Creatine supplementation in health and disease. Effects of chronic creatine ingestion in vivo: Down-regulation of the expression of creatine transporter isoforms in skeletal muscle

Molecular and Cellular Biochemistry

Volumn 184, Issue 1-2, 1998, Pages 427-437

  Guerrero Ontiveros, Maria Lourdes ^a   Wallimann, Theo ^a  

^a ETH ZURICH   (Switzerland)

Author keywords

Bioenergetics; Creatine kinase; Creatine metabolism; Creatine supplementation; Creatine transporter; Creatine transporter isoenzymes; Differential splicing; Muscle diseases; Phosphocreatine

Indexed keywords

CARRIER PROTEIN; CREATINE; RNA;

ADJUVANT THERAPY; ALTERNATIVE RNA SPLICING; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; ENERGY METABOLISM; HOMEOSTASIS; HUMAN; NEUROMUSCULAR DISEASE; NONHUMAN; RAT; SKELETAL MUSCLE;

ANIMALIA;

EID: 0031656529     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1007/978-1-4615-5653-4_30     Document Type: Article

References (95)

1. Hunter A: Monographs on biochemistry: Creatine and creatinine. Longmans, Green and Co., 1928
2. Walker JB: Creatine: Biosynthesis, regulation and function. In: Advances in Enzymology and related areas of Molecular Biology, Vol. 50. John Wiley and Sons, 1979, pp 177-241
3. Maughan RJ: Creatine supplementation and exercise performance. Int J Sport Nut 5: 94-101, 1995
4. Fitch CD, Shields RP, Payne WF, Dacus JM: Creatine metabolism in skeletal muscle. Specificity of the creatine entry process. J Biol Chem 243: 2024-2027, 1968
5. Borsook H, Dubnoff JW: The hydrolysis of phosphocreatine and the origin of urinary creatinine. J Biol Chem 168: 493-510, 1947
6. Fitch CD, Shields RP: Creatine metabolism in skeletal muscle. Creatine movement across muscle membranes. J Biol Chem 241: 3611-3614, 1966
7. Harris RC, Viru M, Greenhaff PL, Hultman E: The effect of oral creatine supplementation on running performance during maximal short term exercise in man. J Physiol 467: 74P, 1993
8. Wallimann T, Wyss M, Brdiczka D, Nicolay K, Eppenberger HM: Significance of intracellular compartmentation, structure and function of creatine kinase isoenzymes for cellular energy homeostasis: 'The Phospho-Creatine Circuit'. Biochem J 281: 21-40, 1992
9. Wyss M, Smeitnik J, Wevers RA, WallimannT: Mitochondrial creatine kinase: A key enzyme of aerobic energy metabolism. Biochim Biophys Acta 1102: 119-166, 1992
10. Daly MM, Seifter S: Uptake of creatine by cultured cells. Arch Biochem Biophys 203: 317-324, 1980
11. Ku CP, Passow H: Creatine and creatinine transport in old and young human red blood cells. Biochim Biophys Acta 600: 212-227, 1980
12. Lolke JD, Somes M, Silverstein SC: Creatine uptake, metabolism, and efflux in human monocytes and macrophages. Am J Physiol 251: C128-C135, 1986
13. Möller A, Hamprecht B: Creatine transport in cultured cells of rat and mouse brain. J Neurochem 52: 544-550, 1989
14. Mayser W, Schloss P, Betz H: Primary structure and functional expression of a choline transporter expressed in the rat nervous system. FEBS Lett 305: 31-36, 1992
15. +-dependent creatine transporter in rabbit brain, muscle, heart, and kidney. J Biol Chem 268: 8418-8421, 1993
16. Nash SR, Giros B, Kingsmore SF, Rochelle JM, Suter ST, Gregor P, Seldin MF, Caron MG: Cloning, pharmacological characterization, and genomic localization of the human creatine transporter. Recep Channels 2: 165-174, 1994
