메뉴 건너뛰기




Volumn 285, Issue 5432, 1999, Pages 1402-1408

GTP binding by class II transactivator: Role in nuclear import

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; HLA D ANTIGEN; TRANSACTIVATOR PROTEIN;

EID: 0033610093     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.285.5432.1402     Document Type: Article
Times cited : (86)

References (55)
  • 2
    • 0028535402 scopus 로고
    • V. Steimle, C. A. Siegrist, A. Mottet, B. Lisowska- Grospierre, B. Mach, Science 265, 106 (1994); K.-C. Chin et al., Immunity 1, 687 (1994); C. H. Chang and R. A. Flavell, J. Exp. Med. 181, 765 (1995).
    • (1994) Immunity , vol.1 , pp. 687
    • Chin, K.-C.1
  • 3
    • 0028924986 scopus 로고
    • V. Steimle, C. A. Siegrist, A. Mottet, B. Lisowska- Grospierre, B. Mach, Science 265, 106 (1994); K.-C. Chin et al., Immunity 1, 687 (1994); C. H. Chang and R. A. Flavell, J. Exp. Med. 181, 765 (1995).
    • (1995) J. Exp. Med. , vol.181 , pp. 765
    • Chang, C.H.1    Flavell, R.A.2
  • 7
    • 0345688356 scopus 로고    scopus 로고
    • J. L. Riley, S. D. Westerheide, J. A. Price, J. A. Brown, J. M. Boss, ibid. 2, 533 (1995); H. Zhou and L. H. Glimcher, ibid., p. 545.
    • Immunity , pp. 545
    • Zhou, H.1    Glimcher, L.H.2
  • 8
    • 0030924770 scopus 로고    scopus 로고
    • T. Scholl, S. K. Mahanta, J. L. Strominger, Proc. Natl. Acad. Sci. U.S.A. 94, 6330 (1997); S. K. Mahanta, T. Scholl, F. C. Yang, J. L. Strominger, ibid. p. 6324; J. D. Fontes, N. Jabrane-Ferrat, C. R. Toth, B. M. Petertin, J. Exp. Med. 183, 2517 (1996); A. Kretsovali et al., Mol. Cell Biol. 18, 6777 (1998); J. D. Fontes, S. Kanazawa, D. Jean, B. M. Peterlin, ibid. 19, 941 (1999).
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 6330
    • Scholl, T.1    Mahanta, S.K.2    Strominger, J.L.3
  • 9
    • 0030987367 scopus 로고    scopus 로고
    • T. Scholl, S. K. Mahanta, J. L. Strominger, Proc. Natl. Acad. Sci. U.S.A. 94, 6330 (1997); S. K. Mahanta, T. Scholl, F. C. Yang, J. L. Strominger, ibid. p. 6324; J. D. Fontes, N. Jabrane-Ferrat, C. R. Toth, B. M. Petertin, J. Exp. Med. 183, 2517 (1996); A. Kretsovali et al., Mol. Cell Biol. 18, 6777 (1998); J. D. Fontes, S. Kanazawa, D. Jean, B. M. Peterlin, ibid. 19, 941 (1999).
    • Proc. Natl. Acad. Sci. U.S.A. , pp. 6324
    • Mahanta, S.K.1    Scholl, T.2    Yang, F.C.3    Strominger, J.L.4
  • 10
    • 0030008916 scopus 로고    scopus 로고
    • T. Scholl, S. K. Mahanta, J. L. Strominger, Proc. Natl. Acad. Sci. U.S.A. 94, 6330 (1997); S. K. Mahanta, T. Scholl, F. C. Yang, J. L. Strominger, ibid. p. 6324; J. D. Fontes, N. Jabrane-Ferrat, C. R. Toth, B. M. Petertin, J. Exp. Med. 183, 2517 (1996); A. Kretsovali et al., Mol. Cell Biol. 18, 6777 (1998); J. D. Fontes, S. Kanazawa, D. Jean, B. M. Peterlin, ibid. 19, 941 (1999).
