitivity of HIV type 1 to complement-mediated virolysis. AIDS Res, Hum. Retroviruses 10:829.
34. Finzi, D., and R. F. Silliciano. 1998. Viral dynamics in HIV-1 infection. Cell 93:665.
35. Wahl, S. M., and J. M. Orenstein. 1997. Immune stimulation and HIV-1 viral replication. J. Leukocyte Biol. 62:67.
36. Chang, C. H., S. C. Hong, C. C. Hughes, C. J. Janeway, and R. A. Flavell. 1995. CIITA activates the expression of MHC class II genes in mouse T cells. Int. Immunol. 7:1515.
37. + T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Nat. Med. 5:512.
38. Moreno, C. S., E. M. Rogers, J. A. Brown, and J. M. Boss. 1997. Regulatory factor X, a bare lymphocyte syndrome transcription factor, is a multimeric phosphoprotein complex. J. Immunol. 158:5841.
39. Westerheide, S. D., P. Louis-Plence, D. Ping, X. F. He, and J. M. Boss. 1997. HLA-DMA and HLA-DMB gene expression functions through the conserved S-X-Y region. J Immunol. 158:4812.
40. Heinemeyer, T., E. Wingender, I. Reuter, H. Hermjakob, A. E. Kel, O. V. Kel. E. V. Ignatieva, E. A. Ananko, O. A. Podkolodnaya, F. A. Kolpakov, et al. 1998. Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL. Nucleic Acids Res. 26:162.
41. Heinemeyer, T., X. Chen. H. Karas, A. E. Kel, O. V. Kel, I. Liebich, T. Meinhardt, I. Reuter, F. Schacherer, and E. Wingender. 1999. Expanding the TRANSFAC database towards an expert system of regulatory molecular mechanisms. Nucleic Acids Res. 27:318.
42. Moreno, C. S., G. W. Beresford, P. Louis-Plence, A. C. Morris, and J. M. Boss. 1999. CREB regulates MHC class II expression in a CIITA-dependent manner. Immunity 10:143.
43. Rabbi, M. F., M. Saifuddin, D. S. Gu, M. F. Kagnoff, and K. A. Roebuck. 1997. U5 region of the human immunodeficiency virus type I long terminal repeat contains TRE-like cAMP-responsive elements that bind both AP-I and CREB/ ATF proteins. Virology 233:235.
44. Rabbi, M. F., L. al-Harthi, M. Saifuddin, and K. A. Roebuck. 1998. The cAMP-dependent protein kinase A and protein kinase C-β pathways synergistically interact to activate HIV-I transcription in latently infected cells of monocyte/macrophage lineage. Virology 245:257.
45. Chrivia, J. C., R. P. Kwok, N. Lamb, M. Hagiwara, M. R. Montminy, and R. H. Goodman. 1993. Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 365:855.
46. Abraham, S. E., S. Lobo, P. Yaciuk, H. G. Wang, and E. Moran. 1993. p300, and p300-associated proteins, are components of TATA-binding protein (TBP) complexes. Oncogene 8:1639.
47. Dallas, P. B., P. Yaciuk, and E. Moran. 1997. Characterization of monoclonal antibodies raised against p300: both p300 and CBP are present in intracellular TBP complexes. J. Virol. 71:1726.
48. el Kharroubi, A., and M. A. Martin. 1996. Cis-acting sequences located downstream of the human immunodeficiency virus type 1 promoter affect its chromatin structure and transcriptional activity. Mol. Cell. Biol. 16:2958.
49. Sheridan, P. L., T. P. Mayall, E. Verdin, and K. A. Jones. 1997. Histone acetyltransferases regulate HIV-1 enhancer activity in vitro. Genes Dev. 11:3327.
50. Van Lint, C., S. Emiliani, M. Ott, and E. Verdin. 1996. Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation. EMBO J. 15:1112.