Transcriptional synergy between LIM-homeodomain proteins and basic helix-loop-helix proteins: The LIM2 domain determines specificity

Molecular and Cellular Biology

Volumn 17, Issue 7, 1997, Pages 3488-3496

  Johnson, Jeffrey D ^a   Zhang, Wengang ^a   Rudnick, Abraham ^a   Rutter, William J ^a   German, Michael S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HELIX LOOP HELIX PROTEIN;

ARTICLE; CELL DIFFERENTIATION; COMPLEX FORMATION; ENZYME SPECIFICITY; FIBROBLAST; GENE CLUSTER; GENETIC TRANSFECTION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; STEM CELL; TRANSCRIPTION REGULATION;

VERTEBRATA;

EID: 0031011850     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.17.7.3488     Document Type: Article

References (42)

1. Arber, S., and P. Caroni. 1996. Specificity of single LIM motifs in targeting and LIM/LIM interactions in situ. Genes Dev. 10:289-300.
2. Archer, V. E. V., J. Breton, I. Sanchez-Garcia, H. Osada, A. Forster, A. J. Thomson, and T. H. Rabbitts. 1994. Cysteine-rich LIM domains of LIM-homeodomain and LIM-only proteins contain zinc but not iron. Proc. Natl. Acad. Sci. USA 91:316-320.
3. Bach, I., S. J. Rhodes, R. V. N. Pearse, T. Heinzel, B. Gloss, K. M. Scully, P. E. Sawchenko, and M. G. Rosenfeld. 1995. P-Lim, a LIM homeodomain factor, is expressed during pituitary organ and cell commitment and synergizes with Pit-1. Proc. Natl. Acad. Sci. USA 92:2720-2724.
4. Chan, S. K., L. Jaffe, M. Capovilla, J. Botas, and R. S. Mann. 1994. The DNA binding specificity of Ultrabithorax is modulated by cooperative interactions with extradenticle, another homeoprotein. Cell 78:603-615.
5. Church, D. M., C. J. Stotler, J. L. Rutter, J. R. Murrell, J. A. Trofatter, and A. J. Buckler. 1994. Isolation of genes from complex sources of mammalian genomic DNA using exon amplification. Nat. Genet. 6:98-105.
6. Dawid, I. B., R. Toyama, and M. Taira. 1995. LIM domain proteins. C. R. Acad. Sci. III 318:295-306.
7. deWet, J., K. V. Wood, M. DeLuca, D. R. Helsinki, and S. Subramani. 1987. Firefly luciferase gene: structure and expression in mammalian cells. Mol. Cell. Biol. 7:725-737.
8. Edman, J. C. 1992. Isolation of telomerelike sequences from Cryptococcus neoformans and their use in high-efficiency transformation. Mol. Cell. Biol. 12:2777-2783.
9. Emens, L. A., D. W. Landers, and L. G. Moss. 1992. Hepatocyte nuclear factor 1-a is expressed in a hamster insulinoma line and transactivates the rat insulin-1 gene. Proc. Natl. Acad. Sci. USA 89:7300-7304.
10. Feuerstein, R., X. Wang, D. Song, N. E. Cooke, and S. A. Liebhaber. 1994. The LIM/double zinc-finger motif functions as a protein dimerization domain. Proc. Natl. Acad. Sci. USA 91:10655-10659.
11. Fields, S., and O. Song. 1989. A novel genetic system to detect protein-protein interactions. Nature 340:245-246.
12. Freyd, G., S. K. Kim, and H. R. Horvitz. 1990. Novel cystein-rich motif and homeodomain in the product of the Caenorhabditis elegans cell lineage gene lin-11. Nature 344:876-879.
13. German, M., J. Wang, A. Fernald, R. Espinosa, M. LeBeau, and G. Bell. 1994. Localization of the genes encoding two transcription factors, lmx-1 and cdx-3, regulating insulin gene expression to human chromosomes 1 and 13. Genomics 24:403-404.
14. German, M. S., L. G. Moss, J. H. Wang and W. J. Rutter. 1992. The insulin and islet amyloid polypeptide genes contain similar cell-specific promoter elements that bind identical β-cell nuclear complexes. Mol. Cell. Biol. 12: 1777-1788.
15. German, M. S., M. A. Blanar, C. Nelson, L. G. Moss, and W. J. Rutter. 1991. Two related helix-loop-helix proteins participate in separate cell-specific complexes that bind to the insulin enhancer. Mol. Endocrinol. 5:292-299.
16. German, M. S., J. Wang, R. B. Chadwick, and W. J. Rutter. 1992. Synergistic activation of the insulin gene by a LIM-homeodomain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complex. Genes Dev. 6:2165-2176.
17. Guillemot, D., L.-X. Lo, J. E. Johnson, A. Auerbach, D. J. Anderson, and A. L. Joyner. 1993. Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons. Cell 75:463-476.
18. Herr, W. 1992. Mechanisms of eukaryotic transcription, p. 1103-1135. In S. McKnight and K. Yamamoto (ed.), Transcriptional regulation. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
