Fas ligand (gld)- and Fas (lpr)-deficient mice do not show alterations in the extravasation or apoptosis of inflammatory neutrophils

Journal of Leukocyte Biology

Volumn 64, Issue 3, 1998, Pages 373-383

  Fecho, Karamarie ^a   Cohen, Philip L ^a,b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Autoimmunity; GR 1; Inflammation; Ly 6G

Indexed keywords

FAS ANTIGEN;

ANIMAL CELL; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; AUTOIMMUNITY; DOWN REGULATION; EXTRAVASATION; FLOW CYTOMETRY; INFLAMMATORY INFILTRATE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL;

ANIMALIA;

EID: 0031685205     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.64.3.373     Document Type: Article

References (67)

1. Watanabe-Fukunaga, R., Brannan, C. I., Copeland, N. G., Jenkins, N. A., Nagata, S. (1992) Lymphoproliferative disorder in mice explained by defects in fas antigen that mediates apoptosis. Nature 356, 314-317.
2. Adachi, M., Watanabe-Fukunaga, R., Nagata, S. (1993) Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice. Proc. Natl. Acad. Sci. USA 90, 1756-1760.
3. Takahashi, T., Tanaka, M., Brannan, C. I., Jenkins, N. A., Copeland, N. G., Suda, T., Nagata, S. (1994) Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand. Cell 76, 969-976.
4. Cohen, P. L., Eisenberg, R. A. (1991) Lpr and gld: Single gene models of systemic autoimmunity and lymphoproliferative disease. Annu. Rev. Immunol. 9, 243-269.
5. Cohen, P. L., Eisenberg, R. A. (1995) Apoptosis and the Immune Response, New York: Wiley-Liss, 169-186.
6. Russell, J. H., Rush, B., Weaver, C., Wang, R. (1993) Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide. Proc. Natl. Acad. Sci. USA 90, 4409-4413.
7. Russell, J. H., Wang, R. (1993) Autoimmune gld mutation uncouples suicide and cytokine/proliferation pathways in activated, mature T cells. Eur. J. Immunol. 23, 2379-2382.
8. Singer, G. G., Abbas, A. K. (1994) The Fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity 1, 365-371.
9. Alderson, M. R., Tough, T. W. Davis-Smith, T. Braddy, S., Falk, B., Schooley, K. A., Goodwin, R. G., Smith, C. A., Ramsdell, F., Lynch, D. H. (1995) Fas ligand mediates activation-induced cell death in human T lymphocytes. J. Exp. Med. 181, 71-77.
10. Adachi, M., Suematsu, S., Kondo, T., Ogasawara, J., Tanaka, T., Yoshida, N., Nagata, S. (1995) Targeted mutation in the fas gene causes hyperplasia in peripheral lymphoid organs and liver. Nature Genetics 11, 294-299.
11. Senju, S., Negishi, I., Motoyama, N., Wang, F., Nakayama, K.-I., Nakayama, K., Lucas, P. J., Hatakeyama, S., Zhang, Q., Yonehara, S., Loh, D. Y. (1996) Functional significance of the Fas molecule in naive lymphocytes. Int. Immunol. 8, 423-431.
12. Rieux-Laucat, F., Le Deist, F., Hivroz, C., Roberts, I. A. G., Debatin, K. M., Fischer, A., de Villartay, J. P. (1995) Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity. Science 268, 1347-1349.
13. Drappa, J., Vaishnaw, A. K., Sullivan, K. E., Chu, J.-L., Elkon, K. B. (1996) Fas gene mutations in the Canale-Smith syndrome, an inherited lymphoproliferative disorder associated with autoimmunity. N. Engl. J. Med. 335, 1643-1649.
14. Sneller, M. C., Wang, J., Dale, J. K., Strober, W., Middleton, L. A., Choi, Y., Fleisher, T. A., Lim, M. S., Jaffe, E. S., Puck, J. M., Lenardo, M. J., Straus, S. E. (1997) Clinical, immunologic, and genetic features of an autoimmune lymphoproliferative syndrome associated with abnormal lymphocyte apoptosis. Blood 89, 1341-1348.