    • (1996) J. Exp. Med. , vol.183 , pp. 2517
    • Fontes, J.D.1    Jabrane-Ferrat, N.2    Toth, C.R.3    Petertin, B.M.4
  • 11
    • 0031773473 scopus 로고    scopus 로고
    • T. Scholl, S. K. Mahanta, J. L. Strominger, Proc. Natl. Acad. Sci. U.S.A. 94, 6330 (1997); S. K. Mahanta, T. Scholl, F. C. Yang, J. L. Strominger, ibid. p. 6324; J. D. Fontes, N. Jabrane-Ferrat, C. R. Toth, B. M. Petertin, J. Exp. Med. 183, 2517 (1996); A. Kretsovali et al., Mol. Cell Biol. 18, 6777 (1998); J. D. Fontes, S. Kanazawa, D. Jean, B. M. Peterlin, ibid. 19, 941 (1999).
    • (1998) Mol. Cell Biol. , vol.18 , pp. 6777
    • Kretsovali, A.1
  • 12
    • 0032937881 scopus 로고    scopus 로고
    • T. Scholl, S. K. Mahanta, J. L. Strominger, Proc. Natl. Acad. Sci. U.S.A. 94, 6330 (1997); S. K. Mahanta, T. Scholl, F. C. Yang, J. L. Strominger, ibid. p. 6324; J. D. Fontes, N. Jabrane-Ferrat, C. R. Toth, B. M. Petertin, J. Exp. Med. 183, 2517 (1996); A. Kretsovali et al., Mol. Cell Biol. 18, 6777 (1998); J. D. Fontes, S. Kanazawa, D. Jean, B. M. Peterlin, ibid. 19, 941 (1999).
    • (1999) Mol. Cell Biol. , vol.19 , pp. 941
    • Fontes, J.D.1    Kanazawa, S.2    Jean, D.3    Peterlin, B.M.4
  • 13
    • 0345688353 scopus 로고    scopus 로고
    • note
    • Abbreviations for amino acid residues are as follows: A, Ala; C, Cys; D, Asp; E, Glu; F, Phe; G, Gly; H, His; I, Ile; K, Lys; L, Leu; M, Met; N, Asn; P, Pro; Q, Gln; R, Arg; S, Ser; T, Thr; V, Val; W, Trp; X, any or other Y, Tyr.
  • 15
    • 0026026818 scopus 로고
    • H. R. Bourne, D. A. Sanders, F. McCormick, Nature 349, 117 (1991); T. E. Dever, M. J. Glynias, W. C. Merrick, Proc. Natl. Acad. Sci. U.S.A. 84, 1814 (1987).
    • (1991) Nature , vol.349 , pp. 117
    • Bourne, H.R.1    Sanders, D.A.2    McCormick, F.3
  • 17
    • 0023619575 scopus 로고
    • M. Trahey and F. McCormick, Science 238, 542 (1987); A. Wolfman and I. G. Macara, ibid. 248, 67 (1990).
    • (1987) Science , vol.238 , pp. 542
    • Trahey, M.1    McCormick, F.2
  • 18
    • 0025277948 scopus 로고
    • M. Trahey and F. McCormick, Science 238, 542 (1987); A. Wolfman and I. G. Macara, ibid. 248, 67 (1990).
    • (1990) Science , vol.248 , pp. 67
    • Wolfman, A.1    Macara, I.G.2
  • 19
    • 0029894664 scopus 로고    scopus 로고
    • R. Foster et al., Mol. Cell Biol. 16, 2689 (1996); L. A. Quilliam et al., ibid. 10, 2901 (1990); P. A. Hart and C. J. Marshall, Oncogene 5, 1099 (1990).
    • (1996) Mol. Cell Biol. , vol.16 , pp. 2689
    • Foster, R.1
  • 20
    • 0025287398 scopus 로고
    • R. Foster et al., Mol. Cell Biol. 16, 2689 (1996); L. A. Quilliam et al., ibid. 10, 2901 (1990); P. A. Hart and C. J. Marshall, Oncogene 5, 1099 (1990).
    • (1990) Mol. Cell Biol. , vol.10 , pp. 2901
    • Quilliam, L.A.1
  • 21
    • 0025362712 scopus 로고
    • R. Foster et al., Mol. Cell Biol. 16, 2689 (1996); L. A. Quilliam et al., ibid. 10, 2901 (1990); P. A. Hart and C. J. Marshall, Oncogene 5, 1099 (1990).
