Role of the lactate transporter (MCT1) in skeletal muscles

American Journal of Physiology

Volumn 271, Issue 1 PART 1, 1996, Pages

  McCullagh, Karl J A ^a,c   Poole, Robert C ^a,b   Halestrap, Andrew P ^a,c   O'Brien, Moira ^a,b   Bonen, Arend ^a,c  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c UNIVERSITY OF WATERLOO   (Canada)

Author keywords

Citrate synthase; Hindlimb perfusion; Lactate dehydrogenase activity; Lactate dehydrogenase isozymes; Monocarboxylate transporter

Indexed keywords

EID: 33745340298     PISSN: 00029513     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Allen, P. J., and G. A. Brooks. Partial purification and reconstitution of the sarcolemmal lactate carrier from rat skeletal muscle. Biochem. J. 303: 207-212,1994.
2. Bonen, A., C. J. Campbell, R. L. Kirby, and A. N. Beicastro. A multiple regression model for blood lactate removal in man. Pflueg. Arch. Eur. J. Physiol. 380: 205-210,1979.
3. Bonen, A., G. C. B. Elder, and M. H. Tan. Hindlimb suspension increases insulin binding and glucose metabolism. J. Appl. Physiol. 65: 1833-1839,1988.
4. Bonen, A., and D. Homonko. Effects of exercise and glycogen depletion on glyconeogenesis in muscle. J. Appl. Physiol. 76: 1753-1758,1994.
5. Bonen, A., and K. J. A. McCullagh. Effects of exercise on lactate transport into mouse skeletal muscles. Can. J. Appl. Physiol. 19: 275-285, 1994.
6. Bonen, A., J. C. McDermott, and M. H. Tan. Glycogenesis and glyconeogenesis in skeletal muscle: effects of pH and hormones. Am. J. Physiol. 258 (Endocrinol. Metab. 21): E693-E700,1990.
7. Carpenter, L., R. C. Poole, and A. P. Halestrap. Cloning and sequencing of the monocarboxylate transporter from mouse Ehrlich-Lettre tumour cells confirms its identity as MCT1 and demonstrates that glycosylation is not required for MCT1 function. Biochim. Biophys. Acta 1279:157-163,1996.
8. Caster, W. O., J. Poncelet, A. B. Simon, and W. D. Armstrong. Tissue weights of the rat. I. Normal values determined by dissection and chemical methods. Proc. Soc. Exp. Biol. Med. 91: 122-126,1956.
9. Chi, M. M.-Y., C. S. Hintz, E. F. Coyle, W. H. Martin, J. L. Ivy, P. M. Nemeth, J. O. Holloszy, and O. H. Lowry. Effects of detraining on enzymes of energy metabolism in individual human muscle fibers. Am. J. Physiol. 244 (Cell Physiol. 13): C276-C287,1983.
10. Garcia, C. K., M. S. Brown, R. K. Pathak, and J. L. Goldstein. cDNA cloning of MCT2, a second monocarboxylate transporter expressed in different cells than MCT1. J. Biol. Chem. 270:1843-1849,1995.
11. Garcia, C. K., J. L. Goldstein, R. K. Pathak, G. W. Anderson, and M. S. Brown. Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle. Cell 76: 865-873,1994.
12. Han, X.-X., T. Ploug, and H. Galbo. Effect of diet on insulinand contraction-mediated glucose transport and uptake in rat muscle. Am. J. Physiol. 269 (Regulatory Integrative Comp. Physiol. 38): R544-R551,1995.
13. Jorfeldt, L. Metabolism of L(+)-lactate in human skeletal muscle during exercise. Acta Physiol. Scared. Suppl. 338: 1-72, 1970.
14. Juel, C. Muscle lactate transport studied in sarcolemmal giant vesicles. Biochim. Biophys. Acta 1065:15-20,1991.
15. Juel, C., A. Honig, and H. Pilegaard. Muscle lactate transport studied in sarcolemmal giant vesicles: dependence on fiber type and age. Acta Physiol Scand. 143: 361-365,1991.
16. Lowry, O. H., and J. V. Passonneau. A Flexible System of Enzymatic Analysis. New York: Academic, 1972.
17. McCullagh, K. J. A., and A. Bonen. Reduced lactate transport in denervated rat skeletal muscle. Am. J. Physiol. 268 (Regulatory Integrative Comp. Physiol. 37): R884-R888,1995.
18. McCullagh, K. J. A., and A. Bonen. L(+)-Lactate binding to a protein in rat skeletal muscle plasma membranes. Can. J. Appl. Physiol 20:112-124,1995.
19. McCullagh, K. J. A., C. Juel, M. O'Brien, and A. Bonen. Chronic muscle stimulation increases lactate transport in rat skeletal muscle. Mol. Cell. Biochem. 156: 51-57,1996.
20. McDermott, J. C., and A. Bonen. Endurance training increases skeletal muscle lactate transport. Acta Physiol. Scand. 147: 323-327,1993.
21. McDermott, J. C., and A. Bonen. Lactate transport by skeletal muscle sarcolemmal vesicles. Mol. Cell. Biochem. 122: 113-121, 1993.
22. McDermott, J. C., and A. Bonen. Lactate transport in rat sarcolemmal vesicles and intact skeletal muscle, and after muscle contraction. Acta Physiol. Scand. 151:17-28,1994.
23. Megeney, L. A., P. D. Neufer, G. L. Dohm, M. H. Tan, C. A. Blewett, G. C. B. Elder, and A. Bonen. Effects of muscle activity and fiber composition on glucose transport and GLUT4. Am, J. Physiol. 264 (Endocrinol. Metab. 27): E583-E593,1993.
24. Pagliassotti, M. J., and C. J. Donovan. Role of cell type in net lactate removal by skeletal muscle. Am. J. Physiol. 258 (Endocrinol. Metab. 21): E635-E642,1990.
25. Pearse, A. G. E. Histochemistry, Theoretical and Applied. London: Churchill Livingstone, 1972.
26. Pilegaard, H., C. Juel, and F. Wibrand. Lactate transport studied in sarcolemmal giant vesicles from rats: effects of training. Am. J. Physiol. 264 (Endocrinol. Metab. 27): E156-E160, 1993.
27. Poole, R. C., and A. P. Halestrap. Reconstitution of the L-lactate carrier from rat and rabbit erythrocyte plasma membranes. Biochem. J. 254: 385-390,1988.
28. Poole, R. C., and A. P. Halestrap. Inhibition and labelling of the erythrocyte lactate transporter by stilbene disulphonates. Biochem. Soc. Trans. 18: 1245-1246,1990.
29. Poole, R. C., and A. P. Halestrap. Identification and purification of the erythrocyte lactate transporter. Biochem. J. 283: 855-862,1992.
30. Poole, R. C., and A. P. Halestrap. Transport of lactate and other monocarboxylates across mammalian plasma membranes. Am. J. Physiol. 264 (Cell Physiol. 33): C761-C782,1993.
31. Poole, R. C., and A, P. Halestrap. N-terminal protein sequence analysis of the rabbit erythrocyte lactate transporter suggests identity with the cloned monocarboxylate transport protein MCT1. Biochem. J. 303: 755-759,1994.
32. Wang, X., A. J. Levi, and A. P. Halestrap. Kinetics of the sarcolemmal lactate carrier in single heart cells using BCECF to measure pH;. Am. J. Physiol. 267 (Heart Circ. Physiol. 36): H1759-H1769,1994.
33. Wibrand, F., and C. Juel. Reconstitution of the lactate carrier from rat skeletal muscle sarcolemma. Biochem. J. 299: 533-537, 1994.