Caspases mediate tumor necrosis factor-α-induced neutrophil apoptosis and downregulation of reactive oxygen production

Blood

Volumn 93, Issue 2, 1999, Pages 674-685

  Yamashita, Kouhei ^b   Takahashi, Atsushi ^a   Kobayashi, Susumu ^b   Hirata, Hirokazu ^b   Mesner Jr , Peter W ^b   Kaufmann, Scott H ^b   Yonehara, Shin ^b   Yamamoto, Kokichi ^b   Uchiyama, Takashi ^b   Sasada, Masataka ^b  

^a KYOTO UNIVERSITY   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CASPASE 3; CASPASE 6; CASPASE 7; CASPASE 8; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; INFLAMMATORY DISEASE; NEUTROPHIL; PRIORITY JOURNAL; WESTERN BLOTTING;

EID: 0033556157     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v93.2.674.402k26_674_685     Document Type: Article

References (81)

1. Fong Y, Tracey KJ, Moldawer LL, Hesse DG, Manogue KB, Kenney JS, Lee AT, Kuo GC, Allison AC, Lowry SF, Cerami A: Antibodies to cachectin/tumor necrosis factor reduce interleukin 1β and interleukin 6 appearance during lethal bacteremia. J Exp Med 170:1627, 1989
2. Feldmann M, Brennan FM, Maini RN: Rheumatoid arthritis. Cell 85:307, 1996
3. Mege JL, Dilsen N, Sanguedolce V, Gul A, Bongrand P, Roux H, Ocal L, Inanc M, Capo C: Overproduction of monocyte derived tumor necrosis factor alpha, interleukin (IL) 6, IL-8 and increased neutrophil superoxide generation in Behcet's disease. A comparative study with familial Mediterranean fever and healthy subjects. J Rheumatol 20: 1544, 1993
4. Miller EJ, Cohen AB, Nagao S, Griffith D, Maunder RJ, Martin TR, Weiner KJ, Sticherling M, Christophers E, Matthay MA: Elevated levels of NAP-1/interleukin-8 are present in the airspaces of patients with the adult respiratory distress syndrome and are associated with increased mortality. Am Rev Respir Dis 146:427, 1992
5. Liu J, Marino MW, Wong G, Grail D, Dunn A, Bettadapura J, Slavin AJ, Old L, Bernard CC: TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination. Nat Med 4:78, 1998
6. Marino MW, Dunn A, Grail D, Inglese M, Noguchi Y, Richards E, Jungbluth A, Wada H, Moore M, Williamson B, Basu S, Old LJ: Characterization of tumor necrosis factor-deficient mice. Proc Natl Acad Sci USA 94:8093, 1997
7. Takeda Y, Watanabe H, Yonehara S, Yamashita T, Saito S, Sendo F: Rapid acceleration of neutrophil apoptosis by tumor necrosis factor-α. Int Immunol 5:691, 1993
8. Savill JS, Wyllie AH, Henson JE, Walport MJ, Henson PM, Haslett C: Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages. J Clin Invest 83:865, 1989
9. Hebert MJ, Takano T, Holthofer H, Brady HR: Sequential morphologic events during apoptosis of human neutrophils. Modulation by lipoxygenase-derived eicosanoids. J Immunol 157:3105, 1996
10. Brown SB, Bailey K, Savill J: Actin is cleaved during constitutive apoptosis. Biochem J 323:233, 1997
11. Middelhoven PJ, Ager A, Roos D, Verhoeven AJ: Involvement of a metalloprotease in the shedding of human neutrophil FcγRIIIB. FEBS Lett 414:14, 1997
12. Murray J, Barbara JA, Dunkley SA, Lopez AF, Van Ostade X, Condliffe AM, Dransfield I, Haslett C, Chilvers ER: Regulation of neutrophil apoptosis by tumor necrosis factor-α: Requirement for TNFR55 and TNFR75 for induction of apoptosis in vitro. Blood 90:2772, 1997
13. Nagata S: Apoptosis by death factor. Cell 88:355, 1997
14. Medema JP, Scaffidi C, Kischkel FC, Shevchenko A, Mann M, Krammer PH, Peter ME: FLICE is activated by association with the CD95 death-inducing signaling complex (DISC). EMBO J 16:2794, 1997
15. Alnemri ES, Livingston DJ, Nicholson DW, Salvesen G, Thornberry NA, Wong WW, Yuan J: Human ICE/CED-3 protease nomenclature. Cell 87:171, 1996
16. Xiang J, Chao DT, Korsmeyer SJ: BAX-induced cell death may not require interleukin 1β-converting enzyme-like proteases. Proc Natl Acad Sci USA 93:14559, 1996
17. Hirata H, Takahashi A, Kobayashi S, Yonehara S, Sawai H, Okazaki T, Yamamoto K, Sasada M: Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis. J Exp Med 187:587, 1998