    • (1990) Oncogene , vol.5 , pp. 1099
    • Hart, P.A.1    Marshall, C.J.2
  • 22
    • 0032489841 scopus 로고    scopus 로고
    • C. D. Nobes et al., J. Cell Biol. 141, 187 (1998); R. M. Guasch, P. Scambler, G. E. Jones, A. J. Ridley, Mol. Cell. Biol. 18, 4761 (1998).
    • (1998) J. Cell Biol. , vol.141 , pp. 187
    • Nobes, C.D.1
  • 24
    • 0027232605 scopus 로고
    • G. M. Bokoch and C. J. Der, FASEB J. 7, 750 (1993); M. S. Moore and G. Blobel, Nature 365, 661 (1993); C. D. Nobes and A. Hall, Cell 81, 53 (1995).
    • (1993) FASEB J. , vol.7 , pp. 750
    • Bokoch, G.M.1    Der, C.J.2
  • 25
    • 0027376308 scopus 로고
    • G. M. Bokoch and C. J. Der, FASEB J. 7, 750 (1993); M. S. Moore and G. Blobel, Nature 365, 661 (1993); C. D. Nobes and A. Hall, Cell 81, 53 (1995).
    • (1993) Nature , vol.365 , pp. 661
    • Moore, M.S.1    Blobel, G.2
  • 26
    • 0028961293 scopus 로고
    • G. M. Bokoch and C. J. Der, FASEB J. 7, 750 (1993); M. S. Moore and G. Blobel, Nature 365, 661 (1993); C. D. Nobes and A. Hall, Cell 81, 53 (1995).
    • (1995) Cell , vol.81 , pp. 53
    • Nobes, C.D.1    Hall, A.2
  • 29
    • 0344393927 scopus 로고    scopus 로고
    • unpublished material
    • J. A. Harton, unpublished material.
    • Harton, J.A.1
  • 31
    • 0028960178 scopus 로고
    • J. M. Zhong, M. C. Chen-Hwang, Y. W. Hwang, J. Biol. Chem. 270, 10002 (1995); B. Yu, V. Z. Slepak, M. I. Simon, ibid. 272, 18015 (1997); I. S. Sigal et al., Proc. Natl. Acad. Sci. U.S.A. 83, 952 (1986).
    • (1995) J. Biol. Chem. , vol.270 , pp. 10002
    • Zhong, J.M.1    Chen-Hwang, M.C.2    Hwang, Y.W.3
  • 32
    • 0030610571 scopus 로고    scopus 로고
    • J. M. Zhong, M. C. Chen-Hwang, Y. W. Hwang, J. Biol. Chem. 270, 10002 (1995); B. Yu, V. Z. Slepak, M. I. Simon, ibid. 272, 18015 (1997); I. S. Sigal et al., Proc. Natl. Acad. Sci. U.S.A. 83, 952 (1986).
    • (1997) J. Biol. Chem. , vol.272 , pp. 18015
    • Yu, B.1    Slepak, V.Z.2    Simon, M.I.3
  • 33
    • 0345168377 scopus 로고
    • J. M. Zhong, M. C. Chen-Hwang, Y. W. Hwang, J. Biol. Chem. 270, 10002 (1995); B. Yu, V. Z. Slepak, M. I. Simon, ibid. 272, 18015 (1997); I. S. Sigal et al., Proc. Natl. Acad. Sci. U.S.A. 83, 952 (1986).
    • (1986) Proc. Natl. Acad. Sci. U.S.A. , vol.83 , pp. 952
    • Sigal, I.S.1
  • 34
    • 0344825518 scopus 로고    scopus 로고
    • All mutants used in this report were sequenced to verify the intended mutation. Immunoblottingwas performed to verify that expression of these constructs was comparable to that of wild-type CIITA expressing transfectants (available as supplementary material at www. sciencemag.org/feature/data/103790e.shl).
  • 35
    • 0345256794 scopus 로고    scopus 로고
    • unpublished material
    • J. A. Harton, unpublished material.