17. Schloss P, Mayser W, Betz H: The putative rat choline transporter CHOT1 transports creatine and is highly expressed in neural and muscle-rich tissues. Biochem Biophys Res Comm 198: 637-645, 1994
18. Schloss P, Püschel AW, Betz H: Neurotransmitter transporters: New members of known families. Curr Op Cell Biol 6: 595-599, 1994
19. Sora I, Richman J, Santoro G.Wei H, Wang Y, Vanderah T, Horvath R, Nguyen M, Waite S, Roeske WR, Yamamura HI: The cloning and expression of a human creatine transporter. Biochem Biophys Res Commun 204: 419-427, 1994
20. Saltarelli MD, Bauman AL, Moore KR, Bradley CC, Blakely RD: Expression of the rat brain creatine transporter in situ and in transfected HeLa cells. Develop Neurosci 18: 524-534, 1996
21. Wallimann T, Hemmer W: Creatine kinase in non-muscle tissues and cells. Mol Cell Biochem 133/134: 193-220, 1994
22. Gregor P, Nash SR, Caron MG, Seldin MF, Warren ST: Assignment of the creatine transporter gene (SLC6A8) to human chromosome Xq28 telomeric to G6PD. Genomics 25: 332-333, 1995
23. Iyer GS, Krahe R, Goodwin LA, Doggett NA, Siciliano MJ, Funanage VL, Proujansky R: Identification of a testis-expressed creatine transporter gene at 16p11.2 and confirmation of the linked locus to Xq28. Genomics 34: 143-146, 1996
24. Emery AK: X-linked muscular dystrophy with early contractures and cardiomyopathy (Emery-Dreifuss type). Clin Gen 32: 360-367, 1987
25. Conzalez GG, Thomas NS, Stayton NS, Knight SJ, Johnson M, Hopkins LC, Harper PS, Elsas LJ, Warren ST: Assignment of Emery-Dreifuss muscular dystrophy to the distal region of Xq28: The results of a collaborative study. Am J Hum Genet 48: 468-480, 1991
26. Ades LC, Gedeon AK, Wilson MJ, Latham M, Partington MW, Mulley JC, Nelson J, Lui K, Sillence DO: Barth syndrome: Clinical features and confirmation of gene localization to distal Xq28. Am J Med Genet 45: 327-334, 1993
27. Bolhuis PA, Hensels GW, Hulsebos TJM, Baas F, Barth PG: Mapping of the locus for X-linked cardioskeletal myopathy with neutropenia and abnormal mitochondria (Barth syndrome) to Xq28. Am J Hum Genet 48: 481-485, 1991
28. Gedeon AK, Wilson MJ, Colley AC, Sillence DO, Mulley JC: X-linked fatal infantile cardiomyopathy maps to Xq28 and is possibly allelic to Barth Syndrome. J Med Genet 32: 383-388, 1995
29. Thomas NST, Williams H, Cole G, Roberts K, Clarke A, Liechti-Gallati S, Braga S, Gerber A, Meier C, Moser H, Harper PS: X-linked neonatal centronuclear/myotubular myopathy: Evidence for linkage to Xq28 DNA marker loci. J Med Genet 27: 284-287, 1990
30. Loike JD, Zalutsky DL, Kaback E, Miranda AF, Silverstein SC: Extracellular creatine regulates creatine transport in rat and human muscle cells. Proc Natl Acad Sci USA 85: 807-811, 1988
31. Harris RC, Söderlund K, Hultman E: Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin Sci 83: 367-374, 1992
32. Gulmbal C, Kilimann MW: A creatine transporter cDNA from Torpedo illustrates structure/function relationships in the GABA/Noradrenaline transporter family. J Mol Biol 241: 317-324, 1994
33. Delanghe J, De Slypere JP, De Buyzere M, Robbrecht J, Wieme R, Vermeulen A: Normal reference values for creatine, creatinine, and carnitine are lower in vegetarians. Clin Chem 35: 1802-1803, 1989
34. Balsom PD, Söderlund K, Ekblom B: Creatine in humans with special reference to creatine supplementation. Sports Med 18: 268-280, 1994
35. +-pump in apically permeabilized A6 kidney cell epithelia: Role of creatine kinase. Am J Physiol 272: C697-C706, 1997
