Role of plasma membrane transporters in muscle metabolism

Biochemical Journal

Volumn 349, Issue 3, 2000, Pages 667-688

  Zorzano, Antonio ^a   Fandos, César ^a   Palacín, Manuel ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Amino acids; Carnitine; Creatine; Fatty acids; Glucose; Lactate

Indexed keywords

CARNITINE; CREATINE; FATTY ACID; GLUCOSE; GLUCOSE TRANSPORTER; KETONE BODY;

CELL MEMBRANE; GLUCOSE TRANSPORT; MUSCLE METABOLISM; PRIORITY JOURNAL; REVIEW;

EID: 0034254796     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/bj3490667     Document Type: Review

References (322)

1. 1 Harris, R. C., Soderlund, K. and Hultman, E. (1992) Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin. Sci. 83, 367-374
2. 2 Smith, S. A., Montain, S. J., Matott, R. P., Zientara, G. P., Jolesz, F. A. and Fielding, R. A. (1998) Creatine supplementation and age influence muscle metabolism during exercise. J. Appl. Physiol. 85, 1349-1356
3. 3 Snow, R. J., McKenna, M. J., Selig, S. E., Kemp, J., Stathis, C. G. and Zhao, S. (1998) Effect of creatine supplementation on sprint exercise performance and muscle metabolism. J. Appl. Physiol. 84, 1667-1673
4. 4 Prevost, M. C., Nelson, A. G. and Morris, G. S. (1997) Creatine supplementation enhances intermittent work performance. Res. Q. Exercise Sport 68, 233-230
5. 5 McNaughton, L. R., Dalton, B. and Tarr, J. (1998) The effects of creatine supplementation on high-intensity exercise performance in elite performers. Eur. J. Appl. Physiol. 78, 236-240
6. 6 Mujika, I., Chatard, J. C., Lacoste, L., Barale, F. and Geyssant, A. (1996) Creatine supplementation does not improve sprint performance in competitive swimmers. Med. Sci. Sports Exercise 28, 1435-1441
7. 7 Javierre, C., Lizarraga, M. A., Ventura, J. L., Garrido, E. and Segura, R. (1997) Creatine supplementation does not improve physical performance in a 150 m race. Rev. Esp. Fisiol 53, 343-348
8. 8 Seppet, E. K., Adoyaan, A. J., Kallikorm, A. P., Chernousova, G. B., Lyulina, N. V., Sharov, V. G., Severin, V. V., Popovich, M. I. and Saks, V. A. (1985) Hormone regulation of cardiac metabolism. I. Creatine transport across cell membranes of euthyroid and hyperthyroid rat heart. Biochem. Med. 34, 267-279
9. 9 Odoom, J. E., Kemp, G. J. and Radda, G. K. (1996) The regulation of total creatine content in a myoblast cell line. Mol. Cell. Biochem. 158, 179-188
10. 10 Willott, C. A., Young, M. E., Leighton, B., Kemp, G. J., Boehm, E. A., Radda, G. K. and Clarke, K. (1999) Creatine uptake in isolated soleus muscle: kinetics and dependence on sodium, but not on insulin. Acta Physiol. Scand. 166, 99-104
11. 14C by skeletal muscle in normal and X-irradiated rats. Proc. Soc. Exp. Biol. Med. 139, 1265-1271
12. 12 Haughland, R. B. and Chang, D. T. (1975) Insulin effect on creatine transport in skeletal muscle. Proc. Soc. Exp. Biol. Med. 148, 1-4
13. 13 Loike, J. D., Zalutsky, D. L., Kaback, E., Miranda, A. F. and Silverstein, S. C. (1988) Extracellular creatine regulates creatine transport in rat and human muscle cells. Proc. Natl. Acad. Sci. U.S.A. 85, 807-811
14. 14 Green, A. L., Hultman, E., Macdonald, I. A., Sewell, D. A. and Greennaff, P. L. (1996) Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans. Am. J. Physiol. 271, E821-E826
15. 15 Palacín, M., Estévez, R., Bertran, J. and Zorzano, A. (1998) Molecular biology of mammalian plasma membrane amino acid transporters. Physiol. Rev. 78, 969-1054
16. +-dependent creatine transporter in rabbit brain, muscle, heart and kidney. J Biol. Chem. 268, 8418-8421
17. 17 Dai, W., Vinnakota, S., Qian, X., Kunze, D. L. and Sarkar, H. K. (1999) Molecular characterization of the human CRT-1 creatine transporter expressed in Xenopus oocytes. Arch. Biochem. Biophys. 361, 75-84
18. 18 Sora, I., Richman, J., Santoro, G., Wei, H., Wang, Y., Vanderah, T., Horavath, R., Nguyen, M., Waite, S., Roeske, W. R. and Yamamura, H. I. (1994) The cloning and expression of a human creatine transporter. Biochem. Biophys. Res. Commun. 204, 419-427
19. 19 Mayser, W., Schloss, P. and Betz, H. (1992) Primary structure and functional expression of a choline transporter expressed in the rat nervous system. FEBS Lett. 305, 31-36
20. 20 Guimbal, C. and Kilimann, M. W. (1994) A creatine transporter cDNA from Torpedo illustrates structure/function relationships in the GABA/noradrenaline transporter family. J. Mol. Biol. 241, 317-324
21. 21 Nash, S. R., Giros, B., Kingsmore, S. F., Rochelle, J. M., Suter, S. T., Gregor, P., Seldin, M. F. and Caron, M. G. (1994) Cloning, pharmacological characterization and genomic localization of the human creatine transporter. Receptors Channels 2, 165-174
22. 22 Sandoval, N., Bauer, D., Brenner, V., Coy, J. F., Drescher, B., Kioschis, P., Korn, B., Nyakatura, G., Poustka, A., Reichwald, K. et al. (1996) The genomic organization of a human creatine transporter (CRTR) gene located in Xq28. Genomics 35, 383-385
23. 23 Barnwell, L. F., Chaudhuri, G. and Townsel, J. G. (1995) Cloning and sequencing of a cDNA encoding a novel member of the human brain GABA/noradrenaline neurotransmitter transporter family. Gene 159, 287-288
24. 24 Iyer, G. S., Krahe, R., Goodwin, L. A., Doggett, N. A., Siciliano, M. J., Funanage, V. L. and Proujansky, R. (1996) Identification of a testis-expressed creatine transporter gene at 16p11.2 and confirmation of the X-linked locus to Xq28. Genomics 34, 143-146
25. 25 Guerrero-Ontiveros, M. L. and Wallimann, T. (1998) Creatine supplementation in health and disease. Effects of chronic creatine ingestion in vivo: down-regulation of the expression of creatine transporter isoforms in skeletal muscle. Mol. Cell. Biochem. 184, 427-437
26. 26 DeFronzo, R. (1988) The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes 37, 667-687
27. 27 Marshall, B. A., Ren, J. M., Johnson, D. W., Gibbs, E. M., Lillquist, J. S., Soeller, W. C., Holloszy, J. O. and Mueckler, M. (1993) Germline manipulation of glucose homeostasis via alteration of glucose transporter levels in skeletal muscle. J. Biol. Chem. 268, 18442-18445
28. 28 Dohm, G. L., Tapscott, E. B., Pories, W. J., Dabbs, D. J., Flickinger, E. G., Meelheim, D., Fushiki, T., Atkinson, S. M., Elton, C. W. and Caro, J. F. (1988) An in vitro human muscle preparation suitable for metabolic studies. Decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects. J. Clin. Invest. 82, 486-494
29. 29 Bonadonna, R. C., Del Prato, S., Saccomani, M. P., Bonora, E., Gulli, G., Ferrannini, E., Bier, D., Cobelli, C. and DeFronzo, R. A. (1993) Transmembrane glucose transport in skeletal muscle of patients with non-insulin-dependent diabetes. J. Clin. Invest. 92, 486-494
30. 30 Ploug, T., Galbo, H., Vinten, J., Jorgensen, M. and Richter, E. A. (1987) Kinetics of glucose transport in rat muscle: effects of insulin and contractions. Am. J. Physiol. 253, E12-E20
31. 31 Berger, M., Hagg, S. and Ruderman, N. B. (1975) Glucose metabolism in perfused skeletal muscle. Interaction of insulin and exercise on glucose uptake. Biochem. J. 146, 231-238
32. 32 Ziel, F. H., Venkatesan, N. and Davidson, M. B. (1988) Glucose transport is rate-limiting for skeletal muscle glucose metabolism in normal and STZ-induced diabetic rats. Diabetes 37, 885-890
33. 33 Kubo, K. and Foley, J.E (1986) Rate-limiting steps for insulin-mediated glucose uptake into perfused rat hindlimb. Am. J. Physiol. 250, E100-E102
34. 34 Ren, J. M., Marshall, B. A., Gulve, E. A., Gao, J. P., Johnson, D. W., Holloszy, J. O. and Mueckler, M. (1993) Evidence from transgenic mice that glucose transport is rate-limiting for glycogen deposition and glycolysis in skeletal muscle. J. Biol. Chem. 268, 16113-16115
35. 35 Zorzano, A., Muñoz, P., Camps, M., Mora, C., Testar, X. and Palacín, M. (1996) Insulin-induced redistribution of GLUT4 glucose carriers in the muscle fiber. In search of GLUT4 trafficking pathways. Diabetes 45, S70-S81
36. 36 Hundal, H. S., Ahmed, A., Gumà, A., Mitsumoto, Y., Marette, A., Rennie, M. J. and Klip, A. (1992) Biochemical and immunocytochemical localization of the Glut5 glucose transporter in human skeletal muscle. Biochem. J. 286, 339-343
37. 37 Shepherd, P. R., Gibbs, E. M., Wesslau, C., Gould, G. W. and Kahn, B. B. (1992) Human small intestine facilitative fructose/glucose transporter (GLUT5) is also present in insulin-responsive tissues and brain: investigation of biochemical characteristics and translocation. Diabetes 41, 1360-1365
