Regulation of neutrophil apoptosis: A role for protein kinase C and phosphatidylinositol-3-kinase

Apoptosis

Volumn 5, Issue 5, 2000, Pages 451-458

  Webb, P R ^a   Wang, K Q ^a   Scheel Toellner, D ^a   Pongracz, J ^a   Salmon, M ^a   Lord, J M ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Apoptosis; Inflammation; Neutrophil; PI 3 kinase; PKC; T cell

Indexed keywords

CASPASE; FAS ANTIGEN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN KINASE C;

APOPTOSIS; ARTICLE; HUMAN; NEUTROPHIL; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; CYTOKINES; HUMANS; INFLAMMATION; NEUTROPHILS; PROTEIN KINASE C;

BACTERIA (MICROORGANISMS);

EID: 0034469271     PISSN: 13608185     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1009601220552     Document Type: Article

References (73)

1. Macrophage phagocytosis of aging neutrophils in inflammation
2. Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis
3. Resolution of acute inflammation and the role of apoptosis in the tissue fate of granulocytes
4. Type 1 interferons inhibit the resolution of chronic inflammation
5. The function and fate of neutrophils at the inflamed site: Prospects for therapeutic intervention
6. Seeing the wood for the trees: The forgotten role of neutrophils in rheumatoid arthritis
7. Isoenzymes of protein kinase C: Differential involvement in apoptosis and pathogenesis
8. PKB/Akt: Connecting phosphoinositide 3-kinase to cell survival and beyond
9. Involvement of reactive oxygen intermediates in spontaneous and CD95 (Fas/APO-1) - Mediated apoptosis of neutrophils
10. Neutrophil superoxide release is required for spontaneous and fMLP mediated but not TNF-alpha mediated apoptosis
11. Regulation of apoptosis of neutrophils - Fas track to death?
12. The expression of genes modulating programmed cell death in normal human polymorphonuclear neutrophils
13. Differential expression of bcl-2 and susceptibility to anti-Fas-mediated cell death in peripheral blood lymphocytes, monocytes and neutrophils
14. Mcl-1 expression in human neutrophils: Regulation by cytokines and correlation with cell survival
15. Spontaneous neutrophil apoptosis involves caspase 3 mediated activation of PKC-δ
16. Caspase-mediated proteolysis and activation of protein kinase C delta plays a central role in neutrophil apoptosis
17. Phagocytosis triggers macrophage release of Fas ligand and induces apoptosis of bystander leukocytes
18. Fas ligand (gld) and Fas (lpr) deficient mice do not show alterations in the extravasation or apoptosis of inflammatory neutrophils
19. Co-ordinated down regulation of bcl-2 and bax expression during granulocytic and macrophage-like differentiation of HL60 promyelocytic leukaemia cell line
20. A1 is a constitutive and inducible Bcl-2 homologue in mature human neutrophils
21. Analysis of the Bak protein expression in human polymorphonuclear neutrophils
22. Immunoblot analysis of the cellular expression of the Bcl-2 family proteins, Bcl-2, Bax, Bcl-X and Mcl-1, in human neutrophils
23. Accelerated neutrophil apoptosis in mice lacking A1-a, a subtype of the bcl-2 related A1 gene
24. Cytochrome c and dATP-dependent formation of Apaf-1/caspase 9 complex initiates the apoptotic protease cascade
25. Two CD95 (APO-1/Fas) signaling pathways
26. Mitochondria and apoptosis
27. Mammalian capases: Structure, activation, substrates and functions during apoptosis
28. Involvement of caspase 9 in constitutive neutrophil (PMN) programmed cell death (apoptosis)
29. Caspases mediate tumor necrosis factor alpha-induced neutrophil apoptosis and down regulation of reactive oxygen production
30. p38 mitogen-activated protein kinase-dependent and -independent intracellular signal transduction pathways leading to apoptosis in human neutrophils
31. Delayed neutrophil apoptosis is associated with increased mitochondrial membrane potential and preservation of cytochrome c in experimental and clinical sepsis
32. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C