18. Kothakota S, Azuma T, Reinhard C, Klippel A, Tang J, Chu K, McGarry TJ, Kirschner MW, Koths K, Kwiatkowski DJ, Williams LT: Caspase-3-generated fragment of gelsolin: Effector of morphological change in apoptosis. Science 278:294, 1997
19. Klebanoff SJ, Vadas MA, Harlan JM, Sparks LH, Gamble JR, Agosti JM, Waltersdorph AM: Stimulation of neutrophils by tumor necrosis factor. J Immunol 136:4220, 1986
20. 2+-mobilizing agonists. J Immunol 142:1678, 1989
21. Whyte MK, Meagher LC, MacDermot J, Haslett C: Impairment of function in aging neutrophils is associated with apoptosis. J Immunol 150:5124, 1993
22. Van Antwerp DJ, Martin SJ, Verma IM, Green DR: Inhibition of TNF-induced apoptosis by NF-κB. Trends Cell Biol 8:107, 1998
23. McDonald PP, Bald A, Cassatella MA: Activation of the NF-κB pathway by inflammatory stimuli in human neutrophils. Blood 89:3421, 1997
24. Takahashi A, Hirata H, Yonehara S, Imai Y, Lee KK, Moyer RW, Turner PC, Mesner PW, Okazaki T, Sawai H, Kishi S, Yamamoto K, Okuma M, Sasada M: Affinity labeling displays the stepwise activation of ICE-related proteases by Fas. staurosporine, and CrmA-sensitive caspase-8. Oncogene 14:2741, 1997
25. Takahashi A, Yamamoto K, Okuma M, Sasada M: Transient calcium elevation in polymorphonuclear leukocytes triggered by thrombin-activated platelets. Eur J Haematol 48:196, 1992
26. Martins LM, Mesner PW, Kottke TJ, Basi GS, Sinha S, Tung JS, Svingen PA, Madden BJ, Takahashi A, McCormick DJ, Earnshaw WC, Kaufmann SH: Comparison of caspase activation and subcellular localization in HL-60 and K562 cells undergoing etoposide-induced apoptosis. Blood 90:4283, 1997
27. Babior BM, Kipnes RS, Curnutte JT: Biological defense mechanisms: The production by leukocytes of superoxide, a potential bactericidal agent. J Clin Invest 52:741, 1973
28. Asagoe K, Yamamoto K, Takahashi A, Suzuki K, Maeda A, Nohgawa M, Harakawa N, Takano K, Mukaida N, Matsushima K, Okuma M, Sasada M: Down-regulation of CXCR2 expression on human polymorphonuclear leukocytes by TNF-α. J Immunol 160:4518, 1998
29. Witke W, Sharpe AH, Hartwig JH, Azuma T, Stossel TP, Kwiatkowski DJ: Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin. Cell 81:41, 1995
30. Thornberry NA, Rano TA, Peterson EP, Rasper DM, Timkey T, Garcia-Calvo M, Houtzager VM, Nordstrom PA, Roy S, Vaillancourt JP, Chapman KT, Nicholson DW: A combinatorial approach defines specificities of members of the caspase family and granzyme B - Functional, relationships established for key mediators of apoptosis. J Biol Chem 272:17907, 1997
31. Watson RWG, Rotstein OD, Parodo J, Bitar R, Hackam D, Marshall JC: Granulocytic differentiation of HL-60 cells results in spontaneous apoptosis mediated by increased caspase expression. FEBS Lett 412:603, 1997
32. Armstrong RC, Aja T, Xiang J, Gaur S, Krebs JF, Hoang K, Bai X, Korsmeyer SJ, Karanewsky DS, Fritz LC, Tomaselli KJ: Fas-induced activation of the cell death-related protease CPP32 is inhibited by Bcl-2 and by ICE family protease inhibitors. J Biol Chem 271: 16850, 1996
33. Takahashi A, Alnemri ES, Lazebnik YA, Fernandes-Alnemri T, Litwack G, Moir RD, Goldman RD, Poirier GG, Kaufmann SH, Earnshaw WC: Cleavage of lamin A by Mch2α but not CPP32: Multiple ICE-related proteases with distinct substrate recognition properties are active in apoptosis. Proc Natl Acad Sci USA 93:8395, 1996
34. Nicholson DW, Thornberry NA: Caspases: Killer proteases. Trends Biol Sci 22:299, 1997
35. Martins LM, Kottke T, Mesner PW, Basi GS, Sinha S, Frigon NJ, Tatar E, Tung JS, Bryant K, Takahashi A, Svingen PA, Madden BJ, McCormick DJ, Earnshaw WC, Kaufmann SH: Activation of multiple interleukin-1β converting enzyme homologues in cytosol and nuclei of HL-60 human leukemia cells during etoposide-induced apoptosis. J Biol Chem 272:7421, 1997