38. 38 Burant, C. F., Takeda, J., Brot, L. E., Bell, G. I. and Davidson, N. O. (1992) Fructose transporter in human spermatozoa and small intestine is GLUT5. J. Biol. Chem. 267, 14523-14526
39. 39 Ibberson, M., Uldry, M. and Thorens, B. (2000) GLUTX1, a novel mammalian glucose transporter expressed in the central nervous system and insulin-sensitive tissues. J. Biol. Chem. 275, 4607-4612
40. 40 Marette, A., Richardson, J. M., Ramlal, T., Balon, T. W., Vranic, M., Pessin, J. E. and Klip, A. (1992) Differential regulation of Glut1 and Glut4 glucose transporters in skeletal muscle of a new model of Type-II diabetes - the obese SHR/N-cp rat. Am. J. Physiol. 263, C443-C452
41. 41 Zorzano, A., Wilkinson, W., Kotliar, N., Thoidis, G., Wadzinkski, B. E., Ruoho, A. E. and Pilch, P. F. (1989) Insulin-regulated glucose uptake in rat adipocytes is mediated by two transporter isoforms present in at least two vesicle populations. J. Biol. Chem. 264, 12358-12363
42. 42 Barrett, M. P., Walmsley, A. R. and Gould, G. W. (1999) Structure and function of facilitative sugar transporters. Curr. Opin. Cell Biol. 11, 496-502
43. 43 Fischer, Y., Thomas, J., Sevilla, L., Muñoz, P., Becker, C., Holman, G. D., Kozka, I. J., Palacin, M., Testar, X., Kammermeier, H. and Zorzano, A. (1997) Insulin-induced recruitment of glucose transporters GLUT4 and GLUT1 in isolated rat cardiac myocytes. Evidence for the existence of different intracellular GLUT4 vesicle populations. J. Biol. Chem. 272, 7085-7092
44. 44 Santalucía, T., Camps, M., Castelló, A., Muñoz, P., Nuel, A., Testar, X., Palacín, M and Zorzano, A. (1992) Developmental regulation of Glut-1 (erythroid/HepG2) and Glut-4 (muscle/fat) glucose transporter expression in rat heart, skeletal muscle and brown adipose tissue. Endocrinology 130, 837-846
45. 45 Wang, C and Hu, S. M. (1991) Developmental regulation in the expression of rat heart glucose transporters. Biochem. Biophys. Res. Commun. 177, 1095-1100
46. 46 Castelló, A., Rodríguez-Manzaneque, J. C., Camps, M., Pérez-Castillo, A., Testar, X., Palacin, M., Santos, A. and Zorzano, A. (1994) Perinatal hypothyroidism impairs the normal transition of GLUT4 and GLUT1 glucose transporters from fetal to neonatal levels in heart and brown adipose tissue. Evidence for tissue-specific regulation of GLUT4 expression by thyroid hormone. J. Biol. Chem. 269, 5905-5912
47. 47 Clark, Jr, C. M. (1971) Carbohydrate metabolism in the isolated fetal rat heart. Am. J. Physiol. 220, 583-588
48. 48 Casla, A., Rovira, A., Wells, J. A. and Dohm, G. L. (1990) Increased glucose transporter (GLUT4) protein expression in hyperthyoidism. Biochem. Biophys. Res Commun. 171, 182-188
49. 49 Weinstein, S. P., O'Boyle, E. and Haber, R. S. (1994) Thyroid hormone increases basal and insulin-stimulated glucose transport in skeletal muscle. The role of GLUT4 glucose transporter expression. Diabetes 43, 1185-1189
50. 50 Chizzonite, R. A. and Zak, R. (1984) Regulation of myosin isoenzyme composition in fetal and neonatal rat ventricle by endogenous thyroid hormones. J. Biol. Chem. 259, 12628-12632
51. 51 Castelló, A., Cadefau, J., Cussó, R., Testar, X., Hesketh, J. E., Palacín, M. and Zorzano, A. (1993) Glut-4 and Glut-1 glucose-transporter expression is differentially regulated by contractile activity in skeletal muscle. J. Biol. Chem. 268, 14998-15003
52. 52 Block, N. E., Menick, D. R., Robinson, K. A. and Buse, M. G. (1991) Effect of denervation on the expression of two glucose transporter isoforms in rat hindlimb muscle. J. Clin. Invest. 88, 1546-1552
53. 53 Coderre, L., Montar, M. M., Chen, K. S., Heydrick, S. J., Kurowski, T. G., Ruderman, N B. and Pilch, P. F. (1992) Alteration in the expression of GLUT-1 and GLUT-4 protein and messenger RNA levels in denervated rat muscles. Endocrinology 131, 1821-1825
54. 54 Etgen, G. J., Farrar, R. P. and Ivy, J. L. (1993) Effect of chronic electrical stimulation on GLUT-4 protein content in fast-twitch muscle. Am. J. Physiol. 264, R816-R819
55. 55 Hofman, S. and Pette, D. (1994) Low-frequency stimulation of rat fast-twitch muscle enhances the expression of hexokinase II and both the translocation and expression of glucose transporter 4 (GLUT4). Eur. J. Biochem. 219, 307-315
56. 56 Kong, X., Manchester, J., Salmons, S. and Lawrence, Jr, J. C. (1994) Glucose transporters in single skeletal muscle fibers. Relationship to hexokinase and regulation by contractile activity. J. Biol. Chem. 269, 12963-12967
57. 57 Houmard, J.A, Egan, P. C., Neufer, P. D., Friedman, J. E., Wheeler, W. S., Israel, R. G. and Dohm, G. L. (1991) Elevated skeletal muscle glucose transporter levels in exercise-trained middle aged men. Am. J. Physiol 261, E437-E443
58. 58 Dela, F., Handberg, A., Mikines, K. J., Vinten, J. and Galbo, H. (1993) GLUT4 and insulin receptor binding and kinase activity in trained human muscle. J. Physiol. (London) 469, 615-624
59. 59 Ploug, T., Stallknecht, B.M, Pedersen, O., Kahn, B. B., Ohkuwa, T., Vinten, J. and Galbo, H. (1990) Effect of endurance training on glucose transport capacity and glucose transporter expression in rat skeletal muscle. Am. J. Physiol. 259, E778-E786
60. 60 Ren, J. M., Semenkovich, C. F., Gulve, E. A., Gao, J. and Holloszy, J. O. (1994) Exercise induces rapid increases in GLUT4 expression, glucose transport and insulin-stimulated glycopen storage in muscle. J. Biol. Chem. 269, 14396-14401
61. 61 Friedman, J. E., Sherman, W. M., Reed, M. J., Elton, C. W. and Dohm, G. L. (1990) Exercise training increases glucose transporter protein Glut-4 in skeletal muscle of obese Zucker (fa/fa) rats. FEBS Lett. 268, 13-16
62. 62 Liu, M. L., Olson, A. L., Moye-Rowley, W. S., Buse, J. B., Bell, G. I. and Pessin, J. E. (1992) Expression and regulation of the human GLUT4/muscle-fat facilitative glucose transporter gene in transgenic mice. J. Biol. Chem. 267, 11673-11676
63. 63 Olson, A. L. and Pessin, J. E. (1995) Transcriptional regulation of the human GLUT4 gene promoter in diabetic transgenic mice. J. Biol. Chem. 270, 23491-23495
64. 64 Liu, M.-L., Olson, A. L., Edgington, N. P., Moye-Rowley, W. S. and Pessin, J. E. (1994) Myocyte enhancer factor 2 (MEF2) binding site is essential for C2C12 myotube-specific expression of the rat GLUT4/muscle-adipose facilitative glucose transporter gene. J. Biol. Chem. 269, 28514-28521
65. 65 Richardson, J. M. and Pessin, J. E. (1993) Identification of a skeletal muscle-specific regulatory domain in the rat GLUT4/muscle-fat gene. J. Biol. Chem. 268, 21021-21027
66. 66 Torrance, C. J., Usala, S. J., Pessin, J. E. and Dohm, G. L. (1997) Characterization of a low affinity thyroid hormone receptor binding site within the rat GLUT4 gene promoter. Endocrinology 138, 1215-1223
67. 67 Camps, M., Castelló, A., Muñoz, P., Monfar, M., Testar, X., Palacin, M. and Zorzano, A. (1992) Effect of diabetes and fasting on GLUT-4 (muscle/fat) glucose-transporter expression in insulin-sensitive tissues. Heterogeneous response in heart, red and white muscle. Biochem. J. 282, 765-772
68. 68 Muñoz, P., Chillarón, J., Camps, M., Castelló, A., Furriols, M., Testar, X., Palacín, M. and Zorzano, A. (1996) Evidence for posttranscriptional regulation of GLUT4 expression in muscle and adipose tissue from streptozotocin-induced diabetic and benfluorex-treated rats. Biochem. Pharmacol. 52, 1665-1673
69. 69 Olichon-Berthe, C., Gautier, N., Van Obberghen, E. and Le Marchand-Brustel, Y. (1993) Expression of the glucose Iransporter GLUT4 in the muscular dystrophic mdx mouse. Biochem. J 291, 257-261
70. 70 Weinstein, S. P. and Haber, R. S. (1992) Differential regulation of glucose transporter isoforms by thyroid hormone in rat heart. Biochim. Biophys. Acta 1136, 302-308
71. 71 Hager, S. R., Pastorek, D., Jochen, A. L. and Meier, D. (1991) Divergence between GLUT4 mRNA and protein abundance in skeletal muscle of insulin resistant rats. Biochem. Biophys. Res. Commun. 181, 240-245
72. 72 Hoenack, C. and Rosen, P. (1996) Inhibition of angiotensin type 1 receptor prevents decline of glucose transporter (GLUT4) in diabetic rat-heart. Diabetes 45, S82-S87
73. 73 Muñoz, P., Rosemblatt, M. R., Testar, X., Palacín, M. and Zorzano, A. (1995) Isolation and characterization of distinct domains of sarcolemma and T-tubules from rat skeletal muscle. Biochem. J. 307, 273-280
74. 74 Ploug, T., van Deurs, B., Ai, H., Cushman, S. W. and Ralston, E. (1998) Analysis of GLUT4 distribution in whole skeletal muscle fibers: identification of distinct compartments that are recruited by insulin and muscle contractions. J. Cell Biol. 142, 1429-1446
