Distribution of the lactate/H+ transporter isoforms MCT1 and MCT4 in human skeletal muscle

American Journal of Physiology - Endocrinology and Metabolism

Volumn 276, Issue 5 39-5, 1999, Pages

  Pilegaard, Henriette ^a   Terzis, Gerasimos ^a   Halestrap, Andrew ^b   Juel, Garsten ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Fiber type; Immunofluorescence microscopy; Monocarboxylate transporter; Western blotting

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; CARRIER PROTEIN;

ADULT; ARTICLE; CLINICAL ARTICLE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOFLUORESCENCE MICROSCOPY; MALE; MUSCLE CELL; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; SKELETAL MUSCLE; SOLEUS MUSCLE; TRICEPS BRACHII MUSCLE; VASTUS LATERALIS MUSCLE;

EID: 0032968185     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1999.276.5.e843     Document Type: Article

References (23)

1. Bonen, A., K. J. A. McCullagh, C. T. Putman, E. Hultman, N. L. Jones, and G. J. F. Heigenhauser. Short-term training increases human muscle MCT1 and femoral venous lactate in relation to muscle lactate. Am. J. Physiol. 274 (Endocrinol. Metab. 37): E102-E107, 1998.
2. Carpenter, L., R. C. Poole, and A. P. Halestrap. Cloning and sequencing of the monocarboxylate transporter from mouse Ehrlich Lettre tumour cell confirms its identity as MCT1 and demonstrates that glycosylation is not required for MCT1 function. Biochim. Biophys. Acta 1279: 157-163, 1996.
3. Delp, M. D., and C. Duan. Composition and size of type I, IIA, IID/X, and IIB fibers and citrate synthase activity of rat muscle. J. Appl. Physiol. 80: 261-270, 1996.
4. Fitts, R. H. Cellular mechanisms of muscle fatigue. Physiol. Rev. 74: 49-94, 1994.
5. Fry, A. C., C. A. Allmeier, and R. S. Staron. Correlation between percentage fiber type area and myosin heavy chain content in human skeletal muscle. Eur. J. Appl. Physiol. 68: 246-251, 1994.
6. Garcia, C. K., J. L. Goldstein, R. K. Pathak, R. G. W. Anderson, and M. S. Brown. Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle. Cell 76: 865-873, 1994.
7. Garcia, C. K., M. S. Brown, R. K. Pathak, and J. L. Goldstein. cDNA cloning of MCT2, a second monocarboxylate transporter expressed in different cells than MCT1. J. Biol. Chem. 270: 1843-1849, 1995.
8. Jackson, V. N., N. T. Price, and A. P. Halestrap. cDNA cloning of MCT1, a monocarboxylate transporter from rat skeletal muscle. Biochim. Biophys. Acta 1238: 193-196, 1995.
9. Jackson, V. N., N. T. Price, L. Carpenter, and A. P. Halestrap. Cloning of the monocarboxylate transporter isoform MCT2 from rat testis provides evidence that expression in tissues is species-specific and may involve post-transcriptional regulation. Biochem. J. 324: 447-453, 1997.
10. Juel, C. Regulation of cellular pH in skeletal muscle fiber types, studied with sarcolemmal giant vesicles obtained from rat muscles. Biochim. Biophys. Acta 1265: 127-132, 1995.
11. Juel, C. Lactate-proton cotransport in skeletal muscle. Physiol. Rev. 77: 321-358, 1997.
12. McCullagh., J. A., R. C. Poole, A. P. Halestrap, M. O'Brien, and A. Bonen. Role of the lactate transporter (MCT1) in skeletal muscle. Am. J. Physiol. 271 (Endocrinol. Metab. 34): E143-E150, 1996.
13. Pette, D., and R. S. Staron. Cellular and molecular diversities of mammalian skeletal muscle fibers. Rev. Physiol. Biochem. Pharmacol. 116: 1-76, 1990.
14. Philp, N. J., H. Yoon, and E. F. Grollman. Monocarboxylate transporter MCT1 is located in the apical membrane and MCT3 in the basal membrane of rat RPE. Am. J. Physiol. 274 (Regulatory Integrative Comp. Physiol. 43): R1824-R1828, 1998.
15. Pilegaard, H., J. Bangsbo, E. A. Richter, and C. Juel. Lactate transport studied in sarcolemmal giant vesicles from human muscle biopsies: relation to training status. J. Appl. Physiol. 77: 1858-1862, 1994.
16. + transport in human skeletal muscle. Am. J. Physiol. 276 (Endocrinol. Metab. 39): E255-E261, 1999.
17. Poole, R. C., and A. P. Halestrap. Transport of lactate and other monocarboxylates across mammalian plasma membranes. Am. J. Physiol. 264 (Cell Physiol. 33): C761-C782, 1993.
18. +/lactate cotransporter (MCT1). Biochem. J. 320: 817-824, 1996.
19. Price, N. T., V. N. Jackson, and A. P. Halestrap. Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. Biochem. J. 329: 321-328, 1998.
20. Saltin, B., and P. D. Gollnick. Skeletal muscle adaptability: significance for metabolism and performance. In: Handbook of Physiology. Skeletal Muscle. Bethesda, MD: Am. Physiol. Soc., 1983, sect. 10, chapt. 19, p. 555-631.
21. Smerdu, V., I. Karch-Mizrachi, M. Campoine, L. A. Leinwand, and S. Schiaffino. Type IIx myosin heavy chain transcripts are expressed in type IIb fibers in human skeletal muscle. Am. J. Physiol. 267 (Cell Physiol. 36): C1723-C1728, 1994.
22. Wilson, M. C., V. N. Jackson, C. Heddle, N. T. Price, H. Pilegaard, C. Juel, A. Bonen, I. Montgomery, O. F. Hutter, and A. P. Halestrap. Lactic acid efflux from white skeletal muscle is catalyzed by the monocarboxylate transporter isoform MCT3. J. Biol. Chem. 273: 15920-15926, 1998.
23. Yoon, H., A. Fanelli, E. F. Grollman, and N. J. Philp. Identification of a unique monocarboxylate transporter (MCT3) in retinal pigment epithelium. Biochem. Biophys. Res. Commun. 234: 90-94, 1997.