36. Cohen GM: Caspases: The executioners of apoptosis. Biochem J 326:1, 1997
37. Slee EA, Zhu H, Chow SC, MacFarlane M, Nicholson DW, Cohen GM: Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32. Biochem J 315:21, 1996
38. Fraser A, Evan G: A license to kill. Cell 85:781, 1996
39. Muzio M, Stockwell BR, Stennicke HR, Salvesen GS, Dixit VM: An induced proximity model for caspase-8 activation. J Biol Chem 273:2926, 1998
40. Bossy-Wetzel E, Newmeyer DD, Green DR: Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization. EMBO J 17:37, 1998
41. Susin SA, Zamzami N, Castedo M, Daugas E, Wang HG, Geley S, Fassy F, Reed JC, Kroemer G: The central executioner of apoptosis: Multiple connections between protease activation and mitochondria in Fas/APO-1/CD95-and ceramide-induced apoptosis. J Exp Med 186:25, 1997
42. Liu X, Kim CN, Yang J, Jemmerson R, Wang X: Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c. Cell 86:147, 1996
43. Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X: Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91:479, 1997
44. Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, Peng T-I, Jones DP, Wang X: Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked. Science 275:1129, 1997
45. Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD: The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis. Science 275:1132, 1997
46. Kroemer G, Zamzami N, Susin SA: Mitochondrial control of apoptosis. Immunol Today 18:44, 1997
47. Vayssiere JL, Petit PX, Risler Y, Mignotte B: Commitment to apoptosis is associated with changes in mitochondrial biogenesis and activity in cell lines conditionally immortalized with simian virus 40. Proc Natl Acad Sci USA 91:11752, 1994
48. Nunn AV, Barnard ML, Bhakoo K, Murray J, Chilvers EJ, Bell JD: Characterisation of secondary metabolites associated with neutrophil apoptosis. FEBS Lett 392:295, 1996
49. Kass GE, Eriksson JE, Weis M, Orrenius S, Chow SC: Chromatin condensation during apoptosis requires ATP. Biochem J 318:749, 1996
50. Leist M, Single B, Castoldi AF, Kuhnle S, Nicotera P: Intracellular adenosine triphosphate (ATP) concentration: A switch in the decision between apoptosis and necrosis. J Exp Med 185:1481, 1997
51. Eguchi Y, Shimizu S, Tsujimoto Y: Intracellular ATP levels determine cell death fate by apoptosis or necrosis. Cancer Res 57:1835, 1997
52. Woo M, Hakem R, Soengas MS, Duncan GS, Shahinian A, Kägi D, Hakem A, McCurrach M, Khoo W, Kaufman SA, Senaldi G, Howard T, Lowe SW, Mak TW: Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes. Genes Dev 12:806, 1998
53. Kuida K, Zheng TS, Na S, Kuan C-Y, Yang D, Karasuyama H, Rakic P, Flavell RA: Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 384:368, 1996
54. Boldin MP, Goncharov TM, Goltsev YV, Wallach D: Involvement of MACH, a novel MORT1/FADD-interacting protease in Fas/ APO-1-and TNF receptor-induced cell death. Cell 85:803, 1996
55. Yang X, Chang HY, Baltimore D: Autoproteolytic activation of pro-caspases by oligomerization. Mol Cell 1:319, 1998
56. Martin DA, Siegel RM, Zheng LX, Lenardo MJ: Membrane oligomerization and cleavage activates the caspase-8 (FLICE/ MACHα1) death signal. J Biol Chem 273:4345, 1998
57. Han ZY, Hendrickson EA, Bremner TA, Wyche JH: A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro. J Biol Chem 272:13432, 1997
58. Mancini M, Nicholson DW, Roy S, Thornberry NA, Peterson EP, Casciola-Rosen LA, Rosen A: The caspase-3 precursor has a cytosolic and mitochondrial distribution: Implications for apoptotic signaling. J Cell Biol 140:1485, 1998
59. Brancolini C, Lazarevic D, Rodriguez J, Schneider C: Dismantling cell-cell contacts during apoptosis is coupled to a caspase-dependent proteolytic cleavage of β-catenin. J Cell Biol 139:759, 1997
60. Wen LP, Fahrni JA, Troie S, Guan JL, Orth K, Rosen GD: Cleavage of focal adhesion kinase by caspases during apoptosis. J Biol Chem 272:26056, 1997