75. 75 Wang, W., Hansen, P. A., Marshall, B. A., Holloszy, J. O. and Mueckler, M. (1996) Insulin unmasks a COOH-terminal GLUT4 epitope and increases glucose transport across T-tubules in skeletal muscle. J. Cell Biol. 135, 415-430
76. 76 Fischer, Y., Thomas, J., Holman, G. D., Rose, H. and Kammermeier, H. (1996) Contraction-independent effects of catecholamines on glucose transport in isolated rat cardiomyocytes. Am. J. Physiol. 270, C1204-C1210
77. 77 Slot, J. W., Geuze, H. J., Gigengack, S., James, D. E. and Lienhard, G. E. (1991) Translocation of the glucose transporter Glut4 in cardiac myocytes of the rat. Proc. Natl. Acad. Sci. U.S.A 88, 7815-7819
78. 78 Zorzano, A., Sevilla, L., Camps, M., Becker, C., Meyer, J., Kammermeier, H., Muñoz, P., Gumà, A., Testar, X., Palacín, M. et al. (1997) Regulation of glucose transport and glucose transporters expression and trafficking in the heart: studies in cardiac myocytes. Am. J. Cardiol. 80, 65A-76A
79. 79 Marette, A., Burdett, E., Douen, A., Vranic, M. and Klip, A. (1992) Insulin induces the translocation of GLUT4 from a unique intracellular organelle to transverse tubules in rat skeletal muscle. Diabetes 41, 1562-1569
80. 80 Muñoz, P., Rosemblatt, M., Testar, X., Palacìn, M., Thoidis, G., Pilch, P. F. and Zorzano, A. (1995) The T-tubule is a cell-surface target for insulin-regulated recycling of membrane proteins in skeletal muscle. Biochem. J. 312, 393-400
81. 81 Rett, K, Wicklmayr, M., Dietze, G. J. and Häring, H. (1996) Insulin-induced glucose transporter (GLUT1 and GLUT4) translocation in cardiac muscle tissue is mimicked by bradykinin. Diabetes 45, S66-S69
82. 82 Hirshman, M. F., Goodyear, L. J., Wardzala, L. J., Horton, E. D. and Horton, E. S. (1990) Identification of an intracellular pool of glucose transporters from basal and insulin-stimulated rat skeletal muscle. J. Biol. Chem. 265, 987-991
83. 83 Douen, A. G., Ramlal, T., Rastogi, S., Bilan, P. J., Cartee, G. D., Vranic, M., Holloszy, J. O. and Klip, A. (1990) Exercise induces recruitment of the insulin-responsive glucose transporter - evidence for distinct intracellular insulin-recruitable and exercise-recruitable transporter pools in skeletal muscle. J. Biol. Chem. 265, 3427-3430
84. 84 Kolter, T., Uphues, I., Wichelhaus, A., Reinauer, H. and Eckel, J. (1992) Contraction-induced translocation of the glucose transporter GLUT4 in isolated ventricular cardiomyocytes. Biochem. Biophys. Res. Commun. 189, 1207-1214
85. 85 Sun, D. Q., Nguyen, N., DeGrado, T. R., Schwaiger, M. and Brosius, F. C. (1994) Ischemia induces translocation of the insulin-responsive glucose transporter GLUT4 to the plasma membrane of cardiac myocytes. Circulation 89, 793-798
86. 86 Zorzano, A., Sevilla, L., Tomàs, E., Camps, M., Gumà, A. and Palacín, M. (1998) Trafficking pathway of glucose transporters in muscle. Int. J. Mol. Med. 2, 263-271
87. 87 Coderre, L., Kandror, K V., Vallega, G. and Pilch, P. F. (1995) Identification and characterization of an exercise-sensitive pool of glucose transporters in skeletal muscle. J. Biol. Chem. 270, 27584-27588
88. 88 Muñoz, P., Mora, S., Sevilla, L., Kaliman, P., Tomàs, E., Gumà, A., Testar, X., Palacin, M. and Zorzano, A. (1996) Expression and insulin-regulated distribution of caveolin in skeletal muscle. Caveolin does not colocalize with GLUT4 in intracellular membranes. J. Biol. Chem. 271, 8133-8139
89. 89 Aledo, J. C., Hajduch, E., Darakhshan, F. and Hundal, H. S. (1996) Analyses of the co-localization of cellubrevin and the GLUT4 glucose transporter in rat and human insulin-responsive tissues. FEBS Lett 395, 211-216
90. 90 Aledo, J. C., Lavoie, L., Volchuk, A., Keller, S. R., Klip, A. and Hundal, H. S. (1997) Identification and characterization of two distinct intracellular GLUT4 pools in rat skeletal muscle: evidence for an endosomal and an insulin-sensitive GLUT4 compartment. Biochem. J. 325, 727-732
91. 91 Sevilla, L., Tomàs, E., Muñoz, P., Gumà, A., Fischer, Y., Thomas, J., Ruiz-Montasell, B., Testar, X., Palacín, M., Blasi, J. and Zorano, A. (1997) Characterization of two distinct intracellular GLUT4 membrane populations in muscle fiber. Differential protein composition and sensitivity to insulin. Endocrinology 138, 3006-3015
92. 92 Baldini, G., Hohman, R., Cnarron, M. J. and Lodish, H. F. (1991) Insulin and nonhydrolyzable GTP analogs induce translocation of GLUT4 to the plasma membrane in alpha-toxin-permeabilized rat adipose cells. J. Biol. Chem. 266, 4037-4040
93. 2+ and GTP(γ-S)-induced translocation of the glucose transporter GLUT4 to the plasma membrane of permeabilized cardiomyocytes determined using a novel immunoprecipitation method. Eur. J. Physiol. 430, 333-339
94. 94 Cormont, M., Tanti, F., Zahraoui, A., Van Obberghen, E., Tavitian, A. and Le Marchand-Brustel, Y. (1993) Insulin and okadaic acid induce rab4 redistribution in adipocytes. J. Biol Chem. 268, 19491-19497
95. 95 Sherman, L. A., Hishman, M. F., Cormont, M., Le Marchand-Brustel, Y. and Goodyear, L. J. (1996) Differential effects of insulin and exercise on rab4 distribution in rat skeletal muscle. Endocrinology 137, 266-273
96. 96 Van der Sluijs, P., Hull, M., Zahraoui, A., Tavitian, A., Goud, B. and Mellman, I. (1991) The small GTP-binding protein rab4 is associated with early endosomes. Proc. Natl. Acad. Sci. U.S.A. 88, 6313-6317
97. 97 Daro, E., Van der Sluijs, P., Galli, T. and Mellman, I. (1996) Rab4 and cellubrevin define different early endosome populations on the pathway of transferrin receptor recycling. Proc. Natl. Acad. Sci. U.S.A. 93, 9559-9564
98. 98 Van der Sluijs, P., Hull, M., Webster, P., Male, P., Goud, B. and Mellman, I. (1992) The small GTP-binding protein rab4 controls an early sorting event on the endocytic pathway. Cell 70, 729-740
99. 99 Cormont, M., Bortoluzzi, M. N., Gautier, N., Mari, M., Van Obberghen, E. and Le Marchand-Brustel, Y. (1996) Potential role of rab4 in the regulation of subcellular localization of GLUT4 in adipocytes. Mol. Cell. Biol. 16, 6879-6886
100. 100 Mora, S., Monden, I., Zorzano, A. and Keller, K. (1997) Heterologous expression of rab4 reduces glucose transport and GLUT4 abundance at the cell surface in oocytes Biochem. J. 324, 455-459
101. 101 Shibata, H., Omata, W., Suzuki, Y., Tanaka, S. and Kojima, I. (1996) A synthetic peptide corresponding to the rab4 hypervariable carboxyl-terminal domain inhibits insulin action on glucose transport in rat adipocytes. J. Biol. Chem 271, 9704-9709
102. 102 Uphues, I., Kolter, T., Goud, B. and Eckel, J. (1994) Insulin-induced translocation of glucose transporter GLUT4 in cardiac muscle. Studies on the role of small molecular mass GTP binding proteins. Biochem. J. 301, 177-182
103. 103 Sumitani, S., Ramlal, T., Liu, Z. and Klip, A. (1995) Expression of syntaxin 4 in rat skeletal muscle and rat skeletal muscle cells in culture. Biochem. Biophys. Res. Commun 213, 462-468
104. 104 Cain, C. C., Trimble, W. S. and Lienhard, G. E. (1992) Members of the Vamp family of synaptic vesicle proteins are components of glucose transporter-containing vesicles from rat adipocyles. J. Biol. Chem. 267, 1681-1684
105. 105 Martin, S., Tellam, J., Livingstone, C., Slot, J. W., Gould, G. W. and James, D. E. (1996) The glucose transporter (GLUT4) and vesicle-associated membrane protein-2 (VAMP-2) are seggregated from recycling endosomes in insulin-sensitive cells. J. Cell Biol. 134, 625-635
106. 106 Cheatham, B., Volchuk, A., Kahn, C. R., Wang, L., Rhodes, C. J. and Klip, A. (1996) Insulin-stimulated translocation of GLUT4 glucose transporters requires SNARE-complex proteins. Proc. Natl. Acad. Sci. U.S.A. 93, 15169-15173
107. 107 Tamori, Y., Hashiramoto, M., Araki, S., Kamata, Y., Takahashi, M., Kozaki, S. and Kasuga, M. (1996) Cleavage of vesicle-associated membrane protein (VAMP)-2 and cellubrevin on GLUT4-containing vesicles inhibits the translocation of GLUT4 in 3T3-L1 adipocytes. Biochem. Biophys. Res. Commun. 220, 740-745
108. 108 Olson, A. L., Knight, J. B. and Pessin, J. E. (1997) Syntaxin 4, VAMP2 and/or VAMP3/cellubrevin are functional target membrane and vesicle SNAP receptors for insulin-stimulated GLUT4 translocation in adipocytes. Mol. Cell. Biol. 17, 2425-2435
109. 109 Chilcote, T. J., Galli, T., Mundigl, O., Edelmann, L., McPherson, P. S., Takei, K and De Camilli, P. (1995) Cellubrevin and synaptobrevins: similar subcellular localization and biochemical properties in PC12 cells. J. Cell Biol. 129, 219-231