15. + cytotoxic T cells. Proc. Natl. Acad. Sci. USA 91, 4185-4189.
16. Kägi, D., Vignaux, F., Ledermann, B., Bürki, K., Depraetere, V., Nagata, S., Hengartner, H., Goldstein, P. (1994) Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. Science 265, 528-530.
17. Lowin, B., Hahne, M., Mattmann, C., Tschopp, J. (1994) Cytolytic T-cell cytotoxicity is mediated through perforin and fas lytic pathways. Nature 370, 650-652.
18. Bellgrau, D., Gold, D., Selawry, H., Moore, J., Franzusoff, A., Duke, R. C. (1995) A role for CD95 ligand in preventing graft rejection. Nature 377, 630-632.
19. Griffith, T. S., Brunner, T., Fletcher, S. M., Green, D. R., Ferguson, T. A. (1995) Fas ligand-induced apoptosis as a mechanism of immune privilege. Science 270, 1189-1192.
20. Via, C. S., Nguyen, P., Shustov, A., Drappa, J., Elkon, K. B. (1996) A major role for the Fas pathway in acute graft-versus-host disease. J. Immunol. 157, 5387-5393.
21. O'Connell, J., O'Sullivan, G. C., Collins, J. K., Shanahan, F. (1996) The fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing fas ligand. J. Exp. Med. 184, 1075-1082.
22. Villunger, A., Egle, A., Marschitz, I., Kos, M., Böck, G., Ludwig, H., Geley, S., Kofler, R., Greil, R. (1997) Constitutive expression of Fas (APO-/ CD95) ligand on multiple myeloma cells: A potential mechanism of tumor-induced suppression of immune surveillance. Blood 90, 12-20.
23. Iwai, K., Miyawaki, T., Takizawa, T., Konno, A., Ohta, K., Yachie, A., Seki, H., Taniguchi, N. (1994) Differential expression of bcl-2 and susceptibility to anti-Fas-mediated cell death in peripheral blood lymphocytes, monocytes, and neutrophils. Blood 84, 1201-1208.
24. Liles, W. C., Kiener, P. A., Ledbetter, J. A., Aruffo, A., Klebanoff, S. J. (1996) Differential expression of fas (CD95) and fas ligand on normal human phagocytes: Implications for the regulation of apoptosis in neutrophils. J. Exp. Med. 184, 429-440.
25. Newman, S. L., Henson, J. E., Henson, P. M. (1982) Phagocytosis of senescent neutrophils by human monocyte-derived macrophages and rabbit inflammatory macrophages. J. Exp. Med. 156, 430-442.
26. Sanui, H., Yoshida, S.-I., Nomoto, K., Ohhara, R., Adachi, Y. (1982) Peritoneal macrophages which phagocytose autologous polymorphonuclear leukocytes in guinea-pigs. I. Induction by irritants and microorganisms and inhibition by colchicine. Br. J. Exp. Pathol. 63, 278-285.
27. Savill, J. S., Wyllie, A. H., Henson, J. E., Walport, M. J., Henson, P. M., Haslett, C. (1989) Macrophage phagocytosis of aging neutrophils in inflammation: Programmed cell death in the neutrophil leads to its recognition by macrophages. J. Clin. Invest. 83, 865-875.
28. Afford, S. C., Pongracz, J., Stockley, R. A., Crocker, J., Burnett, D. (1992) The induction by human interleukin-6 of apoptosis in the promonocytic cell line U937 and human neutrophils. J. Biol. Chem. 267, 21612-21616.
29. Takeda, Y., Watanabe, H., Yonehara, S., Yamashita, T., Saito, S., Sendo, F. (1993) Rapid acceleration of neutrophil apoptosis by tumor necrosis factor-α. Int. Immunol. 5, 691-694.
30. Biffl, W. L., Moore, E. E., Moore, F. A., Barnett, C. C., Jr. (1995) Interleukin-6 suppression of neutrophil apoptosis is neutrophil concentration dependent. J. Leukoc. Biol. 58, 582-584.
31. Tsuchida, H., Takeda, Y., Takei, H., Shinzawa, H., Takahashi, T., Sendo, F. (1995) In vivo regulation of rat neutrophil apoptosis occuring spontaneously or induced with TNF-α or cyclohexamide. J. Immunol. 154, 2403-2412.