    • Harton, J.A.1
  • 37
    • 0032502681 scopus 로고    scopus 로고
    • S. Atherton-Fessler, L. L. Parker, R. L. Geahlen, H. Piwnica-Worms, Mol. Cell Biol. 13, 1675 (1993); S. Ramaswamy and P. Kaur, J. Biol. Chem. 273, 9243 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 9243
    • Ramaswamy, S.1    Kaur, P.2
  • 38
    • 0344393928 scopus 로고    scopus 로고
    • These data are available as a supplementary figure at www.sciencemag.org/feature/data/1037908.shl.
  • 39
    • 0345688349 scopus 로고    scopus 로고
    • unpublished material
    • J. A. Harton, unpublished material.
    • Harton, J.A.1
  • 41
    • 0022471217 scopus 로고
    • C. J. Der, T. Finkel, C. M. Cooper, Cell 44, 167 (1986); F. R. Bischoff, C. Klebe, J. Kretschmer, A. Wittinghofer, H. Ponstingl, Proc. Natl. Acad. Sci. U.S.A. 91, 2587 (1994); C. A. Landis et al., Nature 340, 592 (1989).
    • (1986) Cell , vol.44 , pp. 167
    • Der, C.J.1    Finkel, T.2    Cooper, C.M.3
  • 43
    • 0022471217 scopus 로고
    • C. J. Der, T. Finkel, C. M. Cooper, Cell 44, 167 (1986); F. R. Bischoff, C. Klebe, J. Kretschmer, A. Wittinghofer, H. Ponstingl, Proc. Natl. Acad. Sci. U.S.A. 91, 2587 (1994); C. A. Landis et al., Nature 340, 592 (1989).
    • (1989) Nature , vol.340 , pp. 592
    • Landis, C.A.1
  • 49
    • 0023408705 scopus 로고
    • J. J. Gu, J. Spychala, B. S. Mitchell, J. Biol. Chem. 272, 4458 (1997); F. R. Collart and E. Huberman, Mol. Cell. Biol. 7, 3328 (1987).
    • (1987) Mol. Cell. Biol. , vol.7 , pp. 3328
    • Collart, F.R.1    Huberman, E.2
  • 52
    • 0028055116 scopus 로고
    • C. L. Peterson, A. Dingwall, M. P. Scott, Proc. Natl. Acad. Sci. U.S.A. 91, 2905 (1994); T. Tsukiyama, P. B. Becker, C. Wu, Nature 367, 525 (1994).
    • (1994) Nature , vol.367 , pp. 525
    • Tsukiyama, T.1    Becker, P.B.2    Wu, C.3
  • 53
    • 0029100197 scopus 로고
    • 32P]GTP was assayed on a scintillation counter. For GTPase assays, IPs were prepared as described above and tested for GTPase activity with CIITAs incubated at 37°C as the only modification.
    • (1995) Methods Enzymol. , vol.255 , pp. 110
    • Downward, J.1
  • 54
    • 0031930873 scopus 로고    scopus 로고
    • 2 and protease inhibitors. NF-YA, CIITA, and G3 constructs were immunoprecipitated with anti-FLAG(M2) and Ras was immunoprecipitated with anti-Ras. Elution and thin-layer chromatography (TLC) were performed as described by Overmeyer et at. The results were quantitated by phosphoimage analysis, and background counts were subtracted. The differences in the molecular weights of molecules were normalized to NF-Y.
    • (1998) Mol. Biol. Cell , vol.9 , pp. 223
    • Overmeyer, J.H.1    Wilson, A.L.2    Erdman, R.A.3    Maltese, W.A.4
  • 55
    • 0345688344 scopus 로고    scopus 로고
    • note
    • Supported by grants from the National Institutes of Health (NIH) (Al45580, Al41751, and Al29564 to J.P.-Y.T.; CA42978 to C.J.D.), the National Multiple Sclerosis Society (7815 to J.P.-Y.T.), and NIH training grants (D.E.C. and J.A.H.). D.E.C. is supported by an NIH postdoctoral fellowship. J.A.H. is supported by a postdoctoral fellowship from the American Cancer Society. We thank A. Cox, S. Campbell, and L. Quilliam for helpful advice.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.