110. 110 Galli, T., Chilcote, T., Mundigl, O., Binz, T., Niemann, H. and De Camilli, P. (1994) Tetanus toxin-mediated cleavage of cellubrevin impairs exocytosis of transferrin receptor-containing vesicles in CHO cells. J. Cell Biol. 125, 1015-1024
111. 111 Link, E., McMahon, H., Fischer von Mollard, G., Yamasaki, S., Niemann, H., Sudhol, T. C. and Jahn, R. (1993) Cleavage of cellubrevin by tetanus toxin does not affect fusion of early endosomes. J. Biol. Chem. 268, 18423-18426
112. 112 Timmers, K. I., Clark, A. E., Omatsu-Kanbe, M., Whiteheart, S. W., Bennett, M. K., Holman, G. D. and Cushman, S. W. (1996) Identification of SNAP receptors in rat adipose cell membrane fractions and in SNARE complexes co-immunoprecipitated with epitope-tagged N-ethylmaleimide-sensitive fusion protein. Biochem. J. 320, 429-436
113. 113 Wang, G., Witkin, J. W., Hao, G., Bankaitis, V. A., Scherer, P. E. and Baldini, G. (1997) Syndet is a novel SNAP-25 related protein expressed in many tissues. J. Cell Sci. 110, 505-513
114. 114 Morris, N. J., Ducret, A., Aebersold, R., Ross, S. A., Keller, S. R. and Lienhard, G. E. (1997) Membrane amine oxidase cloning and identification as a major protein in the adipocyte plasma membrane. J. Biol. Chem. 272, 9388-9392
115. 115 Enrique-Tarancón, G., Marti, L., Morin, N., Lizcano, J. M., Unzeta, M., Sevilla, L., Camps, M., Palacin, M., Testar, X., Carpéné, C. and Zorzano, A. (1998) Role of semicarbazide-sensitive amine oxidase on glucose transport and GLUT4 recruitment to the cell surface in adipose cells. J. Biol. Chem. 273, 8025-8032
116. 116 Marti, L., Morin, N., Enrique-Tarancón, G., Prevot, D., Lafontan, M., Testar, X., Zorzano, A. and Carpéné, C. (1998) Tyramine and vanadate synergistically stimulate glucose transport in rat adipocytes by amine oxidase-dependent generation of hydrogen peroxide. J. Pharmacol. Exp. Ther. 285, 342-349
117. 117 Brozinick, J. T. and Birnbaum, M. J. (1998) Insulin, but not contraction, activates Akt/PKB in isolated rat skeletal muscle. J. Biol. Chem. 273, 14769-14782
118. 118 Calera, M. R., Martínez, C., Liu, H., Jack, A. K., Birnbaum, M. J. and Pilch, P. F. (1998) Insulin increases the association of akt-2 with Glut4-containing vesicles. J. Biol. Chem. 273, 7201-7204
119. 119 Kupriyanova, T. A. and Kandror, K. V. (1999) Akt-2 binds to GLUT4-containing vesicles and phosphorylates their component proteins in response to insulin. J. Biol. Chem. 274, 1458-1464
120. 120 Bangsbo, J., Gollnick, P. D., Graham, T. E. and Saltin, B. (1991) Substrates for muscle glycogen synthesis in recovery from intense exercise in man. J. Physiol. (London) 434, 423-440
121. 121 Pagliassotti, M. J. and Donovan, C. M. (1990) Role of cell type in net lactate removal by skeletal muscle. Am. J. Physiol. 258, E635-E642
122. 122 Bonen, A., McDermott, J. C. and Tan, M. H. (1990) Glycogenesis and glyconeogenesis in skeletal muscle: effects of pH and hormones. Am. J. Physiol. 258, E693-E700
123. 123 Goldberg, A. L. and Chang, T. W. (1978) Regulation and significance of amino acid metabolism in skeletal muscle. Fed. Proc. Fed. Am. Soc. Exp. Biol. 37, 2301-2307
124. 124 Hutson, S. M., Cree, T. G. and Harper, A. E. (1978) Regulation of leucine and α-ketoisocaproate metabolism in skeletal muscle. J. Biol. Chem. 253, 8126-8133
125. 125 Juel, C. (1997) Lactate-proton cotransport in skeletal muscle. Physiol. Rev. 77, 321-358
126. 126 McDermott, J. C. and Bonen, A. (1994) Lactate transport in rat sarcolemmal vesicles and intact skeletal muscle and after muscle contraction. Acta Physiol. Scand 151, 17-28
127. 127 Juel, C. (1988) Intracellular pH recovery and lactate efflux in mouse soleus muscle stimulated in vitro: the involvement of sodium/proton exchange and a lactate carrier. Acta Physiol. Scand. 132, 363-371
128. 128 Juel, C. (1996) Symmetry and pH dependency of the lactate/proton carrier in skeletal muscle studied with rat sarcolemmal giant vesicles. Biochim. Biophys. Acta 1283, 106-110
129. 129 Juel, C. (1991) Muscle lactate transport studied in sarcolemmal giant vesicles. Biochim. Biophys. Acta 1065, 15-20
130. + uptake in inactive muscles during intense exercise in man. J. Physiol. (London) 481, 219-229
131. 131 Gladden, L. B. (1991) Net lactate uptake during progressive steady-state contractions in canine skeletal muscle. J. Appl. Physiol. 71, 514-520
132. 132 Gladden, L. B. and Yates, J. W. (1983) Lactic acid infusion in dogs: effects of varying infusate pH. J. Appl. Physiol 54, 1254-1260
133. 133 Bonen, A. and McCullagh, K. J. A. (1994) Effect of exercise on lactate transport in mouse skeletal muscles. Can. J. Appl. Physiol. 19, 275-285
134. 134 Juel, C., Honig, A. and Pilegaard, H. (1991) Muscle lactate transport studied in sarcolemmal giant vesicles: dependence in fibre type and age. Acta Physiol. Scand. 143, 361-365
135. 135 Pilegaard, H., Bangsbo, J., Richter, E. A. and Juel, C. (1994) Lactate transport studied in sarcolemmal giant vesicles from human muscle biopsies: relation to training status. J. Appl. Physiol. 77, 1858-1862
136. 136 Pilegaard, H., Juei, C. and Wibrand, F. (1993) Lactate transport studied in sarcolemmal giant vesicles from rats: effects of training. Am. J. Physiol. 264, E156-E160
137. 137 McCullagh, J. A., Poole, R. C., Halestrap, A. P., O'Brian, M. and Bonen, A. (1996) The role of the lactate transporter (MCT1) in skeletal muscles. Am. J. Physiol. 271, E143-E150
138. 138 Juel, C. (1996) Lactate/proton co-transport in skeletal muscle: regulation and importance for pH homeostasis. Acta Physiol. Scand. 156, 369-374
139. 139 McCullagh, K. J. A. and Bonen, A. (1995) Reduced lactate transport in denervated rat skeletal muscle. Am. J. Physiol. 268, R884-R888
140. 140 Pilegaard, H. and Juel, C. (1995) Lactate transport studied in sarcolemmal giant vesicles from rat skeletal muscle: effect of denervation. Am. J. Physiol. 269, E679-E682
141. 141 Dubouchaud, H., Granier, P., Mercier, J., Le Peuch, C. and Préfaut, C. (1996) Lactate uptake by skeletal muscle sarcolemmal vesicles decreases after 4 weeks of hindlimb unweighting in rats. J. Appl. Physiol. 80, 416-421
142. 142 Halestrap, A. P. and Price, N. T. (1999) The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Biochem. J. 343, 281-299
143. 143 Garcia, C. K., Goldstein, J. L., Pathak, R. K., Anderson, R. G. W. and Brown, M. S. (1994) Molecular characterization of a membrane transporter for lactate, pyruvate and other monocarboxylates: implications for the Cori cycle. Cell 76, 865-873
144. 144 Garcia, C. K., Li, X., Luna, J. and Francke, U. (1994) cDNA cloning of the human monocarboxylate transporter I and chromosomal localization of the SLC16A1 locus to 1p13.2-p12. Genomics 23, 500-503
145. 145 Jackson, V. N., Price, N. T. and Halestrap, A. P. (1995) cDNA cloning of MCT1, a monocarboxylate transporter from rat skeletal muscle. Biochim. Biopys. Acta 1238, 193-196
146. 146 Carpenter, L., Poole, R. C. and Halestrap, A. P. (1996) Cloning and sequencing of the monocarboxylate transporter from mouse Ehrlich Lettré tumour cells confirms its identity as MCT1 and demonstrates that glycosylation is not required for MCT1 function. Biochim. Biopys. Acta 1279, 157-163
147. 147 Takanaga, H., Tamai, I., Inaba, S., Sai, Y., Higashida, H., Yamamoto, H. and Tsuji, A. (1995) cDNA cloning and functional characterization of rat intestinal monocarboxylate transporter. Biochem. Biophys. Res. Commun 217, 370-377
148. 148 Koehler-Stec, E. M., Simpson, I. A., Vannucci, S. J., Landschulz, K. T. and Landschulz, W. H. (1998) Monocarboxylate transporter expression in mouse brain. Am. J. Physiol. 275, E516-E524
149. 149 Price, N. T., Jackson, V. N. and Halestrap, A. P. (1998) Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. Biochem. J. 329, 321-328
150. +/lactate co-transporter (MCT1). Biochem. J. 320, 817-824
151. 151 De Bruijne, A. W., Vreeberg, H. and Van Steveninck, J. (1983) Kinetic analysis of L-lactate transport in human erythrocytes via the monocarboxylate-specific carrier system. Biochim. Biophys. Acta 732, 562-568
152. 152 De Bruijne, A. W., Vreeberg, H. and Van Steveninck, J. (1985) Alternative-substrate inhibition of L-lactate transport via the monocarboxylate-specitic carrier system in human erythrocytes. Biochim. Biophys. Acta 812, 841-844
153. 153 Broer, S., Rahman, B., Pellegri, G., Pellerin, L., Martin, J. L., Verleysdonk, S., Hamprecht, B. and Magistretti, P. J. (1997) Comparison of lactate transport in astroglial cells and monocarboxylate transporter 1 (MCT 1) expressing Xenopus laevis oocytes. Expression of two different monocarboxylate transporters in astroglial cells and neurons. J. Biol. Chem. 272, 30096-30102