36. Walker JB: Metabolic control of creatine biosynthesis. I. Effect of dietary creatine. J Biol Chem 235: 2357-2361, 1960
37. Odoom JE, Kemp GJ, Radda GK: The regulation of total creatine content in a myoblast cell line. Mol Cell Biochem 158: 179-188, 1996
38. Balsom PD, Ekblom B, Söderlund K, Sjödin B, Hultman E: Creatine supplementation and dynamic high-intensity intermittent exercise. Scand J Med Sci Sports 3: 143-149, 1993
39. Birch R, Noble D, Greenhaff PL: The influence of dietary creatine supplementation on performance during repeated bouts of maximal isokinetic cycling in man. J Appl Physiol 69: 268-270, 1994
40. Earnest CP, Snell PG, Rodriguez R, Almada AL: The effect of creatine monohydrate ingestion on anaerobic power indices, muscular strength and body composition. Acta Physiol Scand 153: 207-209, 1995
41. Greenhaff PL, Casey A, Short AH, Harris R, Söderlund K, Hultman E: Influence of oral creatine supplementation of muscle torque during repeated bouts of maximal voluntary exercise in man. Clin Sci 84: 565-571, 1993
42. Casey A, Constantin-Teodosiu D, Howell S, Hultman E, Greenhaff PL: Creatine ingestion favorably affects performance and muscle metabolism during maximal exercise in humans. Am Physiol Soc 271: E31-E37, 1996
43. 14C by skeletal muscle in normal and X-irradiated rats. Proc Soc Exp Biol Med 139: 1265-1271, 1972
44. Haughland RB, Chang DT: Insulin effect on creatine transport in skeletal muscle. Proc Soc Exp Biol Med 148: 1-4, 1975
45. Green AL, Hultman E, Macdonald IA, Sewell DA, Greenhaff PL: Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in man. Am J Physiol 271: E821-E826, 1996
46. Clausen T, Flatman JA: The effect of catecholamines on Na-K transport and membrane potential in rat soleus muscle. J Physiol 270: 383-414, 1977
47. + transport in skeletal muscle. Physiol Rev 66: 542-580, 1986
48. Vandenberghe K, Gillis N, Van Leemputte M, Van Hecke P, Vanstapel F, Hespel P: Caffeine counteracts the ergogenic action of muscle creatine loading. J Appl Physiol 80: 452-457, 1996
49. Söderlund K, Balsom PD, Ekblom B: Creatine supplementation and high intensity exercise: Influence on performance and muscle metabolism. Clin Sci 87(suppl): 120-121, 1994
50. Greenhaff PL: Kreatin: Seine Rolle in Bezug auf die körperliche Leistungsfähigkeit sowie Ermüdung; seine Anwendung als ein Sporternäahrungs-Supplement. In: F Browns, S Stromme, C Wenk, C Williams (eds). Insider, News on Sport Nutrition, Isostar Sport Nutrition Foundation 3: 1-4, 1995
51. Dawson B, Cutler M, Moody A, Lawrence S, Goodman C, Randall N: Effects of oral creatine loading on single and repeated maximal short sprints. Aus J Sci Med Sport 27: 56-61, 1995
52. Hultman E, Söderlund K, Timmons JA, Cederblad G, Greenhaff PL: Muscle creatine loading in men. J Appl Physiol 81: 232-237, 1996
53. Brönnimann M: Spitzenleistungenohne "sauer" zu werden? Move 6: 5-6, 1995
54. O'Gorman E, Beutner G, WallimannT, Brdiczka D: Differential effects of creatine depletion on the regulation of enzyme activities and on creatine-stimulated mitochondrial respiration in skeletal muscle, heart, and brain. Biochim Biophys Acta 1276: 161-170, 1996
55. Chanutin A: The fate of creatine when administered to man. J Biol Chem 67: 29-37, 1926
56. 31P-NMR magnetization transfer study of the isolated ferret heart. Circ Res 63: 1-15, 1988
