Creatine uptake in isolated soleus muscle: Kinetics and dependence on sodium, but not on insulin

Acta Physiologica Scandinavica

Volumn 166, Issue 2, 1999, Pages 99-104

  Willott, C A ^a   Young, M E ^a   Leighton, B ^b   Kemp, G J ^c   Boehm, E A ^d   Radda, G K ^a   Clarke, Kieran ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b BOSTON UNIVERSITY MEDICAL CENTER   (United States)

^c ASTRAZENECA   (United Kingdom)

^d UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

14C creatine; Creatine uptake; Extensor digitorum longus muscle; Insulin; Skeletal muscle; Sodium; Soleus muscle

Indexed keywords

CREATINE; INSULIN; SODIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATHLETE; BLOOD LEVEL; CONTROLLED STUDY; DIET SUPPLEMENTATION; EXTENSOR DIGITORUM LONGUS MUSCLE; ISOTOPE LABELING; MALE; MUSCLE METABOLISM; NONHUMAN; PHYSICAL PERFORMANCE; PRIORITY JOURNAL; RAT; SOLEUS MUSCLE;

ANIMALS; CARBON RADIOISOTOPES; CREATINE; GUANIDINES; INSULIN; MALE; MUSCLE, SKELETAL; PROPIONIC ACIDS; RATS; RATS, WISTAR; SODIUM;

EID: 0032971067     PISSN: 00016772     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-201x.1999.00539.x     Document Type: Article

References (23)

1. Balsom, P., Soderlund, K. & Ekblom, B. 1994. Creatine in humans with special reference to creatine supplementation. Sports Med 18, 268-280.
2. Bloch, K., Schoenheimer, R. & Rittenberg, D. 1941. Rate of formation and disappearance of body creatine in normal animals. J Biol Chem 138, 155-166.
3. Casey, A., Constantin-Teodosiu, D., Howell, S., Hultman, E. & Greenhaff, P. 1996a. Creatine ingestion favorably affects performance and muscle metabolism during maximal exercise in humans. Am J Physiol 271, E31-E37.
4. Casey, A., Constantin-Teodosiu, D., Howell, S., Hultman, E. & Greenhaff, P. 1996b. Metabolic response of type I and II muscle fibers during repeated bouts of maximal exercise in humans. Am J Physiol 271, E38-E43.
5. Conn, R. 1960. Fluorimetric determination of creatine. Clin Chem 6, 537-548.
6. Crettaz, M., Prentki, M., Zaninetti, D. & Jeanrenaud, B. 1980. Insulin resistance in soleus muscle from obese Zucker rats. Biochem J 186, 525-534.
7. Dimitriadis, G., Leighton, B., Parry-Billings, M. et al. 1997. Effects of glucocorticoid excess on the sensitivity of glucose uptake and metabolism to insulin in rat skeletal muscle. Biochem J 321, 707-712.
8. Fitch, C. & Rahmanian, M. 1969. Creatine entry into skeletal muscle of normal and of dystrophic mice. Proc Soc Exp Biol Med 131, 236-239.
9. Green, A., Hultman E., MacDonald, I., Sewell, D. & Greenhaff, P. 1996. Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans. Am J Physiol 271, E821-E826
10. Greenhaff, P. 1997. The nutritional biochemistry of creatine. Nutr Biochem 8, 610-618.
11. Guerrero-Ontiveros, M. & Wallimann, T. 1998. Creatine supplementation in health and disease. Effects of chronic creatine ingestion in vivo: Downregulation of the expression of creatine transporter isoforms in skeletal muscle. Mol Cell Biochem 184, 427-437.
12. +-dependent creatine transporter in rabbit brain, muscle, heart, and kidney. J Biol Chem 268, 8418-8421.
13. Harris, R., Soderlund, K. & Hultman, E. 1992. Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin Sci 83, 367-374.
14. Koszalka, T. & Andrew, C. 1972. Effect of insulin on the uptake of creatine-1-14C by skeletal muscle in normal and X-irradiated rats. Proc Soc Exp. Biol Med 139, 1265-1271.
15. Ku, C.-P. & Passow, H. 1980. Creatine and creatinine uptake in old and young human red blood cells. Biochim Biophys Acta 600, 212-227.
16. Leighton, B., Dimitriadis, G.D., Parry-Billings, M., Lozeman, F.J. & Newsholme, E.A. 1989. Effects of aging on the responsiveness and insulin sensitivity of glucose metabolism to insulin in the incubated soleus muscle isolated from Sprague-Dawley and Wistar rats. Biochem J 261, 383-387.
17. Loike, J., Somes, M. & Silverstein, S. 1986. Creatine uptake, metabolism, and efflux in human monocytes and macrophages. Am J Physiol 251, C128-C135.
18. Loike, J., Zalutsky, D., Kaback, E., Miranda, A. & Silverstein, S. 1988. Extracellular creatine regulates creatine uptake in rat and human muscle cells. Proc Natl Acad Sci USA 85, 807-811.
19. Moller, A. & Hamprecht, B. 1989. Creatine uptake in cultured cells of rat and mouse brain. J Neurochem 52, 544-550.
20. Saltarelli, M., Bauman, A., Moore K., Bradley C. & Blakely, R. 1996. Expression of the rat brain creatine transporter in situ and in transfected HeLa cells. Dev Neurosci 18, 524-534.
21. Syllm-Rapoport, I., Daniel, A. & Rapoport, S. 1980. Creatine uptake into red blood cells. Acta biol med germ 39, 771-779.
22. Tesch, P., Thorsson, A. & Fujitsuka, N. 1989. Creatine phosphate in fiber types of skeletal muscle before and after exhaustive exercise. J Appl Physiol 66, 1756-1759.
23. 31P NMR study. J Mol Cell Cardiol 29, A103.