154. 154 Broer, S., Schneider, H. P., Broer, A., Rahman, B., Hamprecht, B. and Deitmer, J. W. (1998) Characterization of the monocarboxylate transporter 1 expressed in Xenopus laevis oocytes by changes in cytosolic pH. Biochem. J 333, 167-174
155. 155 Juel, C. and Halestrap, A. P. (1999) Lactate transport in skeletal muscle - role and regulation of the monocarboxylate transporter. J. Physiol. (London) 517, 633-642
156. 156 Wilson, M. C., Jackson, V. N., Heddle, C., Price, N. T., Pilegaard, H., Juel, C., Bonen, A., Montgomery, I., Hutter, O. F. and Halestrap, A. P. (1998) Lactic acid efflux from white skeletal muscle is catalyzed by the monocarboxylate transporter isoform MCT3. J. Biol. Chem. 273, 15920-15926
157. 157 McCullagh, K. J. A., Poole, R. C., Halestrap, A. P., O'Brien, M. and Bonen, A. (1996) Role of the laclate transporter (MCT1) in skeletal muscles. Am. J. Physiol. 271, E143-E150
158. + transporter isoforms MCT1 and MCT4 in human skeletal muscle. Am. J. Physiol. 276, E843-E848
159. 159 Garcia, C. K., Brown, M. S., Pathak, R. K. and Goldstein, J. L. (1995) cDNA cloning of MCT2, a second monocarboxylate transporter expressed in difterent cells than MCT1. J. Biol. Chem. 270, 1843-1849
160. 160 Baker, S. K., McCullagh, K. J. A. and Bonen, A. (1998) Training intensity-dependent and tissue-specific increases in lactate uptake and MCT-1 in heart and muscle. J. Appl. Physiol. 84, 987-994
161. 161 Bonen, A., McCullagh, K. J. A., Putman, C. T., Hultman, E., Jones, N. L. and Heigenhauser, G. J. F. (1998) Short-term training increases human muscle MCT1 and femoral venous lactate in relation to muscle lactate. Am. J. Physiol. 274, E102-E107
162. 162 Hamilton, J. A. (1998) Fatty acid transport: difficult or easy? J. Lipid Res. 39, 467-481
163. 163 Abumrad, N., Coburn, C. and Ibrahimi, A. (1999) Membrane proteins implicated in long-chain fatty acid uptake by mammalian cells: CD36, FATP and FABPm. Biochim. Biophys. Acta 1441, 4-13
164. 164 Noy, N. and Zakim, D. (1985) Fatty acids bound to unilamellar vesicles as substrates for microsomal acyl-CoA ligase. Biochemistry 24, 3521-3525
165. 165 Daniels, C., Noy, N. and Zakim, D. (1985) Rates of hydration of fatty acid bound to unilamellar vesicles of phosphatidylcholine or to albumin. Biochemistry 24, 3286-3292
166. 166 Kamp, F. and Hamilton, J. A. (1993) Movement of fatty acids, fatty-acid analogues and bile acids across phospholipid bilayers. Biochemistry 32, 11074-11085
167. 167 Kamp, F. and Hamilton, J. A. (1992) pH gradients across phospholipid membranes caused by fast flip-flop of un-ionized fatty acids. Proc. Natl. Acad. Sci. U.S.A. 89, 11367-11370
168. 168 Kleinfeld, A. M., Chu, P. and Storch, J. (1997) Flip-flop is slow and rate limiting for the movement of long chain anthroyloxy fatty acids across lipid vesicles. Biochemistry 36, 5702-5711
169. 169 Luiken, J. J. F. P., Van Nieuwenhoven, F. A., America, G., Van Der Vusse, G. J. and Glatz, J. F. C. (1997) Uptake and metabolism of palmitate by isolated cardiac myocytes from adult rats: involvement of sarcolemmal proteins. J. Lipid Res. 38, 745-758
170. 170 Glatz, J. F. C., Luiken, J. J. F. P., Van Nieuwenhoven, F. A. and Van Der Vusse, G. J. (1997) Molecular mechanisms of cellular uptake and intracellular translocation of fatty acids. Prosteglandins Leukotrienes Essential Fatty Acids 57, 3-9
171. 171 Luiken, J. J., Schaap, F. G., van Niewenhoven, F. A., van der Vusse, G. J., Bonen, A. and Glatz, J. F. (1999) Cellular fatty acid transport in heart and skeletal muscle as facilitated by proteins. Lipids 34, 169-175
172. 172 Bonen, A., Dyck, D. J. and Luiken, J. J. (1998) Skeletal muscle fatty acid transport and transporters. Adv. Exp. Med. Biol. 441, 193-205
173. 173 Berk, P. D., Wada, H., Horio, Y., Potter, B. J., Sorrentino, D., Zhou, S.-L., Isola, L. M., Stump, D., Kiang, C.-L. and Thung, S. (1990) Plasma membrane fatty acid-binding protein and mitochondrial glutamic-oxaloacetic transaminase of rat liver are related. Proc. Natl. Acad. Sci. U.S.A. 87, 3484-3488
174. 174 Stump, D. D., Zhou, S. L. and Berk, P. D. (1993) Comparison of plasma membrane FABP and mitochondrial isoform of aspartate aminotransferase in rat liver. Am. J. Physiol. 265, G894-G902
175. 175 Sorrentino, D., Stump, D., Potter, B. J., Robinson, R. B., White, R., Kiang, C. L. and Berk, P. D. (1988) Oleate uptake by cardiac myocytes is carrier mediated and involves a 40 kD plasma membrane fatty acid binding protein similar to that in liver, adipose tissue and gut. J. Clin. Invest. 82, 928-935
176. 176 Zhou, S. L., Stump, D., Kiang, C. L., Isola, L. M. and Berk, P. D. (1995) Mitochondrial aspartate aminotransferase expressed on the surface of 3T3-L1 adipocytes mediates saturable fatty acid uptake. Proc. Soc. Exp. Biol. Med. 208, 263-270
177. 177 Luiken, J. J., Turcotte, L. P. and Bonen, A. (1999) Protein-mediated palmitate uptake and expression of fatty acid transport proteins in heart giant vesicles. J. Lipid Res. 40, 1007-1016
178. 178 Isola, L. M., Zhou, S. L., Kiang, C. L., Stump, D. D., Bradbury, M. W. and Berk, P. D. (1995) 3T3 fibroblasts transfected with a cDNA for mitochondrial aspartate aminotransferase express plasma membrane fatty acid-binding protein and saturable fatty acid uptake. Proc. Natl. Acad. Sci. U.S.A. 92, 9866-9870
179. 179 Van Niewenhoven, F. A., Willemsen, P. H., van der Vusse, G. J. and Glatz, J. F. (1999) Co-expression in rat heart and skeletal muscle of four genes coding for proteins implicated in long-chain fatty acid uptake. Int. J. Biochem. Cell Biol. 31, 489-498
180. 180 Bonen, A., Luiken, J. J., Liu, S., Dyck, D. J., Kiens, B., Kristiansen, S., Turcotte, L. P., Van der Vusse, G. J. and Glatz, J. F. (1998) Palmitate transport and fatty acid transporters in red and white muscles. Am. J. Physiol. 275, 471-478
181. 181 Kiens, B., Kristiansen, S., Jensen, P., Richter, E. A. and Turcotte, L. P. (1997) Membrane associated fatty acid bindng protein (FABPpm) in human skeletal muscle is increased by endurance training. Biochem. Biophys. Res. Commun. 231, 463-465
182. 182 Abumrad, N. A., El-Maghrabi, M. R., Amri, E. Z., Lopez, E. and Grimaldi, P. A. (1993) Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36. J. Biol. Chem. 268, 17665-17668
183. 183 Rasmussen, J. T., Berglund, L., Rasmussen, M. S. and Petersen, T. E. (1998) Assignment of disullide bridges in bovine CD36. Eur. J. Biochem. 257, 488-494
184. 184 Baillie, A. G. S., Coburn, C. T. and Abumrad, N. (1996) Reversible binding of long-chain fatty acids to purified FAT, the adipose CD36 homolog. J. Membr. Biol. 153, 75-81
185. 185 Ibrahimi, A., Sfeir, Z., Magharaie, H., Amri, E. Z., Grimaldi, P. and Abumrad, N. A. (1996) Expression of the CD36 homolog (FAT) in fibroblast cells: effects on fatty acid transport. Proc. Natl. Acad. Sci. U.S.A. 93, 2646-2651
186. 186 Ibrahimi, A., Bonen, A., Blinn, W. D., Hajri, T., Li, X., Zhong, K., Cameron, R. and Abumrad, N. A. (1999) Muscle-specific overexpression of FAT/CD36 enhances fatty acid oxidation by contractile muscle, reduces plasma triglycerides and fatty acids and increases plasma glucose and insulin. J. Biol. Chem. 274, 26761-26766
187. 187 Van Niewenhoven, F. A., Luiken, J. J., De Jong, Y. F., Grimaldi, P. A., van der Vusse, G. J. and Glatz, J. F. (1998) Stable transfection of fatty acid translocase (CD36) in a rat heart muscle cell line (H9c2). J. Lipid Res. 39, 2039-2047
188. 188 Aitman, T. J., Glazier, A. N., Wallace, C. A., Cooper, L. D., Norsworthy, P. J., Wahid, F. N., Al-Majali, K. M., Trembling, P. M., Mann, C. J., Shoulders, C. C. et al. (1999) Identification of cd36 (fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats. Nat. Genet. 21, 76-83
189. 189 Gotoda, T., Lizuka, Y., Kato, N., Osuga, J., Bihoreau, M. T., Murakami, T., Yamori, Y, Shimano, H., Ishibashi, S. and Yamada, N. (1999) Absence of Cd36 mutation in the original spontaneously hypertensive rats with insulin resistance. Nat. Genet. 22, 226-228
190. 190 Van Niewenhoven, F. A., Verstijnen, C. P., Abumrad, N. A., Willemsen, P. H., Van Eys, G. J., van der Vusse, G. J. and Glatz, J. F. (1995) Putative membrane fatty acid translocase and cytoplasmic fatty acid-binding protein are co-expressed in rat heart and skeletal muscles. Biochem. Biophys. Res. Commun. 207, 747-752