57. Whittingham TS, Lipton P: Cerebral synaptic transmission during anoxia is protected by creatine. J Neurochem 37: 1618-1621, 1981
58. Carter AJ, Müller RE, Pschom U, Stransky W: Preincubation with creatine enhances levels of creatine phosphate and prevents anoxic damage in rat hippocampal slices. J Neurochem 64: 2691-2699, 1995
59. Stöckler S, Holzbach U, Hanefeld F, Marquardt I, Helms G, Requart M, HänickeW, F rahm J: Creatine deficiency in the brain: A new, treatable inborn error of metabolism. Pediatric Res 36: 409-413, 1994
60. Liao R, Nascimben L, Friedrich J, Gwathmey JK, Ingwall JS: Decreased energy reserve in an animal model of dilated cardiomyopathy. Relationship to contractile performance. Circ Res 78: 893-902, 1996
61. Ciafaloni E, Ricci E, Shanske S: MELAS: Clinical features, biochemistry, and molecular genetics. Ann Neurol 31: 391-398, 1992
62. Hagenfeldt L, von Döbeln U, Solders G, Kaijser L: Creatine treatment in MELAS. Muscle Nerve 17: 1236, 1994
63. StadhoudersAM, Jap PHK, Winkler HP, Eppenberger HM, Wallimann T: Mitochondrial creatine kinase: A major constituent of pathological inclusions seen in mitochondrial myopathies. Proc Natl Acad Sci USA 91: 5089-5093, 1994
64. Eppenberger-Eberhardt M, Riesinger I, Messerli M, Schwarb P, Müller M, Eppenberger HM, WallimannT: Adult rat cardiomyocytes cultured in creatine-deficient medium display large mitochondria with paracrystalline inclusions, enriched for creatine kinase. J Cell Biol 113: 289-302, 1991
65. Sipilä I, Simell O, Rapola J, Sainio K, Tuuteri L: Gyrate atrophy of the choroid and retina with hyperornithonemia: Tubular aggregates and type 2 fiber atrophy in muscle. Neurology 29: 996-1005, 1979
66. Sipilä I, Valle D, Brusilow S: Low guanidinoacetic acid and creatine concentrations in gyrate atrophy of the choroid and retina (GA). In: PP De Deyn, B Marescau, V Stalon, IA Qureshi (eds). Guanidino Compounds in Biology and Medicine, Vol. John Libbey and Company Ltd., 1992, pp 379-383
67. Trijbels JMF, Sengers RC A, Bakkeren JAJM, De Kort AFM, Deutman AF: L-ornithine-ketoacid transaminase deficiency in cultured fibroblasts of a patient with hyperomithinemia and gyrate atrophy of the choroid and retina. Clin Chim Acta 79: 371-377, 1977
68. Shih VE, Berson EL, Mandell R, Schmidt SY: Ornithine ketoacid transaminase deficiency in gyrate atrophy of the choroid and retina. Am J Hum Genet 30: 174-179, 1978
69. Sipilä I, Simell O, Arjomaa P: Gyrate atrophy of the chorid and retina with hyperomithinemia. J Clin Invest 66: 684-687, 1980
70. Sipilä I, Rapola J, Simell O, Vannas A: Supplementary creatine as a treatment for gyrate atrophy of the choroid and retina. New Engl J Med 304: 867-870, 1981
71. Bigge T: Mein Selbstversuch mit Kreatin-Monohydrat. Deutscher Muskelreport 3: 23-25, 1996
72. Kass I, Lipton P: Mechanisms involved in irreversible anoxic damage to the in vitro rat hippocampal slice. J Physiol 332: 459-472, 1982
73. Conway MA, Clark JF: Biochemical basis for a therapeutic role of creatine and creatine phosphate. In: Creatine and Creatine Phosphate: Scientific and Clinical Perspectives. Harcourt Brace and Company, Publishers, London, 1996, pp91-123
74. 2-terminus of the low density lipoprotein receptor in the plasma membrane of fibroblasts. J Biol Chem 97: 1635-1640, 1983
75. Bradford M: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254, 1976
76. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685, 1970
77. Schneppenheim R, Budde U, Dahlmann N, Rautenberg P: Luminography - a new, highly sensitive visualization method for electrophoresis. Electrophoresis 12: 367-372, 1991
78. Rowley GL, Greenleaf AL, Kenyon GL: On the specificity of creatine kinase. New glycocyamines and glycocyamine analogs related to creatine. J Am Chem Soc 93: 5542-5551, 1971
79. Gonzalez AM, Uhl GR: 'Choline/orphan V8-2-1/creatine transporter' mRNA is expressed in nervous, renal and gastrointestinal systems. Mol Brain Res 23: 266-270, 1994
80. Barnwell LF, Chaudhuri G, Townsel JG: Cloning and sequencing of a cDNA encoding a novel member of the human brain GABA/noradrenaline neurotransmitter transporter family. Gene 159: 287-288, 1995
81. Garber AT, Winkfein RJ, Dixon GH: A novel creatine kinase cDNA whose transcript shows enhanced testicular expression. Biochim Biophys Acta 1087: 256-258, 1990
82. Saudrais C, Garber AT, McKay DJ, Dixon GH, Loir M: Creatine kinase in trout male germ cells - purification, gene expression, and localization in the testis. Mol Reprod Dev 44: 433-442, 1996
83. Kaldis P, Kamp G, Piendl T, Wallimann T: Functions of creatine kinase isoenzymes in spermatozoa. Adv Devel Biochem 5: 275-312, 1997
84. Wyss M, Wallimann T: Creatine metabolism and the consequences of creatine depletion in muscle. Mol Cell Biochem 133/134: 51-66, 1994
85. O'Gorman E, Fuchs KH, Tittmann P, Gross H, WallimannT: Crystalline mitochondrial inclusion bodies isolated from creatine depleted rat soleus muscle. J Cell Sci 110: 1403-1411, 1997
86. O'Gorman E, Piendl T, Müller M, Brdiczka D, Wallimann T: Mitochondrial intermembrane inclusion bodies: The common denominator between human mitochondrial myopathies and creatine depletion, due to impairment of cellular energetics. Mol Cell Biochem 174: 283-289, 1997
87. Wallimann T: Einnahme von Kreatin als moegliche Hilfstherapie filer Patienten mit verschiedenen neuromuskulaeren Erkrankungen. Mitteilungsblatt der Schweizerischen Gesellschaft fuer Muskelkranke 41: 6-9, 1997
88. Broennimann M, WallimannT: Kreatin: Durchbruch in der Behandlung neuromuskulaerer Krankheiten. Mitteilungsblatt der Schweizerischen Gesellschaft fuer Muskelkranke 41: 3-11, 1997
89. Hanefeld F, Hobbiebrunken E: Kreatin zur Verbesserung von Kraft und Ausdauer bei Muskelkranken. Deutscher Muskelreport 4: 10-11, 1996
90. Kekelidze TN, Hermes R, Goodwyn D, Blakely RD, Saltarelli MD: Analysis of creatine transporter expression in rat brain and cell lines using specific polyclonal antisera. Soc Neurosci 23 (Abstr.): 586.15, 1997
91. Matthews RT, Yang L, Jenkins BG, Ferrante RJ, Rosen BR, KaddurahDaouk R, Beal MF: Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease. J Neurosci 18: 156-163, 1998
92. Wilken B, Ramirez JM, Hanefeld F, Richter DW: Supplementary creatine enhances hypoxic augmentation in vivo by preventing ATP depletion. Soc Neurosci 23 (Abstr.): 171.23, 1997
93. Holtzman D, Meyers R, O'Gorman E, Khait I, Wallimann T, Alfred E, Jensen F: In vivo brain phosphocreatine and ATP regulation in mice fed a creatine analog. Am J Physiol 272: C1567-C1577, 1997
94. O'Gorman E, Beutner G, Dolder M, Koretsky A, Bridczka D, Wallimann T: The role of creatine kinase in inhibition of mitochondrial permeability transition. FEBS Lett 414: 253-257, 1997
95. Greenhaff PL: The nutritional biochemistry of creatine. Nutr Biochem 8: 610-618, 1997