61. Kondo T, Takeuchi K, Doi Y, Yonemura S, Nagata S, Tsukita S: ERM (ezrin/radixin/moesin)-based molecular mechanism of microvillar breakdown at an early stage of apoptosis. J Cell Biol 139:749, 1997
62. Wong K, Li XB, Hunchuk N: N-acetylsphingosine (C2-ceramide) inhibited neutrophil superoxide formation and calcium influx. J Biol Chem 270:3056, 1995
63. Yanaga F, Watson SP: Ceramide does not mediate the effect of tumour necrosis factor a on superoxide generation in human neutrophils. Biochem J 298:733, 1994
64. Skulachev VP: Cytochrome c in the apoptotic and antioxidant cascades. FEBS Lett 423:275, 1998
65. Na S, Chuang T-H, Cunningham A, Turi TG, Hanke JH, Bokoch GM, Danley DE: D4-GD1, a substrate of CPP32, is proteolyzed during Fas-induced apoptosis. J Biol Chem 271:11209, 1996
66. Guillemot JC, Kruskal BA, Adra CN, Zhu S, Ko JL, Burch P, Nocka K, Seetoo K, Simons E, Lim B: Targeted disruption of guanosine diphosphate-dissociation inhibitor for Rho-related proteins, GDID4: Normal hematopoietic differentiation but subtle defect in superoxide production by macrophages derived from in vitro embryonal stem cell differentiation. Blood 88:2722, 1996
67. Enari M, Sakahira H, Yokoyama H, Okawa K, Iwamatsu A, Nagata S: A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 391:43, 1998
68. Sakahira H, Enari M, Nagata S: Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. Nature 391:96, 1998
69. Hooper NM, Karran EH, Turner AJ: Membrane protein secretases. Biochem J 321:265, 1997
70. Porteu F, Nathan C: Shedding of tumor necrosis factor receptors by activated human neutrophils. J Exp Med 172:599, 1990
71. Wei S, Liu JH, Epling Burnette PK, Gamero AM, Ussery D, Pearson EW, Elkabani ME, Diaz JI, Djeu JY: Critical role of Lyn kinase in inhibition of neutrophil apoptosis by granulocyte-macrophage colony-stimulating factor. J Immunol 157:5155, 1996
72. Franke TF, Cantley LC: Apoptosis. A Bad kinase makes good. Nature 390:116, 1997
73. Al-Shami A, Bourgoin SG, Naccache PH: Granulocyte-macrophage colony-stimulating factor-activated signaling pathways in human neutrophils. I. Tyrosine phosphorylation-dependent stimulation of phosphatidylinositol 3-kinase and inhibition by phorbol esters. Blood 89:1035, 1997
74. D'Sa-Elipper C, Chinnadurai G: Functional dissection of Bfl-1, a Bcl-2 homolog: anti-apoptosis, oncogene-cooperation and cell proliferation activities. Oncogene 16:3105, 1998
75. Lin EY, Orlofsky A, Wang HG, Reed JC, Prystowsky MB: A1, a Bcl-2 family member, prolongs cell survival and permits myeloid differentiation. Blood 87:983, 1996
76. Xia ZG, Dickens M, Raingeaud J, Davis RJ, Greenberg ME: Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270:1326, 1995
77. Yuo A, Okuma E, Kitagawa S, Takaku F: Tyrosine phosphorylation of p38 but not extracellular signal-regulated kinase in normal human neutrophils stimulated by tumor necrosis factor: Comparative study with granulocyte-macrophage colony-stimulating factor. Biochem Biophys Res Commun 235:42, 1997
78. DeNichilo MO, Stewart AG, Vadas MA, Lopez AF: Granulocyte-macrophage colony-stimulating factor is a stimulant of platelet-activating factor and superoxide anion generation by human neutrophils. J Biol Chem 266:4896, 1991
79. Tsuchida H, Takeda Y, Takei H, Shinzawa H, Takahashi T, Sendo F: In vivo regulation of rat neutrophil apoptosis occurring spontaneously or induced with TNF-α or cycloheximide. J Immunol 154:2403, 1995
80. Matute-Bello G, Liles WC, Radella F, Steinberg KP, Ruzinski JT, Jonas M, Chi EY, Hudson LD, Martin TR: Neutrophil apoptosis in the acute respiratory distress syndrome. Am J Respir Crit Care Med 156:1969, 1997
81. Parvathenani LK, Buescher ES, Chacon-Cruz E, Beebe SJ: Type I cAMP-dependent protein kinase delays apoptosis in human neutrophils at a site upstream of caspase-3. J BIol Chem 273:6736, 1998