191. 191 Pelsers, M. M., Lutgerink, J. T., Niewenhoven, F. A., Tandon, N. N., van der Vusse, G. J., Arends, J. W., Hoogenboom, H. R. and Glatz, J. F. (1999) A sensitive immunoassay for rat fatty acid translocase (CD36) using phage antibodies selected on cell transfectants: abundant presence of fatty acid translocase/CD36 in cardiac and muscle and up-regulation in diabetes. Biochem. J. 337, 407-414
192. 192 Bonen, A., Dyck, D. J., Ibrahimi, A. and Abumrad, N. A. (1999) Muscle contractile activity increases fatty acid metabolism and transport and FAT/CD36. Am. J. Physiol. 276, E642-E649
193. 193 Schaffer, J. E. and Lodish, H. F. (1994) Expression, cloning and characterization of a novel adipocyte long chain fatty acid transport protein. Cell 79, 427-436
194. 194 Stuhlsatz-Krouper, S. M., Bennett, N. E. and Schaffer, J. E. (1998) Substitution of alanine for serine 250 in the murine fatty àcid transport protein inhibits long chain fatty acid transport. J. Biol. Chem. 273, 28642-28650
195. 195 Schaap, F. G., Hamers, L., Van Der Vusse, G. J. and Glatz, J. F. (1997) Molecular cloning of fatty acid-transport protein cDNA from rat. Biochim. Biophys. Acta 1354, 29-34
196. 196 Watkins, P. A., Lu, J. F., Steinberg, S. J., Gould, S. J., Smith, K. D. and Braiterman, L. T. (1998) Disruption of the Saccharomyces cerevisiae FAT1 gene decreases very long-chain fatty acyl-CoA synthetase activity and elevates very long-chain fatty acid concentrations. J. Biol. Chem. 273, 18210-18219
197. 197 Hirsch, D., Stahl, A. and Lodish, H. F. (1998) A family of fatty acid transporters conserved from mycobacterium to man. Proc. Natl. Acad. Sci. U.S.A. 95, 8625-8629
198. 198 Man, M. Z., Hui, T. Y., Schaffer, J. E., Lodish, H. F. and Bernlohr, D. A. (1996) Regulation of the murine adipocyte fatty acid transporter gene by insulin. Mol. Endocrinol. 10, 1021-1028
199. 199 Hui, T. Y., Frohnert, B. I., Smith, A. J., Schaffer, J. E. and Bernlohr, D. A. (1998) Characterization of the murine faty acid transport protein gene and its insulin response sequence. J. Biol. Chem. 273, 27420-27429
200. 200 Memon, R. A., Feingold, K. R., Moser, A. H., Fuller, J. and Grunfeld, C. (1998) Regulation of fatty acid transport protein and fatty acid translocase mRNA levels by endotoxin and cytokines. Am. J. Physiol. 274, E210-E217
201. 201 Broquist, H. P. (1982) Carnitine biosynthesis and function. Introductory remarks. Fed. Proc. Fed. Am. Soc. Exp. Biol. 41, 2840-2842
202. 202 Chapoy, P. R., Angelini, C., Brown, W. J., Stiff, J. E., Shug, A. L. and Cederbaum, S. D. (1980) Systemic carnitine deficiency - a treatable inherited lipid-storage disease presenting as Reye's syndrome. N. Engl. J. Med. 303, 1389-1394
203. 203 Burlina, A. P., Sershen, H., Debler, E. A. and Latjha, A. (1989) Uptake of acetyl-L-carnitine in the brain. Neurochem. Res. 14, 489-493
204. 204 Christiansen, R. Z. and Bremer, J. (1976) Active transport of butyrobetaine and carnitine into isolated liver cells. Biochim. Biophys. Acta 448, 562-577
205. 205 Kispal, G., Meleg, B., Alkonyi, I. and Sandor, A. (1987) Enhanced uptake of carnitine by perfused rat liver following starvation. Biochim. Biophys. Acta 896, 96-102
206. 206 Rebouche, C. J. and Engel, A. G. (1982) Carnitine transport in cultured muscle cells and skin fibroblasts from patients with primary systemic carnitine deficiency. In Vitro 18, 495-500
207. 207 Treem, W. R., Stanley, C. A., Finegold, D. N., Hales, D. E. and Coatres, P. M. (1988) Primary carnitine deficiency due to a failure of carnitine transport in kidney, muscle and fibroblasts. N. Engl. J. Med. 319, 1331-1336
208. 208 Tein, I., De Vivo, D C., Bierman, F., Pulver, P., De Meirleir, L. J., Cvitanovic-Sojat, L., Pagon, R. A., Bertini, E., Dionisi-Vici, C., Servidei, S. and DiMauro, S. (1990) Impaired skin fibroblast carnitine uptake in primary systemic carnitine deficiency manifested by childhood carnitine-responsive cardiomyopathy. Pediatr. Res. 28, 247-255
209. 209 Bahl, J. J. and Bressler, R. (1987) The pharmacology of carnitine. Annu. Rev. Pharmacol. Toxicol. 27, 257-277
210. 210 Stieger, B., O'Neill, B. and Krähenbühl, S. (1995) Characterization of L-carnitine transport by rat kidney brush-border-membrane vesicles. Biochem. J. 309, 643-647
211. 211 Cambridge, G. and Stern, C. M. M. (1981) The uptake of tritium-labelled carnitine by monolayer cultures of human fetal muscle and its potential as a label in cytotoxicity studies. Clin. Exp. Immunol. 43, 211-219
212. 212 Martinuzzi, A., Vergani, L., Rosa, M. and Angelini, C. (1991) L-Carnitine uptake in differentiating human cultured muscle. Biochim. Biophys. Acta 1095, 217-222
213. 213 Vergani, L. and Angelini, C. (1999) Infantile lipid storage myopathy with nocturnal hypoventilation shows abnormal low-affinity muscle carnitine uptake in vitro. Neuromuscular Disord. 9, 320-322
214. 214 Rebouche, C. J. (1977) Carnitine movement across muscle cell membranes. Studies in isolated rat muscle. Biochim. Biophys. Acta 471, 145-155
215. 215 Willner, J. H., Ginsburg, S. and Di Mauro, S. (1978) Active transport of carnitine into skeletal muscle. Neurology 28, 721-724
216. 216 Wu, X., Prasad, P. D., Leibach, F. H. and Ganapathy, V. (1998) cDNA, sequence, transport function and genomic organization of human OCTN2, a new member of the organic cation transporter family. Biochem. Biophys. Res. Commun. 246, 589-595
217. 217 Sekine, T., Kusuhara, H., Utsunomiya-Tale, N., Tsuda, M., Sugiyama, Y., Kanai, Y. and Endou, H. (1998) Molecular cloning and characterization of high-affinity carnitine transporter from rat intestine. Biochem. Biophys. Res. Commun. 251, 586-591
218. 218 Tamai, I., Ohashi, R., Nezu, J., Yabuuchi, H., Oku, A., Shimane, M., Sai, Y. and Tsuji, A. (1998) Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2. J. Biol. Chem 273, 20378-20382
219. +-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J. Pharmacol. Exp. Ther. 291, 778-784
220. 220 Wu, X., Huang, W., Prasad, P. D., Seth, P., Rajan, D. P., Leibach, F. H., Chen, J., Conway, S. J. and Ganapathy, V. (1999) Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter. J. Pharmacol. Exp. Ther. 290, 1482-1492
221. 221 Schömig, E., Spitzenberger, F., Engelhardt, M., Martel, F., Ording, N. and Gründermann, D. (1998) Molecular cloning and characterization of two novel transport proteins from rat kidney. FEBS Lett. 425, 79-86
222. 222 Hashimoto, N., Suzuki, F., Tamai, I., Nikaido, H., Kuwajima, M., Hayakawa, J. and Tsuji, A. (1998) Gene-dose effect on carnitine transport activity in embryonic tibroblasls of JVS mice as a model of human carnitine transporter deficiency. Biochem. Pharmacol. 55, 1729-1732
223. 223 Lamhonwah, A. M. and Tein, I. (1998) Carnitine uptake defect: frameshift mutations in the human pfasmafemmal carnitine transporter gene. Biochem. Biophys. Res. Commun. 252, 396-401
224. 224 Nezu, J., Tamai, I., Oku, A., Ohashi, R., Yabuuchi, H., Hashimoto, N., Nikaido, H., Sai, Y., Koizumi, A., Shoji, Y. et al. (1999) Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter. Nat. Genet. 21, 91-94
225. 225 Wang, Y., Ye, Y., Ganapathy, V. and Longo, N. (1999) Mutations in the organic cation/carnitine transporter OCTN2 in primary carnitine deficiency. Proc. Natl. Acad Sci. U.S.A. 96, 2356-2360
226. 226 Tang, N. L. S., Ganapathy, V, Wu, X., Hui, J., Seth, P., Yuen, P. M. P., Fok, T. F. and Hjelm, N. M. (1999) Mutations of OCTN2, an organic cation/carnitine transporter, lead to deficient cellular carnitine uptake in primary carnitine deficiency. Hum. Mol. Genet. 8, 655-660
227. 227 Burwinkel, B., Kreuder, J., Schweitzer, S., Vorgerd, M., Gempel, K., Gerbitz, K. D. and Kilimann, M. W. (1999) Carnitine transporter OCTN2 mutations in systemic primary carnitine deficiency: a novel Arg169GIn mutation and a recurrent Arg282ter mutation associated with an unconventional splicing abnormality. Biochem. Biophys. Res. Commun. 261, 484-487
228. 228 Vaz, F. M., Scholte, H. R., Ruiter, J., Hussaarts-Odijk, L. M., Pereira, R. R., Schweitzer, S., de Klerk, J. B., Waterham, H. R. and Wanders, R. J. (1999) Identification of two novel mutations in OCTN2 of three patients with systemic carnitine deficiency. Hum. Genet. 105, 157-161
229. 229 Engel, A. G. and Angelini, C. (1973) Carnitine deficiency of human skeletal muscle with associated lipid storage myopathy: a new syndrome. Science 179, 899-901
230. 230 Cahill, G. F. (1971) Metabolic role of muscle. In Muscle Metabolism During Exercise (Pernow, B. and Saltin, B., eds), pp. 103-109, Plenum Press, New York