32. 2 integrin CD11b/CD18 in neutrophil apoptosis: A homeostatic mechanism in inflammation. Immunity 5, 653-666.
33. Jutila, M. A., Kroese, F. G. M., Jutila, K. L., Stall, A. M., Fiering, S., Herzenberg, L. A., Berg, E. L., Butcher, E. C. (1988) Ly-6C is a monocyte/macrophage and endothelial cell differentiation antigen regulated by interferon-gamma. Eur. J. Immunol. 18, 1819-1826.
34. Shevach, E. M., Korty, P. E. (1989) Ly-6: A multigene family in search of a function. Immunol. Today 10, 195-200.
35. Hestdal, K., Ruscetti, F. W, Ihle, J. N., Jacobsen, S. E. W., Dubois, C. M., Kopp, W. C., Longo, D. L., Keller, J. R. (1991) Characterization and regulation of RB6-8C5 antigen expression on murine bone marrow cells. J. Immunol. 147, 22-28.
36. Martin, S. J., Reutelingsperger, C. P. M., McGahon, A. J., Rader, J. A., van Schie, R. C. A. A., LaFace, D. M., Green, D. R. (1995) Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: Inhibition by overexpression of bcl-2 and abl. J. Exp. Med. 182, 1545-1556.
37. Castedo, M., Hirsch, T., Susin, S. A., Zamzami, N., Marchetti, P., Macho, A., Kroemer, G. (1996) Sequential acquisition of mitochondrial and plasma membrane alterations during early lymphocyte apoptosis. J. Immunol. 157, 512-521.
38. Belloc, F., Dumain, P., Boisseau, M. R., Jalloustre, C., Reiffers, J., Bernard, P., Lacombe, F. (1994) A flow cytometric method using Hoechst 33342 and propidium iodide for simultaneous cell cycle analysis and apoptosis determination in unfixed cells. Cytometry 17, 59-65.
39. Reap, E. A., Sobel, E. S., Cohen, P. L., Eisenberg, R. A. (1993) Conventional B cells, not B-1 cells, are responsible for producing autoantibodies in lpr mice. J. Exp. Med. 177, 69-78.
40. Sobel, E. S., Kakkanaiah, V. N., Rapoport, R. G., Eisenberg, R. A., Cohen, P. L. (1995) The abnormal lpr double-negative T cell fails to proliferate in vivo. Clin. Immunol. Immunopathol. 74, 177-184.
41. Payne, C. M., Glasser, L., Tischler, M. E., Wyckoff, D., Cromey, D., Fiederlein, R., Bohnert, O. (1994) Programmed cell death of the normal human neutrophil: An in vitro model of senescence. Microsc. Res. Tech. 28, 327-344.
42. Unkeless, J. C. (1979) Characterization of a monoclonal antibody directed against mouse macrophage and lymphocyte Fc receptors. J. Exp. Med. 150, 580-596.
43. Chu, J.-L., Drappa, J., Parnassa, A., Elkon, K. B. (1993) The defect in fas mRNA expression in MRL/lpr mice is associated with insertion of the retrotransposon. ETn. J. Exp. Med. 178, 723-730.
44. Mariani, S. M., Matiba, B., Armandola, E. A., Krammer, P. H. (1994) The APO-1/Fas(CD95) receptor is expressed in homozygous MRL/lpr mice. Eur. J. Immunol. 24, 3119-3123.
45. hi cells in SCG and MRL-lpr/lpr mice which produce normal Fas mRNA and Fas molecules from the lpr gene. Eur. J. Immunol. 26, 1409-1416.
46. Fleming, T. J., Fleming, M. L., Malek, T. R. (1993) Selective expression of Ly-6G on myeloid lineage cells in mouse bone marrow: RB6-8C5 mAb to granulocyte-differentiation antigen (Gr-1) detects members of the Ly-6 family. J. Immunol. 151, 2399-2408.
47. Dumont, F. (1982) Xenoantisera directed against the proliferating T-cells of MRL/Mp-lpr/lpr mice. Immunol. Lett. 5, 7-10.
48. Dumont, F. J., Coker, L. Z., Habbersett, R. C., Treffinger, J. A. (1985) Xenogeneic monoclonal antibody to an Ly-6-linked murine cell surface antigen: Differential reactivity with T cell subpopulations and bone marrow cells. J. Immunol. 134, 2357-2365.