33. Protein kinase C theta cooperates with calcineurin to induce fas ligand expression during activation induced T cell death
34. Vav regulates peptide-specific apoptosis in thymocytes
35. Ceramide inactivates cellular protein kinase C alpha
36. Apoptosis is induced in glioma cells by antisense oligonucleotides to protein kinase C alpha and is enhanced by cycloheximide
37. Loss of protein kinase C function induces an apoptotic response
38. Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A
39. Cleavage of ζPKC but not λ/ιPKC by caspase 3 during uv-induced apoptosis
40. Proteolytic activation of protein kinase C δ by an ICE-like protease in apoptotic cells
41. Proteolytic activation of protein kinase C delta by an ICE/CED3-like protease induces characteristics of apoptosis
42. Caspase 3 mediated cleavage of protein kinase C theta during induction apoptosis
43. Protein kinase C isotypes and signal transduction in human neutrophils - Selective substrate specificity of calcium-dependent beta PKC and novel calcium independent nPKC
44. Immunochemical identification and translocation of protein kinase C zeta in human neutrophils
45. The activation of the neutrophil respiratory burst by anti-neutrophil cytoplasmic autoantibody (ANCA) from patients with systemic vasculitis requires tyrosine kinases and protein kinase C activation
46. Superoxide production in human neutrophils: Evidence for signal redundancy and the involvement of more than one PKC isoenzyme class
47. Inhibition of T-cell apoptosis by IFN-β rapidly reverses nuclear translocation of protein kinase C-δ
48. Inactivation of DNA-dependent protein kinase by protein kinase C-δ: Implications for apoptosis
49. Protein kinase C-δ is an apoptotic lamin kinase
50. Protein kinase C delta targets the mitochondria, alters mitochondrial membrane potential, and induces apoptosis in normal and neoplastic keratinocytes when overexpressed by an adenoviral vector
51. Inhibition of apoptosis and prolongation of neutrophil functional longevity by inflammatory mediators
52. Sodium butyrate delays neutrophil apoptosis: Role of protein biosynthesis in neutrophil survival
53. Prolongation of survival of human polymorphonuclear neutrophils by granulocyte-macrophage colony stimulating factor is caused by inhibition of programmed cell death
54. Interleukin-6 suppression of neutrophil apoptosis is neutrophil concentration dependent
55. CXC chemokine suppression of polymorphonuclear leukocytes apoptosis and preservation of function is oxidative stress independent
56. Molecular physiology of granulocyte-macrophage colony stimulating factor
57. Interferon-β mediates stromal cell rescue of T cells from apoptosis
58. Mechanisms and consequences of activation of protein kinase B/Akt
59. The PI3K-PDK1 connection: More than just a road to PKB
60. Protein kinase B (c-Akt): A multi functional mediator of phosphatidylinositol 3-kinase activation
61. AKT phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
62. Regulation of cell death protease caspase 9 by phosphorylation
63. Akt is more than just a Bad kinase
64. NF-κ B is a target in antiapoptotic PDGF signaling
65. NF-κ B antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase 8 activation
66. Akt/protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria
67. NF-κ B activation is a critical regulator of human granulocyte apoptosis in vitro
68. G-protein coupled receptors and Fc gamma receptors mediate activation of Akt protein kinase B in human neutrophils
69. Granulocyte-macrophage colony stimulating factor and IL-5 activated mitogen-activated protein kinase through Jak2 and phosphatidylinositol 3-kinase in human eosinophils
70. STAT3 as an adaptor to couple phosphatidylinositol-3-kinase to the IFNAR1 chain of the type 1 interferon receptor
71. Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1
72. Neutrophil mediated injury to endothelial cells: Enhancement by endotoxin and essential role of neutrophil elastase