231. 231 London, D. R., Foley, T. H. and Webb, C. G. (1965) Evidence for the release of individual amino acids from the resting human forearm. Nature (London) 208, 588-589
232. 232 Pozefsky, T., Felig, P., Tobin, J. D., Soeldner, J. S. and Cahill, Jr, G. F. (1969) Amino acid balance across the tissue of the forearm in postabsorptive man: Effects of insulin at two dose levels J. Clin. Invest. 48, 2273-2282
233. 233 Ruderman, N. B. and Berger, M (1974) The formation of glutamine and alanine in skeletal muscle. J. Biol. Chem. 249, 5500-5506
234. 234 Chang, T. W. and Goldberg, A. L. (1978) The metabolic fates of amino acids and the formation of glutamine in skeletal muscle. J. Biol. Chem. 253, 3685-3695
235. 235 Garber, A. J., Karl, I. E. and Kipnis, D. M. (1976) Alanine and glutamine synthesis and release from skeletal muscle. I. Glycolysis and amino acid release. J. Biol Chem. 251, 826-835
236. 236 Adibi, S. A. (1976) Metabolism of branched-chain amino acids in altered nutrition. Metab. Clin. Exp. 25, 1287-1302
237. 237 Beatty, C. H., Curtis, S., Young, M. K. and Bacek, R. M. (1974) Oxidation of amino acids by red and white muscle fiber groups Am. J. Physiol. 227, 268-272
238. 238 Manchester, K. L. (1965) Oxidation of amino acids by isolated rat diaphragm and the influence of insulin. Biochim. Biophys. Acta 100, 295-298
239. 239 Snell, K. (1980) Muscle alanine biosynthesis and hepatic gluconeogenesis. Biochem. Soc. Trans. 8, 205-213
240. 240 Akedo, H. and Christensen, H N. (1962) Nature of insulin action on amino acid uptake by isolated diaphragm. J. Biol. Chem. 237, 118-127
241. 241 Kipnis, D. M. and Parrish, J. M. (1965) Role of Na and K on sugar (2-deoxyglucose) and amino acid (aminoisobutyric acid) transport in striated muscle. Fed. Proc. Fed. Am. Soc. Exp. Biol. 24, 1051-1059
242. 242 Riggs, T. R. and McKirahan, K. J. (1973) Action of insulin on transport of L-alanine into rat diaphragm in vitro. J. Biol. Chem. 248, 6450-6455
243. 243 Hundal, H. S., Rennie, M. J. and Watt, P. W. (1987) Characteristics of L-glutamine transport in perfused rat skeletal muscle. J. Physiol. (London) 393, 283-305
244. 244 Maroni, B. J., Karapanos, G. and Mitch, W E. (1986) System ASC and sodium-independent neutral amino acid transport in muscle of uremic rats. Am. J. Physiol. 251, F81-F86
245. 245 Bressler, R., Grosso, D. S. and Roeske, W. R. (1977) Carrier-mediated taurine uptake in the fetal mouse heart. Trans. Assoc. Am. Physicians 90, 257-269
246. 246 Hundal, H. S., Rennie, M. J. and Watt, P. W. (1989) Characteristics of acidic, basic and neutral amino acid transport in the perfused rat hindlimb. J. Physiol. (London) 408, 93-114
247. 247 Low, S. Y., Rennie, M. J. and Taylor, P. M. (1994) Sodium-dependent glutamate transport in cultured rat myotubes increases after glutamine deprivation. FASEB J. 8, 127-131
248. 248 Elsas, L. J., Albrecht, I. and Rosenberg, L. E. (1968) Insulin stimulation of amino acid uptake in rat diaphragm: relationship to protein synthesis. J. Biol. Chem. 243, 1846-1853
249. 249 Manchester, K. L., Guidotti, G. G., Borghetti, A. F. and Luneburg, N. (1971) Evaluation of kinetic parameters for uptake of amino acids by cells: effect of insulin on the accumulation of aminoisobutyrate and cycloleucine by isolated rat diaphragm muscle and chick embryo cells. Biochim. Biophys. Acta 241, 226-241
250. 250 Narahara, H. T. and Holloszy, J. O. (1974) The actions of insulin, trypsin and electrical stimulation on amino acid transport in muscle. J. Biol. Chem. 249, 5435-5443
251. 251 Elsas, L. J., Wheeler, F. B., Danner, D. J. and De Haan, R. L. (1975) Amino acid transport by aggregates of cultured chicken heart cells. J. Biol. Chem. 250, 9381-9390
252. 252 Le Marchand-Brustel, Y., Moulard, N. and Freychet, P. (1982) Aminoisobutyric acid transport in soleus muscles of lean and gold thioglucose-obese mice. Am. J. Physiol. 243, E74-E79
253. +-ATPase independent pathway. Biochem. Biophys. Res. Commun. 134, 1342-1349
254. 254 Bonadonna, R. C., Saccomani, M. P., Cobelli, C. and DeFronzo, R. A. (1993) Effect of insulin on system A amino acid transport in human skeletal muscle. J. Clin Invest. 91, 514-521
255. 255 Gumà, A., Castelló, A., Testar, X., Palacín, M. and Zorzano, A. (1992) Differential sensitivity of insulin-and adaptive-regulation-induced system A activation to microtubular function in skeletal muscle. Biochem. J. 281, 407-411
256. 256 Gumà, A., Testar, X., Palacin, M. and Zorzano, A. (1988) Insulin-stimulated α-(methyl)aminoisobutyric acid uptake in skeletal muscle. Biochem. J. 253, 625-629
257. 257 Gumà, A., Viñals, F., Testar, X., Palacín, M. and Zorzano, A. (1993) Regulation of system A amino acid transport activity by phospholipase C and cAMP-inducing agents in skeletal muscle: modulation of insulin action. Biochim. Biophys. Acta 1176, 155-161
258. 258 Muñoz, P., Gumà, A., Camps, M., Furriols, M., Testar, X., Palacín, M. and Zorzano, A. (1992) Vanadate stimulates system A amino acid transport activity in skeletal muscle. Evidence for the involvement of intracellular pH as a mediator of vanadate action. J. Biol. Chem. 267, 10381-10388
259. 259 Gumà, A., Mora, C., Santalucia, T., Viñals, F., Teslar, X., Palacín, M. and Zorzano, A. (1992) System A transport activity is stimulated in skeletal muscle in response to diabetes. FEBS Lett. 310, 51-54
260. 260 Tadros, L. B., Willhoft, N. M., Taylor, P. M. and Rennie, M. J. (1993) Effects of glutamine deprivation on glutamine transport and synthesis in primary culture of rat skeletal muscle. Am. J. Physiol. 265, E935-E942
261. 261 Tadros, L. B., Taylor, P. M. and Rennie, M. J. (1993) Characteristics of glutamine transport in primary tissue culture of rat skeletal muscle. Am. J. Physiol. 265, E135-E144
262. 262 Low, S. Y., Taylor, P. M. and Rennie, M. J. (1996) Responses of glutamine transport in cultured rat skeletal muscle to osmotically induced changes in cell volume. J. Physiol. (London) 492, 877-885
263. 263 Low, S. Y., Rennie, M. J and Taylor, P. M. (1997) Signaling elements involved in amino acid transport responses to altered muscle cell volume. FASEB J. 11, 1111-1117
264. 264 Chaudhry, F. A., Reimer, R. J., Krizaj, D., Barber, D., Storm-Mathisen, J., Copenhagen, D. R. and Edwards, R. H. (1999) Molecular analysis of system N suggests novel physiological roles in nitrogen metabolism and synaptic transmission. Cell 99, 769-780
265. 265 Iwata, H., Obara, T., Kim, B. K. and Baba, A. (1986) Regulation of taurine transport in rat skeletal muscle. J. Neurochem. 47, 158-163
266. 266 Iwata, H., Kim, B. K., Fukui, Y. and Baba, A. (1987) Neural regulation of taurine transport in skeletal muscle. Adv. Exp. Med. Biol. 217, 199-205
267. 267 Manolopoulos, V. G., Droggmans, G. and Nilius, B. (1997) Hypotonicity and thrombin activate taurine efflux in BC3H1 and C2C12 myoblasts that is down regulated during differentiation. Biochem. Biophys. Res. Commun. 232, 74-79
268. 268 Aoki, T. T., Brennan, M. F., Müller, W. A., Moore, F. D. and Cahill, Jr, G. F. (1972) Effect of insulin on muscle glutamate uptake. Whole blood versus plasma glutamate analysis. J. Clin. Invest. 51, 2889-2894
269. 269 MacLeod, C. L. (1996) Regulation of cationic amino acid transporter (CAT) gene expression. Biochem. Soc. Trans. 24, 846-852
270. 270 Closs, E. I. (1996) CATs, a family of three distinct mammalian cationic amino acid transporters. Amino Acids 11, 193-208
271. 271 MacLeod, C. L. and Kakuda, D. K. (1996) Regulation of CAT: cationic amino acid transporter gene expression. Amino Acids 11, 171-191
272. +-independent transport (uniport) of amino acids and glucose in mammalian cells. J. Exp. Biol. 196, 93-108
273. + basic amino acid transporter. Biochemistry 32, 5781-5785
274. + type cationic amino acid transport in Xenopus oocytes and show different tissue expression patterns. Transgene 1, 91-101
275. 275 Wang, H., Kavanaugh, M. P., North, R. A. and Kabat, D. (1991) Cell-surface receptor for ecotropic murine retroviruses is a basic amino acid transporter. Nature (London) 352, 729-731
276. 276 Closs, E. I., Albritton, L. M., Kim, J. W. and Cunningham, J. M. (1993) Identification of a low affinity, high capacity transporter of cationic amino acids in mouse liver. J. Biol. Chem. 268, 7538-7544
277. 277 Closs, E. I., Lyons, R., Kelly, C. and Cunningham, J. M. (1993) Characterization of the third member of the CAT family of cationic amino acid transporters. J. Biol. Chem 268, 20796-20800