49. Dumont, F. J. (987) Stimulation of murine T cells via the Ly-6C antigen: Lack of proliferative response in aberrant T cells from lpr/lpr and gld/gld mice despite high Ly-6c antigen expression. J. Immunol. 138, 4106-4113.
50. int cells in the lymph nodes and other peripheral organs of mice carrying the lpr gene. Cell. Immunol. 177, 144-153.
51. Haslett, C. (1992) Resolution of acute inflammation and the role of apoptosis in the tissue fate of granulocytes. Clin. Sci. 83, 639-648.
52. Squier, M. K. T., Sehnert, A. J., Cohen, J. J. (1995) Apoptosis in leukocytes. J. Leukoc. Biol. 57, 2-10.
53. Savill, J. (1997) Apoptosis in resolution of inflammation. J. Leukoc. Biol. 61, 375-380.
54. Liles, W. C., Klebanoff, S. J. (1995) Regulation of apoptosis in neutrophils -fas track to death? J. Immunol. 155, 3289-3291.
55. Hueber, A.-O., Zörnig, M., Lyon, D., Suda, T., Nagata, S., Evan, G. I. (1997) Requirement for the CD95 receptor-ligand pathway in c-Myc-induced apoptosis. Science 278, 1305-1309.
56. Bluethmann, H., Rothe, J., Schultze, N., Tkachuk, M., Koebel, P. (1994) Establishment of the role of IL-6 and TNF receptor 1 using gene knockout mice. J. Leukoc. Biol. 56, 565-570.
57. Nagata, S. (1997) Apoptosis by death factor. Cell 88, 355-365.
58. Lagasse, E., Weissman, I. L. (1994) bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophages. J. Exp. Med. 179, 1047-1052.
59. Delia, D., Aiello, A., Soligo, D., Fontanella, E., Melani, C., Pezzella, F., Pierotti, M. A., Delia Porta, G. (1992) bcl-2 proto-oncogene expression in normal and neoplastic human myeloid cells. Blood 79, 1291-1298.
60. Gresham, H. D., Ray, C. J., O'Sullivan, F. X. (1991) Defective neutrophil function in the autoimmune mouse strain MRL/lpr: Potential role of transforming growth factor-β. J. Immunol. 146, 3911-3921.
61. Lowrance, J. H., O'Sullivan, F. X., Caver, T. E., Waegell, W., Gresham, H. D. (1994) Spontaneous elaboration of transforming growth factor β suppresses host defense against bacterial infection in autoimmune MRL/lpr mice. J. Exp. Med. 180, 1693-1703.
62. + human marrow cells is induced by interferon γ and tumor necrosis factor α and potentiates cytokine-mediated hematopoietic suppression in vitro. Blood 85, 3183-3190.
63. Nagafuji, K., Shibuya, T., Harada, M., Mizuno, S. I., Takenaka, K., Miyamoto, T., Okamura, T., Gondo, H., Niho, Y. (1995) Functional expression of fas antigen (CD95) on hematopoietic progenitor cells. Blood 86, 883-889.
64. Barcena, A., Park, S. W., Banapour, B., Muench, M. O., Mechetner, E. (1996) Expression of Fas/CD95 and bcl-2 by primitive hematopoietic progenitors freshly isolated from human fetal liver. Blood 88, 2013-2025.
65. Owen-Schaub, L. B., Yonehara, S., Crump, W. L., III, Grimm, E. A. (1992) DNA fragmentation and cell death is selectively triggered in activated human lymphocytes by fas antigen engagement. Cell. Immunol. 140, 197-205.
66. Alderson, M. R., Armitage, R. J., Maraskovsky, E., Tough, T. W., Roux, E., Schooley, K., Ramsdell, F., Lynch, D. H. (1993) Fas transduces activation signals in normal human T lymphocytes. J. Exp. Med. 178, 2231-2235.
67. Mapara, M. Y., Bargou, R., Zugck, C., Donner, H., Ustaoglu, F., Jonker, R. R., Krammer, P. H., Dörken, B. (1993) APO-1 mediated apoptosis or proliferation in human chronic B lymphocytic leukemia: Correlation with bcl-2 oncogene expression. Eur. J. Immunol. 23, 702-708.