19. Iannotti, C. A., H. Inoue, E. Bernal, M. Aoki, Y. Tanizawa, L. Lium, H. Donis-Keller, M. S. German and M. A. Permutt. Human LMX1-related gene, LMX1B/LMX1.2: tissue-specific expression and lineage mapping on chromosome 9. Genomics, in press.
20. 19a.Johnson, J. D., H. Odagiri, and M. S. German. Unpublished data.
21. Karlsson, O., T. Edlund, J. B. Moss, W. J. Rutter, and M. D. Walker. 1987. A mutational analysis of the insulin gene transcription control region: expression in β-cells is dependent on two related sequences within the enhancer. Proc. Natl. Acad. Sci. USA 84:8819-8823.
22. Larson, R. C., I. Lavenir, T. A. Larson, R. Baer, A. J. Warren, I. Wadman, K. Nottage, and T. H. Rabbitts. 1996. Protein dimerization between Lmo2 (Rbtn2) and Tall alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice. EMBO J. 15:1021-1027.
23. Lundgren, S. E., C. A. Callahan, S. Thor, and J. B. Thomas. 1995. Control of neuronal pathway selection by the Drosophila LIM homeodomain gene apterous. Development 121:1769-1773.
24. McGinnis, W., and R. Krumlauf. 1992. Homeobox genes and axial patterning. Cell 68:283-302.
25. Miller, J. H. 1972. Experiments in molecular genetics. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
26. Peers, B., J. Leonard, S. Sharma, G. Teitelman, and M. R. Montminy. 1994. Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1. Mol. Endocrinol. 8:1798-1806.
27. Perez-Alvarado, G. C., C. Miles, J. W. Michelsen, H. A. Louis, D. R. Winge, M. C. Beckerle, and M. F. Summers. 1994. Structure of the carboxy-terminal LIM domain from the cysteine rich protein CRP. Nat. Struct. Biol. 1:388-398.
28. Pfaff, S. L., M. Mendelsohn, C. L. Stewart, T. Edlund, and T. M. Jessell. 1996. Requirement for LIM homeohox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation. Cell 84:309-320.
29. Riddle, R. D., M. Ensini, C. Nelson, T. Tsuchida, T. M. Jessell, and C. Tabin. 1995. Induction of the LIM homeohox gene Lmx1 by WNT7a establishes dorsoventral pattern in the vertebrate limb. Cell 83:631-640.
30. Schmeichel, K. L., and M. C. Beckerle. 1994. The LIM domain is a modular protein-binding interface. Cell 79:211-219.
31. Shawlot, W., and R. R. Behringer. 1995. Requirement for Lim1 in head-organizer function. Nature 374:425-430.
32. Sheng, H. Z., A. B. Zhadanov, B. Mosinger, Jr., T. Fujii, S. Bertuzzi, A. Grinberg, E. J. Lee, S.-P. Huang, K. A. Mahon, and H. Westphal. 1996. Specification of pituitary cell lineages by the LIM homeobox gene Lhx3. Science 272:1004-1007.
33. Taira, M., H. Otani, J. P. Saint-Jeannet, and I. B. Dawid. 1994. Role of the LIM class homeodomain protein Xlim-1 in neural and muscle induction by the Spemann organizer in Xenopus. Nature 372:677-679.
34. Treisman, R. 1994. Ternary complex factors: growth factor regulated transcriptional activators. Curr. Opin. Genet. Dev. 4:96-101.
35. Tsuchida, T., M. Ensini, S. B. Morton, M. Baldassare, T. Edlund, T. M. Jessell, and S. L. Pfaff. 1994. Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes. Cell 79:957-970.
36. Valge-Archer, V. E., H. Osada, A. J. Warren, A. Forster, J. Li, R. Baer, and T. H. Rabbitts. 1994. The LIM protein RBTN2 and the basic helix-loop-hela protein TALI are present in a complex in erythroid cells. Proc. Natl. Acad. Sci. USA 91:8617-8621.
37. Vogel, A., C. Rodriguez, W. Warnken, and J. C. Izpisua Belmonte. 1995. Dorsal cell fate specified by chick Lmx1 during vertebrate limb development. Nature 378:716-720.
38. Wadman, I., J. Li, R. O. Bash, A. Forster, H. Osada, T. H. Rabbitts, and R. Baer. 1994. Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia. EMBO J. 13:4831-4839.
39. Warren, A. J., W. H. Colledge, M. B. Carlton, M. J. Evans, A. J. Smith, and T. H. Rabbitts. 1994. The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development. Cell 78:45-57.
40. Way, J. C., and M. Chalfie. 1988. mec-3, a homeobox-containing gene that specifies differentiation of the touch receptor neurons in C. elegans. Cell 54:5-16.
41. Yamagata, K., N. Oda, P. J. Kaisaki, S. Menzel, H. Furuta, M. Vaxillaire, L. Southam, R. D. Cox, G. M. Lathrop, V. V. Boriraj, X. Chen, N. J. Cox, Y. Oda, H. Yano, M. M. LeBeau, S. Yamada, H. Nishigori, J. Takeda, S. S. Fajans, A. T. Hattersley, N. Iwasaki, T. Hansen, O. Pederson, K. S. Polonsky, R. C. Turner, G. Velho, J.-C. Chevre, P. Froguel, and G. I. Bell. 1996. Mutations in the hepatocyte nuclear factor-1a gene in maturity-onset diabetes of the young (MODY3). Nature 384:455-458.
42. Zhang, W. Unpublished data.