278. 278 Kavanaugh, M. P., Wang, H., Zhang, Z., Zhang, W., Wu, Y.-N., Dechant, E., North, R. and Kabat, D. (1994) Control of cationic amino acid transport and retroviral receptor functions in a membrane protein family. J. Biol. Chem. 269, 15445-15450
279. 279 MacLeod, C. L., Fong, A. M., Seal, B. S., Walls, L. M. and Wilkinson, W. F. (1990) Isolation of novel murine thymocyte cDNA clones: one encodes a putative membrane spanning protein. Cell Growth Differ. 1, 271-279
280. 280 Albritton, L. M., Kim, J. W., Tseng, L. and Cunningham, J. M. (1993) Envelope binding domain in the cationic amino acid transporter determines the host range of ecotropic murine retroviruses. J. Virol. 67, 2091-2096
281. 281 Fletcher, E. J. and Johnston, G. A. R. (1991) Regional heterogeneity of L-glutamate and L-aspartate high affinity uptake systems in the rat CNS. J. Neurochem. 57, 911-915
282. 282 Kakuda, D. K., Finley, K. D., Maruyama, M. and MacLeod, C. L. (1998) Stress differentially induces cationic amino acid transporter gene expression. Biochim. Biophys. Acta 1414, 75-84
283. 283 Blakely, R. D., DeFelice, L. J. and Hartzell, H. C. (1994) Molecular physiology of norepinephrine and serotonin transporters. J. Exp. Biol 196, 263-282
284. 284 Kanner, B. I. (1994) Sodium-coupled neurotransrmitter transport: structure, function and regulation. J. Exp. Biol. 196, 237-249
285. 285 Rasola, A., Galietta, L. J. V, Barone, V., Romeo, G. and Bagnasco, S. (1995) Molecular cloning and functional characterization of GABA/betaine transporter from human kidney. FEBS Lett. 373, 229-233
286. 286 Jhiang, S. M., Fithian, L., Smanik, P., McGill, J., Tong, Q. and Mazzaferri, E. L. (1993) Cloning of the human taurine transporter and characterization of taurine uptake in thryroid cells. FEBS Lett. 318, 139-144
287. --dependent betaine transporter that is regulated by hypertonicity. J. Biol. Chem. 267, 649-652
288. 288 Borden, L. A., Smith, K. E., Gustafson, E. L., Branchek, T. A. and Weinshank, R. L. (1995) Cloning and expression of a betaine/GABA transporter from human brain. J. Neurochem. 64, 977-984
289. 289 Liu, Q.-R., López-Corcuera, B., Nelson, H., Mandiyan, S. and Nelson, S. (1992) Cloning and expression of a cDNA encoding the transporter of taurine and β-alanine in mouse brain. Proc. Natl. Acad. Sci. U.S.A. 89, 12145-12149
290. --dependent taurine transporter that is regulated by hypertonicity. Proc. Natl. Acad. Sci. U.S.A. 89, 8230-8234
291. 291 Smith, K. E., Borden, L. A., Wang, C.-H. D., Hartig, P. R., Branchek, T. A. and Weinshank, R. L. (1992) Cloning and expression of a high affinity taurine transporter from rat brain Mol. Pharmacol. 42, 563-569
292. 292 Ramamoorthy, S., Leibach, F. H., Mahesh, V. B., Han, H., Yang-Feng, T., Blakely, R. D. and Ganapathy, V. (1994) Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta. Biochem. J 300, 893-900
293. 293 Kwon, H. M. (1996) Transcriptional regulation of the betaine/γ-aminobutyric acid transporter by hypertonicity. Biochem. Soc. Trans. 24, 853-856
294. 294 Warskulat, U., Wettstein, M. and Häussinger, D. (1995) Betaine is an osmolyte in RAW 264.7 mouse macrophages. FEBS Lett. 377, 47-50
295. 295 Warskulat, U, Wettstein, M. and Häussinger, D. (1997) Osmo-regutated taurine transport in H4IIE hepatoma cells and perfused rat liver. Biochem. J. 321, 683-690
296. -)-coupled γ-aminobutyric acid transporter from rat brain. J. Biol. Chem. 272, 1203-1210
297. 297 Olivares, L., Aragón, C., Giménez, C. and Zafra, F. (1997) Analysis of the transmembrane topology of the glycine transporter GLYT1. J. Biol. Chem. 272, 1211-1217
298. 298 Arriza, J. L., Fairman, W. A., Wadiche, J. I., Murdoch, G. H., Kavanaugh, M. P. and Amara, S. G. (1994) Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex. J. Neurosci. 14, 5559-5569
299. 299 Kanai, Y. and Hediger, M. A. (1992) Primary structure and functional characterization of a high-affinity glutamate transporter. Nature (London) 360, 467-471
300. 300 Arriza, J. L., Eliasof, S., Kavanaugh, M. P. and Amara, S. G. (1997) Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance. Proc. Natl. Acad. Sci. U.S.A. 94, 4155-4160
301. +/glutamate cotransporters. J. Biol. Chem. 268, 15351-15355
302. +-dependent neutral amino acid transporter. J. Biol. Chem. 271, 14883-14890
303. 303 Fairman, W. A., Vandenberg, R. J., Arriza, J. L., Kavanaugh, M. P. and Amara, S. (1995) An excitatory amino-acid transporter with properties of a ligand-gated chloride channel. Nature (London) 375, 599-603
304. 304 Zerangue, N. and Kavanaugh, M. P. (1996) ASCT-1 is a neutral amino acid exchanger with chloride channel activity. J. Biol. Chem. 271, 27991-27994
305. 305 Sonders, M. S. and Amara, S.-G. (1996) Channels in transporters. Curr. Opin. Neurobiol. 6, 294-302
306. 306 Grunewald, M., Bendahan, A. and Kanner, B. I. (1998) Biotinylation of single cysteine mutants of the glutamate transporter GLT-1 from rat brain reveals its unusual topology. Neuron 21, 623-632
307. 307 Mastroberardino, L., Spindler, B., Pfeiffer, R., Skelly, P. J., Lolfing, J., Shoemaker, C. B. and Verrey, F. (1998) Amino acid transport by heterodimers of 4F2/CD98 and members of a permease family. Nature (London) 395, 288-291
308. 308 Kanai, Y., Segawa, H., Miyamoto, K., Uchino, H., Takeda, E. and Endou, H. (1998) Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98). J. Biol. Chem 273, 23629-23632
309. 309 Torrents, D., Estévez, R., Pineda, M., Fernández, E., Lloberas, J., Shi, Y. B., Zorzano, A. and Palacín, M. (1998) Identification and characterization of a membrane protein (y + L amino acid transporter-1) that associates with 4F2hc to encode the amino acid transport activity y+L. J. Biol. Chem. 273, 32437-32445
310. 310 Pfeiffer, R., Rossier, G., Spindler, B., Meier, C., Kühn, L. and Verrey, F. (1999) Amino acid transport of y + L-type by heterodimers of 4F2/CD98 and members of the glycoprotein-associated amino acid transporter family. EMBO J. 18, 49-57
311. 311 Pineda, M., Fernández, E., Torrents, D., Estévez, R., López, C., Camps, M., Lloberas, J., Zorzano, A. and Palacín, M. (1999) Identification of a membrane protein LAT-2 that co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids. J. Biol. Chem. 274, 19738-19744
312. 312 Rossìer, G., Meier, C., Bauch, C., Summa, V., Sordat, B., Verrey, F. and Kühn, L. C. (1999) LAT2, a new basolateral 4F2/CD98-associated amino acid transporter of kidney and intestine. J. Biol. Chem. 274, 34948-34954
313. +-independent neutral amino acid transporter with broad substrate selectivity. J. Biol. Chem. 274, 19745-19751
314. 0+AT) of rBAT. Nat. Genet. 23, 52-57
315. 315 Pfeiffer, R., Loffing, J., Rossier, G., Bauch, C., Meier, C, Eggermann, T., Loffing-Cueni, D., Kühn, L. C. and Verrey, F. (1999) Luminal heterodimeric amino acid transporter detective in cystinuria. Mol. Biol. Cell 10, 4135-4147
316. 316 Sato, H., Tamba, M., Ishii, T. and Bannai, S. (1999) Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins. J. Biol. Chem. 274, 11455-11458
317. 317 Calonge, M. J., Gasparini, P., Chillarón, J., Chillón, M., Gallucci, M., Rousaud, F., Zelante, L., Testar, X., Dallaplccola, B., Di Silverio, F, et al. (1994) Cystinuria caused by mutations in rBAT, a gene involved in the transport of cystine. Nat. Genet. 6, 420-425
318. 318 Torrents, D., Mykkänen, J., Pineda, M., Feliubadaló, L, Estévez, R., de Cid, R., Sanjurjo, P., Zorzano, A., Nunes, V., Huoponen, K. et al. (1999) Identification of SLC7A7, encoding y + LAT-1, as the lysinuric protein intolerance gene. Nat. Genet. 21, 293-296
319. 319 Borsani, G., Bassi, M. T., Sperandeo, M. P., De Grandi, A., Buoninconti, A., Riboni, M., Manzoni, M., Incerti, B., Pepe, A., Andria, G. et al. (1999) SLC7A7, encoding a putative permease-related protein, is mutated in patients with lysinuric protein intolerance. Nat. Genet. 21, 297-301
320. 2 terminus. J. Biol. Chem. 262, 9574-9580
321. 321 Quackenbush, E., Clabby, M., Gottesdiener, K. M., Barbosa, J., Jones, N. H., Strominger, J. L., Speck, S. and Leiden, J. M. (1987) Molecular cloning of complementary cDNAs encoding the heavy chain of the human 4F2 cell-surface antigen : a type II membrane glycoprotein involved in normal and neoplastic cell growth. Proc. Natl. Acad. Sci. U.S.A. 84, 6526-6530
322. 322 Lumadue, J. A., Glick, A. B. and Ruddle, F. H. (1987) Cloning, sequence analysis and expression of the large subunit of the human lymphocyte activation antigen 4F2. Proc. Natl Acad. Sci. U.S.A. 84, 9204-9208